In this study, the authors analyzed the ethnopharmacological use of 55 medicinal plant species (herbalists, healers, and shamans) by the population of Central and Eastern Yakutia. The results indicate that the most commonly used plants belong to the Asteraceae, Rosaceae, and Lamiaceae families. In Eastern Yakutia, the population most widely uses Dryopteris fragrans, Pinus pumila, Dracocephalum palmatum, and Juniperus sibirica. The population of Central Yakutia uses the species of Artemisia and Thymus genera, as well as Veronica incana and Phlojodicarpus sibiricus species. The most commonly used medicine forms are decoctions, infusions, and tinctures (60%). They are generally made from grass or leaves. The survey indicates that 34.5% of the plants are used as anti-inflammatory or invigorating means. The qualitative analysis shows that 48% of the plants accumulate phenolic compounds.