Application Of Knowledge Research Articles

Anti-Angiogenic Activity of Sabungai (Gynura procumbens) using a Cancer-induced Chicken Embryo

Cancer has been increasing over recent years and is considered the primary cause of mortality following cardiovascular disease. Angiogenesis, the biological process by which new blood vessels are generated, plays a crucial role in the growth and spread of tumors. The objective of this study was to assess the anti-angiogenic activity of different Sabungai (Gynura procumbens) leaf extract concentrations in the Chorioallantoic Membrane (CAM) of cancer-induced chicken embryos. The results of a one-way analysis of variance (25.20 ± 2.70, 27.20 ± 1.08, and 22.80 ± 1.66) indicated a statistically significant difference in CAM vascularization between the various treatments. Post hoc analysis utilizing Tukey's Honest Significant Difference (HSD) test revealed that Treatment 2 (300ppt) significantly affected CAM vascularization, as evidenced by an average vascularization count of 27.20 ± 1.08, followed by Treatment 1 (100ppt) and Treatment 3 (500ppt). The results indicated that the extract from Sabungai leaves effectively hinders the formation of new blood vessels in a dose-dependent manner. The highest concentration of leaf extract (500 ppt) resulted in an average vascularization of 22.80 ± 1.66. However, excessively high doses can cause bleeding and embryo death. The results demonstrated that sabungai leaf extract affected blood vessel development in chicken embryos. The results of this research have various implications that contribute to scientific knowledge and potential applications in cancer treatment.

Human Capital Research Program: Contemporary Bulgarian Projections

The research question discussed in the present article can be summarised as the recognition of theoretical and methodological solutions in the scientific service of the functioning of the modern Bulgarian labour market through the operating human capital research program. The analysis is close to its contemporary national projections, presented in terms of a positive result, negative scenarios and opportunities for socio-characteristic evaluation. This presupposes the need for a brief overview of the main aspects of capital formation, of basic concepts of human capital and of the foundation of related competence. Sustaining the function of human capital as a moderator (the ongoing creation and application of knowledge and skills-based behavioral construct) in the Republic of Bulgaria is presented with a view of the Lakatoska idea about the organisation the cognitive process through the creation and functioning of scientific research programs. Thus, the constructive power of the analysed capital is expressed not only in the created and productively realised competence resource, but also in the future benefit hidden behind the problematic areas of this process. These research expectations based on the Bulgarian environment define the guidelines for searching for the advancement of human capital studies as a modern paradigm of human resource management. The study is organised on the basis of the theoretical understanding of the main highlights of the Bulgarian research panorama of human capital in order to outline the results achieved and summarise existing challenges that science and practice face. An attempt is made to summarise the defining moments for the assessment of the sociofunctional nature (progression or degeneration) of the interpreted research programme.

Pre-treatment of Cucurbita maxima ‘Hokkaido orange’ by Viscum album aqueous extracts in search of allelopathic potential

Viscum album L. (VA) is a unique plant with regard to its biological content. It is rich in many different metabolites with high potential in various spheres of human activity. We conducted a pilot study with 5 VA aqueous extracts of different host-tree species for pre-sowing treatment of Cucurbita maxima ‘Hokkaido orange’ seeds. We set the following objectives consisting of hypotheses (1) H01 is based on different effects of tested VA extracts depending on host trees and time of pre-treatment; (2) H02 focuses on the allopathic properties of the tested extracts affecting the plant growth and development by dose–response relationship; (3) A01 considers highly biologically active compounds of VA extracts also containing allelochemicals that can be used to regulate plant growth processes and create eco-friendly and resilient cities. The analysis of the stimulatory allelopathy index for 7 parameters demonstrates the direct effect of VA extracts in 62.3% of cases. The variability of the broad spectrum of effects of VA extracts of different host trees on the ontogenesis of C. maxima plants shows the presence of potential allelochemicals, resulting from the vital products of the host-parasite relationship. These effects are not fully explained by total polyphenol content and antioxidant activity as in previous studies of other mistletoe species. The authors consider this work a pilot study that expands the areas of application of VA extracts and knowledge about potential sources of allelochemicals.

A Survey of Knowledge Graph Approaches and Applications in Education

A Survey of Knowledge Graph Approaches and Applications in Education

Effectiveness of 5a’s Instructional Module in Teaching Grade 12 Physics: An Experimental Study

The study aimed to investigate the impact of the 5A's instructional module on students' Physics knowledge and application of knowledge in Physics. The research included understanding the pre-test and post-test profiles of the participants, comparing the students' levels of Physics knowledge and application of knowledge between the experimental and control groups, and assessing their perceptions of the 5A's instructional module. The study used a quasi-experimental design with a time-series design, employing mean, standard deviation, and paired-sample t-tests to examine the data statistically. The participants were Senior High School STEM students from Cagdianao National High School, Dinagat Islands Province. Four instruments were used: the 5A’s instructional module, physics knowledge test, application of knowledge test, and Likert scale assessment on the 5A's instructional module. The results showed varied performance across physics topics under the conventional approach, with a mixed pattern of improvement observed in Newton’s Law of Motion and Application, having a pre-test mean score of 21.27 and a post-test mean score of 23.47. The 5A's instructional approach demonstrated significant improvement patterns across the three topics, particularly notable in enhancing application of knowledge, with a mean pre-test score of around 10.13 and 18.63 in the posttest of topic B, Kinematics. The paired-sample t-tests revealed significant improvements in post-test scores across all topics with the experimental approach, indicating its efficacy in enhancing understanding and performance. Positive perceptions regarding content quality, instructional quality, and overall impact on learning were observed with the 5A's instructional module. Additionally, continuous refinement based on student feedback is crucial to achieving educational objectives and improving learning experiences.

The rapid generation of E-learning tools under resource constraints approach

Enhancing the efficiency of Ukraine's security and defense sector is one of the key prerequisites for maintaining state sovereignty and achieving victory in the war. This is particularly relevant to the training and education system for specialists of the State Service of Special Communications and Information Protection of Ukraine (SSSCIP). The active phase of Russia's war against Ukraine has significantly exacerbated the contradiction between the necessity to improve the efficiency of this system on one hand and the stringent requirement to economize resources (financial, human, and temporal) on the other. Resolving this contradiction is feasible through the intensive implementation of various e-learning tools and technologies, along with associated pedagogical methodologies. One of the factors limiting the effectiveness of e-learning is the complexity of the traditional process of creating these tools. The negative impact of this factor can be mitigated by developing approaches for the rapid generation of e-learning tools. Thus, there is a need to develop an integrated approach that enables the quick creation of educational content and e-learning tools through the use of innovative technologies. Such tools should save time and enhance the efficiency of learning material assimilation. The primary requirements for this approach include the rational use of limited resources and the adaptability of outcomes to the needs of each specialist. The article proposes an integrated approach to the rapid generation of e-learning tools for studying hardware and software devices and systems. This approach includes the following stages: developing a paper version of the learning material, which is the foundation for further enhancements; supplementing the paper version with an eBook based on H5P, which ensures interactivity and flexibility in learning; introducing a simulator module that allows for the emulation of device operation, stimulates student engagement, and deepens understanding of the material; adding an augmented reality module that visualizes complex concepts and provides opportunities for practical knowledge application. The implementation of the integrated approach to the rapid generation of e-learning tools is demonstrated using the educational module "Fortinet FG-60E Firewall." This module exemplifies how the integrated approach can be applied to prepare specialists in Ukraine's security and defense sector under wartime conditions. Survey results from participants who utilized the developed integrated learning approach indicate its high effectiveness.

Zalunfiban: A Review of Current Knowledge and Future Applications of an Innovative Antiplatelet Agent.

Zalunfiban is a novel glycoprotein IIb/IIIa inhibitor currently being tested for its use in the prehospital setting for antiplatelet effect in patients with ST-elevation myocardial infarction. It has shown to be safe and effective in both phase 1 and phase 2 trials and is under investigation in phase 3 trials. In this review, we discuss zalunfiban in detail, including its mechanism of action, adverse effects, current recommendations for use, and ongoing trials.

Seventy five years of public administration teaching and learning in public Administration and development: Looking back and looking forward

AbstractThrough a narrative review of 75 years of research in public administration teaching and learning in the journal of Public Administration and Development, this article focusses on the challenges and evolution of approaches for decolonizing countries. These challenges are contextualised within broader debates within the discipline of public administration. Three themes are explored: the assumption of universality of knowledge; appropriate contextualization and the applicability of knowledge; and teaching in and for decolonizing countries. Research interest in this topic has nonetheless declined in recent years, so three areas for future research are suggested: the need to support an empirical agenda which privileges the experiences of managing the tensions between imposed and indigenous systems; the need to support scholars in decolonizing countries to critically reflect on and share their approaches to teaching and learning; and the need to support a research agenda on teaching public administration which embraces more flexible and relational models for public administration and includes diverse ontologies.

Readiness for Change in the Hospitality Industry in Indonesia

This study aims to obtain empirical evidence regarding the influence of organizational culture, perceived organizational support, and organizational commitment on readiness for change. This type of quantitative research is quantitative research where the sample is 111 respondents who were analyzed using SEM-PLS. The results showed that organizational culture, perceived organizational support, and organizational commitment positively affect readiness for change. Studies show that if the organizational culture, perceived organizational support, and organizational commitment are reasonable, it will increase employee readiness for change during the COVID-19 pandemic in Indonesia. This research implies that The Royale Krakatau Hotel can create a web-based knowledge management system or application that can distribute employee knowledge anywhere and anytime. Second, it is important to pay attention to non-financial support, such as providing a more transparent employee of the month so that employees feel that the assessment is correct. Third, the organization can routinely look up to and calculate the workload of each employee so that the compensation and workload provided by the company are by the provisions without harming employees. Fourth, a change agent should be formed to manage any resistance to change and be more sensitive to the reasons why employees resist change to improve the employees' ability to understand and manage resistance to change.

ФОРМИРОВАНИЕ КОММУНИКАТИВНЫХ УНИВЕРСАЛЬНЫХ УЧЕБНЫХ ДЕЙСТВИЙ НА УРОКАХ ИНОСТРАННОГО ЯЗЫКА

The English language provides certain opportunities for the formation of UEA. The modern system of teaching English is characterized by the fact that the content of training includes an activity compo-nent: activities that include specific universal learning activities that ensure the creative application of knowledge to solve life problems, and initial self-education skills. The article presents methods for the formation of communicative UEA

Hoping the best, expecting the worst: Forecasting forest fire risk in Algeria using fuzzy logic and GIS

Forest fires pose severe threats to ecosystems and communities globally, especially in vulnerable semi-arid regions like North Africa. Understanding the key factors influencing forest fire dynamics is essential for effective management and mitigation. This study aims to comprehensively analyze forest fire risk patterns in Djebel El Ouahch's massif (Algeria), focusing on integrating bioclimatic, fuel, geomorphological, and human factors through advanced fuzzy logic and geographic information system (GIS) techniques. Climatic station data, satellite imagery, and GIS were employed to map bioclimatic parameters, land cover, and geomorphological features. Fuzzy logic systems were applied to integrate these factors, assigning appropriate weights based on their significance. The resulting forest fire prediction model was defuzzified to generate predictive maps indicating varying vulnerability levels within the study area. Predictive maps delineated areas of low to high forest fire risk. Low-risk zones were characterized by sparse vegetation, while high-risk regions featured densely vegetated slopes near human settlements. The study identified critical factors influencing vulnerability, emphasizing the impact of climate, terrain, and human activities. Urgent attention was directed toward high-risk areas, necessitating tailored fire prevention measures and strategic urban planning to minimize human-induced risks. The results underscored the complex interaction of natural and anthropogenic factors in shaping forest fire susceptibility. Understanding these dynamics facilitates evidence-based policymaking, enhancing forest fire preparedness, biodiversity preservation, and community safety. Additionally, the study emphasized the need for continuous research incorporating real-time climate data and socio-economic factors to refine predictive models. This research provided valuable insights into forest fire risk patterns in Djebel El Ouahch, serving as a foundation for targeted fire management strategies. By bridging the gap between theoretical knowledge and practical application, this study contributes significantly to sustainable forest management and disaster mitigation efforts globally, emphasizing the importance of proactive measures in safeguarding vulnerable ecosystems and communities.

Knowledge of basic life support amongst Medical/Paramedical Professionals, in a Tertiary Care Hospital, Karachi, Pakistan

Background: Cardiopulmonary resuscitation (CPR), a critical skill within basic life support (BLS), is essential for medical professionals in cases of cardiac or respiratory failure. This study aims to evaluate the BLS knowledge and practical application among healthcare professionals at a tertiary care hospital in Karachi, Pakistan, to enhance training outcomes. Objective: The primary objective was to assess the knowledge and practical skills of BLS among medical and paramedical staff at Ziauddin Hospital and identify gaps in training to improve emergency response effectiveness. Methods: This cross-sectional descriptive study involved 400 healthcare workers from various departments of Ziauddin Hospital between February and April 2024. Participants were selected to represent a diverse group of doctors, nurses, and paramedical staff. Data was collected using a standardized questionnaire based on European standards and guidelines from the American Heart Association and the Resuscitation Council. The questionnaire included both theoretical and practical aspects of BLS. Data were analyzed using SPSS version 25, with frequencies, percentages, and chi-square tests applied to assess associations between variables. Ethical approval was obtained from the Ziauddin Hospital Ethical Review Committee, ensuring adherence to the Declaration of Helsinki. Results: The study revealed that 80% of participants knew the abbreviation for BLS. However, only 26.8% correctly identified the immediate action for an unconscious victim. The correct site for chest compressions in adults and infants was known by 88% and 84.5% of participants, respectively. Awareness of AEDs and EMS was high, at 95% and 93%. Practical skills were notably weaker, with significant variability in emergency responses: 26.8% would give two breaths immediately to an unconscious victim, and 76% incorrectly chose to compress the abdomen for a victim submerged in water. The mean age of participants was 27±4.9 years, with a gender distribution of 51.5% female and 48.5% male. Conclusion: While healthcare professionals at Ziauddin Hospital possess strong theoretical knowledge of BLS, there are significant gaps in practical application, especially in emergency scenarios. To improve patient outcomes in emergencies, more practical, scenario-based training is necessary. This study underscores the need for ongoing, hands-on training sessions to bridge the gap between knowledge and practice.

A hybrid framework for sustaining and managing Somali indigenous knowledge

This paper represents the important of preserving Somali Indigenous Knowledge for the future generations to come. This paper presents a systematic review of the indigenous knowledge Management Systems deployed for different sectors in Africa and other countries in the world. The acquisition and management of IK is being used to rejuvenate endangered cultural practices and improve domestic socio-economic sustainability of Somali society. This paper presents how social media platforms and their components could be integrated into the KMS to manage and sustain Somali Indigenous knowledge (IK). The discovery of knowledge and its utilization is now fueled by the advancement of technology, which connects users to external sources through different platforms. The rapidly increasing use of SM and mobile technologies creates opportunities to form knowledge networks that can facilitate the process of creating, preserving, and sharing knowledge and skills that are unique to communities in the Somali context. As an oral society with rich IK and other cultural practices, Somali society lacked a framework to organize the existing knowledge in various methods. We used knowledge products from journal articles, policy documents, working papers, policy briefs, and other gray literature. The paper refers to existing methodology E-learning and KM functions. If properly integrated, this method first identifies functional similarities between SM, E-Learning, and KM systems and their interactions. The proposed framework consists of two functional parts; KM and SM. The KM part involves knowledge capturing, validation, formatting, storing, and distribution. SM part of the framework involves knowledge presentation, sharing, and application. Since the Somalis are said to be an oral society, this framework helps to capture and disseminate IK residing in knowledge holders.

Трансдисциплинарность современной науки как форма социального консенсуса

Introduction. Transdisciplinarity can be reinterpreted from a scientific and philosophical category to a socio-philosophical one by referring to the theoretical constructions of social consensus. In this case, its general social functions are emphasized, which are the social and communication effect of transdisciplinary interactions between science and society. Theoretical analysis. The socio-philosophical analysis of transdisciplinarity is formed in the field of categories of sociality, time, object, truth and values. They are revealed in the autopoietic analysis of the society made by N. Luhmann, which continues the Weberian traditions in relation to the study of scientific rationality. Linking the logical, axiological and social plans of the formation of truth into a single whole in the dialogue between science and society is actualized in the real context of social time. The growth of scientific specialization, which breaks the unified image of science, determines the axiologization and ethicization of scientific knowledge. Transdisciplinarity, based on the social recognition of specific scientific knowledge in everyday life, becomes a tool for gathering disparate academic groups into a symbolic social subject of science. Conclusion. Transdisciplinary science as a hybrid social subject is capable of autonomous communicative behavior, which allows it to act as an agent of policy related to the application of scientific knowledge and thereby legitimize its claims to social authority.

The impact of robotics on STEM education: Facilitating cognitive and interdisciplinary advancements

This paper investigates the transformative role of robotics in enhancing STEM education by improving cognitive skills, fostering interdisciplinary learning, and bridging the gap between theory and practice. Through the analysis of various educational settings, the study highlights the significant enhancements in students problem-solving abilities, engagement, and application of scientific principles via robotics. We present quantitative evidence and case studies that showcase the impact of robotics on boosting analytical skills, increasing student motivation, and enhancing practical knowledge application. The research underscores robotics as a critical educational tool, capable of adapting to diverse teaching environments and contributing to educational equity and innovation worldwide. This integration not only nurtures a deeper understanding of STEM fields but also prepares students for future challenges in a technologically advanced world.

Tips and tricks for successfully conducting a multicenter study

Multicenter studies play a crucial role in medical research and advancement, facilitating the application of new knowledge to clinical practice. These studies are associated with multiple benefits but are more complex than those involving a single center. With the philosophy that most of the qualities required to lead a multicenter study depend on attitude and can be learned, developed, and improved, in this manuscript, we share with the reader a series of recommendations that we consider important for successfully conducting such studies. The tips and tricks that will be discussed in detail are as follows: effectively leading the project; clearly defining viable and relevant objectives; designing a clear and detailed protocol; carefully selecting centers and collaborating investigators; meticulously designing the case report form; centrally managing the project efficiently; maintaining fluent communication with investigators; and, finally, designing a clear authorship policy and ensuring the appropriate publication of the study results. We hope that these suggestions encourage potential researchers to conduct multicenter studies, thereby collectively enhancing the quality of research and its application to clinical practice.

Parental education level on the development of children's oral hygiene skills

Introduction. Dental caries is a significant public health issue due to its high incidence among the population. While modern scientific research highlights effective treatments for this condition, prevention remains crucial, directly impacting health and quality of life, especially when early preventive habits are instilled. This study aims to explore how parents' educational levels and other factors influence the acquisition, use, and proper application of oral hygiene knowledge among primary school children. Material and methods. The study surveyed 678 parents of primary school children across 9 administrative regions, including both urban and rural areas of the Republic of Moldova. It employed a randomized approach, involving respondents from all social groups. Results. This study found that parental education level is a crucial factor influencing the proper development of oral hygiene skills, which can prevent dental conditions. Higher parental education was positively associated with urban living environment and family income. Additionally, well-educated parents tend to visit dentists more regularly, which also reflects in better oral hygiene practices at home for their children. Conclusions. Children's oral hygiene habits are strongly shaped by socioeconomic factors and the care parents show. Increasing parental education levels, whether in urban or rural settings, plays a pivotal role in fostering correct dental hygiene practices early in life, thereby ensuring long-term oral health habits into adulthood.

Evaluating the efficacy of simulation-based training on clinical competency transfer

Introduction. Efficient learning transfer is crucial for training specialists to ensure the provision of quality medical services. This study investigates the impact of simulation-based training on the transfer of medical students' clinical competencies in parenteral drug administration: subcutaneous (SC), intramuscular (IM), and intravenous (IV). Material and methods. Using a quasi-experimental design, the research incorporates pre- and post-intervention testing, observational assessments, and a satisfaction survey to evaluate the educational impact. Results. The results indicate significant improvements in theoretical knowledge and practical skills post-intervention, with notable score increases for all types of injections (SC: from 50% to 83.33%, IM: from 57.14% to 85.71%, IV: from 42.86% to 85.71%; p<0.001). Similarly, improved clinical performance was demonstrated, highlighting the transferability of the learned competencies to real settings. Student satisfaction recorded a score of 4.71 (95% CI 4.64; 4.79), reflecting strong acceptance and appreciation of the training. Conclusions. The study emphasizes the crucial role of simulation in competency-based medical education, bridging the gap between theoretical knowledge and practical application, and advocates for the systematic integration of simulation into the medical curriculum, suggesting future research directions for optimizing the design and implementation of simulations.

Meningkatkan Semangat Kebangsaan di Sanggar Bimbingan Sungai Buloh Malaysia

Education at Sanggar Guidance Sungai Buloh, Malaysia, plays a crucial role in shaping the national spirit and national identity in a society that is rich in history and cultural heritage. Through the application of appropriate knowledge and educational strategies, education at this studio aims to strengthen awareness of national values ​​and develop a sense of pride in local cultural heritage. In this context, community service activities become an important means of strengthening the relationship between education, national identity and community empowerment. Sanggar Guidance Sungai Buloh offers various opportunities for the development of sustainable national education, however challenges such as limited educational accessibility and inequality in education still remain. needs to be addressed. The studio has become an important learning center in its community, with student numbers increasing significantly from 15 to 103. The diverse learning structure and comprehensive curriculum provide opportunities for students to develop holistically. Teachers at the studio have an important role in guiding their students, while the introduction of Indonesian culture strengthens the national spirit. Collaboration with Changemaker Indonesia is a significant step in expanding the influence and impact of service at the Sungai Buloh Guidance Studio. Opportunities are open for the exchange of experience and knowledge between the two countries, giving studio teachers the opportunity to develop their skills. In addition, this collaboration allows for cultural exchange between two different countries, opening up opportunities to enrich the learning experience of students at the studio. It is hoped that, through continued collaboration, the quality of education in the studio can continue to improve and the younger generation can be ready to face future challenges.

A Review and Prospects of Manufacturing Process Knowledge Acquisition, Representation, and Application

The evolution of knowledge acquisition and representation in manufacturing technologies is vital for translating complex manufacturing data into actionable insights and advancing a comprehensive knowledge framework. This framework is pivotal in driving innovation and efficiency in intelligent manufacturing. This review aggregates recent research on knowledge acquisition and representation within the manufacturing process, addressing existing challenges and mapping potential future developments. It includes an analysis of 123 papers that focus on harnessing advanced intelligent analytics to extract operationally relevant knowledge from the extensive datasets typical in manufacturing environments. The narrative then examines the methodologies for constructing models of knowledge in manufacturing processes and explores their applications in manufacturing principles, design, management, and decision-making. This paper highlights the limitations of current technologies and projects emerging research avenues in the acquisition and representation of process knowledge within intelligent manufacturing systems, with the objective of informing future technological breakthroughs.