The use of innovative multimedia technology continues to evolve and has now become a primary technology tool in education. Currently, the utilization of virtual reality (VR) technology is being used as an immersive medium for learning, especially in the field of medicine. Immersive technology is presented in 3D visualization, approaching real and relevant objects in medical education as an alternative to traditional teaching aids such as cadavers. In this research, an exploration of the VR environment was conducted in a case study of the skeletal system using 3D skull bone objects. The exploration involved tasks such as preparing the 3D skull bone object data assets in the 3D development environment, exporting data assets to the 3D-VR environment, and configuring aspects related to visualization and object control based on visual C#. So far, documentation of the 3D-VR application development environment and the trial results of the case study object development on the Unity platform have been produced. Additionally, documentation of the interface design application using Rapid Application Development (RAD) has also been generated. The Android-based VR application has functioned well in accommodating the skull object, designed with 3 layers of the skeletal system adjusted to their respective depths. The skull consists of 22 components, including cranium.