Article Reviews Research Articles

Two decades of progress in glioma methylation research: the rise of temozolomide resistance and immunotherapy insights

AimsThis study aims to systematically analyze the global trends in glioma methylation research using bibliometric methodologies. We focus on identifying the scholarly trajectory and key research interests, and we utilize these insights to predict future research directions within the epigenetic context of glioma.MethodsWe performed a comprehensive literature search of the Web of Science Core Collection (WoSCC) to identify articles related to glioma methylation published from January 1, 2004, to December 31, 2023. The analysis included full-text publications in the English language and excluded non-research publications. Analysis and visualization were performed using GraphPad Prism, CiteSpace, and VOSviewer software.ResultsThe search identified 3,744 publications within the WoSCC database, including 3,124 original research articles and 620 review articles. The research output gradually increased from 2004 to 2007, followed by a significant increase after 2008, which peaked in 2022. A minor decline in publication output was noted during 2020–2021, potentially linked to the coronavirus disease 2019 pandemic. The United States and China were the leading contributors, collectively accounting for 57.85% of the total research output. The Helmholtz Association of Germany, the German Cancer Research Center (DKFZ), and the Ruprecht Karls University of Heidelberg were the most productive institutions. The Journal of Neuro-Oncology led in terms of publication volume, while Neuro-Oncology had the highest Impact Factor. The analysis of publishing authors revealed Michael Weller as the most prolific contributor. The co-citation network analysis identified David N. Louis's article as the most frequently cited. The keyword analysis revealed “temozolomide,” “expression,” “survival,” and “DNA methylation” as the most prominent keywords, while “heterogeneity,” “overall survival,” and “tumor microenvironment” showed the strongest citation bursts.ConclusionsThe findings of this study illustrate the increasing scholarly interest in glioma methylation, with a notable increase in research output over the past two decades. This study provides a comprehensive overview of the research landscape, highlighting the importance of temozolomide, DNA methylation, and the tumor microenvironment in glioma research. Despite its limitations, this study offers valuable insights into the current research trends and potential future directions, particularly in the realm of immunotherapy and epigenetic editing techniques.

Exploring the Prospective of Curcumin-loaded Nanomedicine in Brain Cancer Therapy: An Overview of Recent Updates and Patented Nanoformulations.

Cancer is a complex, one of the fatal non-communicable diseases, and its treatment has enormous challenges, with variable efficacy of traditional anti-cancer agents. By 2025, it is expected that 420 million additional cases of cancer will be diagnosed yearly. However, among various types of cancer, brain cancer treatment is most difficult due to the presence of blood-brain barriers. Nowadays, phytoconstituents are gaining popularity because of their biosafety and low toxicity to healthy cells. This article reviews various aspects related to curcumin for brain cancer therapeutics, including epidemiology, the role of nanotechnology, and various challenges for development and clinical trials. Furthermore, it elaborates on the prospects of curcumin for brain cancer therapeutics. In this article, our objective is to illuminate the anti-cancer potential of curcumin for brain cancer therapy. Moreover, it also explores how to defeat its constraints of clinical application because of poor bioavailability, stability, and rapid metabolism. This review also emphasizes the possibility of curcumin for the cure of brain cancer using cuttingedge biotechnological methods based on nanomedicine. This review further highlights the recent patents on curcumin-loaded nanoformulations for brain cancer. Overall, this article provides an overview of curcumin's potential in brain cancer therapy by considering challenges to be overwhelmed and future prospective. Moreover, this review summarizes the reported literature on the latest research related to the utility of curcumin in brain cancer therapy and aims to provide a reference for advanced investigation on brain cancer treatment.

A Review on Synthetic Thiazole Derivatives as an Antimalarial Agent.

Thiazole is a widely studied core structure in heterocyclic chemistry and has proven to be a valuable scaffold in medicinal chemistry. The presence of thiazole in both naturally occurring and synthetic pharmacologically active compounds demonstrates the adaptability of these derivatives. The current study attempted to review and compile the contributions of numerous researchers over the last 20 years to the medicinal importance of these scaffolds, with a primary focus on antimalarial activity. The review is based on an extensive search of PubMed, Google Scholar, Elsevier, and other renowned journal sites for a thorough literature survey involving various research and review articles. A comprehensive review of the antimalarial activity of the thiazole scaffold revealed potential therapeutic targets in Plasmodium species. Furthermore, the correlation of structure-activity-relationship (SAR) studies from various articles suggests that the thiazole ring has therapeutic potential. This article intends to point researchers in the right direction for developing potential thiazole-based compounds as antimalarial agents in the future.

IEEE CEM: Call for Research & Review Articles

IEEE CEM: Call for Research & Review Articles

The role of SRC-3 in prostate cancer progression and implications for therapeutic targeting: A systematic review

Context: Prostate cancer remains a significant global health concern, and understanding the molecular drivers of this disease is crucial for developing effective diagnostic and therapeutic strategies. Steroid receptor coactivator-3 (SRC-3), a member of the SRC family, has emerged as a key player in prostate cancer pathogenesis. Aims: To examine the role of SRC-3 in prostate cancer, encompassing molecular mechanisms, clinical implications, and therapeutic opportunities. Methods: A systematic literature search following PRISMA guidelines was conducted in PubMed, PMC, and other relevant databases to identify studies that investigate SRC-3 in prostate cancer. Results: 785 articles were retrieved from databases using specific keywords and MeSH terms related to SRC-3 and Prostate Cancer. After removing 461 duplicates, 260 articles were excluded based on title and abstract review. Subsequently, a comprehensive screening by three researchers resulted in 47 relevant articles for this systematic review. Evidence suggests that SRC-3 expression correlates with prostate cancer aggressiveness, disease recurrence, and poor patient outcomes. Its potential as a diagnostic biomarker and therapeutic target if explored, offers insights into personalized medicine approaches. Conclusions: SRC-3 plays a pivotal role in prostate cancer, influencing disease progression and clinical outcomes. Understanding the molecular intricacies of SRC-3 in prostate cancer offers new opportunities for precision medicine and innovative therapeutic approaches. This review provides a comprehensive overview of SRC-3's involvement in prostate cancer, emphasizing its clinical relevance and potential as a therapeutic target, ultimately contributing to improved patient care in the era of personalized oncology.

In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review.

This article reviews computational research on benzimidazole derivatives. Cytotoxicity for all compounds against cancer cell lines was measured and the results revealed that many compounds exhibited high inhibitions. This research examines the varied pharmacological properties like anticancer, antibacterial, antioxidant, anti-inflammatory and anticonvulsant activities of benzimidazole derivatives. The suggested method summarises In silico research for each activity. This review examines benzimidazole derivative structure-activity relationships and pharmacological effects. In silico investigations can anticipate structural alterations and their effects on these derivative's pharmacological characteristics and efficacy through many computational methods. Molecular docking, molecular dynamics simulations and virtual screening help anticipate pharmacological effects and optimize chemical design. These trials will improve lead optimization, target selection, and ADMET property prediction in drug development. In silico benzimidazole derivative studies will be assessed for gaps and future research. Prospective studies might include empirical verification, pharmacodynamic analysis, and computational methodology improvement. This review discusses benzimidazole derivative In silico research to understand their specific pharmacological effects. This will help scientists design new drugs and guide future research. Latest, authentic and published reports on various benzimidazole derivatives and their activities are being thoroughly studied and analyzed. The overview of benzimidazole derivatives is more comprehensive, highlighting their structural diversity, synthetic strategies, mechanisms of action, and the computational tools used to study them. In silico studies help to understand the structure-activity relationship (SAR) of benzimidazole derivatives. Through meticulous alterations of substituents, ring modifications, and linker groups, this study identified the structural factors influencing the pharmacological activity of benzimidazole derivatives. These findings enable the rational design and optimization of more potent and selective compounds.

3D Printing for Traumatic Orthopedics: A Review of Current Trends and Opportunities

Three-dimensional (3D) printing enables the fabrication of functional scaffolding structures, prototypes, and implants with complex geometries suitable for various biomedical applications. As 3D printing continues to grow, there has been an increasing trend in reshaping the future of biomedical implants and prototypes in orthopedics, particularly in traumatic orthopedics. For example, 3D printing can be employed to create customized implant guides and prostheses to match the anatomical shape and structure of the defective part of the patient and resolve issues associated with clinical treatment. In addition, 3D printing can be used to print patient-specific prototypes, which is helpful for physicians to have a better 3D Printing for Traumatic Orthopedics: understanding of the anatomy and pAreRoepveierawtivoef Cduiarrgennot sTirsenodfsthaneddOepfepcotrttuonibtieesfixed. Keeping these points in viHewan, tehtisal. article reviews current trends and opportunities for 3D printing in traumatic orthopedics.

The Human Side of Leadership: Forging a Path to Human-Centered Leadership

Abstract: This article examines the importance of human-centered leadership approaches grounded in principles of empathy, respect, and courage. After introducing the concept through the author's experience as an organizational consultant and researcher, the article reviews research demonstrating that addressing employees' basic psychological needs for autonomy, competence, relatedness and purpose significantly enhances motivation, well-being and performance. Additionally, empirical studies show supportive leadership behaviors have physiological impact in reducing stress while increasing trust and cooperation. The article then outlines core strategies including cultivating empathy, respect and courage, providing advice on developing these capacities. Finally, practical examples from technology, non-profit and manufacturing sectors illustrate human-centered leadership implementation through empathetic culture changes and inclusive problem-solving with courage during times of change and uncertainty.

Infants' reliance on rhythm to distinguish languages: A critical review.

This article reviews empirical methods and findings on early language discrimination, questioning rhythm-class based hypotheses on language discrimination in infancy, as well as the assumption that early language discrimination is driven primarily (or solely) by temporal prosodic cues. The present work argues that within-rhythm class discrimination which - according to the rhythmic hypothesis - is not applicable very early in life, has not been sufficiently tested with infants under 4months of age, that familiarity with a language is not a prerequisite for its discrimination from another rhythmically similar language, and that the temporal rhythm properties may not universally be the primary cues to language discrimination. Although rhythm taxonomy is now by many understood as outdated, some developmental literature still draws on the assumption that rhythm classification determines infants' language discrimination; other studies consider rhythm along a continuous scale and only a few account for cues to language discrimination other than temporal ones. It is proposed that studies on early language discrimination systematically test the contribution of other than temporal rhythm cues, similarly to recent work on multidimensional psychoacoustic salience in the acquisition of segmental categories.

ARRITMIAS CARDÍACAS EM ATLETAS: DIAGNÓSTICO E PREVENÇÃO

Introduction: Cardiac arrhythmias in athletes have attracted significant attention from professionals in the field, considering that they can be associated with more serious conditions requiring detailed clinical evaluation including physical examination and medical history. Objective: This review aims to describe cardiac arrhythmias in athletes, focusing on diagnosis and prevention. Method: This study is an integrative bibliographic review that includes original and review articles to select relevant information for this research outcome. Results: Various cardiovascular diseases can be found in athletes, with the electrocardiogram (ECG) being the initial step to identify irregularities in heartbeats. Additionally, physical examinations and evaluation of family history are necessary. Conclusion: Monitoring cardiac arrhythmias is essential for athlete safety, requiring not only accurate diagnosis but also preventive strategies such as pre-participation evaluations, management of pre-existing conditions, and education about arrhythmia symptoms.

Women's Health across the Lifespan: A Sex- and Gender-Focused Perspective.

Women's health in physical therapy has historically focused on sexual and reproductive health. The biological and social constructs of sex and gender, respectively, are determinants of health, including pathophysiology of disease and therapeutic outcomes, and an expansion of the concept of "women's health" is warranted. This Perspective explores the role of sex and gender as key determinants of women's and girls' health and highlight factors pertinent to physical therapist practice. The Scale for the Assessment for Narrative Review Articles (SANRA), a 6-point assessment to evaluate the quality of narrative reviews, was used a priori and consulted throughout. Across the lifespan, sex- and gender-based health disparities exist. These include sex-based disparities in maternal-fetal outcomes linking female fetal sex to maternal hypertensive disorders of pregnancy, along with a sex-based female advantage in birth outcomes and the emergence of gender differences in motor development. A complex interplay of biologic and socially influenced factors contribute to an increased care burden for women throughout adulthood and specific risks for the development of cardiovascular and pelvic floor conditions, decreased function, and increased disability. Sex- and gender-disaggregated data is lacking in outcomes literature. A sex- and gender-informed approach in physical therapy, including analyzing data by sex and gender, may better meet the needs of patients and better prepare physical therapist professionals to contribute to women's health across the lifespan. Success will take coordinated effort involving many stakeholders within and adjacent to the physical therapist community. The influence of sex and gender are lifelong determinants of health, making them critically important to consider in physical therapist practice, education, research, advocacy, and policy. In women's health, focusing on sexual and reproductive health is limiting and insufficient.

ARRITMIAS CARDÍACAS EM ATLETAS: DIAGNÓSTICO E PREVENÇÃO

Introduction: Cardiac arrhythmias in athletes have attracted significant attention from professionals in the field, considering that they can be associated with more serious conditions requiring detailed clinical evaluation including physical examination and medical history. Objective: This review aims to describe cardiac arrhythmias in athletes, focusing on diagnosis and prevention. Method: This study is an integrative bibliographic review that includes original and review articles to select relevant information for this research outcome. Results: Various cardiovascular diseases can be found in athletes, with the electrocardiogram (ECG) being the initial step to identify irregularities in heartbeats. Additionally, physical examinations and evaluation of family history are necessary. Conclusion: Monitoring cardiac arrhythmias is essential for athlete safety, requiring not only accurate diagnosis but also preventive strategies such as pre-participation evaluations, management of pre-existing conditions, and education about arrhythmia symptoms.

The convergence of edge computing and supply chain resilience in retail marketing

In the fast-paced world of retail, having a strong and flexible supply chain is essential for success as businesses face increasing customer expectations and market uncertainties. Edge computing is emerging as a key technology that can enhance supply chain resilience by processing data in real-time, reducing delays, and improving responsiveness. This article explores how edge computing and supply chain resilience intersect within retail marketing and how they can optimize marketing strategies and customer experiences. Edge computing works by handling data close to where it is generated, which speeds up processing and reduces delays compared to traditional cloud systems. This real-time data processing is crucial for retailers who need to manage inventory, track shipments, and adjust to market changes quickly. With edge computing, retailers can get immediate insights into their supply chains, enabling faster and more accurate decision-making. The article reviews current research and case studies to illustrate the benefits of edge computing in retail. These benefits include better inventory management through real-time updates, more personalized and engaging marketing campaigns, and increased efficiency in logistics by automating processes. Edge computing also enhances the in-store experience with technologies like augmented reality, which can boost customer interaction and satisfaction. However, adopting edge computing also comes with challenges, such as high implementation costs, the complexity of integrating new systems, and concerns about data security. The article addresses these challenges and provides strategies for overcoming them, offering practical advice for effectively using edge computing. In summary, the article argues that edge computing will be a vital factor in retail’s future success and innovation. By making supply chains more agile, responsive, and efficient, edge computing helps retailers meet market demands and stay ahead of the competition. As technology continues to evolve, the role of edge computing in improving supply chain resilience and transforming retail marketing will become even more significant.

Clinical implications and costs of in-hospital versus outpatient orthopedic surgeries

Objective: This article reviews clinical implications and costs associated with orthopedic surgeries performed in inpatient versusoutpatient settings. Methods: Studies spanning the publication period between 2000 and 2023 were included, exploring a variety of study designs. Results: Results indicate that outpatient surgeries are associated with lower rates of postoperative complications, shorter recovery times, and greater patient satisfaction, as well as with significantly lower direct and indirect costs. Analysis of postoperative complications suggests that factors such as the home recovery environment and early mobilization may contribute to improved clinical outcomes, corroborating existing literature on the safety and efficacy of outpatient surgeries. Faster recovery after outpatient surgeries was consistently observed, with patients returning to normal activities an average of two weeks earlier compared with those undergoing inpatient surgeries. The greater patient satisfaction with outpatient surgeries reflects the convenience of avoiding hospitalization, with less disruption to daily life and reduced anxiety associated with the hospital environment. In economic terms, outpatient surgeries have been shown to be a financially advantageous alternative, with reduced direct costs due to the lower hospital fees and nursing services required, as well as lower indirect costs due to reduced productivity loss and transportation expenses. Conclusion: Findings are particularly relevant in a context of increasing pressure to contain spending in the health system. Level of Evidence I; Systematic review of level I studies.

Challenges in Supervised and Unsupervised Learning: A Comprehensive Overview

Data science and machine learning are at the forefront of modern technological advancements, promising automated insights, predictions, and decision-making. Supervised and unsupervised learning are pivotal paradigms within this dynamic landscape, each presenting its unique challenges. This article provides a comprehensive overview of the multifaceted challenges inherent to both supervised and unsupervised learning. This article reviews research studies published between 2019 and 2023. This article discusses the challenges of supervised and unsupervised learning. In supervised learning, challenges include data labeling, overfitting, limited generalization, and balancing mistake equivalence and decision-making goals. In unsupervised learning, difficulties encompass issues like overfitting, choosing the appropriate algorithm, and interpreting results. This includes evaluating the quality of clustering, deciding the optimal number of clusters, and managing noise and outliers. The article aims to provide insights into these challenges, enhancing the understanding of machine learning for both novices and experts. Researchers and practitioners constantly evolve their methods and tools to overcome these complexities. This article is a valuable reference for researchers and experts in the field, empowering them to navigate these challenges confidently. As technology advances, a thorough understanding of these challenges is essential for unlocking the full potential of these powerful tools. Finally, several recommendations were given to guide future researchers in applying machine learning in the journey of data-driven discovery and automation, offering challenges and opportunities for those who embark on it.

Targeting Endoplasmic Reticulum Stress by Natural and Chemical Compounds Ameliorates Cisplatin-Induced Nephrotoxicity: A Review.

Cisplatin is a chemotherapeutic that dose-dependently causes renal complications such as decreased kidney function and acute kidney injury. The endoplasmic reticulum (ER) is responsible for calcium homeostasis and protein folding and plays a major part in cisplatin's nephrotoxicity. The current article reviews how chemical and natural compounds modulate cisplatin-induced apoptosis, autophagy, and inflammation by inhibiting ER stress signaling pathways. The available evidence indicates that natural compounds (Achyranthes aspera water-soluble extract, morin hydrate, fucoidan, isoliquiritigenin, leonurine, epigallocatechin-3-gallate, grape seed proanthocyanidin, and ginseng polysaccharide) and chemicals (Sal003, NSC228155, TUG891, dorsomorphin (compound C), HC-030031, dexmedetomidine, and recombinant human erythropoietin (rHuEpo)) can alleviate cisplatin nephrotoxicity by suppression of ER stress signaling pathways including IRE1α/ASK1/JNK, PERK-eIF2α-ATF4, and ATF6, as well as PI3K/AKT signaling pathway. Since ER and related signaling pathways are important in cisplatin nephrotoxicity, agents that can inhibit the abovementioned signaling pathways may hold promise in alleviating this untoward adverse effect.

The effect of traditional Chinese medicine on psychological conditions among elderly patients with cancer: a scoping review.

Coping with cancer presents a multitude of challenges that encompass every aspect of a patient's life. These challenges not only strain the body but also weigh heavily on the mind, often culminating in profound psychological distress for cancer patients. The cumulative burden of these experiences can heighten the risk of developing psychiatric disorders, exacerbating the already daunting landscape of cancer care. Therefore, this study reviewed the available research with the aim of investigating the effects of traditional Chinese medicine on psychological conditions in elderly cancer patients. In this scoping review, we applied specific criteria to select studies that focused on elderly patients with cancer. We performed an extensive search across electronic databases, including Embase, Science Direct, PubMed, Google Scholar, Scopus, Cochrane Library and Web of Science. In our investigation, we identified a total of 3870 articles related to the topic under review. Following a meticulous screening process that involved evaluating titles, abstracts, and full texts, we ultimately selected five articles deemed relevant for inclusion in this review. Among these articles, three were randomised studies, while the remaining two were review articles. The outcomes of our analysis revealed that herbal decoctions, nutritional counselling, Tai Chi and acupressure, can effectively improve various psychological outcomes in elderly cancer patients. These interventions reduce fatigue, depression, anxiety, and stress, while also enhancing sleep quality and overall mental health. The present study highlights the importance of traditional Chinese medicine in addressing the needs of elderly patients with cancer. As a result, it is recommended that further extensive research be conducted to comprehensively assess the efficacy and safety of traditional Chinese medicine in managing cancer in the elderly.

Urticaria in Patients with COVID -19 Infections

Introduction: The relationship between viral infections and acute or chronic urticaria is rarely reported in some articles. But its exact mechanisms are not known. There is evidence of urticaria in the patients with covid-19 infection. Therefore, there was no structured research to clarify the role of the corona virus in the pathogenesis of urticaria. Methods: The articles that were published from January 2020 to October 2022 were reviewed by "PubMed" and "Google scholar" databases using the keywords acute urticarial urticaria, chronic urticaria along with COVID-19. Inclusion criteria were articles reporting acute or chronic urticaria in the patients with confirmed COVID-19 infection in English. Review articles and studies that reported suspected corona infection and in which urticaria were related to drug hypersensitivity and other allergic diseases were considered as exclusion criteria. Results: In this search, 43 articles were reviewed that were related to our goals. Among these articles, 27 studies that met the inclusion criteria were selected. 16 articles were case reports, case series, letters to the editor and 7 original articles. In this review, it was reported 17 patients in 16 case reports and case series with urticaria associated with COVID-19. Conclusion: The severity of chronic urticaria may increase with corona infection. Acute urticaria may be a precursor symptom of COVID-19 infection. Finally, due to the small number of articles and some contradictory results, more studies are suggested in this field.

Editorial: Review of the Aims and Scope of Jurnal Psikologi

The editorial team of Jurnal Psikologi is excited to announce the renewal of our aims and scope to include emerging areas of psychological research, while reinforcing our commitment to the study of Indonesian psychology. The revised aims and scope offer a more precise and direct focus on understanding the unique ways cultural, social, environmental, and technological influences shape the mental processes and behavior of Indonesians. These insights can be presented in the form of original research and review articles, as we recognize that human knowledge can flourish and advance thanks to the empirical results reported in original research, while reviews help to refine our awareness of important subjects. In highlighting the unique psychological landscape of Indonesia, our goal is to enrich the psychological research based on Indonesians’ vast and diverse characteristics, enabling both local and global society to discover an in-depth understanding and empathetic utilization of the information. We are especially interested in several topics regarding the Indonesian psyche, including the influences of environment, technology, and the digital world. Why? We argue that these aspects play a crucial role in (re)shaping and cementing the psychological landscape of Indonesia. Other topics, such as neuroscience and cognition, also potentially contribute significantly to explaining the psychology of the Indonesian people. With the updated aims and scope in mind, we encourage authors to explicitly address the impact of their work on the current state of propose improvements to existing practices. The editor and reviewers will specifically evaluate this discussion within the manuscript.

Recent developments in two-dimensional molybdenum disulfide-based multimodal cancer theranostics.

Recent advancements in cancer research have led to the generation of innovative nanomaterials for improved diagnostic and therapeutic strategies. Despite the proven potential of two-dimensional (2D) molybdenum disulfide (MoS2) as a versatile platform in biomedical applications, few review articles have focused on MoS2-based platforms for cancer theranostics. This review aims to fill this gap by providing a comprehensive overview of the latest developments in 2D MoS2 cancer theranostics and emerging strategies in this field. This review highlights the potential applications of 2D MoS2 in single-model imaging and therapy, including fluorescence imaging, photoacoustic imaging, photothermal therapy, and catalytic therapy. This review further classifies the potential of 2D MoS2 in multimodal imaging for diagnostic and synergistic theranostic platforms. In particular, this review underscores the progress of 2D MoS2 as an integrated drug delivery system, covering a broad spectrum of therapeutic strategies from chemotherapy and gene therapy to immunotherapy and photodynamic therapy. Finally, this review discusses the current challenges and future perspectives in meeting the diverse demands of advanced cancer diagnostic and theranostic applications.