Antiulcer Properties Research Articles

Preparations from Various Organs of Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) as Important Regulators of Hemostasis and Their Role in the Treatment and Prevention of Cardiovascular Diseases.

Numerous studies on the chemical composition of various organs of sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) have found the plant to be a rich source of vitamins, phenolic compounds, amino acids, fatty acids, and micro- and macro-elements. Furthermore, other studies on preparations from various organs have found them to have significant anti-cancer, anti-ulcer, and hepatoprotective properties, as well as various antibacterial and antiviral activities. This paper reviews the current literature concerning the effect of different sea buckthorn preparations, i.e., extracts and fractions with various chemical contents, on hemostasis, and their positive role in the treatment and prevention of cardiovascular diseases. It also sheds new light on the mechanisms involved in their action on hemostasis both in vivo and in vitro. For these studies, biological materials, including blood platelets, plasma, and blood, were isolated from healthy subjects and those with cardiovascular risk factors. In addition, it describes the cardioprotective potential of commercial products from different organs of sea buckthorn.

Evidence of anti-inflammatory and anti-ulcer properties of aerial parts of Centaurea tougourensis Boiss. and Reut.

Purpose: To determine the anti-inflammatory and anti-ulcer properties of the aerial parts of Centaurea tougourensis Boiss. & Reut.
 Methods: The effects of n-butanol (n-BuOH) extract of the aerial part of Centaurea tougourensis on carrageenan-induced paw edema and ethanol-induced gastric mucosal damage were determined at 2 doses (200 and 400 mg/kg, po) in a mouse model. For each test, the animals were randomly divided into negative and positive control groups, as well as extract-treated groups. The mice were observed for any sign of inflammation for a period of 24h.
 Results: Reduction of paw edema by C. tougourensis extract was highly significant (p < 0.001) at a dose of 400 mg/kg 24 h after carrageenan injection, with 55.26 % inhibition, followed very closely by 53.15 % inhibition at the dose of 200 mg/kg; indomethacin group showed an inhibition of 60 %. Histological examination supported the inhibition results. A significant reduction in inflammation by the extract at a dose of 400 mg/kg was also observed. No sign of ulcer was observed with C. tougourensis at the two doses (200 and 400 mg/kg). The total polyphenol content of the n-BuOH extract was 85.44 цg gallic acid equivalent/mg of extract. Tannins were the most abundant fraction (51.87 цg tannic acid equivalent/mg of extract), followed by flavonoids (25.55 цg quercetin equivalent/mg of extract).
 Conclusion: The results indicate that C. tougourensis may have potential beneficial effects in the treatment of diseases associated with inflammation and pain, besides its protective effect on the gastrointestinal tract.

Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis-A Review.

The genus Crepis L., included within the Asteraceae family, has a very wide distribution, expanding throughout the northern hemisphere, including Europe, northern Africa, and temperate Asia. This genus has a fundamental value from biodynamic and ecological perspectives, with the different species often being chosen for soil conservation, for environmental sustainability, and for their attraction towards pollinating species. Furthermore, various species of Crepis have been used in the popular medicine of several countries as medicinal herbs and food since ancient times. In most cases, the species is consumed either in the form of a decoction, or as a salad, and is used for its cardiovascular properties, as a digestive, for problems related to sight, for the treatment of diabetes, and for joint diseases. This literature review, the first one of the Crepis genus, includes publications with the word ‘Crepis’, and considers the single metabolites identified, characterised, and tested to evaluate their biological potential. The various isolated compounds, including in most cases sesquiterpenes and flavonoids, were obtained by extracting the roots and aerial parts of the different species. The secondary metabolites, extracted using traditional (solvent extraction, column chromatography, preparative thin layer chromatography, preparative HPLC, vacuum liquid chromatography), and modern systems such as ultrasounds, microwaves, etc., and characterised by mono- and bi- dimensional NMR experiments and by HPLC-MS, have a varied application spectrum at a biological level, with antimicrobial, antioxidant, antidiabetic, antitumor, antiviral, antiulcer, phytotoxic, and nutritional properties having been reported. Unfortunately, in vitro tests have not always been accompanied by in vivo tests, and this is the major critical aspect that emerges from the study of the scientific aspects related to this genus. Therefore, extensive investigations are necessary to evaluate the real capacity of the different species used in food, and above all to discover what the different plants that have never been analysed could offer at a scientific level.

Preparation and optimization of moringa leaf powder for edible purpose

In the current scenario, people are highly concerned regarding their health and constantly desire a healthy and nutritious diet. Moringa oleifera is traditionally known as saijhan or drumstick tree. The plant is native to tropical Asia and thus found in various parts of the country India. Being a nutrient-rich plant, Moringa leaves play a vital role in the treatment of malnutrition. It also has anti-inflammatory, anti-spasmodic, anti-asthmatic, anti-ulcer, hypocholesterolemic, and hypoglycemic properties. Fresh fruits have also been desirable and in growing demand, because of healthy food consumption trends worldwide. The following study was undertaken to provide nutrient-rich food in the busy growing lifestyle. Thus, in this study, preparation and optimization of the Moringa leaf powder have been done. The final product is developed by incorporating Moringa leaf powder into pomegranate juice to prepare a ready-to-serve (RTS) beverage. On the basis of this study, it concluded that 100:2:2.8:0.2 concentration of Pomegranate, Moringa oleifera leaf powder, Sugar, Citric Acid is suitable for the preparation of Ready to Serve Beverage. In this study, proximate analysis and sensory evaluation have been performed to understand the overall acceptability of the final product.

Investigation on Anti-Ulcer Activity of Momordica dioica Fruits in Wistar Rat

To present study was carried out to investigate antiulcer activity of Ethanolic extract of Momordica dioica fruits in pylorus ligatated and Cold stress induced ulceration in the wistar rats. Pylorus ligation induced ulcer is one of the most widely used methods for studying the effect of drug on gastric secretion. Effect of distilled water in pylorus ligation has caused the accumulation of gastric sectretion and decreased the pH. Ranitidine and Ethanolic extracts of Momordica dioica significantly decreased the gastric volume, total acidity, free acidity, ulcer score, number of ulcer and ulcer index and raise the pH (shown in graph. 1, 2, 3, 4, 5, 6,).Similar studies support our results. Ethanolic extract of Momordica dioica at a dose of (400mg/kg. p.o) showed significant inhibition of ulcerative lesion by 46.33% and 54.66%, respectively, as compared to the control value The Ethanol extract of Momordica dioica fruits possess significant antiulcer properties in a dose dependent manner.

Gastroprotective effect of low dose Eugenol in experimental rats against ethanol induced toxicity: Involvement of antiinflammatory and antioxidant mechanism

Ethnopharmacological relevanceSyzygium aromaticum L. volatile oil (clove oil) has been traditionally used for various stomach disorders including inflammatory conditions. Eugenol is the major constituent present in the volatile oil, and it has been established as a gastroprotective agent through many published studies, but the exact and complete mechanism of ulcer protection is not delineated yet. Moreover, it plays precisely the opposite effect in higher dose in antiulcer properties with worsening the ulcer at a higher dose. AimThis study aims to carry out the prophylactic cytoprotective effect of eugenol with single low doses and explore the probable interrelated underlying transcriptional and translational level mechanism of cytoprotection such as antioxidative, anti-inflammatory, mucous generation in rats using ethanol-induced ulcer model. MethodsRats were administered with different doses of eugenol before ethanol intragastrically. The effects of the eugenol on mucous production, Nitric oxide generation, PGE2 synthesis, lipid peroxidation were recorded together with cytokines measurement in the blood. TNF-α and IL-6, two key cytokines, were also studied in specific. In addition, studies on the immunohistochemical and gene expression of HSP70 and iNOS indicators have been conducted. ResultsAccording to our findings, Eugenol substantially reduced the ulcer index and completely protected the mucosa from lesions. By restoring the lowered GSH and NP-SH levels, the protective effect of the eugenol was found to be augmented at both doses. This finding has corresponded to an increase in MDA, which was lowered by ethanol administration. Pre-treatment with eugenol on the ethanol-induced ulcer reduced the plasma NO levels and increased PGE2 along with a decreased TNF-α and IL-6 concentration. Additionally, significant transcriptional and translational upregulation of HSP70 and downregulation of iNOS were detected in the eugenol-treated rat stomach tissue. ConclusionOur findings demonstrated that eugenol had a considerable gastroprotective impact at low doses, which could be attributed to its ability to regulate inflammatory reactions and antioxidant capacity.

Therapeutic applications and characteristics of Falcaria vulgaris in traditional medicine and experimental studies.

Objective: Falcaria vulgaris is a herb with various applications in traditional medicine, including treatment of skin and gastric ulcers, liver diseases and gastrointestinal problems. It contains many valuable and important compounds with antioxidants and anti-ulcer properties, including carvacrol, spathulenol, limonene, tannins and saponins. In recent years, besides confirming many of its conventional uses, new beneficial properties of this plant have been identified. The purpose of this review is to investigate the therapeutic applications and botanical characteristics of F. vulgaris in traditional medicine and experimental studies.Materials and Methods:This study was a systematic review using the keywords "Falcaria vulgaris," "Therapeutic properties" and "Animal studies", 100 articles were extracted from various databases, including PubMed, SinceDirect, SID (scientific information database) and google search engines without time limit; after several stages of title monitoring and abstracts review, finally, 70 articles were selected for this study.Results: In traditional medicine of different countries, several therapeutic properties have been reported for F. vulgaris, most of which are attributed to its antioxidant content and the presence of tannins and saponins. In recent decades, many studies have been done to identify and confirm the medicinal properties of F. vulgaris, including antioxidant, antimicrobial and anti-diabetic effects, healing properties of skin and stomach ulcers, and protection of the liver and kidney.Conclusion: F. vulgaris has a variety of biological properties and is used as a valuable plant in medical research that helps to improve health and prevent some diseases.

Oral health benefits of Phyllanthus emblica

Globally the oral disorders of teeth and periodontium are causing serious health issues. Most of the times antibiotics and other antimicrobial drugs are used for their management. However, the resistance to these drugs stress on the role of antimicrobial extracts obtained from plant sources. The Indian gooseberry, also known as Amla comes from family of Euphorbiaceae. It has various health beneficial properties such as antiaging, antidiabetic, and hepatoprotective. Phyllanthus emblica is commonly found in Asia. P. emblica fruit contains Vitamin C and many biologically active phytochemicals. It has antimicrobial and anti-ulcerative properties. It is used for the management of oral ulcers and periodontal diseases. This article aims to review the literature currently available on the benefits, usage, and effects of P. emblica.

Protective effect of the traditional Korean herbal prescription, Bojangunbi-tang, on non-steroidal anti-inflammatory drug-induced small bowel injury

Background: Bojanggunbi-tang (BGT) is a well-known combination of ancient Korean herbal medicines and has been widely used for treating gastrointestinal symptoms. Objectives: This study was aimed at investigating whether BGT protects against non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury (NSI), by using a murine model of indomethacin-induced NSI. Materials and Methods: NSI was induced in the mice by subcutaneous injections of 15 mg/kg indomethacin. BGT was administered at doses of 50, 150, and 450 mg/kg, while the positive control received sodium alginate. The treatments were orally administered twice, 30 min before and 6 h after the induction of NSI. The body weight, length of small intestine, macroscopic damages, and histological damages were assessed after 24 h of induction. Results: Gross anatomical analysis revealed that BGT inhibited the shortening of the small intestine and reduced the area of ulceration. Histological analysis revealed that BGT lowered the ulceration and inflammation scores. However, there was no difference between the groups with respect to weight loss. Conclusion: BGT ameliorated NSI via its anti-inflammatory and anti-ulcerative properties. The current study suggests that BGT could be a therapeutic option for NSI.

Assessment of the antiulcer properties of Lawsonia inermis L. leaves and its nano-formulation against prolonged effect of acute ulcer in rats

Peptic ulcer syndrome (PUD) has been acknowledged as one of the most frequent causes of morbidity and mortality worldwide throughout the 20th and 21st centuries. Several reports indicated the ability of plant derived dosages as antiulcer agents. Many prior investigations have implied some biological activities of Lawsonia inermis L. The aim of this current investigation was to estimate the antiulcer capability of Lawsonia inermis L. leaves and its nano formulation against hazardous biochemical and histological changes in aspirin-induced ulcer rats. Methods divided into 6 groups (6 rats/group), Normal control (negative), Group (1) receiving dose of (200 g/kg) Lawsonia inermis L. for 8 weeks, Group (2) receiving (200 g/kg) nano Lawsonia inermis L. leaves for 8 weeks, Group (3) ulcer control group receiving a single dose (500 mg aspirin/kg rat body weight),groups 4& 5 receiving aspirin and either Lawsonia inermis L. leaves or nano Lawsonia inermis L. leaves for 8 weeks. Results: improvements in all the tested parameters as well as hepatic enzymes activities and some blood biochemical parameters. Conclusion Lawsonia inermis L.at the tested dose could prevent ulcer formation in the tested animals that may offer safe and low cost effective treatment for gastric ulcer.

Effects of alcoholic extract of Myristica fragrans (nutmeg) on pregnancy outcome in female Wistar rats

Myristica fragrans has been reported to be a medicinal plant as it possesses hepatoprotective, antimicrobial, anti-oxidant, antiulcer, anticancer and immunostimulatory properties, as well as antifertility potentials. This study therefore aimed to investigate the effects of alcoholic extract of M. fragrans on dam size, litter size, pup weight, ovarian follicles, endometrial glands and histopathological indices on pregnancy outcomes in female Wistar rats using standard methods. Pregnancy was induced in forty-eight (48) female Wistar rats that were randomly selected and assigned into four (4) groups of twelve (12) rats each: Group 1 (pregestational phase of pregnancy), Group 2 (germinal phase of pregnancy), Group 3 (embryonic phase of pregnancy) and Group 4 (Fetal phase of pregnancy). The treated animals all received 1500 mg of alcoholic extract of M. fragrans. Administration of distilled water and the extract was by orogastric tube. Data were subjected to statistical analysis using the IBM SPSS statistics software (Statistical Package for Social Science) (Version 25) and relevant statistical values were obtained. The extract prevented the proliferation of ovarian follicles and endometrial glands. In addition, during the pregestational, germinal and embryonic phases, there were significant increases in weight of pups when the treated animals were compared to the control group. The dams also showed decreases in body weight during the embryonic phase. This study therefore demonstrated that alcohol extract of Myristica fragrans may serve as a contraceptive agent in view of its anti-fertility effect.

Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases.

Moringa oleifera, popularly known as a miracle tree or tree of life, has been extensively used as a functional food and nutritional asset worldwide. Ethnomedicinal and traditional uses of M. oleifera indicate that this plant might have a pleiotropic therapeutic efficacy against most human ailments. In fact, M. oleifera is reported to have several pharmacological activities, including antioxidant, antibacterial, antifungal, antidiabetic, antipyretic, antiulcer, antispasmodic, antihypertensive, antitumor, hepatoprotective, and cardiac stimulant properties. Recently, a few experimental studies reported the neuroprotective effects of M. oleifera against Alzheimer's disease, dementia, Parkinson's disease, stroke, and neurotoxicity-related symptoms. In addition, several neuroprotective phytochemicals have been isolated from M. oleifera, which signifies that it can have promising neuroprotective effects. Therefore, this review aimed to explore the current updates and future prospective of neuroprotective efficacies of M. oleifera.

GC-MS, FTIR and Antiulcer Screening of Aqueous Seed Extract and Oil of Nigella sativa in Wistar Rats

Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. This study was aimed at evaluating the antiulcer activity of the aqueous extract of Nigella sativa (black seed) and its constitutents. The pharmacognostic properties of the dry seeds were determined. The seeds were extracted using two methods digestion and hydro-distillation. The acute toxicity, phytochemical constituents and the antiulcer evaluation were performed on ethanol-induced ulcer in wistar rats using a standard method. FTIR and GC-MS analysis of the aqueous seed extract was also determined using standard methods. Nigella sativa seed shows the presence of starch grains, lignified tissues, tannins, cellulose, protein and oil globules. The aqueous extract has a high safety margin. The phytochemical studies revealed the presence of saponins, flavonoids, alkaloids, tannins, glycosides, fats and oil. The black seed aqueous and oil extract at 500 mg/kg significantly reduced the acidity, total acidity, and ulcer index, and pH of gastric content when compared with the positive control (Famotidine). The FTIR analysis identified the presence of the following functional groups chloro, ether, amine, carboxylic acid, nitriles, methylene, alcohol, while the GC-MS identified five compounds such as glycerin, n-Hexadecanoic acid, 9, 12-octadecadienoic acid-methyl ester, 9, 12-octadecadienoic acid and 9, 12-octadecadienoyl chloride. The pharmacognostic properties can act as a reliable tool for the standardization of the plant part. This study suggests that aqueous and oil extract possess antiulcer properties. Thus the aqueous and oil extract of black seed can be considered as antiulcer medication traditionally.
 Keywords: Nigella sativa, Black seed, Pharmacognostic, Phytochemical, Acute toxicity (LD50), Antiulcer.

Physicochemical properties and health benefits of camel milk and its applications in dairy products

Despite the similarity of its components with other milks, camel milk has a considerable attention from both dairy market producers and scientists lately. It is a good substitute for human milk as it contains low αs1-CN, high β-CN, high unsaturated FA, and does not contain β-LG. However, camel milk differs from other ruminants in the proportions of some ingredients with high biological activity. It's low in cholesterol, and high in C & B vitamins, α-hydroxyl acids and minerals. The high concentration of β-CN makes camel milk easier to digest by chymotrypsin than cow's milk, while the lack of β-LG makes it a suitable choice for people who are suffering from allergy to cow's milk. The α-hydroxy acids improve skin smoothness and skin disorders such as dermatitis, and eczema. Camel milk is a rich source of protective proteins; lactoferrin, immunoglobulins, and lysozyme, which have antimicrobial and anti-tumor properties. It contains a large amount of insulin that is not destroyed in the stomach and thus becomes more effective in improving blood sugar in the long term in diabetic patients compared to cow's milk. It's also rich in minerals, especially zinc and magnesium, which have anti-ulcer properties, and iron, which helps treat iron deficiency anemia. Additionally, camel milk composition allows the manufacture of some accepted products, such as those made from cow's milk. It can be used in some dairy products such as fermented milk, soft cheese, butter, and ice cream, by optimization of the processing parameters. So, it could be said that camel milk is a grant from the creator.

Review On: Medicinal Uses, Phytochemistry And Pharmacological Action Of The Plant Bauhinia Racemosa (Lam.).

Herbal medicines are now attracting attention as potential sources to treat so many diseases or disorders. Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Bauhinia racemosa (Lam.) belongs to family Caesalpiniaceae, is a small deciduous tree with drooping branches. This plant grows in poor and very harsh climatic conditions the leaves and stem bark of the plant Bauhinia racemosa (Lam.) are usefull in headache, dysentery, diarrhoea, skin disease, fever and blood diseases. The plant reported to have antiulcer, antidiabetic, anticoagulant, hyperlipidemia, antitumor, antimicrobial, antioxidant, antianxiety, anthelmintic, analgesic, antipyretic, antihistaminic, anti-inflammatory, and hepatoprotective properties. The plant reported to have antiulcer, antidiabetic, anticoagulant, hyperlipidemia, antitumor, antimicrobial, antioxidant, antianxiety, anthelmintic, analgesic, antipyretic, antihistaminic, anti-inflammatory, and hepatoprotective properties. This review provides detailed information on plant Bauhinia racemosa (Lam.).

An integrative review on bioactive compounds from Indian mangroves for future drug discovery

The mangrove ecosystem is being intensively studied with the hope of discovering new chemical entities with biomedical potentials. A number of biologically active compounds with varying degrees of action such as anticancer, antiulcer, antioxidant, antidiabetic and antimicrobial properties have been isolated from mangroves. Totally 81 mangrove species have been reported worldwide, of which 46 species are reported to occur in India. Among these, around 36 mangrove species are used in traditional medicine. Approximately 249 bioactive compounds have been isolated from 18 species, and the remaining species are yet to be screened. Biologically active compounds such as limonoids, terpenoids, alkaloids, glycosides, steroids, flavonoids, esters, quinones, phenols, acids, aliphatic alcohol, amides, lactones, aliphatic ketones, and benzodioxols have been derived from the leaves, stems, barks, fruits, and seeds of Indian mangrove plants. This review examines the current trends in the screening and biological activity of metabolites from the Indian mangroves. This comprehensive review in turn can serve as a potential resource for future drug development endeavours.

REVIEW ON COMPILATION OF ETHNOPHARMACOLOGICAL PROPERTIES OF BERGENIA CILIATA: THE MEDICINAL HERB OF HIMALAYAS

As mentioned in the texts such as Vedas, Charaka Samhita and Sushruta Samhita, Bergenia ciliata is a known to be the ancient and medicinal plant belonging to the family Saxifragaceae. It can be found as a shrub or an herb, while some are trees or vines. The family includes about 80 genera, 1250 species and has biological properties that are possessed by the different plant parts including antibacterial, antiviral, antioxidant, anti-ulcer, anti-diabetic, analgesic, anti-plasmodial, antitumor, antitussive activity, antineoplastic, diuretic and anti-inflammatory properties. Many of its members grow in rocky places. Bergenia ciliata itself shows that the plant originate between rocks and appears to break them or that it possesses lithotroptic property. It’s different plant parts are reported to have different medicinal properties. There are three species of Bergenia found in India Bergenia ligulata, Bergenia ciliata, Bergenia stracheyi. The rhizomes of these plants are used in the indigenous system of medicines.

Origin, Evolution, Breeding, and Omics of Chayote, an Important Cucurbitaceae Vegetable Crop.

Chayote (Sechium edule), a member of the Cucurbitaceae family, is cultivated throughout tropical and subtropical regions of the world and utilized in pharmaceutical, cosmetic and food industries because it is an excellent source of minerals, dietary fibers, protein, vitamins, carotenoids, polysaccharides, phenolic and flavonoid compounds, and other nutrients. Chayote extracts process various medicinal properties, such as anti-cardiovascular, antidiabetic, antiobesity, antiulcer, and anticancer properties. With the rapid advancements of molecular biology and sequencing technology, studies on chayote have been carried out. Research advances, including molecular makers, breeding, genomic research, chemical composition, and pests and diseases, regarding chayote are reviewed in this paper. Future exploration and application trends are briefly described. This review provides a reference for basic and applied research on chayote, an important Cucurbitaceae vegetable crop.

Phyllanthus reticulatus Prevents Ethanol-Induced Gastric Ulcer via Downregulation of IL-8 and TNF-α Levels.

The current study aimed to determine the protective effect of P. reticulatus on ethanol-induced gastric ulcer. For this purpose, thirty-six Sprague-Dawley rats were divided into six groups. The first group served as normal control, while, in other five groups, absolute ethanol was used to induce gastric ulcer. Group II served as a diseased group, while groups III, IV, and V were treated with methanol extract, ethyl acetate fraction, and n-hexane fraction, respectively, in a dose of 400 mg/kg bodyweight. Group VI was given omeprazole in a dose 20 mg/kg bodyweight. The stomachs were removed, ulcer score was evaluated, and histopathological examination of gastric lumen was conducted. Total acidity and pH values were determined in gastric juice. TNF-α and IL-8 mRNA expressions levels were determined using the reverse transcription real-time PCR method. The data indicated that P. reticulatus protected against gastric ulcer, which was evident by attenuation of ulcer score. The pretreatment with P. reticulatus raised the gastric pH and improved all evaluated histopathological parameters such as ulcer score, erosion score, hemorrhage score, fibrinoid necrosis score, inflammatory infiltrate score, and edema score. P. reticulatus significantly reduced mRNA expression levels of TNF-α and IL-8. In conclusion, P. reticulatus possess antiulcer property which might be attributed to downregulation of TNF-α and IL-8 expression levels.

Safety Profile, In Vitro Anti-Inflammatory Activity, and In Vivo Antiulcerogenic Potential of Root Barks from Annona senegalensis Pers. (Annonaceae).

Annona senegalensis (Annonaceae) is a tropical shrub widely distributed in Burkina Faso. This plant is traditionally used as a medicine against many pathologies including typhoid fever, gastrointestinal disorders, ulcers, and inflammatory and infectious diseases. The present study was conducted to evaluate the anti-inflammatory and antiulcer properties of Annona senegalensis root bark extracts. Therefore, toxicity tests were first performed, followed by other biological tests. For this purpose, we first undertook to evaluate the toxicity tests before considering the other biological tests in a second step. The results showed that the extracted fractions had a significant effect for the different methods used (protein denaturation inhibition activity, hyaluronidase inhibition activity, and xanthine oxidase inhibition activity). However, of the extracted fractions used, the ethyl acetate fraction was the most anti-inflammatory fraction. The antiulcer activity was evaluated using the best bioactive fraction. The antiulcer effect of the ethyl acetate fraction may be due to both the reduction of gastric acid secretion and gastric cytoprotection. The results of this study also showed that the bioactive fraction reduced ethanol-induced ulceration and pyloric ligation in a dose-dependent manner, and at the highest dose (200 mg/kg), the effect was similar to that of the reference drug. In summary, the ethyl acetate fraction was found to have the best anti-inflammatory and antiulcerogenic activities. The ethyl acetate fraction at a dose of 200 mg/kg also showed a rather interesting level of cytoprotection. The anti-inflammatory and antiulcer activities could be due to the different secondary metabolites contained in the fractions extracted from Annona senegalensis, notably flavonoids, triterpenoids, steroids, saponins, and tannins. As the mechanisms of action are still little or not understood, we will consider in the future identifying the phytoconstituents and the mechanisms of action involved in the results.