Thermal systems in the contemporary world need effective cooling and heating methods. Heat transfer technology plays a vital role in various industries, including aerospace, electronic equipment, automobiles, and transportation. Considering the importance of effective cooling and heating processes, this framework explores the hydromagnetic stagnation point flow with binary chemical reactions, ohmic heating, Arrhenius activation energy, nonlinear thermal radiation, thermophoresis, and Brownian motion. At first, the flow equations are determined in a formal way as dimensional partial differential equations. Then, they are transformed into simpler, dimensionless ordinary differential equations using self-similar variables. The present study describes a novel approach to intelligent numerical computing, utilizing a Levenberg-Marquard algorithm-based MLP (Multi-Layer Perceptron) feed-forward back-propagation ANN (Artificial Neural Networks) implementation. The collection of data was conducted to facilitate the evaluation, validation, and instruction of the artificial neural network model. The utilization of appropriate self-similarity variables has facilitated the conversion of fluid transport equations into ordinary differential equations. The Runge–Kutta–Fehlberg (RKF) technique was used to solve these equations. The numerical results are presented visually for numerous constraints of the governing parameters. The increased values of the velocity ratio enhanced the fluid velocity. The nonlinear thermal radiation and temperature differential characteristics significantly raise the temperature of the fluid. Increasing the nonlinear radiation and magnetic field parameters improves the rate of heat transfer. The temperature of the fluid decreases as the size of stagnation increases. The skin friction coefficients decrease as the wall thickness and magnetic parameters increase.