Abstract
Cancer and microbial infectious diseases are considered a global threat. Plants have been investigated across the world to exploit their potential anticancer and antimicrobial effective agents. In this study, two medicinal plant species native to Saudi Arabia, namely; Artemisia judaica and Artemisia sieberi were screened to assess their antioxidant, anticancer and antimicrobial potential activities as well as phytochemical compositions. The collected aerial parts were extracted by maceration with methanol. Cytotoxic and antimicrobial activities were investigated using the MTT and MIC assays, respectively. Free radical scavenging and antioxidant potential were assessed respectively by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. The total flavonoid and phenolic contents of the crude methanolic extract were quantified using standard methods. Artemisia judaica displayed a strong cytotoxicity compared to A. sieberi while both species showed approximately similar bacterial and fungal growth inhibition. In contrast, A. sieberi displayed the highest phenol and flavonoid contents between the two species which was consistent with the higher antioxidant activity found in A. sieberi. It is concluded that both Artemisia species could be a promising source of antioxidant, anticancer and antimicrobial agents. Key words: Artemisia judaica, Artemisia sieberi, anticancer, antimicrobial.
Highlights
Plants have played a crucial role in preserving and enhancing humans’ quality of life
The results of this study reported that A. sieberi showed higher antioxidant activity than A. judaica
We reported that A. judaica and A. sieberi are considered as a promising source of phenolic and flavonoids compounds
Summary
Plants have played a crucial role in preserving and enhancing humans’ quality of life. Plants were and still represent a rich source of new therapeutic agents for the treatment of several primary health care ailments. Plants are still being investigated across the world to exploit their potential of anticancer agents. Increasing attention has turned to medicinal plant as a potential source of new antimicrobials (AliShtayeh et al, 1998)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
