Application Of Nanomaterials Research Articles

Targeted delivery of berberine using bionic nanomaterials for Atherosclerosis therapy

Atherosclerosis (AS) is a prevalent chronic vascular inflammatory disease globally, initiated by injury to vascular endothelial cells (VECs). Macrophages play a pivotal role in disease pathogenesis, involving lipid metabolism and inflammation. The application of nanomaterials has been hindered by their rapid clearance by the immune system. Utilizing macrophage cell membranes can mitigate abnormal immune responses and induce a "homing" effect. Here, M2 macrophage cell membranes (M2) were coated onto berberine polylactic-hydroxylase-polylactide (PLGA) nanoparticles (BBR NPs), employing M2 macrophage immune escape, "homing" ability, and membrane coating nanotechnology, and loaded with mannose (Man) to create bionic nanoparticles (BBR NPs@Man/M2). Subsequently, the physical properties of BBR NPs@Man/M2 were characterized. The biocompatibility and biological function of BBR NPs@Man/M2 were assessed in vitro. Finally, the targeting, therapeutic efficacy, and safety of BBR NPs@M2 were investigated in an AS mouse model. The newly developed BBR NPs@Man/M2 exhibited good biocompatibility. Owing to their M2 coating, the nanoparticles effectively targeted macrophages in vitro, inducing a shift from a pro-inflammatory to an anti-inflammatory state. This transition reduced inflammation in endothelial cells and facilitated the repair of damaged endothelial cells. Moreover, M2-coated nanoparticles efficiently targeted and accumulated in atherosclerotic lesions in vivo. Following four weeks of treatment, BBR NPs@Man/M2 significantly delayed AS progression. Furthermore, BBR NPs@Man/M2 demonstrated a good safety profile after long-term administration. In conclusion, BBR NPs@Man/M2 effectively and safely inhibited AS progression. Biomimetic nanoparticles represent a promising approach for the safe and effective delivery of anti-AS drugs.

Recent Advances of Amorphous Nanomaterials: Synthesis and Applications

Comprehensive SummaryAmorphous nanomaterials are metastable nanomaterials which only have short‐range order within a few neighboring atoms, based on the local chemical bondings. Different from crystalline materials, the amorphous nanomaterials lack of long‐range order exhibit many intriguing and unique structu ral features, such as abundant active sites, structural flexibility, intrinsic isotropy and fast ionic transport. However, due to the unco nventional structural complexity, the systematic study and understanding of amorphous nanomaterials are still in the early stage. In this review, we will describe our journey to the synthesis, characterization and applications of amorphous nanomaterials, including catalysis, energy storage, optics and mechanics.What is the most favorite and original chemistry developed in your research group?Our group developed a variety of universal methods, such as "coordination etching" method, "self‐hydrolytic etch‐precipitation" method, photoetching method, co‐precipitation method, etc., to achieve the controllable preparation of amorphous nanomaterials with different morphology, size and dimension, and the catalytic, mechanical and optical properties of the materials and their potential applications were also studied. Moreover, the relevant mechanisms were proposed, the structure‐activity relationship was established, and the development and application of amorphous micro‐nanomaterials were promoted.How do you get into this specific field? Could you please share some experiences with our readers?My journey into the field of amorphous nanomaterials began 20 years ago when I developed a fascination for materials science and nanotechnology. During my early research experiences, I encountered the intriguing world of amorphous nanomaterials. These materials, lacking a long‐range crystalline order, presented both challenges and opportunities in terms of their synthesis and understanding their properties. It's a field where creativity and precision intersect, driving me to continually seek innovative solutions and deepen my understanding of nanoscale phenomena.How do you supervise your students?As a professor, I supervise students by setting clear expectations, holding regular meetings for feedback and guidance, and encouragingindependent thinking. I support their career development by identifying opportunities and creating a collaborative environment. Adapting to individual needs, I foster a fair and consistent approach to help students grow professionally and academically.What is the most important personality for scientific research?One of the most important traits for scientific research is curiosity. It drives researchers to ask questions, explore new ideas, and seek innovative solutions. Curiosity fuels the desire to understand the unknown, propelling scientific discovery and breakthroughs. Additionally, persistence is crucial as research often involves challenges and setbacks that require perseverance to overcome. Clear communication skills are also vital for sharing findings and collaborating effectively within the scientific community.Who influences you mostly in your life?As a researcher, my greatest influences come from my mentors, Prof. Hesun Zhu, Qianshu Li and Shihe Yang who guide my academic journey and collaborators who inspire new ideas and perspectives. My mentors, who provide guidance and expertise play a crucial role in shaping my approach to research and career development. Their insights and support empower me to navigate challenges and continuously strive for excellence in my scientific endeavors.What are your hobbies?My hobbies are a blend of activities that complement and enrich my professional life. I enjoy participating in discussions and workshops within my academic community, where I can exchange ideas and learn from peers outside of formal research settings.Key Scientists

The role of macrophage polarization in the osteogenesis of nanomaterials: A bibliometric study

ObjectiveIn recent years, with the development of nanotechnology and related disciplines, researchers have conducted much research on the use of nanomaterials for bone regeneration. Our research aims to summarize the application of nanomaterials in the field of bone repair and guide future research directions in this field. MethodsWe summarised all publications in this field in the WoS database, and visual analysis was carried out via bibliometric methods. Based on the above results, we conducted a more in-depth study on the core of this nanomaterial and bone repair. ResultsThe number of publications in this field is increasing annually, with China and the United States contributing the most. Close cooperation between countries guarantees research quality in this field, and interactions between disciplines, especially between materials, biology, physics and chemistry, are also important. Most importantly, in terms of the research focus in this field, we found that macrophage polarization and the immune response are the focus of future research. The polarization of M2 macrophages is the most important area of research. ConclusionThe amount of research on nanomaterials in the field of bone repair will continue to increase, and this study investigated the role of M2 macrophages via in-depth analysis. Our study will guide the research direction of nanomaterials in the field of bone repair to a large extent.

Classification and Application of Ultrasound-Responsive Nanomaterials in Anti-Inflammatory Therapy

Ultrasound, a high-frequency mechanical wave with excellent tissue penetration, has been widely applied in medical diagnostic imaging. Furthermore, it has been reported that ultrasound has broad prospects for extensive applications in the field of disease treatment in recent years due to its non-invasiveness and high efficiency. Ultrasound-responsive nanomaterials have the unique advantages of a small size and a high reactivity. Such materials have the capability for precision control of drug release under ultrasound stimulation, which provides a new approach to enhancing the efficiency of drug therapy. Therefore, these materials have attracted the attention of a wide range of scholars. Inflammation is a defensive response produced by organisms to deal with injuries. However, excessive inflammatory response may lead to various tissue damages in organisms and even endanger patients' lives. Many studies have demonstrated that limiting the inflammatory response using ultrasound-responsive nanomaterials is a viable way of treating diseases. Currently, there are still challenges in the application of ultrasound-responsive nanomaterials in anti-inflammatory therapy. The design and synthesis process of nanomaterials is complicated, and further verification of the biocompatibility and safety of these materials is needed. Therefore, in this review, we summarized and classified common ultrasound-responsive nanomaterials in the field of anti-inflammation and systematically introduced the properties of different nanomaterials. In addition, the anti-inflammatory applications of ultrasound-responsive nanomaterials in various diseases, such as bone diseases, skin and muscle diseases, autoimmune diseases, and respiratory diseases, are also described in detail. It is expected that this review will provide insights for further research and clinical applications in the realms of precision treatment, targeted drug delivery, and clinical trial validation of ultrasound-responsive nanomaterials used in anti-inflammatory therapies.

Highly dispersed Pd nanoparticles supported by magnetically separable Fe3O4@ SiO2 nanotube for catalytic hydrogenation of nitroaromatics

Selective hydrogenation of nitroaromatics is a crucial industrial reaction, but there are still challenges in developing nanocatalysts with stable active centers, yet easily recyclable characteristics. Here, a magnetically separable Pd/Fe3O4@SiO2 nanocatalyst was prepared through the seeding growth of silica on the Fe3O4 nanocrystal cluster (NC) followed by in situ reduction of Pd nanoparticles (NPs) on the amino group modified Fe3O4@SiO2 nannotube (NT). The nanocatalyst showed good activity and stability in the hydrogenation of a series of nitroaromatics as the Pd NPs were highly dispersed on the nanotubes. Meanwhile, it could be easily separated from the reaction solution and well-redispersed in the solvent for the next-round reaction due to the superparamagnetic property of the Fe3O4 NC and the good dispersibility of silica in many organic solvents. The magnetically separable nanocatalyst combined the high activity of the nanocatalyst and the convenient separation of a traditional heterogeneous catalyst, which effectively promote the practical application of nanomaterials in catalysis.

Advancements in Nanoparticle-Based Strategies for Enhanced Antibacterial Interventions.

The escalating global threat of antibiotic resistance underscores the urgent need for innovative antimicrobial strategies. This review explores the cutting-edge applications of nanotechnology in combating bacterial infections, addressing a critical healthcare challenge. We critically assess the antimicrobial properties and mechanisms of diverse nanoparticle systems, including liposomes, polymeric micelles, solid lipid nanoparticles, dendrimers, zinc oxide, silver, and gold nanoparticles, as well as nanoencapsulated essential oils. These nanomaterials offer distinct advantages, such as enhanced drug delivery, improved bioavailability, and efficacy against antibiotic-resistant strains. Recent advancements in nanoparticle synthesis, functionalization, and their synergistic interactions with conventional antibiotics are highlighted. The review emphasizes biocompatibility considerations, stressing the need for rigorous safety assessments in nanomaterial applications. By synthesizing current knowledge and identifying emerging trends, this review provides crucial insights for researchers and clinicians aiming to leverage nanotechnology for next-generation antimicrobial therapies. The integration of nanotechnology represents a promising frontier in combating infectious diseases, underscoring the timeliness and imperative of this comprehensive analysis.

Preparation and Application of Co-Doped Zinc Oxide: A Review.

Due to a wide band gap and large exciton binding energy, zinc oxide (ZnO) is currently receiving much attention in various areas, and can be prepared in various forms including nanorods, nanowires, nanoflowers, and so on. The reliability of ZnO produced by a single dopant is unstable, which in turn promotes the development of co-doping techniques. Co-doping is a very promising technique to effectively modulate the optical, electrical, magnetic, and photocatalytic properties of ZnO, as well as the ability to form various structures. In this paper, the important advances in co-doped ZnO nanomaterials are summarized, as well as the preparation of co-doped ZnO nanomaterials by using different methods, including hydrothermal, solvothermal, sol-gel, and acoustic chemistry. In addition, the wide range of applications of co-doped ZnO nanomaterials in photocatalysis, solar cells, gas sensors, and biomedicine are discussed. Finally, the challenges and future prospects in the field of co-doped ZnO nanomaterials are also elucidated.

Role of Nanomaterials in Pharmaceutical Preparation: A Review

Aim & objective: This study aims to explore the multifaceted applications of nanomaterials and assess their potential advantages and disadvantages. Understanding the different physicochemical properties of nanomaterials & excipients. Method: This study reviews current literature and research findings to compile a comprehensive overview of nanomaterials. Key aspects covered include synthesis methods, characterization techniques, and notable applications in different industries. The review also discusses the advantages and disadvantages associated with nanomaterials, highlighting their potential benefits and challenges. Advantages & disadvantages: Nanomaterials offer numerous advantages such as enhanced mechanical, electrical, and optical properties, which make them suitable for developing advanced technologies. However, challenges include concerns over their potential environmental and health impacts, as well as the scalability of production processes from laboratory to industrial scales. Additionally, the high cost of synthesis and regulatory uncertainties pose hurdles to widespread adoption. Conclusion: In conclusion, nanomaterials present a paradigm shift in materials science and engineering with vast potential to address pressing global challenges. Their unique properties enable innovative solutions across various sectors, promising significant advancements in healthcare, electronics, energy, and environmental sustainability. However, realizing these benefits requires continued research to mitigate risks and optimize their applications. Establishing robust regulatory frameworks and fostering interdisciplinary collaborations are essential to harnessing the full potential of nanomaterials while ensuring their safe and sustainable integration into society.

Optical properties and applications of metal nanomaterials in ultrafast photonics: a review

Optical properties and applications of metal nanomaterials in ultrafast photonics: a review

Conjugated cobalt‐based metal complex nanosheet for fabricating high‐performance supercapacitor electrode

AbstractIn order to cope with the increasingly serious problem of energy shortage, supercapacitors have been developed as a clean and renewable energy source, and the supercapacitors with excellent energy density and long cycle life are imperative. Here, by employing a facile liquid–liquid (L‐L) interfacial method at room temperature (RT), a set of two‐dimensional (2D) metal complex nanosheets N1‐N3 have been synthesized by the facile coordination between Co2+ ion and 2,3,6,7,10,11‐hexaiminotriphenylene (HITP). Given the layered superstructure with well‐ordered nanopores, the N1‐N3 electrodes displayed excellent capacities of 4751.9, 5770.9 and 6075.2 F g−1 at 1 A g−1, and a good cyclic stability with 92.1% capacity retention after 1000 cycles for the N3 electrode. The asymmetric supercapacitor device with N3 as the positive electrode delivers a maximum energy density of 238.2 Wh kg−1 at a power density of 1610.1 W kg−1 and an excellent cycling stability with a capacitance retention of 109.1% after 5000 cycles. This is the best electroactive bottom‐up metal complex nanosheet reported so far for use in supercapacitor, which greatly expands the applicability of this 2D nanomaterial in energy device applications.image

Determination of the Localized Surface Plasmon Resonance Alteration of AgNPs via Multiwavelength Evanescent Scattering Microscopy for Pb(II) Detection.

We developed multiwavelength evanescent scattering microscopy (MWESM), which can acquire plasmonic nanoparticle images at the particle level using the evanescent field as the incident source and distinguish different LSPR (localized surface plasmon resonance) spectral peaks among four wavelengths. Our microscope could be easily and simply built by modifying a commercial total internal reflection fluorescence microscope (TIRFM) with the substitution of a beamsplitter and the addition of a semicircular stop. The ultrathin depth of illumination and rejection of the reflected incident source together contribute to the high sensitivity and contrast of single nanoparticle imaging. We first validated the capability of our imaging system in distinguishing plasmonic nanoparticles bearing different LSPR spectral peaks, and the results were consistent with the scattering spectra results of hyperspectral imaging. Moreover, we demonstrated high imaging quality from the aspects of the signal/noise ratio and point spread function of the single-particle images. Meaningfully, the system can be utilized in rapidly determining the concentration of toxic lead ions in environmental and biological samples with good linearity and sensitivity, based on single-particle evanescent scattering imaging through the detection of the alteration of the LSPR of silver nanoparticles. This system holds the potential to advance the field of nanoparticle imaging and foster the application of nanomaterials as sensors.

Green Synthesis of Biochar@Al2O3 Nanocomposite from Waste Melia azedarach Fruit Biomass Pyrolysis: A Sustainable Solution for Photocatalytic Methylene Blue Dye Degradation

In this work, a green and sustainable approach used for synthesis of novel biochar@Al2O3 nanocomposite through pyrolysis of Melia azedarach (chinaberry) biomass coupled with Al2O3 nanoparticles from Phyllanthus emblica seed extract. The synthesized nanocomposite was analysed by UV-Vis spectroscope, FTIR, SEM, EDX and XRD were used to authenticate the distinct properties of the biochar@Al2O3 nanocomposite. These techniques are further used to examine the nanocomposite after photocatalytic degradation of methylene blue. Additionally, the scavenger impacts on dye degradation, stability and the potential reusability of the biochar@Al2O3 nanocomposite were examined in detail. The investigation evaluating the photocatalytic capability of biochar@Al2O3 nanocomposite for methylene blue degradation in wastewater revealed an impressive degradation efficiency of 97.36 %. Furthermore, after five cycles of reuse the nanocomposite retained a substantial degradation efficiency of 84.59 %. This research highlights the importance of presenting an efficient and eco-friendly method for water purification, emphasizing the role of biochar@Al2O3 nanocomposites in addressing environmental pollution through innovative nanomaterial applications. Significantly progresses was made in the development of sustainable materials for wastewater treatment, in particular the promising potential of the biochar@Al2O3 nanocomposite in methylene blue dye degradation.

Zinc oxide nanoparticles and nano-hydroxyapatite enhanced Cd immobilization, activated antioxidant activity, improved wheat growth, and minimized dietary health risks in soil-wheat system

Cadmium (Cd) accumulation in alkaline soils has posed a serious global food safety and health threat. In this work, the effects of zinc oxide nanoparticles (ZnO NPs) and nano-hydroxyapatite (n-HAP) on Cd uptake by wheat in Cd-contaminated soils were evaluated by potting experiments. Results revealed that wheat grain yield increased with the application of nanomaterials (NPs), particularly at higher concentrations. The addition of ZnO NPs or n-HAP reduced Cd concentrations in wheat grains, shoots, and roots by 8.40∼44.54 %, 34.50∼57.28 %, 9.32∼41.26 % and 6.72∼14.29 %, 18.18∼32.19 %, and 1.08∼11.02 % compared with those in controls, respectively, while simultaneously increasing leaf antioxidative activity of SOD, POD, and CAT and decreasing MDA content. Soil pH increased and exchangeable Cd was transformed into more stable organically-bound and residual-bound Cd, thereby reducing soil available Cd content (0.1 g/kg ZnO NPs:16.97 %; 2.0 g/kg n-HAP:14.98 %). As a result, Cd enrichment in wheat tissues was reduced significantly by 0.1 g/kg ZnO NPs or 2.0 g/kg n-HAP. The health risk was assessed, and the Target Hazard Quotient (THQ) value was <1 with 0.1 g/kg ZnO NPs, which was within the safe range (P<0.05). Principal component analysis (PCA) suggested that ZnO NPs were more effective than n-HAP in preventing Cd from entering plant roots. Furthermore, soil availability Cd was most affected by soil fractionation, whereas Cd concentrations in wheat tissues had the greatest effect on grain Cd accumulation. These results provide a key basis for the safe and sustainable application of nanoparticles and indicate that type and concentration should be fully considered when selecting nanomaterials to control Cd stress.

A Numerical Simulation of the Magneto-Micropolar Nanofluid Flow Configured by the Stimulus Energies and Chemical Interaction

Inspired by the numerous applications of non-Newtonian nanomaterials in science and industries, the two-dimensional convective hydromagnetic movement in a micropolar nanofluid within an expanding permeable surface with the existence of binary chemical reaction and convective boundary constraints is examined in this study. Thermal radiation, energy generation, and activation energy interactions are employed to handle the nanofluid flow. The underlying equations are transformed via the similarity transitions into an array of non-linear ODE. The BVP4C MATLAB package is applied to solve the system of equations numerically. The necessary outcomes of the micropolar fluid velocity, micro-rotation, temperature, concentration, friction factor, mass transfer, and heat transfer rates are shown graphically and thoroughly analyzed quantitatively. The micropolar nanofluid’s mobility is reduced by the heating and solutal Grashof numbers. It is noted that the magnetic coefficient decreases velocity, it has the opposite impact on the degree of temperature. The plotted outcomes also show that the temperature increases as the increase in stimulation radiation variable. Meanwhile, the thermal field exhibits strengthen as the intensity of Biot number and Eckert number responses enhances. The growth of the activation energy leads to a noticeable enrichment in the concentration profile.

Chirality Determination of Nanocrystals by Electron Crystallography.

Chirality is a common phenomenon in nature and plays an important role in the properties of matter. The rational synthesis of chiral compounds and exploration of their applications in various fields require an unambiguous determination of their handedness. However, in many cases, determinations of the chiral crystal structure and chiral morphology have been a challenging task due to the lack of proper characterization methods, especially for nanosized crystals. Therefore, it is crucial to develop novel and efficient characterization methods. Owing to the strong interactions between matter and electrons, electron crystallography has become a powerful tool for structural analysis of nanomaterials. In recent years, methods based on electron crystallography, such as high-resolution electron microscopy imaging and electron diffraction, have been developed to unravel the chirality of nanomaterials. This brings new opportunities to the design, synthesis, and applications of versatile chiral nanomaterials. In this perspective, we summarize the recent methodology developments and ongoing research of electron crystallography for chiral structure and morphology determination of nanocrystals, including inorganic and organic materials, as well as highlight the potential and further improvement of these methods in the future.

Metal-Doping Strategy for Carbon-Based Sonosensitizer in Sonodynamic Therapy of Glioblastoma.

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and known for its challenging prognosis. Sonodynamic therapy (SDT) is an innovative therapeutic approach that shows promise in tumor elimination by activating sonosensitizers with low-intensity ultrasound. In this study, a novel sonosensitizer is synthesized using Cu-doped carbon dots (Cu-CDs) for the sonodynamic treatment of GBM. Doping with copper transforms the carbon dots into a p-n type semiconductor having a bandgap of 1.58eV, a prolonged lifespan of 10.7 µs, and an improved electron- and hole-separation efficiency. The sonodynamic effect is efficiency enhanced. Western blot analysis reveals that the Cu-CDs induces a biological response leading to cell death, termed as cuproptosis. Specifically, Cu-CDs upregulate dihydrosulfanyl transacetylase expression, thereby establishing a synergistic therapeutic effect against tumor cell death when combined with SDT. Furthermore, Cu-CDs exhibit excellent permeability through the blood-brain barrier and potent anti-tumor activity. Importantly, the Cu-CDs effectively impede the growth of glioblastoma tumors and prolong the survival of mice bearing these tumors. This study provides support for the application of carbon-based nanomaterials as sonosensitizers in tumor therapy.

Recent Progress of Oral Functional Nanomaterials for Intestinal Microbiota Regulation.

The gut microbiota is closely associated with human health, and alterations in gut microbiota can influence various physiological and pathological activities in the human body. Therefore, microbiota regulation has become an important strategy in current disease treatment, albeit facing numerous challenges. Nanomaterials, owing to their excellent protective properties, drug release capabilities, targeting abilities, and good biocompatibility, have been widely developed and utilized in pharmaceuticals and dietary fields. In recent years, significant progress has been made in research on utilizing nanomaterials to assist in regulating gut microbiota for disease intervention. This review explores the latest advancements in the application of nanomaterials for microbiota regulation and offers insights into the future development of nanomaterials in modulating gut microbiota.

Evaluation of Heavy Metal Mobility in Contaminated Soils and its Effects on Mechanical Properties: Applications of Nanomaterials in Remediation

Evaluation of Heavy Metal Mobility in Contaminated Soils and its Effects on Mechanical Properties: Applications of Nanomaterials in Remediation

Polaron engineering promotes NIR-II absorption of carbon quantum dots for bioimaging and cancer therapy.

Recent years have witnessed a surge of interest in tuning the optical properties of organic semiconductors for diverse applications. However, achieving control over the optical bandgap in the second near-infrared (NIR-II) window has remained a major challenge. To address this, here we report a polaron engineering strategy that introduces diverse defects into carbon quantum dots (CQDs). These defects induce lattice distortions resulting in the formation of polarons, which can absorb the near-field scattered light. Furthermore, the formed polarons in N-related vacancies can generate thermal energy through the coupling of lattice vibrations, while the portion associated with O-related defects can return to the ground state in the form of NIR-II fluorescence. On the basis of this optical absorption model, these CQDs have been successfully applied to NIR-II fluorescence imaging and photothermal therapy. This discovery could open a promising route for the polarons of organic semiconductor materials as NIR-II absorbers in nanomedical applications.

Metabolite responses of cucumber on copper toxicity in presence of fullerene C60 derivatives

Copper (Cu) toxicity in crops is a result of excessive release of Cu into environment. Little is known about mitigation of Cu toxicity through the application of carbon-based nanomaterials including water-soluble fullerene C60 derivatives. Two derivatives of fullerene were examined: polyhydroxylated C60 (fullerenol) and arginine C60 derivative. In order to study the response of Cu-stressed plants (Cucumis sativus L.) to these nanomaterials, metabolomics analysis by gas chromatography-mass spectrometry (GC-MS) was performed. Excess Cu (15 μM) caused substantial increase in xylem sap Cu, retarded dry biomass and leaf chlorosis of hydroponically grown cucumber. In Cu-stressed leaves, metabolomes was disturbed towards suppression metabolism of nitrogen (N) compounds and activation metabolism of hexoses. Also, upregulation of some metabolites involving in antioxidant defense system, such as ascorbic acid, tocopherol and ferulic acid, was occurred in Cu-stressed leaves. Hydroponically added fullerene adducts decreased the xylem sap Cu and alleviated Cu toxicity with effectiveness has been most pronounced for arginine C60 derivative. Metabolic responses of plants subjected to high Cu with fullerene derivatives were opposite to that observed under Cu alone. Fatty acids up-regulation (linolenic acid) and antioxidant molecules (tocopherol) down-regulation might indicate that arginine C60 adduct can alleviate Cu induced oxidative stress. Although fullerenol slightly improved cucumber growth, its effect on metabolic state of Cu-stressed plants was not statistically significant. We suggest that tested fullerene C60 adducts have a potential to prevent Cu toxicity in plants through a mechanism associated with their capability to restrict xylem transport of Cu from roots to shoot, and to maintain antioxidative properties of plants.