ABSTRACT A combined study of whole-rock geochemical and Sr-Nd isotopic data, and zircon U-Pb geochronological and Hf isotopes has been carried out for several Neoproterozoic intrusions, including the Lung Thang, Posen and Sin Quyen in the Phan Si Pan Zone, northwest Vietnam to constrain their age, petrogenesis and tectonic implications. The Lung Thang and Posen intrusions, mainly composed of granodiorite, were formed at 803–777 Ma and are characterized by moderate SiO2 (64.43–66.65 wt.%), and K2O (4.05–4.89 wt.%), with A/CNK and A/NK values of (0.94–1.03) and (1.72–2.11), respectively. They have negative whole-rock εNd(t) (−6.16 to −3.73) and zircon εHf(t) values (−7.9 to −4.1), which suggest that the Lung Thang and Posen intrusions were generated by partial melting of ancient, K-rich crustal rocks. The Sin Quyen intrusion, occurring as dykes, is composed of monzodiorite and was emplaced at 742 ± 3 Ma. The Sin Quyen intrusion has high alkalies (K2O+Na2O = 7.42–7.47 wt.%), and low MgO (<1.31 wt.%) and Ni (6.55–6.93 ppm), with A/CNK and A/NK values of (0.67–0.68) and (1.64–1.68), respectively. Their whole-rock εNd(t) and zircon εHf(t) values are −6.15 to −5.92 and −5.8 to + 8, respectively. These geochemical characteristics suggest that the Sin Quyen intrusion was produced by the partial melting of ancient crustal sources mingled with mantle-derived components. Geochemically, the Lung Thang, Posen and Sin Quyen intrusions are medium- to high-K, calc-alkaline in nature and show enrichment in LILE (Th, U, K, Rb) and LREE, and strong negative anomalies of Nb, Ta, and Ti. Such geochemical characteristics suggest that they formed in a subduction-related tectonic environment. The geochronological and geochemical correlation of these intrusions with those along the southwestern margin of the Yangtze Block in South China suggests that the Phan Si Pan zone in northwestern Vietnam is a constituent of the SW Yangtze Block. Additionally, these intrusions show a significant correlation with other contemporaneous magmatic rocks in the northeast Indochina Block, Lhasa Block, the northwestern margin of Greater India as well as those in Seychelles and northern Madagascar. This correlation suggests a similar history and synchronous episode of crustal growth/recycling in an Andean-type arc system along the western and northern margin of the Rodinia supercontinent during the Neoproterozoic.