The article examines the principles, methods, types, forms and models of interaction between the government and business in the implementation of socially significant projects. The research paper delves into the appraisal of institutions that enable the interaction between the state, society, and business. It further explores different models of interaction between business and government. Moreover, the academic study reveals an expert evaluation of the collaborative efforts between regional authorities, businesses, and the public. Throughout the scrutiny of the interaction between authorities and business structures, the study identifies priority areas for effectively addressing the primary issues in the region. It also assesses the level of competence and willingness of local authorities to engage in dialogue, their readiness to contribute to solving regional problems, and their involvement in public-private partnerships and anti-corruption initiatives. The interaction between the state and business is evaluated as a collection of power institutions and market management actors, representing a complex system of interconnected relationships and feedback loops. The comprehensive plan for the development of social projects covers all areas of regional life and is being implemented on the basis of the plan for its large-scale development, the creation of the Turkestan region and the transfer of the regional center to the city of Turkestan. It is of great social importance, that is, by building cooperation between the state and entrepreneurs, it is possible to direct the solution of the problems provided for in the «Social Code» of the Republic of Kazakhstan proposed in 2023. Selection of projects with a high potential of direct and indirect impact on socio-economic development of the region and creation of stable jobs was carried out. Keywords: authorities, business structures, public representatives, regional management, public-private partnership.