Artificial Intelligence Prediction Research Articles

Histomolecular classification of urothelial carcinoma of the urinary bladder : From histological phenotype to genotype and back

Of all urothelial carcinomas (UCs), 25% are muscle invasive and associated with a5-year overall survival rate of 50%. Findings regarding the molecular classification of muscle-invasive urothelial carcinomas (MIUCs) have not yet found their way into clinical practice. Prediction of molecular consensus subtypes in MIUCs with artificial intelligence (AI) based on histologic hematoxylin-eosin (HE) sections. Pathologic review and annotation of The Cancer Genome Atlas (TCGA) Bladder Cancer (BLCA) Cohort (N = 412) and the Dr. Senckenberg Institute of Pathology (SIP) BLCA Cohort (N = 181). An AI model for the prediction of molecular subtypes based on annotated histomorphology was trained. For afive-fold cross-validation with TCGA cases (N = 274), an internal TCGA test set (N = 18) and an external SIP test set (N = 27), we reached mean area under the receiver operating characteristic curve (AUROC) scores of 0.73, 0.8 and 0.75 for the classification of the used molecular subtypes "luminal", "basal/squamous" and "stroma-rich". By training on correlations to individual molecular subtypes, rather than training on one subtype assignment per case, the AI prediction of subtypes could be significantly improved. Follow-up studies with RNA extraction from various areas of AI-predicted molecular heterogeneity may improve molecular classifications and thereby AI algorithms trained on these classifications.

How can the Pearl River Delta urban agglomeration achieve the carbon peak target: Based on the perspective of an optimal stable economic growth path

The Pearl River Delta (PRD) has high concentrations of energy consumption and carbon emissions, and the conflict between its economic development and environmental protection is relatively prominent. Beginning from the ideal path of economic growth, this study proposes a framework for carbon emission prediction under the optimal economic growth path of the PRD via the cross-analysis of low-carbon economic analysis and artificial intelligence prediction. First, the generalized Divisia index method (GDIM) is used to decompose carbon emissions to quantify the contribution rate of each influencing factor. Then, the genetic algorithm (GA) is introduced to optimize the backpropagation (BP) neural network to construct a GA-BP combined prediction model. Finally, the optimal economic growth rate models under different scenarios are constructed, and the carbon peak in the PRD under stable economic growth is accurately predicted. The results show that under the optimal economic growth path, the carbon peak in the PRD under the scenario with carbon constraints will be reached in 2029, while that under the scenario without carbon constraints will only begin to appear around 2035. Thus, the achievement of the carbon peak target in the PRD still requires insisting on stringent carbon emission reduction measures.

Machine learning assisted rational design of antimicrobial peptides based on human endogenous proteins and their applications for cosmetic preservative system optimization

Preservatives are essential components in cosmetic products, but their safety issues have attracted widespread attention. There is an urgent need for safe and effective alternatives. Antimicrobial peptides (AMPs) are part of the innate immune system and have potent antimicrobial properties. Using machine learning-assisted rational design, we obtained a novel antibacterial peptide, IK-16-1, with significant antibacterial activity and maintaining safety based on β-defensins. IK-16-1 has broad-spectrum antimicrobial properties against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans, and has no haemolytic activity. The use of IK-16-1 holds promise in the cosmetics industry, since it can serve as a preservative synergist to reduce the amount of other preservatives in cosmetics. This study verified the feasibility of combining computational design with artificial intelligence prediction to design AMPs, achieving rapid screening and reducing development costs.

Evaluating the clinical utility of artificial intelligence assistance and its explanation on the glioma grading task

Clinical evaluation evidence and model explainability are key gatekeepers to ensure the safe, accountable, and effective use of artificial intelligence (AI) in clinical settings. We conducted a clinical user-centered evaluation with 35 neurosurgeons to assess the utility of AI assistance and its explanation on the glioma grading task. Each participant read 25 brain MRI scans of patients with gliomas, and gave their judgment on the glioma grading without and with the assistance of AI prediction and explanation. The AI model was trained on the BraTS dataset with 88.0% accuracy. The AI explanation was generated using the explainable AI algorithm of SmoothGrad, which was selected from 16 algorithms based on the criterion of being truthful to the AI decision process. Results showed that compared to the average accuracy of 82.5±8.7% when physicians performed the task alone, physicians’ task performance increased to 87.7±7.3% with statistical significance (p-value = 0.002) when assisted by AI prediction, and remained at almost the same level of 88.5±7.0% (p-value = 0.35) with the additional assistance of AI explanation. Based on quantitative and qualitative results, the observed improvement in physicians’ task performance assisted by AI prediction was mainly because physicians’ decision patterns converged to be similar to AI, as physicians only switched their decisions when disagreeing with AI. The insignificant change in physicians’ performance with the additional assistance of AI explanation was because the AI explanations did not provide explicit reasons, contexts, or descriptions of clinical features to help doctors discern potentially incorrect AI predictions. The evaluation showed the clinical utility of AI to assist physicians on the glioma grading task, and identified the limitations and clinical usage gaps of existing explainable AI techniques for future improvement.

The Use of Artificial Intelligence in Third Molar Surgery Risk Assessment

Third molar removal complication rates can be as high as 30%. Risk assessment tools may lower these rates. Artificial intelligence (AI) driven prediction models are a promising approach to predict possible unfavourable outcomes and cone beam computed tomography imaging may play an important role. AI prediction models are showing excellent results in research settings. To be implemented in clinical practice they will need to overcome some robustness, security, liability, and practical issues. If they do, AI prediction models can be integrated in electronic patient record systems by alerting clinicians in case of an imminent unfavourable outcome so it can be avoided. CPD/Clinical Relevance: Artificial intelligence-driven risk assessment tools will lower complications in third molar surgery.

Impact of Using Predictive Artificial Intelligence on Contract Duration

In a constantly changingbusiness environment, the integration of artificial intelligence (AI) is becoming a fundamental direction in achieving increased revenues and sales volumes for companies. AI and its various applications contribute to identifying patterns in consumer choices, which at the same time contributes to the more effective formation of marketing and sales strategies of companies. Predictive AI (AI), which uses algorithms and data analytics to predict future trends and behavior, is now widely developed, enabling companies to make informed decisions, and overcome competitive challenges.The accuracy and reliability of forecasts depend on the quality of the data that enters the system.Thus, understanding the importance of data quality is vital for organizations seeking to take advantage of the broad capabilities of PAI. The analysis of literary sources makes it possible to conclude that the implementation of AI algorithms in the work of marketing departments of companies is developing widely.At the same time, most of the known studies focus on marketing data. An important indicator when agreeing with a company and a client is the length of the period from the qualification of a potential buyer to the first real order.Such data in open sources is not enough. This research aims to analyze the impact of the use of PAI on the duration of the period of transition from the qualification of a potential client to his conversion, that is, on the duration of the conclusion of the agreement. A study of the impact of PAI on the duration of deals showed an increase in the time for successful deals by 59.5% and an increase in the time to process losing deals by 62.3%.The correct implementation and use of forecasts and PAI effectively affect various indicators of commercial departments, including the length of the transition period from the qualification of a potential client to his conversion.Thanks to the use of PAI, the commercial department processes new inquiries and contracts much faster, and accordingly has more time to work with potential, new, and existing customers. The results of the analysis of PAI opportunities and its role in shaping the future of business are useful for ensuring its stable growth and success.

Harnessing the power of artificial intelligence in predicting all-cause mortality in transcatheter aortic valve replacement: a systematic review and meta-analysis.

In recent years, the use of artificial intelligence (AI) models to generate individualised risk assessments and predict patient outcomes post-Transcatheter Aortic Valve Implantation (TAVI) has been a topic of increasing relevance in literature. This study aims to evaluate the predictive accuracy of AI algorithms in forecasting post-TAVI mortality as compared to traditional risk scores. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses for Systematic Reviews (PRISMA) standard, a systematic review was carried out. We searched four databases in total-PubMed, Medline, Embase, and Cochrane-from 19 June 2023-24 June, 2023. From 2,239 identified records, 1,504 duplicates were removed, 735 manuscripts were screened, and 10 studies were included in our review. Our pooled analysis of 5 studies and 9,398 patients revealed a significantly higher mean area under curve (AUC) associated with AI mortality predictions than traditional score predictions (MD: -0.16, CI: -0.22 to -0.10, p < 0.00001). Subgroup analyses of 30-day mortality (MD: -0.08, CI: -0.13 to -0.03, p = 0.001) and 1-year mortality (MD: -0.18, CI: -0.27 to -0.10, p < 0.0001) also showed significantly higher mean AUC with AI predictions than traditional score predictions. Pooled mean AUC of all 10 studies and 22,933 patients was 0.79 [0.73, 0.85]. AI models have a higher predictive accuracy as compared to traditional risk scores in predicting post-TAVI mortality. Overall, this review demonstrates the potential of AI in achieving personalised risk assessment in TAVI patients. This systematic review and meta-analysis was registered under the International Prospective Register of Systematic Reviews (PROSPERO), under the registration name "All-Cause Mortality in Transcatheter Aortic Valve Replacement Assessed by Artificial Intelligence" and registration number CRD42023437705. A review protocol was not prepared. There were no amendments to the information provided at registration. https://www.crd.york.ac.uk/, PROSPERO (CRD42023437705).

Artificial Intelligence Prediction of One-Part Geopolymer Compressive Strength for Sustainable Concrete

Artificial Intelligence Prediction of One-Part Geopolymer Compressive Strength for Sustainable Concrete

An Artificial Intelligence Prediction Approach for Behavioral Intentions of Health Tourism: a Protection Motivation Theory-based Perspective

Abstract This study applies an artificial intelligence (AI) method, informed by the Protection Motivation Theory (PMT), to predict the behavioral intentions of tourists in a healthy town in Yunnan. This study looks at online search data to guess when a lot of tourists will come by combining text mining with the SPCA-LSTM model. This model combines seasonal and trend decomposition using Loess (STL) with Long Short-Term Memory (LSTM) networks. The model is more accurate than traditional forecasting methods and provides a daily average tourist flow estimate of 3,247 with minimal prediction errors. The average absolute error of 806.4074 and the root mean square error (RMSE) of 959.775 further highlight the model’s performance. This research contributes significantly to tourism management and strategic planning, particularly in health-related destinations. The model provides a reliable benchmark for predicting tourist flows enhancing decision-making processes in the tourism sector.

Explainable artificial intelligence prediction based model in advanced laparoscopic liver surgery: an international multicenter study

Explainable artificial intelligence prediction based model in advanced laparoscopic liver surgery: an international multicenter study

Explainable & Safe Artificial Intelligence in Radiology

Artificial intelligence (AI) is transforming radiology with improved diagnostic accuracy and efficiency, but prediction uncertainty remains a critical challenge. This review examines key sources of uncertainty-out-of-distribution, aleatoric, and model uncertainties-and highlights the importance of independent confidence metrics and explainable AI for safe integration. Independent confidence metrics assess the reliability of AI predictions, while explainable AI provides transparency, enhancing collaboration between AI and radiologists. The development of zero-error tolerance models, designed to minimize errors, sets new standards for safety. Addressing these challenges will enable AI to become a trusted partner in radiology, advancing care standards and patient outcomes.

Evaluating the performance of an AI-powered VBAC prediction system within a decision-aid birth choice platform for shared decision-making.

Vaginal birth after cesarean (VBAC) is generally regarded as a safe and viable birthing option for most women with prior cesarean delivery. Nonetheless, concerns about heightened risks of adverse maternal and perinatal outcomes have often dissuaded women from considering VBAC. This study aimed to assess the performance of an artificial intelligence (AI)-powered VBAC prediction system integrated into a decision-aid birth choice platform for shared decision-making (SDM). Employing a retrospective design, we collected medical records from a regional hospital in northern Taiwan from January 2019 to May 2023. To explore a suitable model for tabular data, we compared two prevailing modeling approaches: tree-based models and logistic regression models. We subjected the tree-based algorithm, CatBoost, to binary classification. Forty pregnant women with 347 records were included. The CatBoost model demonstrated a robust performance, boasting an accuracy rate of 0.91 (95% confidence interval (CI): 0.86-0.94) and an area under the curve of 0.89 (95% CI: 0.86-0.93), surpassing both regression models and other boosting techniques. CatBoost captured the data characteristics on the significant impact of gravidity and the positive influence of previous vaginal birth, reinforcing established clinical guidelines, as substantiated by the SHapley Additive exPlanations analysis. Using AI techniques offers a more accurate assessment of VBAC risks, boosting women's confidence in selecting VBAC as a viable birthing option. The seamless integration of AI prediction systems with SDM platforms holds a promising potential for enhancing the effectiveness of clinical applications in the domain of women's healthcare.

Ensemble of explainable artificial intelligence predictions through discriminate regions: A model to identify COVID-19 from chest X-ray images

Abstract In 2019, lung disease severely affected human health and was later renamed coronavirus disease 2019 (COVID-2019). Since then, several research methods have been proposed, such as reverse transcription polymerase chain reaction (RT-PCR), and disease identification through chest X-rays and computed tomography (CT) scans, to help the healthcare sector. RT-PCR was time-consuming when more patients were present, and a CT scan was costly. Several deep-learning (DL) methods were used to identify diseases using computer-aided tools. Among those convolutional neural networks (CNNs), the state of the art was adopted in the machinery to predict cancer. However, there is a lack of explainability (XAI) in how CNN predicts the disease. In this article, we construct XAI ensembles with Local Interpretation Model Agnostic Explanation(LIME), Grad CAM, and a Saliency map. It provides a visual explanation for a DL prognostic model that predicts COVID-19 respiratory infection in patients. Our quantitative experimental results have shown that ensemble XAI with an accuracy of 98.85%, although individual LIME has scored an accuracy of 99.62% on test data, is more reliable since it is the combination of models.

Research on EV charging load forecasting and orderly charging scheduling based on model fusion

The randomness and uncertainty of charging behavior of EV users bring great challenges to the short-term prediction of charging load of EV charging stations. Aiming at the low precision of short-term load forecasting of EV charging station under the influence of many factors, this paper takes the optimization of EV charging loss as the objective of optimization, firstly, the time series attributes are combined with the nonlinear attributes, and PLSR and LightGBM are used to extract the attributes from EV charging load series, and the fusion prediction model is established. Secondly, the Bayesian optimization method is introduced to optimize hyper-parameters of the model, and the self-adaptive adjustment of the hyper-parameters are realized, which improves performance of the algorithm and the prediction precision. Finally, taking the actual load data of EV charging pile in a certain area as an example, the experimental analysis is carried out, the second-order cone optimal dispatching scheme is adopted to optimize the EV charging schedule. The results show that the EV prediction model constructed by this paper has higher prediction accuracy than other artificial intelligence prediction algorithms, and provides more accurate data for the second-order cone optimal scheduling scheme, the utility model effectively realizes the safe and stable operation of the power grid.

Identification, synthesis, and characterization of an unprecedented N-(2-carboxyethyl) adduct impurity in an injectable ganirelix formulation.

Ganirelix, a peptide-based drug used to treat female infertility, has been in high market demand, which attracted generic formulation. A hitherto unknown impurity of ganirelix was observed in our formulation process, which reached ~0.3% in 6months and led to a detailed investigation of its structure. In-depth analysis of ESI-MS/MS data of this impurity coupled with an artificial intelligence prediction tool led to a highly unusual putative structure, that is, N-(2-carboxyethyl)-ganirelix (NCE-GA), which was authenticated by chemical synthesis from ganirelix and NMR analysis and via corroborated HPLC and MS/MS data with the formulation-derived impurity.

A Fully Automated Artificial Intelligence System to Assist Pathologists’ Diagnosis to Predict Histologically High-grade Urothelial Carcinoma from Digitized Urine Cytology Slides Using Deep Learning

BackgroundUrine cytology, although a useful screening method for urothelial carcinoma, lacks sensitivity. As an emerging technology, artificial intelligence (AI) improved image analysis accuracy significantly. ObjectiveTo develop a fully automated AI system to assist pathologists in the histological prediction of high-grade urothelial carcinoma (HGUC) from digitized urine cytology slides. Design, setting, and participantsWe digitized 535 consecutive urine cytology slides for AI use. Among these slides, 181 were used for AI development, 39 were used as AI test data to identify HGUC by cell-level classification, and 315 were used as AI test data for slide-level classification. Outcome measurements and statistical analysisOut of the 315 slides, 171 were collected immediately prior to bladder biopsy or transurethral resection of bladder tumor, and then outcomes were compared with the histological presence of HGUC in the surgical specimen. The primary aim was to compare AI prediction of the histological presence of HGUC with the pathologist’s histological diagnosis of HGUC. Secondary aims were to compare the time required for AI evaluation and concordance between the AI's classification and pathologist’s cytology diagnosis. Results and limitationsThe AI capability for predicting the histological presence of HGUC was 0.78 for the area under the curve. Comparing the AI predictive performance with pathologists' diagnosis, the AI sensitivity of 63% for histological HGUC prediction was superior to a pathologists' cytology sensitivity of 46% (p = 0.0037). On the contrary, there was no significant difference between the AI specificity of 83% and pathologists' specificity of 89% (p = 0.13), and AI accuracy of 74% and pathologists' accuracy of 68% (p = 0.08). The time required for AI evaluation was 139 s. With respect to the concordance between the AI prediction and pathologist’s cytology diagnosis, the accuracy was 86%. Agreements with positive and negative findings were 92% and 84%, respectively. ConclusionsWe developed a fully automated AI system to assist pathologists’ histological diagnosis of HGUC using digitized slides. This AI system showed significantly higher sensitivity than a board-certified cytopathologist and may assist pathologists in making urine cytology diagnoses, reducing their workload. Patient summaryIn this study, we present a deep learning–based artificial intelligence (AI) system that classifies urine cytology slides according to the Paris system. An automated AI system was developed and validated with 535 consecutive urine cytology slides. The AI predicted histological high-grade urothelial carcinoma from digitized urine cytology slides with superior sensitivity than pathologists, while maintaining comparable specificity and accuracy.

Improvement of an Artificial Intelligence Algorithm Prediction Model Based on the Similarity Method: A Case Study of Office Building Cooling Load Prediction

Artificial intelligence algorithms (AIAs) have gained widespread adoption in air conditioning load prediction. However, their prediction accuracy is substantially influenced by the quality of training samples. To improve the prediction accuracy of air conditioning load, this study presents an AIA prediction model based on the method of similarity sample screening. Initially, the comprehensive similarity coefficient between samples was obtained by using the gray correlation method improved with information entropy. Subsequently, a subset of closely related samples was extracted from the original dataset and employed to train the artificial intelligence prediction model. Finally, the trained AIA prediction model was used to predict the air conditioning load. The results illustrate that the method of similarity sample screening effectively improved the prediction accuracy of BP neural network (BPNN) and extreme learning machine (ELM) prediction models. However, it is essential to note that this approach may not be suitable for genetic algorithm BPNN (GABPNN) and support vector regression (SVR) models.

Facial profile evaluation and prediction of skeletal class II patients during camouflage extraction treatment: a pilot study

BackgroundThe evaluation of the facial profile of skeletal Class II patients with camouflage treatment is of great importance for patients and orthodontists. The aim of this study is to explore the key factors in evaluating the facial profile esthetics and to predict the posttreatment facial profile esthetics of skeletal Class II extraction patients.Methods124 skeletal Class II extraction patients were included. The pretreatment and posttreatment cephalograms were analyzed by a trained expert orthodontist. The facial profile esthetics of pretreatment and posttreatment lateral photographs were evaluated by 10 expert orthodontists using the visual analog scale (VAS). The correlation between subjective facial profile esthetics and objective cephalometric measurements was assessed. Three machine-learning methods were used to predict posttreatment facial profile esthetics.ResultsThe distances from lower and upper lip to the E plane and U1-APo showed the stronger correlation with profile esthetics. The changes in lower lip to the E plane and U1-APo during extraction exhibited the stronger correlation with changes in VAS score (r = − 0.551 and r = − 0.469). The random forest prediction model had the lowest mean absolute error and root mean square error, demonstrating a better prediction accuracy and fitting effect. In this model, pretreatment upper lip to E plane, pretreatment Pog-NB and the change of U1-GAll were the most important variables in predicting the posttreatment score of facial profile esthetics.ConclusionsThe maxillary incisor protrusion and lower lip protrusion are key objective indicators for evaluating and predicting facial profile esthetics of skeletal Class II extraction patients. An artificial intelligence prediction model could be a new method for predicting the posttreatment esthetics of facial profiles.

AI prediction of extracorporeal shock wave lithotripsy outcomes for ureteral stones by machine learning-based analysis with a variety of stone and patient characteristics.

We propose an artificial intelligence prediction method for extracorporeal shock wave lithotripsy treatment outcomes by analysis of a wide variety of variables. We retrospectively reviewed the records of 171 patients from between January 2009 and November 2019 that underwent shock wave lithotripsy at Wakayama Medical University, Japan, for ureteral stones shown on preoperative non-contrast computed tomography. This prediction method consisted of stone area extraction, stone analyzing factor extraction from non-contrast computed tomography images, and shock wave lithotripsy treatment result prediction by a non-linear support vector machine for analysis of 15 input and automatic measurement factors. Input factors included patient age, skin-to-stone distance, and maximum ureteral wall thickness, and the automatic measurement factors included 11 non-contrast computed tomography image texture factors in the stone area and stone volume. Permutation feature importance was also applied to the artificial intelligence prediction results to analyze the importance of each factor relating to estimate decision grounds. The prediction performance was evaluated by five-fold cross-validation, it obtained 0.742 of the mean area under the receiver operating characteristic curve. The proposed method is shown by these results to have robust data diversity and effective clinical application. As a result of permutation feature importance, some factors that showed high p-values in the significant difference tests were thought to have a high contribution to the proposed prediction method. Future issues include validation using a larger volume of high-resolution clinical non-contrast computed tomography image data and the application of deep learning.

AI and semantic ontology for personalized activity eCoaching in healthy lifestyle recommendations: a meta-heuristic approach

BackgroundAutomated coaches (eCoach) can help people lead a healthy lifestyle (e.g., reduction of sedentary bouts) with continuous health status monitoring and personalized recommendation generation with artificial intelligence (AI). Semantic ontology can play a crucial role in knowledge representation, data integration, and information retrieval.MethodsThis study proposes a semantic ontology model to annotate the AI predictions, forecasting outcomes, and personal preferences to conceptualize a personalized recommendation generation model with a hybrid approach. This study considers a mixed activity projection method that takes individual activity insights from the univariate time-series prediction and ensemble multi-class classification approaches. We have introduced a way to improve the prediction result with a residual error minimization (REM) technique and make it meaningful in recommendation presentation with a Naïve-based interval prediction approach. We have integrated the activity prediction results in an ontology for semantic interpretation. A SPARQL query protocol and RDF Query Language (SPARQL) have generated personalized recommendations in an understandable format. Moreover, we have evaluated the performance of the time-series prediction and classification models against standard metrics on both imbalanced and balanced public PMData and private MOX2-5 activity datasets. We have used Adaptive Synthetic (ADASYN) to generate synthetic data from the minority classes to avoid bias. The activity datasets were collected from healthy adults (n = 16 for public datasets; n = 15 for private datasets). The standard ensemble algorithms have been used to investigate the possibility of classifying daily physical activity levels into the following activity classes: sedentary (0), low active (1), active (2), highly active (3), and rigorous active (4). The daily step count, low physical activity (LPA), medium physical activity (MPA), and vigorous physical activity (VPA) serve as input for the classification models. Subsequently, we re-verify the classifiers on the private MOX2-5 dataset. The performance of the ontology has been assessed with reasoning and SPARQL query execution time. Additionally, we have verified our ontology for effective recommendation generation.ResultsWe have tested several standard AI algorithms and selected the best-performing model with optimized configuration for our use case by empirical testing. We have found that the autoregression model with the REM method outperforms the autoregression model without the REM method for both datasets. Gradient Boost (GB) classifier outperforms other classifiers with a mean accuracy score of 98.00%, and 99.00% for imbalanced PMData and MOX2-5 datasets, respectively, and 98.30%, and 99.80% for balanced PMData and MOX2-5 datasets, respectively. Hermit reasoner performs better than other ontology reasoners under defined settings. Our proposed algorithm shows a direction to combine the AI prediction forecasting results in an ontology to generate personalized activity recommendations in eCoaching.ConclusionThe proposed method combining step-prediction, activity-level classification techniques, and personal preference information with semantic rules is an asset for generating personalized recommendations.