This paper presents the results of the investigations that defined the formation of the sedimentary deposits and the chronological sequence of the Foz do Chapecó archaeological area in the Volta Grande of the Upper Uruguay River, Southern Brazil. This research was undertaken to contribute to the definition of the diachronic, sedimentary and stratigraphic context of the archaeological occupations. To achieve these goals a geoarchaeological prospection by land and water was conducted, focusing on the valley bottoms, in the whole Volta Grande area. It comprehended the characterization of surface sedimentary deposits, the exposure and analysis of stratigraphic profiles, and sedimentological analysis. Four superficially exposed deposits were identified: i.e., fluvial conglomerates, fine sediments with sandy texture, clay colluviums and current and recent alluvial deposits. Six interesting points for the opening of stratigraphic profiles were identified, and subsequently resulted in the identification of sedimentary facies associated with river-bed, colluvial and colluvial-alluvial deposits. Three of these points presented a clear sequence of archaeological levels in the stratigraphic context. The results indicated that the local sediments are predominantly composed of a variable mixture of silt and clay, with sands occurring predominantly in an interdigitated form. The stratigraphic structure of the identified layers led to the establishment of 7 sedimentary facies, associated with colluvium (Cm), colluvium-alluvium (Sm) and alluvium and fluvial channels (Sm, Fl, Gms, Gt, Gp, Gh). The radiocarbon dating gives an age between 12.0 and 0.3 cal kBP, indicating that the filling of the local valley occurred during the end of the Pleistocene and throughout the Holocene by means of both fluvial and colluvial systems. Nine distinct archaeological levels, with a clear stratigraphic, chronological, and technological characterization were identified. The pre-ceramic archaeological sequence shows the following chronology: the oldest occupation occurred between 12.0 and 11.0 cal kBP (Cm facies); this was followed by an occupation between 10.5 and 9.5 cal kBP (Cm, Gt, Gp and Gh facies in three archaeological sites with eleven 14C data), then an occupation between 8.7 and 8.5 cal kBP (Cm facies), another between 5.7 and 5.5 cal kBP, one more between 4.8 and 4.6 cal kBP (Cm facies), and the last between 3.4 and 3.3 cal kBP (Cm and Sm facies). The ceramic phase seems to form a single dense component with the anthropogenic soil formation, and was dated between 0.5 and 0.3 cal kBP (Sm facies). These data present a previously unpublished chronostratigraphic sequence that is unique for the context of open-air sites in inner southern Brazil.