Aqueous Solutions Of Ionic Liquids Research Articles

Relating the physical properties of aqueous solutions of ionic liquids with their chemical structures.

The physical properties of an aqueous solution of a macromolecule primarily depend on its chemical structure and the mesoscopic aggregates formed by many of such molecules. Ionic liquids (ILs) are the macromolecules that have caught significant research interests for their enormous industrial and biomedical applications. In the present paper, the physical properties, such as density, viscosity, ionic conductivity of aqueous solutions of various ILs, have been investigated. These properties are found to systematically depend on the shape and size of the anion and the cation along with the solution concentration. The ionic conductivity and viscosity behavior of the solutions do not strictly follow the Walden rule that relates the conductivity to the viscosity of the solution. However, the modified Walden rule could explain the behavior. A simple calculation based on the geometry of a given molecule could shed the light on the observed results.

Peptides in aqueous protic ionic liquid solutions: Apparent and transfer volumes at 298.15 K and at 0.1 MPa

The densities of glycine based peptides namely glycyl-glycine (digly), glycine-ւ-valine (gly-val), glycyl-ւ-leucine (gly-leu) and glycyl-glycyl-glycine (triglycine/trigly) in aqueous solutions containing ~0.20 mol·kg−1 of triethylammonium acetate [TEAA], triethylammonium glycolate [TEAG], triethylammonium pyruvate [TEAPy] and triethylammonium propionate [TEAP] protic ionic liquids (PILs) are reported at 298.15 K and at atmospheric pressure. Experimental density data obtained for these systems were used to estimate apparent molar volume (ϕV), the limiting apparent molar volume (ϕV0), partial molar volume of solute (V¯2) and partial molar volume of mixed solvent (PILs + water) (V¯1). The change in limiting apparent molar volume due to transfer (ΔtrϕV0) of peptides from water to aqueous ionic liquid solutions were also estimated. The outcomes obtained from all these thermodynamic parameters were discussed in terms of ion–peptide interactions, ion–ion interactions, hydrophobic solvation, peptide group contributions to limiting volumes, etc.

Molecular level insight into stability, activity, and structure of Laccase in aqueous ionic liquid and organic solvents: An experimental and computational research

Herein, we performed meticulous experimental and computational studies to explore the stability, activity, and dynamics of laccase in the presence of various organic and inorganic solvents. It is well known that laccases are eco-friendly enzymes, which can quickly eliminate recalcitrant chemicals from contaminated media. We determined the Asp96 (COO−)---Arg43 (N-H2), Asp131 (COO−)---Arg197(N-H1), Asp138(COO−)---Arg195 (N-H2), Asp140(COO−)---Arg199(N-H2), Asp214(COO−)---Arg260(N-H2), Asp224(COO−)---Arg423(N-H2), Asp424(COO−)---Arg243(N-H1), Asp424(COO−)---Arg243(N-H2), Glu288(COO−)---Arg176(N-H1) and Glu288(COO−)---Arg176(N-H2) salt bridges as the crucial ones in maintaining the structural integrity of laccase. Furthermore, the fluorescence, circular dichroism (CD) spectroscopies, and molecular dynamics simulation outcomes highlighted that the secondary structure elements and tertiary structure of the enzyme did not change significantly in the presence of both selected organic (ethanol and hexane) and inorganic (1-Butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) co-solvents. The obtained experimental results demonstrated that the enzyme was more stable in the hexane and aqueous ionic liquid solutions than in the ethanol solution. Additionally, laccase exhibited more activity in the presence of the hexane and aqueous ionic liquid solutions. Probably due to more accessibility of the substrate to the active site of laccase. Interestingly, the activity of laccase in the presence of the co-solvents was in decreasing order of hexane<[BMIM][PF6] < ethanol and the same order was observed for the number of water molecules in the enzyme's hydration shell. The results also indicated that the biocatalyst may keep a balance between the interactions with both water molecules and co-solvents to maintain its native conformation. The results also showed that there were some co-solvent molecules in the first hydration shell of the enzyme, but they were not enough to make a considerable change in the enzyme structure.

Strong Propensity of Ionic Liquids in Their Aqueous Solutions for an Organic-Modified Metal Surface.

Understanding ionic structure and electrostatic environments near a surface has both fundamental and practical value. In electrochemistry, especially when room temperature ionic liquids (ILs) are involved, the complex ionic structure near the interface is expected to crucially influence reactions. Here we report evidence that even in dilute aqueous solutions of several ILs, the ions aggregate near the surface in ways that are qualitatively different from simple electrolytes. We have used a vibrational probe molecule, 4-mercaptobenzonitrile (MBN), tethered to a metal surface to monitor the behavior of the ionic layers. The characteristic nitrile vibrational frequency of this molecule has distinct values in the presence of pure water (∼2232 cm-1) and pure IL (for example, ∼2226 cm-1 for ethylmethylimidazolium tetrafluoroborate, [EMIM][BF4]). This difference reflects the local electrostatic field and the hydrogen-bonding variations between these two limiting cases. We tracked this frequency shift as a function of IL concentration in water all the way from pure water to pure IL. We report two important findings. First, only one nitrile peak is observed for the entire concentration range, indicating that at least on the length scale of the probe molecule water and ILs do not phase separate within the interface, and no heterogeneously distinct electrostatic environments are formed. Second, and more importantly, we find that even up to a significant mole fraction of bulk water (x ∼ 0.95), the nitrile frequency does not change from that indicative of a pure IL for [EMIM][BF4], indicating preferential aggregation of the ions near the surface. Because this behavior is very similar to surfactants, we chose an imidazolium cation with a longer side chain which resulted in behavior expected from a surfactant, with a preferential layer of the ions on the surface even in dilute water solutions (x ∼ 0.995). This observation indicates that even those ILs that are not nominally categorized as surfactants have a strong tendency to aggregate at the surface. Because ILs serve as electrolytes in a range of electrochemical reactions, including those requiring water, our results are likely useful for mechanistic understanding and tuning of such reactions.

Molecular Dynamics Insights into the Nanoscale Structural Organization and Local Interaction of Aqueous Solutions of Ionic Liquid 1-Butyl-3-methylimidazolium Nitrate.

Considering the growing number of applications of the aqueous ionic liquids (ILs), atomistic molecular dynamics (MD) simulations were used to probe the effect of water molar fraction, xw, ranging from 0.00 to 0.90, on the nanoscale local structure of 1-butyl-3-methylimidazolium nitrate, [bmim][NO3], IL. The results prove that, with water addition, the cation-anion, cation-cation, and anion-anion structural correlations are weakened, while strong anion-water and unconventional cation-water hydrogen bonds are formed in the solutions. Water molecules were detected as bridges between nitrate anions, and the water cluster size distribution at different xw's was investigated. Simulation shows a similar pattern of probability densities for water and anion around the acidic hydrogen atoms of the reference cation ring, while both species move away from the cation butyl chain. Increasing the water concentration to xw = 0.90 causes decreasing of the local arrangement of the nearest-neighboring cations, because of the weakening of cation-cation π-π stacking. In addition, this dilution reduces the probability of the in-plane cation-anion conformation, disrupts both the polar ionic network and nonpolar domains, and diminishes the nanoaggregation of the cation butyl chains compared to those of the neat IL. These results can rationalize the origins of the fluidity enhancements and transport property trends upon adding water to the imidazolium-based ILs. The current study proposes a deep atomistic-level insight into the complex coupling between water concentration, microscopic structure, and local interactions of aqueous imidazolium-based ILs with hydrophilic anions.

In Situ Spectroelectrochemical Investigation of Potential‐Dependent Changes in an Amphiphilic Imidazolium‐Based Ionic Liquid Film on the Au(111) Electrode Surface

AbstractThe stability of ionic liquids (ILs) at charged interfaces makes them very attractive in electrochemical applications. In this work, a Langmuir–Blodgett transfer is used to fabricate a monolayer of an amphiphilic 1‐methyl‐3‐octadecylimidazolium perchlorate IL on the Au(111) surface. The IL monolayer immersed in an aqueous electrolyte solution is very stable over a wide potential window. Polarization modulation infrared reflection absorption spectroscopy is used to monitor structural changes in the model of the electrical double layer of the IL in aqueous solution. The imidazolium cation is in direct contact with the Au(111) surface. The imidazolium ring adopts a rigid orientation, inclined toward the metal surface, in the monolayer on the Au(111) surface. The orientation of hydrocarbon chains responds to electric potentials. At low negative surface charge densities of the Au(111) electrode, the hydrocarbon chains in the amphiphilic cation have a large average tilt versus surface normal. A negative potential shift is accompanied by a reorientation of the hydrophobic hydrocarbon chains that adopt an up‐ward orientation, making the film permeable for counter‐ and/or co‐ions. This transition leads to the formation of an ordered, single‐component monolayer of the amphiphilic cation on the electrode surface.

Separation and purification of curcumin using novel aqueous two-phase micellar systems composed of amphiphilic copolymer and cholinium ionic liquids

Novel aqueous two-phase micellar systems (ATPMS) composed of Pluronic F68, a triblock amphiphilic copolymer, and cholinium-based ionic liquids (ILs) were formulated and applied for separation/purification of curcumin (CCM). CCM stability in the presence of ATPMS components was also evaluated. CCM is stable up to 24 h in copolymer (1.0 – 10.0 wt%) and ILs (0.1 – 3.0 M) aqueous solutions. Very mild phase separation conditions (close to room temperature) were achieved by adding cholinium ILs to the Pluronic F68 + McIlvaine buffer at pH 6.0 solution. The decrease of cloud-point temperature is dependent on the relative hydrophobicity of IL anion, [Hex]− > [But]− > [Pro]− > [Ac]− > Cl−. ATPMS composed of more hydrophobic ILs ([Ch][Hex] > [Ch][But] > [Ch][Pro]) are most efficient in the partition of commercial CCM into polymeric micelles (PMs)-rich phase. The best ATPMS (0.70 M [Ch][But] and 0.60 M [Ch][Hex]-based ATPMS) were then used to purify CCM from a crude extract of Curcuma longa L. Both systems were very selective to separate CCM from protein-based contaminants (selectivity values ≥ 25; purification yields ≥ 12-fold). Pluronic F68-based ATPMS are promising for selective separation of hydrophobic biomolecules by using cholinium-based ILs as adjuvants to adjust phase separation temperatures and biomolecules’ partition.

Concentrating water-soluble ionic liquids from aqueous solutions: Osmotic distillation with hydrophobic membranes

Ionic liquids (ILs) show a wide range of applications as “green” solvents in the new era and the recovery of water-soluble ILs has become an urgent issue. Herein, for the first time, osmotic distillation is applied to concentrate and recover water-soluble ILs with a series of hydrophobic membranes. Poly(vinylidene fluoride) membrane with vertically oriented pores and stainless steel mesh were hydrophobically modified and then compared with commercial membranes to demonstrate the influence of different pore structures on the osmotic distillation concentration process. With the vapor pressure difference between two sides of the membrane being the driving force, the dilute aqueous solutions of ILs can be concentrated to about 84 wt% after 24 h with a water flux of 7.8 kg m−2 h−1. It is also able to achieve ultra-high rejections to ILs and MgCl2 (>99.99%) by this osmotic distillation process. Although there exists a limitation for dewatering the ILs solutions with very high concentrations and thus the final ILs purity cannot reach 100%, this method is promising for practical applications benefiting from its high rejection to ions, easy operability at ambient temperature and remarkable universality in terms of hydrophobic membranes used.

Tracing Local Nanostructure of the Aqueous Solutions of the Biocompatible [Cho][Gly] Ionic Liquid: Importance of Hydrogen Bond Attraction between Like-Charged Ions.

The neat and aqueous solutions of the cholinium glycinate ionic liquid (IL), [Cho][Gly], at different water mole fractions, xws, are studied by molecular dynamics simulations. The changes in the local nanostructure of systems with composition have been determined by calculation of various structural distribution functions. Hydrogen bond (H-bond) attractions determine the major relative orientations of the oppositely and like charged nearest neighbors. The cation-anion H-bonds mainly form between the hydrogen of the hydroxyl or methyl groups of the cation and the carboxylate oxygen of the anion. A preferred (antiparallel) arrangement between adjacent [Cho]+ cations is due to the effective H-bond between the hydroxyl oxygen and the methyl hydrogen sites that promotes the like-charge cluster formation. Adding water decreases the occurrence probability of the [Cho]+···[Gly]-···[Cho]+ bridge structure in the aqueous solutions due to the formation of the [Gly]-···HOH···[Gly]- structure via H-bonding. Observed density trend versus xw is interpreted based on an interstice model and investigating the water cluster size distribution. Finally, the effect of xw on the infrared (IR) vibrational spectra were studied and blue and red shifts were observed for the stretching and bending vibrational modes of the hydroxyl group of [Cho]+, respectively. Current findings will improve the efficient engineering design and task-specific applications of aqueous solutions of bio-ILs consist of [Cho]+ and amino acid anions.

Inhibition of hyperthermostable xylanases by superbase ionic liquids

The use of enzymes in aqueous solutions of ionic liquids (ILs) could be useful for the enzymatic treatment of lignocellulose. Hydrophilic ILs that dissolve lignocellulose are harmful to enzymes. The toleration limits and enzyme-friendly superbase IL combinations were investigated for the hyperthermophilic Thermopolyspora flexuosa GH10 xylanase (endo-1,4-β-xylanase EC 3.2.1.8) TfXYN10A and Dictyoglomus thermophilum GH11 xylanase DtXYN11B. TfXYN10A was more tolerant than DtXYN11B to acetate or propionate-based ILs. However, when the anion of the ILs was bigger (guaiacolate), GH11 xylanase showed higher tolerance to ILs. 1-Ethyl-3-methylimidazolium acetate ([EMIM]OAc), followed by 1,1,3,3-tetramethylguanidine acetate ([TMGH]OAc), were the most enzyme-friendly ILs for TfXYN10A and [TMGH]+-based ILs were tolerated best by DtXYN11B. Double-ring cations and a large size anion were associated with the strongest enzyme inhibition. Competitive inhibition appears to be a general factor in the reduction of enzyme activity. However, with guaiacolate ILs, the denaturation of proteins may also contribute to the reduction in enzyme activity. Molecular docking with IL cations and anions indicated that the binding mode and shape of the active site affect competitive inhibition, and the co-binding of cations and anions to separate active site positions caused the strongest enzyme inhibition.

Physicochemical properties of dilute aqueous solutions of 1-Ethyl-3-Methylimidazolium Ethylsulfate, 1-Ethyl-3-Methylimidazolium Methylsulfate, 1-Ethyl-3-Methylimidazolium Tosylate and 1, 3-Dimethylimidazolium Methylsulfate at different temperatures and at atmospheric pressure

This work presents the experimental data on thermophysical properties of aqueous solutions of imidazolium-based ionic liquids (ILs) such as 1-Ethyl-3-Methylimidazolium Ethylsulfate [EMIM][EtSO4], 1-Ethyl-3-Methylimidazolium Methylsulfate [EMIM][MeSO4], 1-Ethyl-3-Methylimidazolium Tosylate [EMIM][Tos], and 1,3-Dimethylimidazolium Methylsulfate [MMIM][MeSO4] in water at different temperatures. Many researchers have studied imidazolium based ILs in different solvents but there is scarcity of data in dilute region. So the aim of this work is to understand the interactions between imidazolium based ILs and water in dilute region. To understand the ion-ion and ion–solvent interactions between IL and water, the thermophysical properties such as density (ρ), speed of sound (u), and viscosity (η) have been measured at temperatures T = (298.15, 303.15, 308.15 and 313.15) K and at atmospheric pressure. The properties like apparent molar volume, limiting apparent molar volume and coefficient of thermal expansion have been derived from the density data. The speeds of sound and density data were combined to evaluate isentropic and isothermal compressibilities. Using Jones-Dole equation, the viscosity A and B coefficients have been determined. The influence of IL cation chain length, different anions and temperature on the sign, magnitude of BV (the deviation parameter from Debye-Hückel theory) and on viscosity B-coefficient has been discussed.

COSMO-RS predicted 1-octanol/water partition coefficient as useful ion descriptor for predicting phase behavior of aqueous solutions of ionic liquids

Abstract 1-Octanol/water partition coefficients (log P) of 450 cations and 132 anions composing ionic liquids (ILs) were estimated with the conductor-like screening model for real solvents (COSMO-RS). For each cation-anion combination mixed with water, the liquid-liquid equilibrium (LLE) compositions at T = 308.15 K and T = 373.15 K were calculated using COSMO-RS. An influence of cation and anion hydrophobicity (measured by log P) on the phase behavior of the {IL + water} mixture. Distinct domains of log P values corresponding to miscible, immiscible and partial solubility behavior, were observed, in particular those with upper and lower critical solution temperature (UCST/LCST). 18 ILs were chosen from different regions of the resulting plot. The ILs were synthesized and their LLE with water has been measured. The predicted phase behavior is in good agreement with the observed data as well as with the literature data in general. The proposed method is simple and allows for rapid and straightforward evaluation of the phase behavior of {IL + water} systems.

Ionic Liquids: Simple or Complex Electrolytes?

Ionic liquids belong to the most investigated systems in the recent years and this field is still significantly growing with an increased focus on developing ionic liquids for specific applications, along with fundamental research. In the present featured paper the similarity and differences between common, "classical" electrolytes and common surfactants and ionic liquids along with the surface-active ionic liquids are discussed in order to stress their significance and point out on their weak points. A short survey of the literature data reveals namely that ionic liquids in solutions behave like "classical" electrolytes and can be described by existing models in the range of their validity. There is still a lack of models describing well the concentrated electrolyte solutions and here ionic liquids, less limited by solubility as common electrolytes, can serve as model systems. The micellization of surface-active ionic liquids in aqueous solutions can be described in the same way as for common surfactants, but surface-active ionic liquids offer more possibilities to study specific ion and isomer effects. They are also quite promising systems to study the aggregation processes in non-aqueous solutions.

Design, fabrication, and performance evaluation of a novel orientation independent and wickless heat spreader

Concentrated heat loads from electronic components present significant thermal management challenges in defense, space, and commercial applications. Liquid-vapor phase-change promises efficient heat dissipation due to the high latent heat of vaporization of the working fluid. Here we report a novel wickless two-phase heat spreader wherein an aqueous solution of surface-active ionic liquid (SAIL) is completely filled within a narrow gap. Unlike typical two-phase passive devices in literature, our device does not rely on gravity or wicks for fluid recirculation. The force of repulsion due to the interaction of SAILs adsorbed at the liquid-vapor interfaces of thin-liquid films contained between neighboring bubbles nucleating at the hotspots is strong enough to cause bubble departure at all orientations. High-speed bubble visualization and infrared thermography suggest that these non-coalescing bubbles quickly spread over a larger area and condense to release the heat to a sink placed at a gap of 2.5 mm. This passive mechanism of heat dissipation demonstrates orientation independent and near-isothermal performance from 0.5−1.1 MW/m2 in the two-phase regime. We believe that the orientation independent performance of this easy to fabricate passive device provides a platform to design next generation thermal management strategies for earth and microgravity applications.

Alkali lignin degradation with aqueous ammonium-based ionic liquid solutions

In this work, we developed a green route to increase the added value of the lignocellulose material. Our proposed method involves ammonium-based ionic liquid selective fractionation of the lignin into essential poly-hydroxy or phenolic compounds. The selected ionic liquids (ILs) are di-isopropylethylammonium chloride ([DIPEA][Cl]) and di-isopropylethylammoniumbenzoate ([DIPEA][Bn]). The depolymerized solution was characterized by chromatographic (GPC and GCMS) and spectroscopic (FT-IR, 1HNMR and 13CNMR) techniques. The results of the analysis proved that the polymeric structure of lignin is converted into its monomers and oligomers. This confirms the potentiality of [DIPEA][Cl] and [DIPEA][Bn] ILs for the conversion of lignin into valuable aromatic compounds. In addition, our study reveals the bi-functional nature (solvation medium + catalytic agent) of the selected ILs for the depolymerization of the lignin. Since lignin is well recognized as a suitable resource for the essential chemicals, therefore, the present study is very useful in refining an alternative source for the clean production of the valuable chemicals.

Temperature-Dependent Thermodynamic Properties of Amino Acids in Aqueous Imidazolium-Based Ionic Liquid

Molecular interactions of amino acids with ionic liquids are significant to study the molecular stability and physicochemical properties of amino acids. Mixtures of amino acids l-leucine and N-acetyl-l-leucine + (0.005, 0.010, 0.030, and 0.050 mol·kg–1) aqueous solution of ionic liquid (1-butyl-3-methylimidazolium chloride) at temperature T = (288.15, 298.15, 308.15, and 318.15 K) have been studied by density and speeds of sound measurements. Volumetric properties have been obtained by utilizing data of density. Volumetric properties include apparent molar volumes, partial molar volumes at infinite dilution, limiting partial molar volumes of transfer at infinite dilution, apparent molar expansibility, etc. Similarly, speeds of sound measurements are utilized to calculate corresponding parameters like apparent molar isentropic compression, Kϕ,s, apparent molar isentropic compression at infinite dilution, Kϕ,s0, and transfer compressibility at infinite dilution ΔKϕ,s0. Results confirmed the predominance of ...

Decoding biomass recalcitrance: Dispersion of ionic liquid in aqueous solution and efficient extraction of lignans with microwave magnetic field.

Alkaline ionic liquid aqueous solutions were used to extract biphenyl cyclooctene lignans derivatives, and hydrolyze to the free-state biphenyl cyclooctene lignans simultaneously from Schisandra chinensis by microwave-assisted heating. The hydrogen bonds formatted between ionic liquid and water molecular attacks the amorphous region of cellulose. Selective heating by microwave produce the more polar regions, which results in swelling and fragmentation of raw materials near the hot spots. Therefore, ionic liquid-microwave-assisted extraction method of free-state biphenyl cyclooctene lignans was set up. The solid residue after treatment was characterized by infrared spectroscopy and scanning electron microscopy, which showed that cellulose, hemicellulose, and lignin were removed partially. The water content of ionic liquid solution affected its viscosity and diffusivity, and in turns the extraction efficiency of lignans. The IL solutions with different mole fractions of IL were detected by FTIR and Raman spectroscopy, the result shows that IL solutions with higher water contents (>0.6) won’t form clusters. The optimum hydrolysis conditions were 0.2 g of ionic liquid catalyst per 5.0 g of S. chinensis fruits, a microwave irradiation power of 600 W, and heating time of 12 min, which gave a yield of free-state biphenyl cyclooctene lignans of 4.12±0.37 mg g−1. Besides, a hydrolysis mechanism of ester-bond biphenyl cyclooctene lignans and decreasing "biomass recalcitrance effect" by ionic liquid microwave-assisted method was proposed.

Measurement and correlation on solubility of acetaminophen in aqueous solutions of 1-octyl-3-methyl imidazolium bromide, 1-butyl-4-methyl pyridinium bromide and 1-octyl-4-methyl pyridinium bromide

Aqueous solubility of acetaminophen in the presence of 1-octyl-3-methyl imidazolium bromide, 1-butyl-4-methyl pyridinium bromide and 1-octyl-4-methyl pyridinium bromide ionic liquid, as co-solvent was investigated at different temperatures and mass fraction of ionic liquid. The obtained results reveal that the solubility of acetaminophen was increased by increasing temperature and concentration of ionic liquid. Solubility of ACP was significantly increased when mass fraction of 1-octyl-3-methyl imidazolium bromide and 1-octyl-4-methyl pyridinium bromide reaches to more than 0.05. The possible reasons behind enhanced solubility of ACP in aqueous solution of ionic liquid are hydrophobic interaction and the formed micelles by cations of ionic liquid. Thermodynamic functions of dissolution were calculated by Van't Hoff equation. The experimental solubility of acetaminophen was correlated with the modified Wilson and the electrolyte-NRTL models as activity coefficient model.

Ionic Liquid-Mediated Recovery of Carotenoids from the Bactris gasipaes Fruit Waste and Their Application in Food-Packaging Chitosan Films

In this work, a process for the extraction and purification of carotenoids from the fruit Bactris gasipaes was developed. Ethanolic and aqueous solutions of ionic liquids (ILs) and surfactants were...

Volumetric, acoustic and infrared spectroscopic study of amino acids in aqueous solutions of pyrrolidinium based ionic liquid, 1–butyl–1–methyl pyrrolidinium bromide

The effect of ionic liquid, 1–butyl–1–methyl pyrrolidinium bromide [C4C1Pyrr]Br on the thermodynamic properties of glycine, L–alanine and L–valine in aqueous solution was studied at the temperature range of 288.15–308.15 K and experimental pressure of p = 0.1 MPa by density, ultrasonic speed and FTIR spectroscopic techniques. Apparent molar volumes, standard partial molar volumes, standard partial molar volumes of transfer and hydration number are evaluated using density data. Side chain contributions and temperature dependence of partial molar volume have been calculated. Apparent molar isentropic compression, standard partial molar isentropic compression, standard partial molar isentropic compression of transfer and hydration number have been calculated using ultrasonic speed data. Fourier transform infrared (FTIR) spectral studies have also have been carried out for the present mixture. These volumetric, acoustic and spectroscopic studies can help to understand the mixing effects and other complex biological processes between amino acids and ionic liquid aqueous solution.