English Articles Research Articles

Fathers' impact on outcomes in the treatment of eating disorders: A scoping review.

Male caregivers' participation in eating disorder (ED) treatment for their affected children is less consistent than female caregivers', with unclear effects. To clarify the impact, this scoping review examined literature on male caregiver involvement in ED treatment, focusing on its impact on fathers, treatment processes, and their affected children. A search encompassing English and French peer-reviewed articles from 1990 to 2022 was conducted. Studies distinguishing between mothers and fathers, addressing Diagnostic and Statistical Manual of Mental Disorders or International Classification of Diseases ED diagnoses, and involving active interventions were included. From 1651 initially identified articles, 251 were retained after abstract and title review, and 45 metall criteria. Documented outcomes indicated fathers' engagement in ED treatment improved their well-being and family functioning, but these gains were not consistently tied to treatment outcomes. Father attendance, improved caregiving skills, and their expectations of treatment correlated with better outcomes for their affected child. Father involvement in ED treatment remains under-explored. This review emphasises fathers' positive impact while highlighting the need to better understand the link with overall patient outcomes. We call for proactive exploration of how to surmount barriers to fathers' involvement and ensure that paternal contributions are optimised in ED treatment alongside those of female caregivers.

A comprehensive meta-analysis of in vitro studies on polycystic ovary syndrome cell lines

Introduction: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. In vitro studies using PCOS cell lines have been instrumental in understanding the pathophysiology and identifying potential therapeutic targets. This meta-analysis aims to synthesize and evaluate the existing literature on PCOS cell line research. Methods: A systematic search of PubMed, Scopus, and Web of Science databases up to January 2024, using relevant keywords and medical subject headings. Inclusion criteria were original research articles in English, focusing on PCOS cell lines and reporting quantitative data. Data extraction included study design, cell line model, outcomes, and main findings. Results: A total of 48 studies met the inclusion criteria, involving human granulosa-derived (KGN, COV434), theca-derived (HsTE-1, HsTE-10), and ovarian surface epithelial (IOSE-80) cell lines. These studies focused on the evaluation of hormonal imbalances, insulin resistance, and inflammation. The meta-analysis revealed that PCOS cell lines exhibited increased androgen production, elevated insulin resistance markers, and pro-inflammatory cytokine expression compared to control cell lines. Conclusion: In vitro studies using PCOS cell lines have provided valuable insights into the molecular mechanisms underlying PCOS pathogenesis. These cell lines serve as valuable tools for understanding the complex interplay between hormonal dysregulation, insulin resistance, and inflammation.

Research Trends and Hotspots of Big Data in Ophthalmology: A Bibliometric Analysis and Visualization

ABSTRACT Purpose The burst of modern information has significantly promoted the development of global medicine into a new era of big data healthcare. Ophthalmology is one of the most prominent medical specialties driven by big data analytics. This study aimed to describe the development status and research hotspots of big data in ophthalmology. Methods English articles and reviews related to big data in ophthalmology published from January 1, 1999, to April 30, 2024, were retrieved from the Web of Science Core Collection. The relevant information was analyzed and visualized using VOSviewer and CiteSpace software. Results A total of 406 qualified documents were included in the analysis. The annual number of publications on big data in ophthalmology reached a rapidly increasing stage since 2019. The United States (n = 147) led in the number of publications, followed by India (n = 77) and China (n = 69). The L.V. Prasad Eye Institute in India was the most productive institution (n = 50), and Anthony Vipin Das was the most influential author with the most relevant literature (n = 45). The electronic medical records were the primary source of ophthalmic big data, and artificial intelligence served as the principal analytics tool. Diabetic retinopathy, glaucoma, and myopia are currently the main topics of interest in this field. Conclusions The application of big data in ophthalmology has experienced rapid growth in recent years. Big data is expected to play an increasingly significant role in shaping the future of research and clinical practice in ophthalmology.

Peer support in paediatrics: A literature review.

Creating an overview of the existing literature about peer support in paediatrics, with a focus on children with chronic diseases. An online search was conducted in MEDLINE and Web of Science. English, Dutch or French articles published between 1 January 2000 and 10 May 2023 were included, based on title and abstract. In this review, 47 articles were included, identifying following themes: Health-Related Quality of Life (n = 8), peer support for parents/siblings (n = 6), social environment (n = 2), and peer support programme for children (n = 31) subdivided in: general concept (n = 13), online (n = 11), camps (n = 6), and development of a peer support programme (n = 1). Peer support aims to improve disease-related knowledge, coping, and management of the disease, as well as creating a positive mindset and decreasing the disease burden. There is no consensus regarding which peer group design was superior. Peer groups aim to increase knowledge and psychological adaptation, and decrease physical symptoms and side effects. It is desired to start the peer mentor programme within 1 year after diagnosis or during a critical incident. Further investigation needs to determine the optimal age to start these groups and the format (online or in-person). Communication between mentors and their mentees was crucial in the succeeding of the programme, as well as creating a safe environment to share experiences. Even though research is still needed concerning peer-to-peer support for children, there is already a lot known about similar programmes for parents of children with chronic diseases.

A worldwide bibliometric analysis on euthanasia

Introduction: Euthanasia, which allows individuals with an incurable disease to end their lives in an honourable way, is a long-debated practice. It is related to various issues such as culture, philosophy, religion, ethics, public value, and efficient use of health resources. While some advocate for the right of individuals to choose euthanasia, others criticize it on ethical, legal, and religious grounds. Methods: In this study bibliometric analysis was used and the data were obtained from the Web of Science Core Collection database on July 26, 2024. Only English publications and articles were included using keywords such as "euthanasia," "end-of-life decisions," "medical assistance in dying," "physician-assisted death," and "physician-assisted suicide" without time restrictions. VOSviewer software was used to create network and density graphs, and SciMAT software was used to create strategic diagrams. Results: A total of 2,230 studies published between 1980 and 2024 were analyzed. The author with the most publications is Deliens, L, with 86 studies. The majority of studies were published in the USA, Netherlands, and Canada (692, 336, 225 respectively). The most frequently used keywords are euthanasia, palliative care, and ethics. The highest number of publications (149) was in the year 2021. In the strategic diagram for the first period (between 1980 and 2001), the themes of care and ethics were prominent, while for the second period (between 2002 and 2024), the clusters of nurse and shared decision-making were notable. Conclusion: After its legalization in the Netherlands, euthanasia has been accepted and implemented in some countries over the years, with variations in scope. Some countries, like the Netherlands and Belgium, also accept health problems related to old age and mental illness as euthanasia requests. The discussion around euthanasia often revolves around the principles of medical ethics, including autonomy, beneficence, non-maleficence, and justice. Studies have focused on the role of physicians and nurses in the process, as well as end-of-life decision-making by patients. Recently, Canada defined the role of nurses in the euthanasia process, marking a significant development.

RADIOGRAPHERS AND EMPATHY - A LITERATURE REVIEW

Purpose: The purpose of this paper was to introduce the concept of empathy in the radiographer profession. We explored why empathy is an important component of the radiographer, the positive impact of empathy on patients and radiographers, the negative impact of empathy on radiographers, how to introduce empathy into the workplace, and what infl uence the expression or non-expression of empathy has on radiographers. Materials and methods: We searched for the following keywords: empathy, emotional labour, radiological engineer, empathy, radiographer, radiologic technologist, burnout in radiography. Articles published from 1991 onwards were considered and only articles in Slovene and English with full text availability were included. Results: 13 articles were included in the analysis, which are summarised in a table. Empathy is a fundamental tool for building a therapeutic relationship between radiographers and patients and contributes to a better diagnostic quality of the examination. Empathy has a positive infl uence on therapeutic outcomes and on radiographers, as it can help to reduce stress and burnout in the workplace and improve the quality of life of professionals. However, constant exposure to stressful and emotionally diffi cult situations can have emotional and motivational consequences, such as empathic anxiety and personal distress. Understanding patients' emotions, opinions and experiences, helps radiographers to assess their needs and act accordingly. Conclusion: Empathy plays an important role in the work of radiographers as it contributes to a better relationship with the patient and helps to improve the diagnostic and therapeutic quality of the examination. Keywords: empathic care, burnout, empathic training, radiographers

Stereotactic Radiosurgery in Primary Treatment of Sporadic Small to Medium (

To analyze the current literature regarding use of SRS as primary treatment of VS to further evaluate efficacy and treatment-related neurologic deficits. Online databases were queried to identify relevant publications from January 2001-December 2020. Full text, English articles for sporadic VS treated primarily with radiosurgery and documented hearing preservation data were reviewed. Papers that had a minimum follow-up period of less than 36 months, did not utilize radiosurgery for primary treatment, or included patients with Neurofibromatosis II were excluded. A total of 33 studies involving 4286 patients with an average follow-up of 62.5 months were included in the final analysis. All 33 studies included eligible hearing data; overall preservation of serviceable hearing was found to be 58.27%. 27 studies with 3822 eligible patients were analyzed for tumor control rates; overall, tumor control was reported in 92.98% of cases. 27 studies were analyzed for post-treatment facial nerve dysfunction which was reported in 1.53% of cases. SRS is a safe and effective primary treatment modality for sporadic vestibular schwannoma as evidenced by the present analysis. Radiosurgery is effective with regard to tumor control and hearing preservation while offering a low rate of post-treatment facial nerve dysfunction.

Identifying Trends in the Most Cited Nursing Articles: Research Topics, Author Gender Representation and Characteristics Correlated With Citation Counts.

To assess the top 1000 cited nursing articles in terms of their impact, conceptual and social characteristics. Bibliometric literature review design. A bibliometric analysis on the 1000 most cited nursing articles in English, focusing on assessing their impact and prevalent terms, keywords, co-occurrence networks and topic trends. Non-parametric statistical tests were used. Web of Science Core Collection (accessed 14 February 2024). The 1000 most cited articles were exported from 201,310 eligible articles. The most cited articles received a total of 319,643 citations. The Journal of Advanced Nursing and the International Journal of Nursing Studies were the most cited journals. Literature reviews accounted for 21% of the most cited articles, compared to only 7% of all eligible articles. Most first authors were female, 63%. The data showed an increase in female first authorship among the most cited articles over time. This may reflect a shift towards greater gender equity in nursing research. Shorter article titles and fewer article pages were associated with more citations. Methodological and conceptual articles received the most citations, likely due to their broad applicability (e.g., across disciplines) and enduring relevance. There was a statistically significant correlation between article brevity and citation count, but the relationship should be viewed with caution given the small effect size. Bibliometrics is important for evidence-based practice because it helps nurses evaluate journals, articles and research topics. Since citation counts do not always indicate research quality, nurses and nursing students would benefit from training in bibliometrics to enhance their critical thinking in this area. Top-cited nursing articles indicate influential research topics and methods. They also influence authors' academic career opportunities, allowing assessment of research equity in terms of dominant countries and author gender representation. The Preferred Reporting Items for Bibliometric Analysis (PRIBA) guidelines. No Patient or Public Contribution.

EFEITOS DOS EXERCÍCIOS NA MELHORA DA DOR PACIENTES COM FIBROMIALGIA: REVISÃO INTEGRATIVA

FM is a complex rheumatic condition characterized by chronic pain without evident inflammation. It primarily affects women between the ages of 55 and 74, impairing quality of life due to pain, fatigue, sleep disturbances, and emotional symptoms. Objective: To identify and report the effects of physical exercise on pain improvement in patients with FM. Methodology: An integrative literature review was conducted using the PICo strategy, covering primary studies from randomized clinical trials published between 2019 and 2024. The search was carried out in the LILACS, PubMed, SciELO, and PEDro databases, focusing on the benefits of exercise in pain management. The inclusion criteria were limited to full-text articles in Portuguese and English. Results: A total of 642 studies were analyzed, of which 9 were included in the final sample. These studies showed that aerobic, resistance, aquatic, and stretching exercises significantly contributed to the reduction of pain and fatigue. Additionally, there was an improvement in sleep quality, functional capacity, and emotional well-being, with a decrease in symptoms such as anxiety and depression. However, some studies did not show statistically significant results. Conclusion: It is concluded that physical exercise, when supervised and adjusted to individual needs, is an effective intervention in the management of fibromyalgia, providing pain relief and improving quality of life. Further studies are needed to investigate the interaction of exercises with other treatments, such as pharmacotherapy, and to evaluate long-term effects.

Impact of breast reconstruction on quality of life in women undergoing mastectomy for breast cancer: a systematic review and meta-analysis using the Breast-Q questionnaire

Introduction: Post-mastectomy breast reconstruction is crucial in breast cancer treatment; however, its impact on women’s quality of life (QOL) remains inadequately understood. The BREAST-Q questionnaire is used for assessing QOL related to breast surgery. Therefore, this study aimed to determine whether there are differences in QOL between women undergoing mastectomy with and without breast reconstruction using the BREAST-Q questionnaire. Methods: We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines and registered in PROSPERO. Articles in English, Portuguese, or Spanish were included, and studies on prophylactic mastectomy or breast-conserving surgery, duplicate studies, duplicate data, articles without original data (reviews, editorials, case reports, technical reports) and those without breast reconstruction were excluded. A comprehensive search was conducted across nine scientific databases. The defined search strategy was related to the terms standardized by the MeSH/PubMed controlled vocabularies, including Medical Subject Headings (MeSH), Embase subject headings (Emtree), and their synonyms. Statistical heterogeneity was assessed using the chi-squared and inconsistency tests. Statistical analyses were performed using the R software. A meta-analysis was performed for each BREAST-Q domain when data from multiple studies were available. Results: Of 1266 studies identified, three with 611 participants were included in the meta-analysis. Of these participants, 248 underwent mastectomy without reconstruction and 363 underwent post-mastectomy breast reconstruction. The meta-analysis revealed significantly higher scores in the domains “satisfaction with the breast,” “physical well-being of the chest,” “psychosocial well-being,” and “physical well-being” in women who underwent breast reconstruction compared with those who did not. Conclusion: This study demonstrates a positive association between breast reconstruction and enhanced QOL in women undergoing breast cancer treatment and mastectomy. Patient-reported outcome measures using questionnaires, such as Breast-Q, can elucidate satisfaction levels with the reconstruction, which will likely improve continuously with advances in modern plastic surgery.

Comparative analysis of the leprosy detection rate regarding its clinical spectrum through PCR using the 16S rRNA gene: a scientometrics and meta-analysis

BackgroundLeprosy is a chronic and disabling infectious disease caused by Mycobacterium leprae. It has a wide clinical spectrum and is operationally classified into paucibacillary (PB) and multibacillary (MB) cases. There is evidence that the 16S rRNA gene can be used in Polymerase Chain Reaction (PCR) for complementary detection with high sensitivity and specificity. However, there is no literature convention on its diagnostic correspondence regarding the particular operational classification of the disease. This study aimed to correlate, through a meta-analysis, the detection rate of leprosy between the PCR method with the 16S rRNA gene in the clinical forms PB and MB in relation to confirmed cases.MethodsThis is a systematic review and meta-analysis study conducted according to the PRISMA 2020 guidelines, using the search descriptors with “AND”: “Leprosy”; “Polymerase Chain Reaction”; “16S rRNA” in the PUBMED, SciELO, LILACS, and Science Direct databases. The search was limited to original observational articles in Portuguese, English, or Spanish, with no defined time frame. The methodological quality assessment of the selected articles was performed using the JBI checklists. A scientometric approach to the article using used the VOS Viewer and Scimago Graphica software. The meta-analysis was conducted using Comprehensive Meta-Analyses software, under Pearson’s Correlation effect test and fixed effect model and subgroup analysis concerning the type of sample analyzed.ResultsThe study was significant from the perspective of the paucibacillary group (Clinical biopsy: -0.45 [95% CI= -0.63 – −0.22], p < 0.001/ Slit smear skin: −0.52 [95% CI= -0.65 – −0.36], p < 0.001 / Overall: −0.50 [95% CI= −0.61 – −0.37], p < 0.001). The PCR diagnostic method for the16S rRNAgene ofM. lepraehas low viability and diagnostic sensitivity in both clinical biopsy samples and leprosy skin smears.ConclusionThis implies little validation of it as a PCR target gene for diagnosing the disease, highlighting limitations in the actual technique.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024588790.

Family caregivers of children with cystic fibrosis: supportive care needs – scoping review

BackgroundCystic fibrosis (CF) in children requires complex and time-consuming daily care, presenting significant challenges for families and caregivers. Family caregivers caring for children with CF report diverse and complex needs.ObjectiveThis...

Climate Change Impact on Photovoltaic Production From the Perspective of Climate Models: a Systematic Review

Objective: This study investigates how the researchers approached the theme the climate change impacts on photovoltaic production (PVP) from the perspective of simulations using climate models. Methodology: A comprehensive literature review was conducted to establish correlations between future PV production and climate change susceptibility on regional and global scales. Keywords related to the theme were used in the Web of Science database. Inclusion criteria selected only complete, free, English scientific articles related to the research theme, published between 1965 and 2023. Results and analysis: As a result, it generated a sample consisted of 58 articles on the impact of climate change on photovoltaic production, with 14 included in the final quantitative synthesis. A wide range of results was presented, stemming from both climate change models and models assessing the influence of weather-related factors on PV production. Patterns in the impacts of climate change on photovoltaic production were observed, and the main climate models used to estimate PVP were recognized, grouped, and discussed. Key databases, commonly used simulation periods, and equations linking meteorological variables to PVP were identified and examined. Conclusion: Numerous publications have emerged on the impacts of climate change on PVP, focusing on empirical equations that relate meteorological variables, cell temperature, and cell efficiency. Most studies adopted a forecast period until the end of the 21st century. The majority of the studies focused on Europe and Asia, with little research on impacts of climate changes on PVP in South and Central America.

Knowledge, Attitudes, and Practices Toward Breast Cancer and Breast Cancer Screening Among Arab Females in the Middle East: A Literature Review.

Breast cancer is one of the most diagnosed cancers in Arab countries. Lack of knowledge and awareness regarding breast cancer screening has increased the breast cancer-related morbidity and mortality. This literature review aimed to assess published research papers with a focus on the levels of knowledge, attitude, practice, and barriers of women in Arab countries of the Middle East toward breast cancer and its screening. SCOPUS, MEDLINE, and Google Scholar were searched using specific terms for relevant, quantitative, original studies published between 2017 and 2022. All English articles that matched the inclusion criteria were included in this review. Fourteen studies focusing on knowledge, attitudes, and barriers regarding breast cancer were included. Two independent reviewers performed screening and extraction. Among the reviewed studies, a range from 19.6% in Oman to 67% in Saudi Arabia had poor knowledge of breast cancer. Past personal or family history was a well-recognized risk factor (n=5), and being worried about the results was the most common barrier to screening. Although most women were aware of screening methods, the majority did not practice screening. Social media and the internet were the most used sources of information used by women to obtain knowledge regarding breast cancer and its screening (n=6). Most of the Arab female population had low levels of knowledge, attitudes, and practices regarding breast cancer and its screening. Programs designed to raise awareness are necessary, and more policy changes must take place on the national level in Arab, Middle Eastern countries to address the low knowledge, the negative attitudes, and the limited access to breast cancer screening.

Physiotherapy in the digital age: A narrative review of the paradigm shift driven by the integration of artificial intelligence and machine learning

Abstract: A variety of physical impairments and functional restrictions are assessed and treated in the practice of physiotherapy. Subjective measures, rater variability, and restricted access to high-quality care are some of the unavoidable problems that contemporary physical therapy practice approaches must overcome. In light of these challenges, cutting-edge technologies such as artificial intelligence (AI) and machine learning (ML) are demonstrating remarkable efficacy in tackling these issues head-on. The focus of this review is to explore how the integration of AI and ML might change physical therapy practice and education in the age of digital communication. It delves into the challenges accompanying this integration and considers future prospects in this domain. A literature search was conducted using data base PubMed, Google Scholar, Web of Science, and Scopus with keywords such as ‘physiotherapy’, ‘artificial intelligence’, and ‘machine learning’, limited to English articles from 2014 to 2024. Results were imported into reference management software, duplicates removed, and relevant articles were screened and assessed for inclusion, with reasons for exclusion documented. Emerging technologies like AI and ML use algorithms to examine patient data and make automatic decisions, enhancing areas such as virtual reality therapy (VR), tele-rehabilitation, clinical decision support, individualized rehabilitation and physical function evaluation. These advance technologies optimize physical therapy and improve outcomes, but further research is needed to address obstacles like bias and data privacy to ensure responsible implementation. AI and ML can revolutionize physical therapy by improving therapy precision, patient monitoring, optimization and individualized therapy plan. However, it’s crucial for physiotherapists to balance technological advancements with compassionate, patient-centred approach.

Case Report: Hemoglobin Hasharon with Concurrent Alpha Thalassemia in a Patient with Maple Syrup Urine Disease

Abstract Hemoglobin Hasharon (Hb Hasharon) is an unstable hemoglobin variant stemming from a mutation in the alpha globin gene. This mutation involves the replacement of aspartic acid with histidine at position 47 of the alpha globin chain. Initially identified in 1967 in Israel, Hb Hasharon has since been sporadically reported in various populations, including in Italy, Greece, Germany, and among Latin Americans of Mediterranean descent. Only three English articles have reported several cases of the combined alpha thalassemia deletion and Hasharon mutation, all between 1978-1980. Notably, there has been no prior report of Hb Hasharon with concurrent alpha thalassemia in patients with maple syrup urine disease (MSUD). We hereby present the first case of Hb Hasharon with alpha thalassemia in a patient diagnosed with MSUD. This patient, a 16-month-old female, received a prenatal diagnosis of MSUD through amniocentesis, confirming homozygosity for a known pathogenic variant in DBT (c.75_76delAT, p.C26wfsX2). Prompt initiation of formula feeding has effectively controlled her MSUD. The patient was referred for further evaluation due to hemoglobin newborn screen showing hemoglobin A, Hb F and “variant hemoglobin”. Her parents denied any family history of hemoglobinopathy. Her complete blood count was predominantly normal except for mild microcytosis, with a mean corpuscular volume of 69.1 fl (normal range 70.0-86.0 fl). The patient didn’t exhibit neonatal jaundice or any other signs or symptoms of hemolysis. The reticulocyte count was also within normal limits. The hemoglobin electrophoresis results revealed a complex pattern, with 28.8% of an unknown hemoglobin between zone 4 and 5 on capillary zone electrophoresis (CZE) as well as a possible A2 variant in zone 1. High-performance liquid chromatography (HPLC) indicated a 29.1% peak at a retention time of 4.72 minutes, along with several smaller peaks, that were indicative of the degradation of the unstable unknown hemoglobin. Although the zones and retention time aligned with Hb Hasharon, the percentage differed from the expected range of 19-20% in CZE and 18-21% in HPLC for this variant, prompting the team to order alpha and beta globin sequencing tests. Beta globin gene complete sequencing yielded negative results, while the sequencing of alpha globin gene revealed that the patient carries one copy of the -alpha3.7 alpha-globin deletion and one copy of the c.142G>C (p.Asp48His) variant in the alpha2-globin (HBA2) gene, resulting in an -alpha/alpha2alpha1 genotype with Hb Hasharon. While Hb Hasharon is generally not clinically significant, its co-occurrence with alpha-thalassemia can lead to hemolytic anemia. In our patient, clinic and chemical parameters were predominantly within normal ranges, except for mild microcytosis. The potential interaction between MSUD and Hb Hasharon with concurrent alpha thalassemia remains unknown. Continued patient monitoring will enable us to evaluate whether these conditions may influence each other’s clinical and biochemical profiles.

The Current Progress of Artificial Intelligence in Approach to Thyroid Nodules: A Narrative Review

Background: Artificial intelligence (AI) can play a significant role in the future of thyroidology. Thyroid nodules are common conditions that may benefit from AI through more accurate and efficient diagnosis, risk stratification, and medical or surgical management. Objective: This paper aims to review the latest developments in AI applications for diagnosing and managing thyroid nodules and cancers. Methods: English full-text articles published in the PubMed and Google Scholar databases from January 2014 to March 2024 were collected and reviewed to provide a comprehensive understanding of the topic. A total of 45 studies were selected based on relevance, robust methodology, statistical significance, and broader topic coverage. Results: Artificial intelligence has emerged as a powerful tool for managing thyroid nodules. First, several studies have demonstrated how AI-powered ultrasound interpretation enhances the diagnosis and classification of nodules while reducing the need for invasive fine-needle aspiration (FNA) biopsies. Second, AI significantly improves the cytopathological differentiation between benign and malignant thyroid nodules by minimizing reliance on pathologists' expertise and implementing standardized diagnostic criteria. When cytopathology is inconclusive, AI also aids in identifying molecular markers from omics data, distinguishing between normal and cancerous cells. Moreover, AI tools have been developed for prognosis assessment, predicting distant metastasis, recurrence, and surveillance by integrating medical imaging features with molecular and clinical factors. Additionally, some AI tools are designed for intraoperative evaluation, improving surgical techniques and reducing complications during thyroidectomy. In non-surgical treatments, several models have been developed to optimize therapeutic doses of radioactive iodine (RAI) and predict the outcomes of new drug formulations. Conclusions: Artificial intelligence has the potential to assist physicians in accurate thyroid nodule diagnosis, classification, decision-making, optimizing treatment strategies, and improving patient outcomes. However, there are still limitations to this technology. Artificial intelligence-driven tools require further advancements before they can be fully integrated into clinical practice and replace specialists.

Aggression in psychiatry: a bibliometric analysis

BackgroundAggression is a common problem in psychiatric clinics, and many studies have been conducted on the issue over the years. This study bibliometrically examines the characteristics and trends of aggression studies in psychiatry, such as the branches, publication years, types, publishers, and impact factors, and compares the focus areas of psychiatry and psychiatric nursing on aggression, to guide future research and readers on this topic. Bibliometric analysis was performed with network metrics, citation analysis, co-authorship analysis, science mapping, and network visualization techniques using WoS analysis reports and the VOSviewer program with data obtained from the Web of Science database on January 11, 2024.ResultsMost studies on aggression in psychiatry were published in 2019 as English articles. Then, 3.37% of these studies are in psychiatric nursing, mainly from Australia. In contrast, most psychiatric studies are from the USA. Psychiatry studies focus on causes, types, and relationships with psychiatric disorders, while psychiatric nursing studies emphasize aggressive attitudes, risk assessment, and aggression management.ConclusionsIt appears that studies on aggression continue to remain current in the literature and will continue to do so, considering that aggression is an ongoing clinical problem worldwide. Despite this, studies on assessing and managing the risk of aggression are still lacking. Future studies should prioritize the management of aggression. While the study showed the presence of multidisciplinary and international collaborations, it is recommended that these collaborations be further expanded. Findings may inform researchers’ keyword and journal choices.

Unveiling the Biological Effects and Pharmacological Properties of Sorbifolin: a Comprehensive Review.

Bioactive phytochemicals act as important factors with preventive and therapeutic potential in the pathogenesis of several disorders, often related to oxidative stress. Many dietary plant secondary metabolites could lower these conditions. Sorbifolin is one of these metabolites. This work is the first review of sorbifolin, a flavone detected in various plant matrices as a major compound. The present study discussed the natural sources, extraction, purification, quantification, and assessment of the biological activities of sorbifolin. Several databases including Google Scholar, Web of Sciences, and Science-Direct were consulted for relevant English articles related to sorbifolin, the phytochemical profiles of several medicinal plants containing this compound, and its biological activities, such as antioxidant, anticancer, antimicrobial, anti-inflammatory, and antidiabetic. The positive in vitro and in silico outcomes reported in the literature should be followed by additional in vivo and clinical investigations to further research the mechanisms of action, pharmacokinetic/pharmacodynamic activities, toxicological effects, pharmacological properties, and therapeutic potential of sorbifolin.

Impact of articles written in non-alphabet languages.

Nowadays, English is the lingua franca of science, and the reference lists in most English articles are dominated by other English articles. Publications in languages other than English are most often in French, Italian, Spanish, or German. The minority written languages, that is, non-alphabet languages, have often not been included in reference lists in the scientific literature. However, to accord with the "diversity, equity, and inclusion" concept, non-alphabet languages should be included and discussed. Failure to cite articles in non-alphabet or non-standard languages ignores knowledge that could be useful to both the author and the reader. We hope the present article will promote more discussion of this often-overlooked topic.