Aqueous Isopropanol Solution Research Articles

Enhancing dehydration performance of isopropanol for flexible hybrid silica composite membranes with spray-coated active layer on polymers

Organically bridged silica has been proven to be promising precursors for fabricating silica-based organic–inorganic hybrid membranes with excellent permselectivity. However, the large-area deposition of defect-free hybrid silica membranes onto the polymer substrate has always been an enormous challenge. Herein, we reported a fast and facile approach for the large-area production of flexible silica-based hybrid membranes, where a thin and uniform ethylene-bridged silica active layer was coated on a microporous polymer substrate via a spray coating process with a single-pass method. First, the optimal deposition conditions were investigated and established, including sol concentrations and different solvent systems that are used to prepare hybrid silica sol, as well as various spray coating conditions. Subsequently, thus-produced flexible hybrid silica composite membranes exhibited superior isopropanol (IPA) dehydration performance by vapor permeation for a 90 wt% isopropanol aqueous solution, with water permeation flux reaching 4.0 kg m-2h−1 and with H2O/IPA separation factor exceeding 1000 (the selectivity of H2O/IPA is 770). This work has shown that the single-pass spray coating is a useful strategy for the large-scale fabrication of the flexible hybrid silica composite membrane.

An experimental study on effect of titanium oxide coated heater substrate on pool boiling enhancement

The present experimental study indicates the effect of coating on the enhancement of heat transfer during pool boiling. For this, the aluminium heater substrate of 22 mm * 20 mm was coated with titanium oxide using high velocity oxy fuel (HVOF) method. The coated surface was then used to heat aqueous solutions of acetone, isopropanol, ethanol and distilled water respectively. Simultaneously, heat transfer coefficient (HTC) and excess temperature (dT) were also obtained using aluminium heater substrate without coating. The boiling parameters during coating and non-coating were kept same so that the HTC and dT obtained can be used for comparative study. The heat transfer parametric study was then conducted and the results were presented in graphical form.

Construction of MoS2 hybrid membranes on ceramic hollow fibers for efficient dehydration of isopropanol solution via pervaporation

Due to environmental issues and intense competition in the marketplace, industries and governmental organizations invest in new technology research to improve productivity, environmental protection, and cost-efficiency. Pervaporation is a membrane-based separation technology, which is cost-effective, environmentally friendly, and efficient in the separation of azeotropic mixtures. Here, we report the fabrication of a hybrid membrane based on molybdenum disulfide (MoS2) material, which can be used to dehydrate alcohol through a pervaporation process. Ceramic hollow fiber (CHF) membrane was used as a substrate in MoS2hybrid membrane, and TiO2 intermediate layer was constructed to reduce the macropores on the CHF surface. Polyethyleneimine (PEI) was used as a binder in the fabrication of the MoS2 layer. MoS2-PEI layer was prepared by vacuum suction method and then crosslinked with trimesoyl chloride (TMC) to prevent the hybrid layer from swelling in an aqueous solution. We investigated the morphology and physicochemical characteristics of the hybrid membranes by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), atomic force microscopy (AFM), energy-dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and water contact angle (WCA) measurements. The fabricated MoS2hybrid membrane possesses a permeation flux of 5697 g m-2h−1 and separation factor of 320 in a 90 wt% isopropanol aqueous solution at 343 K. In this study, we provide a comprehensive understanding of the fabrication of MoS2hybrid membrane on the CHF membrane for efficient dehydration of isopropanol via the pervaporation process.

Significant improving H+/VO2+ permselectivity of Nafion membrane by modification with PDDA in aqueous isopropanol

The modification of Nafion® membranes with poly(diallyldimethylammonium chloride) (PDDA) in aqueous solutions of isopropanol has been investigated. A remarkable decrease in vanadyl ion permeability (by 3.5 orders of magnitude), accompanied by a decrease in proton conductivity sixfold at most, was found for Nafion membranes modified in 30–35 wt% isopropanol solutions providing a high swelling of the membranes. The Bradford reagent has been used for the detection of PDDA on the membrane surface.

Hydrate-based separation of the CO2 + H2 mixtures. Phase equilibria with isopropanol aqueous solutions and hydrogen solubility in CO2 hydrate

The gas hydrates' ability to preferentially bind one of the components of a gas mixture into a hydrate state makes it possible to consider hydrate-based technology as promising for the separation of gas mixtures. When a hydrate is obtained from a gas mixture, mixed hydrates with a complex composition inevitably occur. Issue of their composition determination stays apart. This a rather difficult task, which is complicated by the dissolution of small molecules such as hydrogen in the hydrate phase. This, in turn, impedes the analysis of the data obtained. In this work, the solubility of hydrogen in carbon dioxide hydrate in the range of 269.7–275.7 K and at partial H2 pressure up to 4.5 MPa was experimentally determined. Hydrate composition was found to be CO2·(0.01X)H2·6.5H2O at H2 pressure of X MPa. The equilibrium conditions of hydrates formation in the systems of H2O – CO2 – H2 and H2O – 2-propanol – CO2 – H2 were also determined in a wide range of hydrogen concentrations. Hydrogen seems to be an indifferent diluent gas regarding CO2 hydrate equilibrium pressure. The compositions of the equilibrium phases have been determined as well. It was shown that isopropanol does not form a double hydrate with СО2, only sI СО2 hydrate occurred in the studied systems. The obtained dependencies will be useful in analyzing the process of СО2 + Н2 gas mixtures separation by the hydrate-based method.

The effect of thawing on the antioxidant activity of the leaves and fruit of the grapevine (Vitis vinifera)

Introduction : Grapevine is a valuable source of active health-promoting substances, in particular polyphenols, i.e., flavonoids and phenolic acids, with antioxidant, anti-inflammatory, antibacterial, antiviral and anticancer properties. Grape seeds, peels and leaves also provide a rich source of antioxidants. The aim of the study was to evaluate the antioxidant activity of aqueous and alcoholic extracts of various parts of the Vitis vinifera . Materials and methods : Fresh and frozen grapevine fruits and leaves of a red variety, cultivated by the authors, were evaluated for antioxidant potential. Extracts were prepared with an ultrasound-assisted extraction at 40 kHz for 15, 30 or 60 min. Methanol, ethanol and isopropanol aqueous solutions, as well as water, were used as extractants. Antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis(ethylbenzothiazoline-6 sulphonic acid) (ABTS) methods. Results : The antioxidant potential of extracts prepared from both fresh and frozen plant material was observed. The highest activity, evaluated with the DPPH method, was found in methanolic extracts of fresh leaves, obtained after a 60 min extraction. Similarly, a high activity was observed for frozen grapevine leaf extracts. The highest antioxidant capacity, evaluated by the ABTS method, was found in frozen leaves extracted with isopropanol for 60 min. Freezing and thawing markedly increased the antioxidant properties of the extracts. Conclusions : Extracts from both fresh and frozen parts of the Vitis vinifera showed antioxidant activity, and leaf extracts seemed to be particularly valuable. The freezing-thawing process had a beneficial effect on antioxidant potential and should be considered a useful method to increase extraction efficiency of antioxidants to be used to obtain valuable cosmetic, pharmaceutical or food products.

Innovative color jet 3D printing of levetiracetam personalized paediatric preparations

3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals. This study first reports an innovative color jet 3D printing (CJ-3DP) technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility. For this study, the ideal printing ink consisted of 40% (v/v) isopropanol aqueous solution containing 0.05% (w/w) polyvinylpyrrolidone and 4% (w/w) glycerin, which was satisfied with scale-up of the production. The external and internal spatial structures of the tablets were designed to control the appearance and release, and cartoon tablets with admirable appearances and immediate release characteristics were printed. The dosage model showed a good linear relationship between the model volume and the tablet strength (r > 0.999), which proved the potential of personalized administration. The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug (SpritamⓇ). Moreover, the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior, which could ensure good mechanical properties and rapid dispersion characteristics simultaneously. In conclusion, the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance. Due to the stable formulation and fabrication process, this technology has the potential in scale-up production.

Equilibrium solubility of edaravone in some binary aqueous and non-aqueous solutions reconsidered: Extended Hildebrand solubility approach, transfer property and preferential solvation

The accessible equilibrium solubility data of edaravone in methanol/ethanol/isopropanol (1) + water (2) and ethyl acetate/acetonitrile (1) + methanol/ethanol/n-propanol (2) mixtures was investigated in terms of solvent–solute molecule interactions based on extended Hildebrand solubility method. For methanol (1) + water (2) with x1 (mole fraction) from 0 to 0.8, ethanol (1) + water (2) with x1 from 0 to 0.5 and isopropanol (1) + water (2) with x1 from 0 to 0.3, the interaction energies of solute-solvent molecules were greater than the geometric average values of regular solution, specifying some association between edaravone and mixed solvents. While in the other regions for the three aqueous solutions and ethyl acetate/acetonitrile + methanol/ethanol/n-propanol mixtures, edaravone solutions acted as regular ones at several points. A quartic expression of energy term W in terms of solvent solubility parameter of these mixtures could be successfully used to predict the equilibrium solubility of edaravone in the studied blended mixtures. The preferential solvation of edaravone by means of inverse Kirkwood–Buff integrals tool for the isopropanol/ethanol/methanol + water and ethyl acetate + n-propanol/methanol/ethanol mixtures was analyzed. For the isopropanol/ethanol/methanol + water blended solvents, the drug edaravone was surrounded preferentially by water in water-rich ranges, and by alcohols in other composition regions of binary blended solvents except for isopropanol solutions with isopropanol-rich compositions, where edaravone was preferentially solvated by water. As well, edaravone was preferentially solvated by ethanol for ethyl acetate + ethanol mixture with rich ethyl acetate compositions. The highest degree of preferential solvation was observed in aqueous isopropanol solutions. Selective solvation of the edaravone by water (isopropanol/ethanol/methanol + water mixtures) or ethanol (ethyl acetate + ethanol mixture) was attributable to greater acidity of water or ethanol that enabled interactions with Lewis basic groups of edaravone. In addition, the apparent dissolution enthalpy and transfer Gibbs free energy (ΔtrGo), transfer enthalpy (ΔtrHo) and transfer entropy (ΔtrSo) were derived and deeply discussed.

Boosting the Antimicrobial Activity of Highly Diluted Aqueous Alcoholic Sanitizers by Fortification with Essential Oil Components: I- Carvacrol

The current study aims at developing alcoholic-based sanitizing formula against some pathogenic bacteria based on highly diluted (< 70.0%) aqueous isopropanol solution which is fortified with small amount of an essential oil component like carvacrol. This phenolic compound can act as antimicrobial booster for the compensation of alcohol reduction in the sanitizer. The solubility behavior of carvacrol in the aqueous alcoholic solution containing different ratios of isopropanol and water was investigated using the Gibbs’ phase diagram. Based on that, a selected formula containing 1.0% carvacrol dissolved in the highest possible dilution of isopropanol (45.0%) was chosen for testing its antimicrobial activity against some gram positive and negative pathogenic bacteria in comparison to the standard 70.0% alcohol formula without carvacrol. Results indicated that a 45.0% aqueous isopropanol solution can hold up to 5.0% carvacrol at maximum in a physically stable and homogenous sanitizing formula. Antimicrobial evaluation of the developed diluted aqueous isopropanol fortified with 1.0% carvacrol showed the same inhibition against the tested pathogenic bacteria as the standard 70.0% alcohol sanitizer without carvacrol. In conclusion, 45.0% diluted isopropanol fortified with a minimum of 1.0% up to 5.0% carvacrol (in case of intensive sanitization) can possibly be used as sanitizer for protection against some pathogenic bacteria. The practical significance of this study is the production of diluted alcoholic sanitizing formula for decontamination of surfaces against some pathogenic bacteria with the advantage of increasing alcohol dilution in order to spare the absolute alcohol reserve for more quantitative production of the sanitizer.

Preparation, characterization and biological activity evaluation of pirimiphos-methyl microcapsules

In this study, polyurethane microcapsules loaded with pirimiphos-methyl were prepared by an interfacial polymerization method using modified poly-isocyanate as the precursor and triethanolamine as a curing agent. The microcapsules were fully characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and so on. The results showed that the microcapsules had good morphology, excellent encapsulation efficiency (90.88%) and loading ability (about 50%) for pirimiphos-methyl. Furthermore, the microcapsules exhibited an excellent sustained release property (above 8 days) in 50% isopropanol aqueous solution(v/v). The biological activity on Musca domestica showed that the microcapsules persistence period was above 90 days, which was longer than emulsifiable concentrate formulation.

THE ANALYSIS OF THE BINARY HOMOGENEOUS SOLUTION FILM BEHAVIOR UNDER THERMAL ACTION

Studying the processes occurring in liquid films under thermal influence allows improving a variety of technological systems, since a thin layer aids in providing a high intensity of heat and mass transfer and a significant surface of phase contact with a minimum liquid consumption. Many Russian and international works wrote about theoretical and experimental studies of film flows, though paid insufficient attention to the study of the behavior of films of a binary homogeneous solution. This article studies the behavior of a thin liquid film containing a volatile component during local heating of a solid horizontal substrate. The presented calculations were performed for an aqueous solution of isopropanol. The author describes the formation of a specific surface shape, which is formed with a sufficient increase in the substrate temperature and the initial film thickness — the so-called “liquid drop”, separated from the main volume of the liquid by a thin extended layer, which is explained by the sequential occurrence of thermal and concentration-capillary flows. The results show a significant influence of the Laplace pressure jump on the character of the entire process. In addition, the cooling of the substrate leads to multidirectional flows, but in the opposite directions. The analysis of the functions of the temperature of the film free surface, the volatile component concentration in the solution, and the vapor density over the free surface at different times is carried out. The velocity field in liquid and gas during the evolution of thermocapillary and concentration-capillary flows is illustrated.

Facile Preparation of a Laponite/PVA Mixed Matrix Membrane for Efficient and Sustainable Pervaporative Dehydration of C1-C3 Alcohols.

The exfoliation method was applied for the preparation of high-water selective mixed matrix membranes (MMMs), especially for the dehydration of C1–C3 alcohol–water solutions. Herein, a facile and easy method was employed to fabricate physically cross-linked Laponite nanosilicate clay–PVA MMMs without additional cross-linking by a one-step synthesis route for water dehydration from methanol, ethanol, and isopropanol aqueous solutions. The morphologies, chemical structures, thermal stabilities, and surface hydrophilicity of Laponite–PVA MMMs were investigated properly by different characterization techniques. The Laponite concentration has affected the fractional free volume of the membranes, as proven by positron annihilation lifetime spectroscopy analysis. The MMMs displayed both a significant improvement in the separation factor and remarkable enhancement in the permeation fluxes for the three alcohol systems. The influence of the operating temperature on the MMM performance was investigated for the methanol/water solution. The methanol permeability was 100-fold lower than that of the water, indicating that the membranes are more water selective. Particularly, the Laponite–PVA membrane with 5 mg/mL Laponite loading exhibits excellent separation efficiency for C1–C3 dehydration having water permeabilities higher than most other polymeric membranes from the other literature studies of 2.82, 2.08, and 1.56 mg m–1 h–1 kPa–1 for methanol, ethanol, and isopropanol/water systems, respectively. This membrane development allows a more efficient and sustainable separation of aqueous alcoholic mixtures.

Improved pervaporation efficiency of thin-film composite polyamide membranes fabricated through acetone-assisted interfacial polymerization

•Promoting the separation efficiency of pervaporation membranes is a must to meet the growing demands of society. In this study, acetone-assisted interfacial polymerization was employed to produce thin-film composite (TFC) pervaporation membranes with improved performance. Two monomers were considered—diethylenetriamine (DETA) and trimesoyl chloride (TMC); they reacted with each other to form a thin polyamide layer, which was deposited on a hydrolyzed polyacrylonitrile (HPAN) substrate. Aqueous solutions containing different concentrations of acetone were used to dissolve DETA. Introducing acetone as a cosolvent of water enhanced the sorption of DETA in the HPAN support. It also altered and improved the physicochemical properties of the TFC membranes. An optimum concentration of 50 wt% aqueous acetone solution was established. Through acetone-assisted interfacial polymerization, a TFC membrane was then fabricated, and it exhibited a high separation efficiency: permeation flux = 1641 ± 134 g∙m−2 h−1 and water concentration in the permeate = 98%–99% (feed =70 wt% aqueous isopropanol solution). Moreover, the modified TFC membrane displayed a high separation performance at a wide range of operating conditions.

Alcohol Dehydration by Extractive Distillation with Use of Aminoethers of Boric Acid

Aminoethers of boric acid (AEBA) were studied as potential extractants for the separation of aqueous–alcoholic azeotropic mixtures by extractive distillation. The conditions of vapor–liquid equilibrium in aqueous solutions of ethanol and isopropanol in the presence of AEBA were studied. The division of AEBA molecules into group components was proposed, and previously unknown geometric parameters of the boron group and the energetic pair parameters of the boron group with the alkane group, ether group, amine-3d group, and alcohol group were determined within the framework of the Universal Functional Group Activity Coefficient (UNIFAC) model. The modeling of the extractive rectification process of an ethanol–water mixture with AEBA as extractant has been carried out. The dependences of the cost function on the extractant flow rate, the residual water content in it and the number of theoretical trays were obtained. A technological scheme for ethanol dehydration has been proposed, and its technological characteristics have been calculated.

On the theory of directional crystallization with a two-phase region with vigorous convection

A time-dependent process of directional crystallization with a two-phase (mushy) region with allowance for vigorous convection in the liquid phase is analytically described. An exact solution of non-linear mushy layer equations is found in a parametric form. The temperature and solute concentration distributions, as well as the solid phase fraction profile, are determined in the two-phase and liquid regions. The moving boundary of phase transition, which is placed between the two-phase zone and liquid is defined as a function of time. The present analytical solutions are in good agreement with laboratory experiments on ice grown from aqueous solutions of isopropanol.

Experimental and numerical investigation on bubble behaviors and pool boiling heat transfer of semi-modified copper square pillar arrays

In the present study, bubble growth on the boiling surfaces and pool boiling heat transfer characteristics of semi-modified pillar arrays are experimentally investigated at atmospheric pressure, while the bubble behaviors inside pillar gaps are numerically revealed in different contact angles by lattice Boltzmann method based on the pseudopotential LB model. The hybrid and hierarchical pillars are fabricated by semi-silver-deposition and wire-electrode-cutting respectively. The effects of wettability, surface morphology and surfactant concentration are considered. Deionized water, aqueous isopropanol and n-heptanol solutions with concentrations of 100 ppm, 200 ppm, and 800 ppm are used as the working liquids. The experimental results show that contact angles of isopropanol and n-heptanol solutions on copper plate are changed considerably by silver-deposition. Semi-silver-deposition and additions of isopropanol and n-heptanol considerably affect pool boiling heat transfer and bubble behaviors of straight and hierarchical copper square pillars. The numerical results show that vapor films generate at most gap bottoms at the contact angle of 131.8° which impede liquid supplement process toward the gaps compared with the contact angle of 98.7° on the straight pillar array surface.

High-performance polyamide composite membranes via double-interfacial polymerizations on a nanofibrous substrate for pervaporation dehydration

A novel double-interfacial polymerizations (double-IP) strategy was demonstrated for the maneuverable fabrication of high-performance polyamide (PA) composite membranes based on nanofibrous substrates for efficient isopropanol dehydration by pervaporation. Firstly, an ultra-thin auxiliary polyamide layer (A-PA) was synthesized on a highly porous polyacrylonitrile (PAN) nanofibrous substrate by using low concentration ethylenediamine (EDA) and trimesoyl chloride (TMC) solution, which decreased the reaction rate and prolonged polymerization time to achieve a smooth, relatively loose but intact A-PA layer. Secondly, a more compact PA selective layer (S-PA) was fabricated with relatively high concentration EDA and TMC solution on A-PA surface. Benefiting from the A-PA layer, the amount and diffusion rate of adsorbed EDA solution through the layer to contact TMC solution were effectively controlled in second IP process. S-PA layers tended to be more uniform, and there was no marked void or detachment observed between two PA layers. Significantly, the pervaporation performance of as-prepared membranes were tuned by changing the structure of S-PA layers with the assistant of different A-PA layers. The optimized two-tier polyamide (Bi-PA) thin-film nanofibrous composite (TFNC) pervaporation membranes exhibited high permeate flux (6075 g/(m2 h)) and enhanced separation factor (1314) for dehydrating 90 wt% aqueous isopropanol solution at 70 °C. This work may suggest an efficient and facile approach to fabricate high performance pervaporation membranes.

Per‐6‐Thiol‐Cyclodextrin Engineered [FeFe]‐Hydrogenase Mimic/CdSe Quantum Dot Assembly for Photocatalytic Hydrogen Production

[FeFe]‐hydrogenase ([FeFe]‐H2ase) mimics, inspired by hydrogenases in nature, have emerged as an important class of molecular catalysts toward hydrogen (H2) evolution. Herein, a per‐6‐thiol‐cyclodextrin (CDSH) engineered [FeFe]‐H2ase mimic/CdSe quantum dot (QD) assembly is established for effective photocatalytic H2 evolution. In the assembly, CDSH is first anchored on CdSe QDs via the strong multidentate Cd‐thiol coordination. Then, [FeFe]‐H2ase mimic is assembled on the QD surface via the host–guest supramolecular interaction between the hydrophobic cavity of cyclodextrin (CD) and the adamantyl (AD) group of [FeFe]‐H2ase mimic. In neutral aqueous solution of isopropanol, the Fe2S2‐AD/CDSH/CdSe assembly exhibits a turnover number (TON) of 1.12 × 105 (based on Fe2S2‐AD) under visible light, which is about 12‐fold to the corresponding system without CDSH. Mechanistic insights indicate that the CDSH can not only prevent the aggregation of QDs in acidic conditions, but also balance the interfacial charge (electron and hole) transfer to avoid the photocorrosion of QDs, thereby giving the highest TON of H2 photogeneration based on [FeFe]‐H2ase mimics up to date.

Method Development for Quantitative Determination of Diosgenin from the Seeds of Fenugreek, &lt;i&gt;Trigonella foenum-graecum&lt;/i&gt; L.

Introduction . Modern pharmacognostic research is aimed at searching for plant biologically active individual compounds (RBAIS) isolated from plant extracts. Aim . Study of the content of the steroid sapogenin diosgenin in fenugreek seeds in plant extracts by HPLC-UV method. Materials and methods . The object of study was raw materials-fenugreek seeds produced as medicinal plant raw materials by LLC «Sage» (Irkutsk). Series of extraction and chromatographic separation by HPLC-UV method were performed. Results and discussion . In this work, the method of diosgenin extraction was successfully optimized (after acid hydrolysis of dioscin with a 5 % aqueous solution of hydrochloric acid when heated for at least 4 hours in a sand bath at a power of 150 W) from raw fenugreek seeds using a 50 % aqueous solution of isopropanol, h.h. A simplified technique for chromatographic separation of diosgenin from fenugreek seed extracts using an isocratic mode of 99.9 % acetonitrile elution (h.h.) was proposed. Conclusion . The average content of diosgenin (after acid hydrolysis of dioscin) in fenugreek seeds, taking into account the humidity of raw materials, is (M ± σ ) 5,3 ± 0,05 mg/g (95 % CI: 5,1-5,4 mg/g; n = 6).

Rutaecarpine dissolved in binary aqueous solutions of methanol, ethanol, isopropanol and acetone: Solubility determination, solute-solvent and solvent-solvent interactions and preferential solvation study

The main objective of this work was to report the mole fraction solubility of rutaecarpine in four binary solutions of methanol (1) + water (2), isopropanol (1) + water (2), acetone (1) + water (2) and ethanol (1) + water (2) acquired through the saturation shake-flask technique. All experiments were conducted at temperatures from 283.15 K to 323.15 K. The maximum solubility was observed in the pure solvent of methanol/ethanol/isopropanol/acetone for each solution. The achieved rutaecarpine solubility in mole fraction was mathematically described by two common co-solvency models, namely Jouyban-Acree model and van’t Hoff-Jouyban-Acree model. The calculated relative average deviations were no more than 6.78%; and root-mean-square deviations, no more than 23.69 × 10−6. The linear solvation energy relationships suggested by Kamlet and Taft was used to examine the effect of solvent descriptors on the behaviour of rutaecarpine solubility. The Hildebrand solubility parameter and dipolarity-polarizability were predominant contributors to solvent effect for the four mixtures studied. The local mole fractions of methanol (acetone, isopropanol or ethanol) and water nearby the solute rutaecarpine were quantitatively analyzed through an Inverse Kirkwood–Buff integrals method. For these mixtures within intermediate and methanol/ethanol/isopropanol/acetone-rich compositions, rutaecarpine was preferentially solvated by the methanol/ethanol/isopropanol/acetone; while within water-rich compositions, by the water.