Development of software for calculating the results of medicinal substances bioequivalence

Abstract

International organizations have adopted and recognized drug standards, which should be guided by developers in the field of pharmacology. In practice, there is a problem: how to determine whether a reproduced drug sample really satisfies the world standard for its pharmacological action. It is required to implement an algorithm for checking and confirming the bioequivalence of drugs. The purpose of the study is to automate the verification of standards using an appropriate algorithm, i.e. to develop an application for calculating the results of medicinal substances bioequivalence. The methodology is based on the assumption that the identity in the sense of the created effect of the pharmacokinetic curves of the drug concentration in the blood versus time for the test drug and the standard means their therapeutic equivalence. Research methods include Python programming, use of libraries for data visualization; Visual Studio is an application development environment. The desired algorithm and requirements for the developed application are formulated in the results of the study, based on the study of theoretical issues of determining the medicinal substances bioequivalence. Finally, conclusions about the efficiency of the software are made and options for its improvement are proposed.