AbstractThis study aimed to investigate the failure mechanism of Ti60 titanium alloy in the high cycle fatigue (HCF) and very high cycle fatigue (VHCF) at 500°C. Ti60 specimens were characterized before and after the 500°C VHCF test, and the fracture surfaces were observed. The results show that there are three different fatigue failure mechanisms at 500°C: (i) equiaxed primary α phase (αp) cleavage, forming small unsmooth facets and rough fracture area (RA), and fusion of non‐adjacent facets to grow into the main crack. (ii) αp grains gather into large grain with triple junction, and large grain slip to form large fusion facet. (iii) Oxide shedding and then cracks form. A dynamic recurrent neural network model is used to predict the fatigue life of Ti60 alloy, 91% of the overall predictions were within the scatter band of 3.0, and 100% were within the scatter band of 5.0.