Treatment of purulent wounds remains one of the most important problems of surgery, both theoretically and practically. The aim was to study the effect of biodegradable polymer film "biodep-nano" and hydrated fullerene C60 on the healing of soft tissue wounds and prevention of their infection. We observed 124 patients with purulent-inflammatory soft tissue complications. Scientific group 53 (42.7%) patients who, in addition to complex treatment, performed the proposed therapy. The control group consisted of 71 (57.2%) patients who were treated according to conventional methods. The results showed that the temperature of the study area in the main group returned to normal on the 3rd day (2.8 ± 0.2 days), and in the group where traditionally used wipes on the 5-7th (5.9 ± 0, 4) the day where (p <0.05). Note that the average time of postoperative wound cleansing in patients of the control group was 14.1 ± 0.8 days, the appearance of granulation tissue - 15.6 ± 0.9 days, and the beginning of the marginal epithelialization - 18.4 ± 1.0 days The length of stay of patients in this group on an inpatient bed was 34.3 ± 2.8 days. Thus, from a surgical point of view, a new promising alternative is a combination of surgical treatment of wounds and the use of nano-containing biodegradable polymeric material, which not only destroys pathogenic wound flora, but also can prevent re-infection and purulent-inflammatory recurrence.