With the development and maturity of mid-shallow reservoirs, deep reservoirs have become the main exploration targets recently. Deep oil-gas exploration and evaluation are facing great challenges of multi-source data utilization. The aim of the exploration is to verify the resources, location and scale of deep oil and gas, which could be well managed and calculated by the means of Geographic Information System (GIS). In this paper, a grid management and calculation method of deep oil and gas resources is proposed based on ArcGIS 10.5 software, which was preliminarily applied to evaluate the deep oil and gas resources in Tarim Basin. The hydrocarbon generation intensity is calculated and analyzed according to distinct source rocks, spatial patterns, and temporal sequence. The results show that the hydrocarbon generation intensity in the Lower Cambrian strata of Tarim Basin is considerable in total and concentrated in spatial distribution. The total hydrocarbon generation intensity in argillaceous source rocks is higher than that in carbonate source rocks. Among the four types of hydrocarbons including oil, light oil, gas and methane, the generation intensity of the oil is the highest.