The role of macrophage polarization in the osteogenesis of nanomaterials: A bibliometric study

Abstract

ObjectiveIn recent years, with the development of nanotechnology and related disciplines, researchers have conducted much research on the use of nanomaterials for bone regeneration. Our research aims to summarize the application of nanomaterials in the field of bone repair and guide future research directions in this field. MethodsWe summarised all publications in this field in the WoS database, and visual analysis was carried out via bibliometric methods. Based on the above results, we conducted a more in-depth study on the core of this nanomaterial and bone repair. ResultsThe number of publications in this field is increasing annually, with China and the United States contributing the most. Close cooperation between countries guarantees research quality in this field, and interactions between disciplines, especially between materials, biology, physics and chemistry, are also important. Most importantly, in terms of the research focus in this field, we found that macrophage polarization and the immune response are the focus of future research.The polarization of M2 macrophages is the most important area of research. ConclusionThe amount of research on nanomaterials in the field of bone repair will continue to increase, and this study investigated the role of M2 macrophages via in-depth analysis. Our study will guide the research direction of nanomaterials in the field of bone repair to a large extent.