INTRODUCTION: Uruguay is the Latin American country with the highest rate of real donors (19.1 pmp). The existing coordination model until 2004 was the out-of-hospital model. In 2005, Hospital Transplant Coordination began in three public hospitals in the capital city of the country. The Hospital Transplant Coordinator has the fundamental task of knowing the hospital successes, the Intensive Treatment Center and the encephalic deaths (EM). This allows to make a diagnosis of the situation, in terms of the potential donor generator that may have, and in turn to have a quality control of its activity in the procurement. OBJECTIVES: to evaluate the impact of early hospital screening on donation/procurement during the first eight months of operation of the Hospital Transplant Coordination Unit at the Central Hospital of the Armed Forces. It will be compared with the first eight months of the years 2000 to 2004. MATERIAL AND METHODS: prospective study from January 1 to August 31, 2005, comparing it with the same intervals from 2000 to 2004, analyzing the indicators of ME and Real Donor generating capacity and Global Effectiveness of donation, and comparing them in the referred periods. RESULTS: in the reference period 108 deaths were registered in STI, of which £8 were 76 (70%).11 EM were diagnosed, of which 6 were PD and 5 were RD. The ME/Deaths Hospital generating capacity was 3.4 %, and ME/Deaths Polyvalent: 14 %. Overall effectiveness: RD/ME: 0.45, RD/DP: 0.83; RD/Polyvalent CTI bed: 0.63. DISCUSSION: the great benefit of Hospital Coordination is evidenced by an increase in the ME and RD generating capacity of the referred Hospital. The ME represented 3.4% of hospital deaths and 14% of deaths in CTI, in accordance with international reference values (1 to 4% and 8.5 to 14%). Therefore, these results confirm the need and importance of Hospital Transplant Coordination. Presented at: III Argentine Congress of Organ and Tissue Procurement for Transplantation Mar del Plata, Bs.As. November 17-18, 2005.