Analysis Apparatus Research Articles

Strategy for Microscale Extraction and Proteome Profiling of Peripheral Blood Mononuclear Cells.

Peripheral blood mononuclear cells (PBMCs) play vital roles in physiological and pathological processes and represent a rich source for disease monitoring. Typical molecular profiling on PBMCs involves the sorting of cell subsets and thus requires a large volume of peripheral blood (PB), which impedes the clinical practicability of omics tools in PBMC measurements. It would be clinically invaluable to develop a convenient approach for preparing PBMCs from small volumes of PB and for deep proteome profiling of PBMCs. To this end, here, we designed an apparatus (PBMC-mCap) for microscale enrichment and proteome analysis of PBMCs, which pushed the needed PB volume from the normal 2 mL or higher to 100 μL or lower, comparable to the volume of a drop of finger blood. A PBMC-specific mass spectra library containing 8869 proteins and 121,956 peptides was further built, which, in combination with the optimized data-independent acquisition strategy, helped to identify 6000 and 6500 proteins from PBMCs with 100 μL and 1 mL of PB as initial materials, respectively. Further application of the strategy for PBMC proteomes revealed a steady difference between gender (male vs female) and upon stimulus (COVID-19 vaccination). For the latter, we observed differentially expressed genes and pathways involving the activation of immune cells, including the NF-κB pathway, inflammation response, and antiviral response. Our strategy for the proteome analysis of microscale PBMCs may provide a convenient clinical toolkit for disease diagnosis and healthy state monitoring.

Oxidation kinetics of SPS-densified U3Si2 fuels—Microstructure impact

U3Si2 is a potential candidate for accident tolerant fuels because of its high uranium density and excellent thermal conductivity in comparison to UO2. However, U3Si2 suffers from oxidation, steam corrosion, and subsequent disintegration/pulverization. The detailed investigation of kinetics that incorporates fundamental treatment of oxidation of U3Si2 is scarcely reported, and the oxidation mechanisms have not been fully elucidated. In this paper, the oxidation behavior of microcrystalline (mc-) and nanocrystalline (nc-) U3Si2 have been systematically investigated using a thermogravimetric analysis (TGA) apparatus through a series of isothermal and non-isothermal kinetic studies. The isothermal kinetic study with a model-fitting approach indicates oxidation activation energy of 85 kJ/mol for dense mc-U3Si2 and 96.4 kJ/mol for nc-U3Si2 pellets, while the isoconversional approach leads to an activation energy in the range of 70–85 kJ/mol for mc-U3Si2 and 75–86 kJ/mol for nc-U3Si2 with three most common model-free methods, including Kissinger–Akahira–Sunose, Flynn–Wall–Ozawa, and Friedman methods. The derivation of oxidation activation energies using both isothermal and isoconversional methods highlights the approach to evaluate the oxidation resistance of nuclear materials using TGA quantitatively and makes it possible to compare among various nuclear fuels.

Nexus of ambient flow and squall line via turbulence in the March 2018 meso-scale convective system over Southeast China

On March 4, 2018, an extremely strong squall line occurs suddenly over Southeast China, incurring devastatingly strong surface winds. In this study, we first present a high-resolution model simulation, then apply the recently developed theory of canonical transfer, which bears a form reminiscent of the Poisson bracket in Hamiltonian mechanics, to investigate the underlying dynamical processes. Using a recently developed functional analysis apparatus, multiscale window transform, the fields are reconstructed onto three scale windows, namely, ambient flow window, squall line-scale window, and turbulence window, which for convenience are denoted as windows 0, 1, 2, respectively. It is found that, among all the canonical transfers of kinetic energy (KE), only that between windows 0 and 2, and that between windows 1 and 2, are significant, and the two correspond remarkably well in space, except for opposite signs. Specifically, at the leading edge, KE is first transferred from the ambient flow over the spectrum all the way to the turbulence scale processes, and then goes to window 1 to form the squall line. At the trailing edge, this process is reversed. While the downscale cascading at the leading edge and upscale transfer at the trailing edge are expected in the classical shock hypothesis of squall lines, the existence of the secondary upscale and downscale transfers, respectively, at the leading and trailing edge, are not seen before. Most importantly, these secondary canonical transfers make the turbulence-scale window function like a hub, bridging the ambient flow and the squall line. To our knowledge, such an energetic scenario, i.e., the nexus of two adjacent scales in a spectrum via a “remote mediator” is not seen before in the literature. This study testifies to the importance of turbulent flows in the maintenance of squall lines, and may yield a clue to a better simulation.

Effect of Palm Pollen and Pomegranate Peel Supplementation on Sperm Development in Male Rabbits.

The use of plants, plant extracts, and folk remedies for the treatment of human diseases has been known as traditional medicine. It is approved that the use of herbal medicine dates far back to 60,000 years ago in Iraq. This study aimed to investigate the possible effects of pomegranate and palm pollen, as two powerful herbal remedies with antioxidant, anti-inflammatory, and anti-bacterial effects, on fertility in the male rabbits. A total of 15 healthy New Zealand White male adult rabbits were randomly assigned to three groups (n=5 in each group). Group A: 5 rabbits did not receive herbal treatment (control group). Group B: 5 rabbits were treated with palm pollen at a dose of 2 g by oral gavage daily. Group C: 5 rabbits were treated with pomegranate peel (2 g) treated by oral gavage daily. All animals were euthanized 90 days after the beginning of the experiment. Following the euthanasia, the testis was removed. For sperm recovery, the epididymis was dissected from the testicles and the tail of the epididymis was minced in the sperm washing medium and incubated for 15 min in an atmosphere of humidified 5% CO2, 95% The samples were evaluated by using computerized semen analyzer apparatus (CASA). After 90 days, the treated groups with palm pollen and pomegranate peel (groups B and C) demonstrated a significant increase in the sperm concentration, compared to group (A). Moreover, the recorded data revealed that the sperm concentration in group C was significantly higher than that in group B. The study indicated that the total sperm motility was increased significantly in groups B and C, as compared to that in the control group, while the total sperm motility in group C increased significantly, compared to group B. The histological evolutions signified that in the control group, the epithelial of seminiferous tubules were at different stages of spermatogenesis, the spermatocytogenesis (primary and secondary) with the spermogenesis (spermatids) were found in a cluster at the cavity of the tubule. Furthermore, the results of histological evaluations in groups B and C were distinguished by a significant augmentation of the seminiferous tubules with primary and secondary spermatocytes, as well as some degrees of spermogenesis (round spermatids), compared to group A. Moreover, increased angiogenesis was observed in groups B and C. In conclusion, the results pointed out that herbal remedies have a significant effects in the treatment of reproductive disorders.

Interval methods in the problems of optimal control

The problem of optimal control of a linear dynamic object in conditions of incomplete information about the initial data is considered. The approaches based on various models of the uncertainty description are analyzed. It is shown that the use of the approach based on a probabilistic model for describing uncertainty is advisable when the uncertainty is associated only with randomness, the description of other sources of uncertainty within this model is rather difficult and the formal application of the regression analysis provides the results that are far from true. Though the fuzzy model is suitable for describing a wide range of the uncertainty sources, application of the model faces methodological difficulties when comparing and ranking fuzzy numbers and smoothing fuzzy data. In this regard, it seems promising to use an approach based on an interval model which allows description of a wide class of uncertain and inaccurate initial data. To unify control algorithms for the systems described by equations of state of different types with interval-given parameters, we developed an algorithm of equivalent transformations that provides the transition to special forms of representing the state matrix while maintaining preservation of all the dynamic properties of the original system. The problems of constructing the range of values of the roots of the matrix of the system and its description by an approximation in the form of an interval vector are solved to ensure the implementation of the algorithm. An approach is proposed to solve the problems of terminal control and maximum performance, when the uncertainty of the initial data is described by the interval model and the apparatus of interval analysis is used to solve the problem. It is shown that in this case with the direct use of the classical formulation of the optimal control problem without taking the uncertainty into account, there is no single optimal control which guarantees the exact transfer of the object to the required final state for any value of the parameters from a given range of their possible values. Therefore, in the presence of the interval uncertainty of the initial data, the solution of the problem can’t be obtained in the sense in which it is understood with precisely known parameters and the approach to the formulation of the control problem itself should be revised in order to determine in the future a solution that ensures guaranteed accuracy of the system translation. In this regard, we propose to formulate the control problem in conditions of the interval uncertainty as a problem of determining the set of control actions that guarantee the solution with the accuracy set up to the interval, on the set of initial data known up to the interval. Using an example of the problem with an inaccurately known initial state, it is shown that if the set of possible initial states of an object belongs to a n-dimensional rectangular parallelepiped, then when implementing a control on an object calculated for any initial state from a given set, the set of final states is convex and represents a n-dimensional parallelepiped. To construct the parallelepiped, it is sufficient to determine the coordinates of the vertices corresponding to the vertices of the abovementioned n-dimensional rectangular parallelepiped. We propose a system of inequalities which determines the condition for the membership of a set of finite states of the object obtained upon implementation of control for any possible value of the initial state from a given set to the required set of finite states. On the basis of this system of inequalities, conditions are formulated that provide a priori determination of the solvability of the problem.

White Skin and the Black Mask™

White Skin and the Black Mask™

Mathematical and Computer Modeling of Convective Heat Transfer in Fuel Cartridges of Fuel Elements with Different Shapes and Packing of Rods

The paper consists of three sections and is of an informational and generalizing nature, indicating promising areas for further research. The first section "R-functions method in mathematical modeling of convective heat transfer in fuel cartridges with fuel elements" is devoted to the use of new constructive tools of the R-functions method for mathematical and computer modeling of fuel elements packings with different types of symmetry, as well as the study of convective heat transfer in fuel elements grids and the effect of the type of packing on the distribution of velocity and temperature. An octahedral cartridge with 37 fuel elements packed according to three patterns (cyclic, checkerboard and in-line) is considered. It is noted that when constructing the equations of a cartridge with bundles of fuel elements using the new method, the number of R-operations and, accordingly, the calculation time are significantly reduced. An analysis of the obtained results allows to conclude that the maximum temperature is obtained with cyclic packing. The scheme of the reactor, the cartridges of which are hexagonal casings, with 91 fuel elements placed in each of them both with checkerboard and cyclic packing, is also considered. In the second section "Thermal-hydraulic calculation of fuel elements cartridges in case of violation of the rods packing symmetry", a hexagonal fuel cartridge with 169 fuel elements and checkerboard packing is considered. An increase in temperature is analyzed in case of violation of the packing symmetry while maintaining the parallelism of the rods, as well as in case of a curvature of one of them. The third section "R-functions, fuel element with polyzonal finning of the shell and heat transfer during fluid motion" is focused on the construction of equations for various finning surfaces of fuel elements and the study of hydrodynamic and temperature fields in case of polyzonal finning of the shell. At the same time, using the apparatus of tensor analysis, a transition to a curvilinear non-orthogonal (helical) coordinate system was made. It is noted that mathematical modeling and the associated computer experiment are indispensable in cases where a full-scale experiment is impossible or difficult to conduct for one reason or another. In addition, working with mathematical model of the process and the computational experiment make it possible to investigate the properties and behavior of the process in various situations relatively quickly and without significant expenses. The reliability of the methods, results and conclusions is confirmed by comparison with the information given in the references, the results of the analysis of the numerical convergence of solutions and the calculation of the residual.

Социально-философские основы критических исследований дискурса

The purpose of the study is to analyze the views of the last century's philosophers and find out how they shaped the methodology of discourse analysis. The article examines ideas derived in poststructuralism, postmodernism and the Frankfurt School. The scientific novelty of the paper lies in the philosophical application of discourse studies, as well as singling out the interdisciplinary cooperation between humanities and social studies. As a result, the contribution of M. Foucault, J. Habermas and J. Derrida to the formation of the conceptual apparatus of critical discourse analysis is described; the main categories developed by the above-mentioned authors are summarized, allowing us to apply philosophical methodology to conduct a research of various issues emerging at the intersection of political science, linguistics, sociology, psychology, cultural studies.

The future is not what it used to be: the failure of bipolarisation

ABSTRACT Arguably, the most fundamental question one can ask about a party system is whether it is bipolar or not. Based on theoretical conjectures and on tendencies one observed during the 1990s and early 2000s, as well as reflecting the position of the academic community at the time (e.g. [Bale, T. (2003). Cinderella and Her ugly sisters: The mainstream and extreme right in Europe's bipolarising party systems. West European Politics, 26(3), 67–90; Müller, W., & Fallend, F. (2004). Changing patterns of party competition in Austria: From multipolar to bipolar system. West European Politics, 27(5), 801–835]), Peter Mair had a clear prediction: the future of party politics would be bipolar. Using the Who Governs Europe dataset [Casal Bértoa, F., & Enyedi, Z. (2021a). Party system closure: Party alliances, government alternatives, and democracy in Europe. Oxford: Oxford University Press], the article examines the validity of Mair's predictions. Notwithstanding certain exceptions (e.g. Bulgaria, Luxembourg, Serbia), the article demonstrates that the tendency towards increasingly bipolarised party politics has failed to materialise. Next to the description of empirical patterns the article provides suggestions on how to improve our conceptual apparatus of party system analysis.

Математическое моделирование и исследование оптимальных конфигураций триангуляционной оптико-электронной системы при подсветке пространства предметов одной полосой

The article discusses the theoretical research of triangulation optoelectronic systems consisting of a video camera and a source of structured illumination in the form of a single straight strip. Such optoelectronic systems can be used for solving various problems of three-dimensional modeling, for example, in the problem of detecting obstacles in front of an autonomous mobile robot. The aim of this work is to identify the optimal configuration of such systems to achieve the best accuracy in determining the size of the observed objects, as well as the distances to them. Using the apparatus of analytical geometry, linear algebra and mathematical analysis, a mathematical model of such a system has been developed, taking into account various internal parameters and technical characteristics of the video camera and the structured light source, as well as the relative position and orientation of the camera and the source. Using the constructed mathematical model, equations were obtained allowing estimating the error in calculating the distances to the detected objects. The question of the optimal configuration of such optoelectronic systems is examined, as well as optimality criteria: minimization of errors in determining the distance, the smallest height of the detected objects. The obtained theoretical results can be used in control systems for unmanned vehicles, in systems for non-destructive testing of industrial products, and in further studies of optoelectronic systems of this type

Electro‐responsive shape‐memory composites obtained via dual‐curing processing

AbstractIn this work, electro‐responsive shape‐memory actuators were developed by incorporating a conductive heater in a dual‐curing thiol‐acrylate‐epoxy shape‐memory polymer (SMP). A conductive heater, consisting of an electrically conductive silver‐ink track printed on Kapton® substrate, was assembled to the SMP, taking advantage of the dual‐curing processing. The shape‐memory effect (SME) was activated by the heat dissipated by the Joule effect in the conductive track. Boron nitride agglomerates were dispersed in the thiol‐acrylate‐epoxy layers to increase thermal conductivity and achieve faster shape‐recovery. A thermoelectric control unit was developed to control the shape recovery of the electro‐responsive actuators and provide different activation strategies. The electrically activated SME was investigated and compared to a traditional SME based on an external heating source given by the dynamic mechanical analyzer (DMA) apparatus. Electro‐responsive actuators were found extremely faster than the conventional SMPs based on external heating. The fastest recovery was obtained by the 15% boron nitride actuator, which recovered the 100% of the original shape in only 8 s. The thermoelectric controlling device provided an optimal control of the shape recovery speed based on the pulse width modulation of the heating current under the application of a low voltage (5 V).

New Industrial Models and Management Systems in of State Corporation «Rostec» Companies

The article aims to systematize the characteristics of new industrial models that have developed in the divisions of «Rostec» Group of Companies. The transition to new control systems and industrial models are illustrated by the ongoing changes in the aviation cluster of «Rostec» Group (Russian Helicopters Holding, United Propulsion Corporation) and the United Aircraft Corporation (UAC). The author considered the measures of massive institutional and investment support from the state for defence companies implementing new industrial models. When working on the material of the article, the author used methods of comparison and systematization. Also, the methodological apparatus of factor, structurallogical and institutional analysis was applied, proving the consistency of state policy and the activities of defence companies transforming their industrial models.

Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation.

SUMMARYGait and posture are often perturbed in many neurological, neuromuscular, and neuropsychiatric conditions. Rodents provide a tractable model for elucidating disease mechanisms and interventions. Here, we develop a neural-network-based assay that adopts the commonly used open field apparatus for mouse gait and posture analysis. We quantitate both with high precision across 62 strains of mice. We characterize four mutants with known gait deficits and demonstrate that multiple autism spectrum disorder (ASD) models show gait and posture deficits, implying this is a general feature of ASD. Mouse gait and posture measures are highly heritable and fall into three distinct classes. We conduct a genome-wide association study to define the genetic architecture of stride-level mouse movement in the open field. We provide a method for gait and posture extraction from the open field and one of the largest laboratory mouse gait and posture data resources for the research community.

Structural inertia of economic systems

Systemic inertia forms a transdisciplinary field of studies, which includes interests of natural sciences, technical studies, humanitarian studies, socio-economic studies, etc. Economic science mainly relied on the methods of economic theory and philosophy to analyze this phenomenon. The globality of this subject impeded the formalization of research, and numerical interpretation of inertia were limited to the introduction of a coefficient in an economic and mathematical model. At the same time, the opportunity of getting numerical values of structural inertia in the industry coordinates was provided by basic dynamic input-output balance model, written as a system of basic differential equations. This model’s capital coefficients matrix (according to V. Leontief) is non-singular and can be called the matrix of interindustry inertia. Its elements have time dimensionality. This research presents the methodology for calculating the matrix. Its dimensionality is equal to the dimensionality of the matrix of the formation of the output of goods and services published by ROSSTAT with the interval of two years. This methodology consists of verifiable sequence of algebraic transformations within the input-output methodology with the specified matrix. This research represents the inertia, related to the processes of formation of basic stock, and the inertia of the formation of the gross value added of Russian economy. The high practical importance of the research consists in the development and demonstration of the economic and mathematical apparatus for contrastive analysis of structural dynamic properties of different economies when they are modeled in the coordinates of the same industries.

ОЦЕНКА ГРАНИЦЫ ВОЗНИКНОВЕНИЯ НЕУСТОЙЧИВОСТИ ЭКОНОМИКИ

The problem of finding the borders of the critical value of the economic number and obtaining relationships that allow a qualitative analysis of the state of economics of various macroeconomic objects is considered. To solve this problem, the apparatus of vector analysis and the theory of dimensions are used. As a result of the research the order of change modulus of rate of unstable development of economy during creation of gross product of the given volume is found. It is proved that the growth of the main factors of production is proportional to the scale of the economy. The boundary of the emergence of resistance to the development of the economy, which appears due to external and internal factors, is found. An equality is obtained that allows us to evaluate the effectiveness of the development of investments at any time intervals. The basic properties of the economic number are studied and its application for the study of the economies of various objects is found. An additional tool has been obtained for dynamic comparative analysis of various economies, regardless of their volumes and economic indicators.

Structural inertia of economic systems

Systemic inertia forms a transdisciplinary field of studies, which includes interests of natural sciences, technical studies, humanitarian studies, socio-economic studies, etc. Economic science mainly relied on the methods of economic theory and philosophy to analyze this phenomenon. The globality of this subject impeded the formalization of research, and numerical interpretation of inertia were limited to the introduction of a coefficient in an economic and mathematical model. At the same time, the opportunity of getting numerical values of structural inertia in the industry coordinates was provided by basic dynamic input-output balance model, written as a system of basic differential equations. This model’s capital coefficients matrix (according to V. Leontief) is non-singular and can be called the matrix of interindustry inertia. Its elements have time dimensionality. This research presents the methodology for calculating the matrix. Its dimensionality is equal to the dimensionality of the matrix of the formation of the output of goods and services published by ROSSTAT with the interval of two years. This methodology consists of verifiable sequence of algebraic transformations within the input-output methodology with the specified matrix. This research represents the inertia, related to the processes of formation of basic stock, and the inertia of the formation of the gross value added of Russian economy. The high practical importance of the research consists in the development and demonstration of the economic and mathematical apparatus for contrastive analysis of structural dynamic properties of different economies when they are modeled in the coordinates of the same industries.

Design of Asymmetric Parallel Manipulator for Axial-Bending Dynamic Stiffness Analysis

This paper presents an asymmetric 5-bar parallel manipulator capable of characterizing the dynamic stiffness properties of materials used in robotic joints in 2 degrees of freedom, axial and bending, simultaneously. The end effector is actuated by two stepper motors with linear rails. Two force sensors were added to estimate axial force and moment. Experiments were performed in axial compression, bending, and a mixed axial-bending motion. A spring-mass-spring system was constructed to evaluate the fabricated apparatus for frequency analysis up to 20Hz. The frequency analysis result was accurate when compared to the theoretical response of the system. Axial stiffness estimation had an error of 1.5%, bending stiffness had an error of 3.4%, and mixed-mode had a total error of 1.8%. Future experiments will showcase the versatility of the apparatus and test nonlinear samples.

КОМПЛЕКСНА МОДЕЛЬ СИСТЕМНИХ ДОСЛІДЖЕНЬ ПРОБЛЕМ БЕЗПЕКИ ОБ`ЄКТІВ КРИТИЧНОЇ ІНФРАСТРУКТУРИ

The development of methodological approaches to the solution of an understudied problem, namely to the systematic study of aspects of ensuring the safety of important critical infrastructure facilities is shown in the paper. According to the Law "On the Basics of National Security of Ukraine", the objects of critical infrastructure are: transport and communication; energy and energy supply; provision of housing and communal services; industry and scientific and technical activity in the military-industrial complex; dual purpose technologies; information technologies and information protection; use of subsoil; land on water resources; mineral resources; environmental protection, etc. A system of classifications of prognostic modeling methods has been developed in the form of a three-level structure: by forecasting methods and information bases; according to the material basis of the instrument for obtaining the final result; according to the classification scheme of the specified specific methods. The complex model of system research of critical infrastructure facilities security problems from the position of the Armed Forces of Ukraine has been developed. The mathematical apparatus of analysis and assessment of the level of national (military) security, including military-political, military-economic, military-political models of the state, is presented. The specific features of problem classes by direction, namely well and weakly structured problems, are determined. The use of game theory to compensate for statistical selection is proposed. The main methods of decision-making are given: the methods of utility theory (generalized criterion); the cumulative expected utility as a valid method of decision trees; the methods of prospect theory; the methods of inequality thresholds; the methods of analyzing hierarchies, that are based on a multi-criteria description of the problem; the heuristic methods. It’s shown that the most developed theoretical basis, that finds application in determining the security status of critical infrastructure objects and security in general, are expert methods or methods of multidimensional analysis with elements of taxonomy. However, these approaches assume the existence of reference objects or the scenario of the influence of factors on the final result imagined by experts. An important conclusion was made that the basis of the scientific contradiction is the need to create a sufficiently perfect mechanism for solving the problems of objectively justifying decisions in the military sphere under the conditions of significant limitations in the acquisition of biased data for the prevention of conflicts in the military sphere and the absence of finished scientific theory for determining the result of the complex impact of various factors.

Порівняльний аналіз результатів визначення припусків за нормативами та за розрахунково-аналітичним методом з використанням розмірного аналізу технологічних процесів

A comparative analysis of the results of determining the general allowance according to the standards and the allowance determined using the calculation-analytical method on the example of processing by boring the main hole in the workpiece of the body part was performed. The studies were carried out on the example of the technological process of mechanical processing of the workpiece of the "Hull" type part. The determination of technological dimensions and dimensions of the initial workpiece, as well as intermediate allowances and general allowance for all transitions of processing (boring) of one of the main holes is considered. It was believed that the initial workpiece is casting in shell molds. To determine one of the components of the minimum pass, namely the spatial deviations of the surface of the hole relative to technological bases, the dimensional analysis apparatus of the technological process was used, which takes into account the specific conditions of this process, in particular, the peculiarities of the scheme of basing on the first operation. A comparison of the amount of the total minimum allowance determined using the calculation-analytical method with the amount of the total allowance determined according to the normative tables showed that the calculated allowance exceeds the standard by almost 30%, and the most significant influence on the amount of the calculated total allowance is the value of the spatial deviation of the axis of the hole in the initial workpiece relative to the technological bases. Therefore, if the first operation of the technological process solves the problem of ensuring the dimensional relationship between the processed and untreated surfaces, then the allowance determined according to the standards during the processing of a batch of blanks on a set machine may not be enough to ensure the required surface quality details Therefore, in this case, it is necessary to use the calculation and analytical method to determine both the intermediate allowances and the total allowance.

Прогнозирование окончания строительства на основе моделирования нелинейной зависимости от задержек отдельных работ

Methods of forecasting construction duration can be divided into two classes: firstly, the extrapolation methods, the essence of which is to transfer the results of the current state of the system to its future state based on taking certain characteristics as invariants, and secondly, forecasting methods based on regression determination of the functional relationship between delays in performing individual works and the total construction delay. These methods can be implemented using two different models: multiple regression analysis and neural network modeling. However, to choose one of the models, it should be kept in mind that the accuracy of the prediction is affected by the non-linearity between the total construction delay and the delays of performing individual works. The presented study has shown that nonlinearity is a constant attribute of the estimated work schedules, as demonstrated by the example of calculating a schedule based on the principles of stream-type construction organization. A comparison of the linear regression analysis apparatus and the neural network modeling apparatus showed that the average values of the relative deviations for the two-layer and three-layer perceptrons become smaller than the values calculated using multiple linear regression. And for the three-layer perceptron, these values are guaranteed to be lower than similar values obtained using the multiple linear approximation apparatus.