Artery Aneurysm Rupture Research Articles

Coil embolization to giant left anterior descending artery and left circumflex artery coronary artery aneurysm after failed coronary aneurysmal repair in IgG4-related disease: a case report

BackgroundIgG4-related disease (IgG4-RD) is a chronic fibroinflammatory condition with multiple-organ involvement. Rupture of coronary artery aneurysms (CAAs) in IgG4-RD is rare.Case summaryA 65-year-old man with IgG4-RD has suffered from recurrent episodes of arterial aneurysms since 2003. He presented with chest pain and hypotension caused by localized cardiac tamponade at right ventricle free wall due to the rupture of coronary artery aneurysm (CAA) of left anterior descending artery (LAD). An urgent LAD aneurysm repaired with bovine pericardium and obliterated aneurysmal sac with cryo-acrylate glue was done together with coronary artery bypass grafting (CABG) using saphenous vein graft (SVG) to LAD and SVG to posterior descending artery. Three-month after surgery, the follow-up coronary computed tomography angiography (CCTA) revealed a growing in size of LAD and the second obtuse marginal (OM) branch aneurysm. Heart team discussion agreed to schedule the patient for double coil embolization to LAD and second OM aneurysm under intravascular ultrasound guidance. Both aneurysms were successfully obliterated with vascular coils. Two-week follow-up coronary angiogram showed complete occlusion of LAD aneurysm and near occlusion of the second OM branch aneurysm.DiscussionCoronary artery aneurysm rupture is a life-threatening condition that required prompt detection and treatments. In IgG4-RD patients, acute cardiac tamponade suggesting the rupture of CAA. Coil embolization is an alternative treatment in patients who suffered from recurrent CAA after surgical repair. Serial CCTA is important for early detection of aneurysm in IgG4-RD patients who had vascular involvement.

911 Delayed Presentation of a Re-Bleed from A Traumatic Splenic Artery Rupture Following Endovascular Management in A Patient with Median Arcuate Ligament Syndrome

Abstract Endovascular management of splenic blunt trauma is widely accepted as a safe and effective alternative to open surgery in carefully selected patients. Following a radiologically successful intervention, patients are normally discharged with no follow up after 48-72 hours of haemodynamic stability and satisfactory serial haemoglobin levels. We present a case of a fit and well 24-year-old male patient who presented with abdominal pain, syncope and haemodynamic instability 14 days post successful splenic artery coil-embolization for splenic artery aneurysm rupture secondary to blunt trauma. After initial resuscitation, computed tomography angiography was performed and demonstrated active bleeding from the splenic artery aneurysm which was deemed likely to be a consequence of retrograde filling. The patient underwent successful emergency re-embolization using a combination of embolization coils and Onyx via a trans-splenic approach to eliminate retrograde flow. On further review of the imaging, it was incidentally noted there was evidence suggesting a diagnosis of median arcuate ligament syndrome, which may have predisposed the patient to splanchnic artery aneurysm formation. This case report highlights a potential limitation of endovascular management compared to open surgery and summarises the literature surrounding splenic artery anatomical variations and the implications of median arcuate ligament syndrome. A re-bleed following embolization is a hostile prospect with potentially catastrophic outcomes for patients if not recognised quickly. The authors propose that interval re-imaging should be considered following endovascular management of blunt splenic trauma.

Surgical outcomes of patients after treatment of ruptured anterior communicating artery aneurysms: \u201creal-world\u201d evidence from southern Thailand

BackgroundAnterior communicating artery (AComA) aneurysm rupture is the most common cause of subarachnoid hemorrhage worldwide. In this study, we aimed to determine the factors associated with a poor clinical outcome in patients with ruptured AComA aneurysms undergoing microsurgical clipping.MethodsWe retrospectively reviewed the clinical and radiologic features as well as clinical outcomes of 150 consecutive patients with ruptured AComA aneurysm who underwent surgical clipping during the 11-year study period. Logistic regression analysis was performed to identify independent factors associated with unfavorable clinical outcomes (defined as a modified Rankin scale score of 3–6).ResultsThe study included 83 male and 67 female patients, with a mean age of 51.3 ± 11.5 years. At admission, most of the patients had good neurological status, including 97 (64.7%) patients with a Hunt and Hess grade of 1 or 2 and 109 (72.6%) patients with a World Federation of Neurosurgical Societies grade of 1 or 2. Unfavorable outcomes at 6 months were observed in 23 (22.0%) patients, and the 6-month mortality rate was 8.0%. Multivariate analysis showed that preoperative intraventricular hemorrhage (odds ratio [OR], 19.66; 95% confidence interval [CI], 5.10–75.80; P < 0.001), A1 hypoplasia (OR, 8.90; 95% CI, 2.82–28.04; P < 0.001), and postoperative cerebral infarction (OR, 3.21; 95% CI, 1.16–8.88; P = 0.025) were strong independent risk factors for unfavorable outcomes.ConclusionsProper management of preoperative intraventricular hemorrhage, A1 hypoplasia, and intensive care for postoperative brain infarction are warranted for improved surgical outcomes in patients with ruptured AComA aneurysm undergoing surgical clipping.

A Rare Case of Fibromuscular Dysplasia with Postpartum Renal Artery Rupture in a Non-Hypertensive Woman

Fibromuscular dysplasia (FMD) of the renal artery is a non-atherosclerotic, non-inflammatory vascular disease that causes stenosis, aneurysm, dissection, and occlusion of the vessel. We report a rare case of a postpartum FMD patient who presented with spontaneous acute perirenal hematoma due to renal artery aneurysm rupture after cesarean section. The 40-year-old patient presented with sudden onset of abdominal pain 2 days after an elective cesarean section performed at full gestational term. A computed tomography scan of the abdomen revealed perirenal hematomas with signs of FMD in both renal arteries. The bleeding was successfully controlled by transcatheter arterial embolization. Short-term continuous renal replacement therapy was performed until her renal function recovered. FMD of the renal artery is rare in pregnant patients. Additionally, aneurysm rupture can be life threatening and requires immediate medical attention and prompt management.

Neurological manifestations of polyarteritis nodosa: a tour of the neuroaxis by case series

BackgroundHeterogenous central nervous system (CNS) neurologic manifestations of polyarteritis nodosa (PAN) are underrecognized. We review three cases of patients with PAN that illustrate a range of nervous system pathology, including the classical mononeuritis multiplex as well as uncommon brain and spinal cord vascular manifestations.Case presentationCase 1 presented with mononeuritis multiplex and characteristic skin findings. Case 2 presented with thunderclap headache and myelopathy due to spinal artery aneurysm rupture. Both patients experienced disease remission upon treatment. Case 3 presented with headache and bulbar symptoms due to partially thrombosed intracranial aneurysms, followed by systemic manifestations related to visceral aneurysms. She demonstrated clinical improvement with treatment, was lost to follow-up, then clinically deteriorated and entered hospice care.ConclusionsAlthough the peripheral manifestations of PAN are well-known, PAN association with CNS neurovascular disease is relatively underappreciated. Clinician awareness of the spectrum of neurologic disease is required to reduce diagnostic delay and promote prompt diagnosis and treatment with immunosuppressants.

Charcot-Bouchard Aneurysm Diagnosed with CTA and MRA

Hemorrhage in the basal ganglia resulting to lenticulostriate artery aneurysm rupture is extremely rare. This distal micro-aneurysm of the perforating lenticulostriate arteries is called Charcot-Bouchard aneurysm. We wish to report a case of an hematoma in the basal ganglia due to a Charcot-Bouchard aneurysm demonstrated by Computed Tomography Angiograpy (CTA) and Magnetic Resonance Angiography (MRA) and confirmed by selective catheter angiography.Teaching Point:Charcot-Bouchard aneurysm is a very rare distal micro-aneurysm of the perforating lenticulostriate arteries. Young patients who experience basal ganglia hemorrhage should have contrast-enhanced CT, especially if they don’t have arterial hypertension and if subarachnoid hemorrhage is associated.

Case Analysis of Persistent Vasospasm after Cerebral Artery Aneurysm Rupture by Using Transcranial Color Coded Doppler Ultrasonography

Case Analysis of Persistent Vasospasm after Cerebral Artery Aneurysm Rupture by Using Transcranial Color Coded Doppler Ultrasonography

Spontaneous non-traumatic splenic artery aneurysm rupture : endovascular treatment with a Covera covered stent

Spontaneous non-traumatic splenic artery aneurysm rupture : endovascular treatment with a Covera covered stent

Use of Interventional Neuroradiology Devices (Solitaire AB and Cascade Net) in the Treatment of Complex Renal Aneurysms through Stent-Assisted Coil Embolisation

Introduction: The risk of rupture of true renal artery aneurysms is low but when they are bigger than 2 - 2.5 cm it increases significantly, making treatment essential. The need to use alternatives to conventional techniques in order to avoid predictable complications as coil migration is mandatory. Discussion: Routinely-used techniques in interventional neuroradiology such as flow diverters or those assisted with an occlusion balloon or stent have are suitable alternatives for complex aneurysms. Conclusion: Interventional neuroradiology devices such as the Cascade Net stent (Perflow Medical and Grupo Logsa) and Solitaire AB stent retriever (Medtronic) are valid and safe options. We describe the technique of such devices.

Moyamoya Disease with Intraventricular Hemorrhage due to Rupture of Posterior Choroidal Artery Aneurysms Embolized: Case Report

Moyamoya Disease with Intraventricular Hemorrhage due to Rupture of Posterior Choroidal Artery Aneurysms Embolized: Case Report

1290: Chest Pain and Respiratory Arrest: An Unusual Presentation of Right Gastric Artery Aneurysm Rupture

1290: Chest Pain and Respiratory Arrest: An Unusual Presentation of Right Gastric Artery Aneurysm Rupture

Third Nerve Palsy Due to Posterior Communicating Artery Aneurysm Rupture Into the Subdural Space.

Third Nerve Palsy Due to Posterior Communicating Artery Aneurysm Rupture Into the Subdural Space.

The influence of angiospasm on the results of microsurgical treatment of cerebral arterial aneurysms in the acute period of rupture

The purpose of the study was to study the effect of angiospasm on the results of microsurgical treatment of arterial aneurysms (AA) in the brain in the acute rupture period.Material and methods. A retrospective analysis of 332 case histories of patients with brain AA treated in Mechnikov Dnipropetrovsk Regional Hospital from 2013 to 2018 was performed. All patients were admitted in the acute period of AA rupture, from one to 15 days from the onset of the disease. All patients were divided into 5 groups, depending on the timing of the operation. The group I enrolled 54 patients. They were operated within the first 3 days after the AA rupture. Group II included 56 patients. They were operated in the most unfavorable terms — from 4 to 8 days from the onset of the disease. Group III consisted of 106 patients operated on the 9–14th day from the onset of the disease. Group IV included 103 patients who were operated on the 15–30th day from the onset of the disease. Group V consisted of 13 patients who were operated within more than 30 days after the rupture of AA. In addition to general and biochemical blood tests, all patients underwent spiral computed tomography, cerebral angiography, transcranial dopplerography. The severity of the initial condition was evaluated on a Hunt-Hess scale; the treatment results were assessed on Glasgow Outcome Scale.Results. A clear dependence of treatment results on the severity and prevalence of angiospasm was revealed. When operating in AS grade III, the Glasgow Outcome Scale described the outcome as 4 or 5 scores. Only 4 patients with AS grade II demonstrated relatively decentish results. The patients operated against the background of AS grade I or without AS developed good results. The patients with AS grade II or III demonstrated substantively worse outcomes (p = 0.004174). The lethality was double-fold lower in group 2 compared to group 1; no vegetative state was determined. In group 3, the lethality level was 10.4 % and was slightly lower compared to group 2. In group 4, the lethality level was 7.8 %. No lethal outcome was registered in group 5.Conclusions. The severity and prevalence of angiospasm in aneurysmal SAH are strictly individual. Angiospasm does not always cause cerebral ischemia, but the presence of brain ischemia on SCT always indicates the angiospasm. The results of the microsurgical treatment of AA are statistically significantly worse in patients who were operated against the background of angiospasm of the second and third degrees.

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Among strokes, subarachnoid hemorrhage (SAH) consecutive to the rupture of a cerebral arterial aneurysm represents 5-9% but is responsible for about 30% of the total stroke-related mortality with an important morbidity in terms of neurological outcome. A delayed cerebral vasospasm (CVS) may occur most often in association with a delayed cerebral ischemia. Different animal models of SAH are now being used including endovascular perforation and direct injection of blood into the cisterna magna or even the prechiasmatic cistern, each exhibiting distinct advantages and disadvantages. In this article, a standardized mouse model of SAH by double direct injection of determined volumes of autologous whole blood into the cisterna magna is presented. Briefly, mice were weighed and then anesthetized by isoflurane inhalation. Then, the animal was placed in a reclining position on a heated blanket maintaining a rectal temperature of 37 °C and positioned in a stereotactic frame with a cervical bend of about 30°. Once in place, the tip of an elongated glass micropipette filled with the homologous arterial blood taken from carotid artery of another mouse of the same age and gender (C57Bl/6J) was positioned at a right angle in contact with the atlanto-occipital membrane by means of a micromanipulator. Then 60 µL of blood was injected in the cisterna magna followed by a 30° downward tilt of the animal for 2 minutes. The second infusion of 30 µL of blood into the cisterna magna was performed 24 h after the first one. The individual follow-up of each animal is carried out daily (careful evaluation of weight and well-being). This procedure allows a predictable and highly reproducible distribution of blood, likely accompanied by intracranial pressure elevation that can be mimicked by an equivalent injection of an artificial cerebral spinal fluid (CSF), and represents an acute to mild-model of SAH inducing low mortality.

Vascular Remodeling and Immune Cell Infiltration in Splenic Artery Aneurysms.

Rupture of splenic artery aneurysms (SAAs) is associated with a high mortality rate. The aim of this study was to identify the features of SAAs. Tissue sections from SAAs were compared to nonaneurysmal splenic arteries using various stains. The presence of intraluminal thrombus (ILT), vascular smooth muscle cells (VSMCs), cluster of differentiation (CD)-68+ phagocytes, myeloperoxidase+ neutrophils, CD3+, and CD20+ adaptive immune cells were studied using immunofluorescence microscopy. Analysis of SAAs revealed the presence of atherosclerotic lesions, calcifications, and ILT. Splenic artery aneurysms were characterized by a profound vascular remodeling with a dramatic loss of VSMCs, elastin degradation, adventitial fibrosis associated with enhanced apoptosis, and increased matrix metalloproteinase 9 expression. We observed an infiltration of immune cells comprising macrophages, neutrophils, T, and B cells. The T and B cells were found in the adventitial layer of SAAs, but their organization into tertiary lymphoid organs was halted. We failed to detect germinal centers even in the most organized T/B cell follicles and these lymphoid clusters lacked lymphoid stromal cells. This detailed histopathological characterization of the vascular remodeling during SAA showed that lymphoid neogenesis was incomplete, suggesting that critical mediators of their development must be missing.

Biphasic clinical course of a ruptured right gastric artery aneurysm caused by segmental arterial mediolysis: a case report

BackgroundGastric artery aneurysms are rarely caused by segmental arterial mediolysis (SAM), a condition that often involves multiple vessels. The clinical course of SAM after vessel rupture may vary depending on the involved vessels. For example, the “double-rupture phenomenon” observed following the rupture of the splenic artery aneurysm manifests as a biphasic and relatively slow clinical course. Even in cases of rupture of gastric artery aneurysm, the double-rupture phenomenon has only been reported in two cases so far. However, the rupture was not caused by SAM in either case. Herein, we present the apparent first case of a right gastric artery (RGA) aneurysm rupture caused by SAM that presented with a biphasic clinical course, possibly due to the double-rupture phenomenon.Case presentationA 54-year-old woman was transferred to the emergency department with severe abdominal pain and a cold sweat for a duration of 3 h. She had developed mild abdominal pain and nausea 3 days earlier. Her vital signs were stable. Physical examination revealed tenderness in the epigastric area. Abdominal contrast-enhanced computed tomography revealed an RGA aneurysm with contrast media extravasation. A diagnosis of hemoperitoneum following a ruptured RGA aneurysm was made, and the patient underwent angiography. However, this modality did not reveal any extravasation from the RGA due to an interruption in the peripheral branch of the artery. Nevertheless, to prevent major bleeding, we performed coil embolization at the point of interruption in the RGA, which we suspected to be a ruptured aneurysm. A distal gastrectomy with Roux-en-Y reconstruction for aneurysm resection was performed the following day. There were no postoperative complications, and the patient was discharged 17 days after surgery. Histologically, the RGA demonstrated multiple vacuoles in the medial muscle layer, which were characteristic of SAM.ConclusionsAn RGA aneurysm rupture should be considered a differential diagnosis in patients presenting with hemoperitoneum with a slow or biphasic clinical course.

Posterior Reversible Encephalopathy Syndrome Caused by Induced Hypertension to Treat Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage

The aim of the present study was to describe the case of a patient who had presented to a university hospital with induced-hypertension (IH) posterior reversible encephalopathy syndrome (PRES). We also reviewed all other reports of such patients. We have described the clinical course of a patient who had presented to the university hospital neurosurgical department. We also performed a systematic review of studies related to the incidence of PRES caused by the use of IH in the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. The patient had presented with an acute-onset headache and found to have a subarachnoid hemorrhage due to anterior communicating artery aneurysm rupture. She underwent coiling the next day. During the subsequent days, she demonstrated fluctuating clinical examination findings, aphasia, and decreased levels of arousal. Digital subtraction angiography was performed, and the findings were concerning for mild vasospasm of the anterior and middle cerebral arteries. The systolic blood pressure goal was increased to 180-220 mm Hg for an IH trial, which had initially resulted in some transient clinical improvements in her level of arousal. However, the improvement was not sustained. During the next 36 hours, the patient worsened, and she developed left middle cerebral artery syndrome. Given the concern for a possible ischemic event, magnetic resonance imaging was performed, which demonstrated interval development of multiple areas of cortical-based fluid-attenuated inversion recovery hyperintensity consistent with PRES. The systolic blood pressure goal was relaxed to normotension, and ~48 hours later, the patient's clinical status had significantly improved. IH-PRES is a rare complication that should be remembered in the differential diagnosis for at-risk patients.

Сase of Progressive Fibrodysplasia Ossificans in Combination with a Rupture of Cerebral Arterial Aneurysm and Hyperparathyroidism

A rare clinical observation of a 24-year-old patient with clinical and radiological manifestations of Fibrodysplasia Ossificans Progressiva, combined with rupture of saccular cerebral aneurysm and hyperparathyroidism, is presented. A characteristic feature of this case was a combined pathology of cerebral vessels with Fibrodysplasia Ossificans Progressiva, the first manifestations of which appeared after intracranial haemorrhage with the development of severe motor neurological deficiency. It was accompanied by articulate and severe spastic syndromes, tough muscle and joint contractures, and the signs of Vitamin D deficiency and hyperparathyroidism were found later.

Endovascular treatment of splenic artery aneurysm rupture

A case of successful clinical endovascular treatment for rupture of a splenic artery aneurysm with intraperitoneal bleeding is presented. An emergency open surgery, urgent endovascular aneurysm embolization and planned relaparotomy with the removal of gauze swabs and drains were performed. The staging of surgical treatment was determined by the location of the patient at the time of the complication and the equipment of medical institutions that provided medical care. Regarding the dangerous condition with rupture of the splenic artery aneurysm minimally invasive high-tech surgical care is possible only under certain conditions and depends on the qualifications of doctors, a multidisciplinary approach and the level of equipment of a medical institution. Endovascular embolization of the splenic artery aneurysm when it ruptures is a modern, highly effective and reliable minimally invasive surgical method.

Management of Gastroduodenal Artery Pseudoaneurysm Rupture With Duodenal Ulcer Complicated by Coil Migration

ABSTRACTRupture of visceral artery aneurysms or visceral artery pseudoaneurysms is an unusual cause of upper gastrointestinal bleeding. Although most visceral artery aneurysms and visceral artery pseudoaneurysms occur in the splenic artery or hepatic artery, they can rarely occur in the gastroduodenal artery. These are at high risk for rupture, with a 40%–70% mortality. We report a case of recurrent upper gastrointestinal bleeding due to gastroduodenal artery pseudoaneurysm despite endoscopic treatment and endovascular embolization complicated by coil migration into the duodenum.