Event Abstract Back to Event Immunohistochemical investigation of the developing subventricular zone situated in the lateral ventricle in rat brain I. Adorjan1, E. Berecz1, G. Visolyi1, D. Antal1, E. Kani1 and M. Kalman1 1 Semmelweis University, Department of Anatomy, Histology and Embryology, Hungary The subventricular zone (SVZ) of the lateral ventricle (LV) belongs to the few brain regions where neurogenesis takes place in adulthood. Over the last decade growing number of publications focused on the cellular composition of this territory, the course of neurogenesis and the arrangement of migratory routes. However, limited information is available about the development of this thin but highly organized region. Present study investigates the temporospatial appearance of different cell populations and their phases of maturation along the LV by immunohistochemical detection of intermediate filaments (i.e. nestin, vimentin, GFAP) between embryonic day (E) 12 and postnatal day (P) 60. In the middle of the embryonic period (E12-16) the ventricular zone (VZ) was composed of nestin- and vimentin-immunopostive radial glial perikarya that are the primary source of the ongoing neuro- and gliogenesis. The GFAP-ip radial glia appeared between E17-18 around the interventricular foramen and the dorsal part of the third ventricle. The nestin disappeared from the VZ between P4 -P8 and later it remained characteristic of the lateral SVZ. The vimentin disappeared from the SVZ between P4-P8 and afterwards it became restricted to the VZ except of the dorsolateral SVZ and the rostral migratory stream. Based on our observations the distribution of nestin and vimentin becomes inverse after birth with the exception of the lateral SVZ where similar to the embryonic period they occur together. Keywords: Molecular and cellular neurobiology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Molecular and cellular neurobiology Citation: Adorjan I, Berecz E, Visolyi G, Antal D, Kani E and Kalman M (2011). Immunohistochemical investigation of the developing subventricular zone situated in the lateral ventricle in rat brain. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00078 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers I. Adorjan E. Berecz G. Visolyi D. Antal E. Kani M. Kalman Google I. Adorjan E. Berecz G. Visolyi D. Antal E. Kani M. Kalman Google Scholar I. Adorjan E. Berecz G. Visolyi D. Antal E. Kani M. Kalman PubMed I. Adorjan E. Berecz G. Visolyi D. Antal E. Kani M. Kalman Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.