BackgroundAs an 886-bed tertiary care hospital with both teaching and private physician groups, Cedars-Sinai Medical Center has a unique opportunity to incorporate antimicrobial stewardship pharmacist (ASP) rounds with both a general medicine teaching service (TS) as well as a non-teaching hospitalist group (NTH). The impact of ASP rounds on antimicrobial (ABX) utilization and notable differences in clinical outcomes associated with both rounding models were evaluated.MethodsAn ASP was incorporated into existing teaching rounds for TS and disposition planning rounds for NTH. ASP-TS and ASP-NTH rounds both occurred once daily on weekdays with facetime of 3-4 hours per day for TS and 0.5-1 hour per day for NTH. Metrics included ASP recommendations and acceptance rates, total ASP time, ABX utilization, and clinical outcomes. Chi-squared and the Student’s t-test were used as appropriate.ResultsBetween November 2016 to April 2017, ASPs reviewed 3184 NTH patients and 1322 TS patients. More opportunities for ASP intervention were identified with TS (40% vs. 26%, P < 0.001). Overall recommendation acceptance rates were higher for TS compared with NTH (95% vs. 79%, P < 0.001). Total recommendations identified per ASP-hour were higher for NTH vs. TS (1.76 vs. 0.93). ASP recommendations targeting ABX de-escalation, unnecessary use of fluoroquinolones, and treatment of asymptomatic bacteriuria were similar for both groups.Compared with baseline rates, ASP rounds were associated with a significant reduction (-6%, P = 0.01) in ABX days-of-therapy (DOT) for NTH but not for TS (-1%, P = 0.6). Anti-Pseudomonal (PSA) DOT significantly declined in both NTH (-11%, P = 0.04) and TS (-22%, P = 0.02). No significant changes in mortality, length of stay, and 30-day readmission rates were observed for either group.ConclusionASP rounds identified ample opportunities for improvement in ABX utilization in both NTH and TS models. Rounds were associated with a significant reduction in anti-PSA DOT for both models and a significant reduction in overall ABX DOT for NTH group. Although NTH provided a higher patient volume and allowed for more interventions per ASP-hour compared with the TS model, acceptance rates were lower, which may reflect a shorter amount of time spent on patient discussions.Disclosures All authors: No reported disclosures.