This paper presents a novel approach for pattern recognition based on continuous training inspired by the biological immune system operation. The main objective of this paper is to present a method capable of continually learn, i.e., being able to address new types of patterns without the need to restart the training process (artificial immune system with incremental learning). It is a useful method for solving problems involving a permanent knowledge extraction, e.g., 3D facial expression recognition, whose quality of the solutions is strongly dependent on a continuous training process. In this context, two artificial immune algorithms are employed: (1) the negative selection algorithm, which is responsible for the pattern recognition process and (2) the clonal selection algorithm, which is responsible for the learning process. The main application of this method is in assisting in decision-making on problems related to pattern recognition process. To evaluate and validate the efficiency of this method, the system has been tested on handwritten character recognition, which is a classic problem in the literature. The results show efficiency, accuracy and robustness of the proposed methodology.