Antibacterial Polymer Research Articles

Vancomycin coupled chitosan/PEO nanofibrous scaffold with the desired antibacterial activity as a potential for biomedical application

This study aims to evaluate the Vancomycin (VCM) combination with Chitosan (CS)/ Polyethylene oxide (PEO) nanofibers’ intrinsic antibacterial properties causing a synergistic effect against possible serious bacterial infections (PSBI). VCM/CS nanofiber scaffold was fabricated using the electrospinning method. Characterizations are performed by Fourier transform infrared (FT-IR) to examine the functional groups of each compound, scanning electron microscopy (SEM), and transient electron microscopy (TEM) to evaluate nanofiber diameter and structure. Antibacterial activities of the nanofibrous scaffold were assessed against bacterial strains, including standard Staphylococcus aureus ( S. aureus), VCM-sensitive Enterococcus (VSE), methicillin-resistant S. aureus (MRSA), VCM-resistant Enterococcus (VRE), and Streptococcus group A by microdilution broth methods. The FT-IR, SEM, and TEM examination results confirm the CS/PEO nanofiber scaffold fabrication. The antibacterial examination results showed no significant difference between the minimum inhibitory concentration (MIC) values of VCM and with MIC of VCM/CS nanofibers. Still, there were significant differences between the MIC of CS and VCM/CS nanofibers in S. aureus, but this is not more significant than VCM. This study illustrated that VCM coupled to CS nanofibers had acceptable antibacterial activity against the Gram-positive bacterium. This work motivated researchers’ insight into nanostructures’ potential accompanied by antibacterial polymer and antibiotics synergistic effects against PSBI.

Preparation and characterization of a self-matting waterborne polyurethane with antibacterial function

Self-matting waterborne polyurethane (WPU) with rough surface is often accompanied by poor antibacterial property, which greatly limits its service life. Here, a gemini quaternary ammonium (GQM) with hydrophilic and antimicrobial properties was designed and synthesized. 1,3,5-tris (2-hydroxyethyl) hexahydro-1,3,5-Triazine (TNO) was used as a crosslinking agent, and GQM was selected as chain extender to prepare antibacterial and self-matting WPU resin. The effects of TNO and GQM on the morphology, particle size, gloss, antibacterial rate, and hydrophilicity of WPU were investigated. The results showed that the introduction of TNO and GQM significantly enhanced the self-matting effect and antibacterial activity of WPU. When the contents of TNO and GQM were 1.2 wt% and 4 wt%, the average particle size of emulsion was 6.53 μm, the gloss of coating was 11.05 GU. It is also significant to be noted that the antibacterial rates of S. aureus and E. coli were 95.69 % and 95.18 %, respectively. This prepared WPU was endowed with self-matting and antibacterial properties simultaneously. This finding can provide a novel insight into the research of antibacterial polymers and antiglare coatings.

Benzothiazole Derivatives of Chitosan and Their Derived Nanoparticles: Synthesis and In Vitro and In Vivo Antibacterial Effects.

In this work, we focused on synthesizing and assessing novel chitosan-based antibacterial polymers and their nanoparticles by incorporating benzothiazole substituents. The growing resistance to antibiotics has necessitated the search for alternative antimicrobial compounds. This study aimed to synthesize and evaluate chitosan-based polymers and nanoparticles with benzothiazole substituents for their antibacterial properties and toxicity. The benzothiazole derivatives of chitosan and their nanoparticles were synthesized through electrochemical coupling. The in vivo antibacterial efficacy was tested on white rats with induced peritonitis using a microbial suspension containing S. aureus and E. coli. Additionally, in vitro and in vivo toxicity assessments were conducted. The chitosan-based antibacterial systems showed significant in vivo antibacterial activity, surpassing that of unmodified chitosan and commercial antibiotics. Moreover, the toxicity studies revealed low toxicity levels of the synthesized derivatives, which did not differ significantly from native chitosan. The synthesized chitosan-based polymers and nanoparticles demonstrated potent antibacterial activity and low toxicity, highlighting their potential as effective alternatives to traditional antibiotics. Further investigations in pharmacology and preclinical trials are recommended to explore their application in clinical settings.

Microtopographic superhydrophobic polymer surface to prevent urinary tract infections causing nosocomial drug-resistant bacterial adhesion

Catheter-associated urinary tract infections (CAUTIs) are one of the most prevalent forms of healthcare-associated infections worldwide. Recurrent episodes of infections and development of antibiotic resistance/tolerance among biofilm-forming bacteria are well documented. We developed a simple method of making superhydrophobic micro-structured antibacterial polymer surfaces for coating-free catheters. A two-step fabrication approach was used to turn the hydrophobic polydimethylsiloxane (PDMS) into superhydrophobic surfaces. The nanosecond pulsed Nd:YAG laser was used to fabricate two types of structures (holes and grooves) on a steel mold. The soft-molding technique was adopted to replicate these structures on PDMS films. The pillar structured PDMS surface exhibited a water droplet contact angle (WDCA) of 169○ ± 3° with a low sliding angle of 12○, whereas the grooved surface had 142○ ± 5° contact angle. Moreover, the Luria Broth which is media for bacterial growth shows contact angle of 141○ ± 2° and 120○ ± 3°, respectively. Theoretically, the micro-pillar structures with selected dimensions could sustain the Cassie–Baxter state. The crystal violet binding assay was used to assess the anti-biofilm activity of structured surfaces (grooved and pillared) against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), as well as clinical isolates of Klebsiella pneumonia (K. pneumoniae), E. coli, and S. aureus. Furthermore, the attachment and interaction of bacteria with surfaces were investigated through filed emission scanning electronic microscope (FE-SEM) and confocal microscopy. Overall, the pillar-structured surface reduces the average bacterial attachment more efficiently than a grooved surface (>80% vs. >50% reduction) compared to a plain PDMS surface due to its higher water-repellent property. This work will give new insights into the development of coating-free, long-lasting antibacterial surfaces for polymeric medical devices.

Electrostatic and Covalent Binding of an Antibacterial Polymer to Hydroxyapatite for Protection against Escherichia coli Colonization.

Orthopedic-device-related infections are notorious for causing physical and psychological trauma to patients suffering from them. Traditional methods of treating these infections have relied heavily on antibiotics and are becoming ineffectual due to the rise of antibiotic-resistant bacteria. Mimics of antimicrobial peptides have emerged as exciting alternatives due to their favorable antibacterial properties and lack of propensity for generating resistant bacteria. In this study, the efficacy of an antibacterial polymer as a coating material for hydroxyapatite and glass surfaces, two materials with wide ranging application in orthopedics and the biomedical sciences, is demonstrated. Both physical and covalent modes of attachment of the polymer to these materials were explored. Polymer attachment to the material surfaces was confirmed via X-ray photoelectron spectroscopy and contact angle measurements. The modified surfaces exhibited significant antibacterial activity against the Gram-negative bacterium E. coli, and the activity was retained for a prolonged period on the surfaces of the covalently modified materials.

Citronellol-Based Long-Lasting Antibacterial Cotton Fabrics without Bacterial Resistance.

Antibacterial cotton helps prevent the growth and spread of harmful microorganisms, reduces the risk of infection, and has a prolonged service life by reducing bacterial degradation. However, most antibacterial agents used are toxic to humans and the environment. Citronellol-poly(N,N-dimethyl ethyl methacrylate) (CD), a highly effective antibacterial polymer, is synthesized from natural herbal essential oils (EOs). CD exhibited efficient, rapid bactericidal activity against Gram-positive, Gram-negative, and drug-resistant bacteria. Citronellol's environmental benignity makes CDs less hemolytic. Notably, negligible drug resistance developed after 15 bacterial subcultures. The CD-treated cotton fabric displayed better antibacterial performance than AAA-grade antibacterial fabric, even after repeated washing. This study extends the practical application of EOs to antibacterial surfaces and fabrics, which is promising for use in personal care products and medical settings.

The Design and Preparation of Antibacterial Polymer Brushes with Phthalocyanine Pigments

Phthalocyanine pigments have many problems in waterborne coating applications because of their low polarity, poor dispersion in water, and easy agglomeration properties. In order to solve these problems, the phthalocyanine pigments were encapsulated with a copolymer of methyl methacrylate (MMA) and butyl acrylate (BA) by a mini-emulsion polymerization method. The pigments are effectively dispersed in water and have good compatibility with the resin. Concerning the bacterial reproduction and growth problem for the waterborne system, the resin-encapsulated phthalocyanine pigments were further grafted with antibacterial polymer poly(N-(2-hydroxyethyl) acrylamide) (PHEAA) on its surface using the photoemulsion polymerization technique. Comprehensive properties, including centrifugal stability and chromaticity change, were studied. The polymer encapsulation improved the centrifugal stability of the pigment. The thermogravimetric results showed that the residual mass of C.I. Pigment Green 7 (52.30%) was higher than that of C.I. Pigment Blue 15:3 (30.06%), and the sublimation fastness of PG7 was higher. The TEM results revealed that the shape of the PG7 after encapsulation and grafting was more regular than that of PB15:3. The L* of the pigment decreased after encapsulation but then increased after further grafting. The phthalocyanine pigment composite latex had good antibacterial properties after the grafting of PHEAA.

Fabrication and Characterization of PVC-Based Nanofiber Membranes for Water Filtration Application

Polyvinyl chloride (PVC) dissolved in N-dimethylacetamide (DMAC) and filled with polyvinyl pyrrolidone (PVP) has been studied for water treatment applications due to the material being hydrophobic, rigid, and biodegradable. However, it does not have antibacterial properties. The chitosan nanoparticles (CSNPs) as a natural antibacterial polymer are added into PEO/PVC blend to fabricate nanofiber membranes for well water filtration. We investigate the effects of adding PEO and CSNPs to PVC on the morphology, tensile properties, water contact angle, and water filtration efficiency of the nanofiber membranes. The PEO-PVC polymer solutions are dissolved in DMAC by varying concentrations of 0, 1, 2, 3, and 4% PEO (w/w), then fabricated to be the nanofiber membranes by the electrospinning technique. The PEO/PVC membrane’s contact angle decreases with the PEO concentration and by adding 1% CSNPs. This trend aligns with the average nanofiber diameter but is opposite to the tensile strength. The 1% CSNPs/4% PEO/PVC membrane has shown 78% and 92% efficiency in filtering Coliform and Colitinja bacteria in the well water, respectively.

New indoleacetic acid-functionalized soluble oxidized starch-based nonionic biopolymers as natural antibacterial materials

This study aims to develop a new soluble oxidized starch-based nonionic antibacterial polymer (OCSI) featuring high antibacterial activity and non-leachability by grafting indoleacetic acid monomer (IAA) onto the oxidized corn starch (OCS). The synthesized OCSI was characterized analytically by Nuclear magnetic resonance H-spectrometer (1H NMR), Fourier transform infrared spectroscopy (FTIR), Ultraviolet-visible spectroscopy (UV–Vis), X-ray diffractometer (XRD), X-ray Photoelectron Spectroscopy (XPS), Scanning Electronic Microscopy (SEM), Thermogravimetric Analysis (TGA) and Differential Scanning Calorimetry (DSC). The results showed that the synthesized OCSI was endowed with high thermal stability and favorable solubility, and the substitution degree reached 0.6. Besides, the disk diffusion test revealed a lowest OCSI inhibitory concentration of 5 μg disk−1, and showed significant bactericidal activity against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli). Moreover, the antibacterial films (OCSI-PCL), featuring their good compatibility, mechanical properties, antibacterial activity, non-leachability, and low water vapor permeability (WVP), were also successfully prepared by blending OCSI with biodegradable polycaprolactone (PCL). Finally, CCK-8 assay results confirmed the excellent biocompatibility of the OCSI-PCL films. Overall, this very study evidenced the applicability of the obtained oxidized starch-based biopolymers as an eco-friendly non-ionic antibacterial material and confirmed their promising applications in areas including biomedical materials, medical devices, and food packaging.

Preparation and properties of antibacterial polymer microspheres and their films having renewable cardanol moiety

Polymer microspheres having bio-based cardanol moiety were prepared via suspension polymerization of 2-hydroxy-3-cardanylpropyl methacrylate (CM). The incorporation of the cardanol moiety into polymer microspheres could impart the bactericidal properties and the microspheres were found to have a cross-linked structure formed during the suspension polymerization by the reactions between the double bonds in the cardanol moieties. The cross-linked structure is very useful to prepared physically stable polymer films using the polymer microsphere. The polymer microsphere itself prepared by CM and the polymer film prepared by casting the polymer microsphere suspension were found to have very high antibacterial activity against E.coli; the minimum inhibition concentration (MIC) value of the polymer microsphere against E.coli was 0.403 mg mL−1 and the antibacterial activity of the polymeric film prepared by casting the polymer microsphere suspension against E.coli was larger than 99.9%. Copolymer microspheres prepared by the suspension copolymerization of CM with styrene(ST) and the polymer films prepared from the copolymer microspheres also showed high antibacterial activity. For example, the MIC value of the copolymer microsphere prepared using 80 to 20 mol ratios of ST to CM was 0.519 mg mL−1 and the antibacterial activity of the polymer films of the copolymer microsphere is 99.9%. The bactericidal properties of the polymer films were found to be caused by the disruption of cell wall by contact-killing without any leaching of antibacterial moieties. Furthermore, all the polymeric films from microsphere of the polymer and copolymers showed sufficient biocompatibility, regardless of their monomer compositions.

Diverse Antibacterial Treatments beyond Antibiotics for Diabetic Foot Ulcer Therapy.

Diabetic foot ulcer (DFU), a common complication of diabetes, has become a great burden to both patients and the society. The delayed wound closure of ulcer sites resulting from vascular damage and neutrophil dysfunction facilitates bacterial infection. Once drug resistance occurs or bacterial biofilm is formed, conventional therapy tends to fail and amputation is unavoidable. Therefore, effective antibacterial treatment beyond antibiotics is of utmost importance to accelerate the wound healing process and prevent amputation. Considering the complexity of multidrug resistance, biofilm formation, and special microenvironments (such as hyperglycemia, hypoxia, and abnormal pH value) at the infected site of DFU, several antibacterial agents and different mechanisms have been explored to achieve the desired outcome. The present review focuses on the recent progress of antibacterial treatments, including metal-based medications, natural and synthesized antimicrobial peptides, antibacterial polymers, and sensitizer-based therapy. This review provides a valuable reference for the innovation of antibacterial material design for DFU therapy.

Phytochemicals, Biodegradation, Cytocompatibility and Wound Healing Profiles of Chitosan Film Embedded Green Synthesized Antibacterial ZnO/CuO Nanocomposite

Open wound ulcer treatment remains a great challenge in wound care management especially involving multi drug resistant (MDR) pathogen. Currently, lack of effectiveness of commercially available wound dressing material is one of the primary factors delaying the wound healing. Therefore, transformation of plain Chitosan (Cs) to antibacterial polymer nanocomposite with embedment of Quercetin-ZnO/CuO biocide through green synthesis approach shed light for an efficient wound healing management. The present work studied the phytochemicals, biodegradation, storage, cytocompatibility and wound healing profiles of Cs film embedded with Quercetin-ZnO/CuO from Calotropis gigantea (C. gigantea). HPLC was used to detect Quercetin bioactive constituent. Our cytocompatibility study demonstrated ZnO/CuO-Cs-1wt.% displayed highest cell viability (168.52 ± 14.46%) at 72 h treatment. Besides, the ZnO/CuO-Cs-1wt.% is fully biodegradable. The ZnO/CuO-Cs-1wt.% also exhibited significantly enhanced cell migration (26.81 μm/h) and wound closure (62.35 ± 9.46%) at 12 h. This finding is also supported by our in vivo excisional open wound studies in Sprague-Dawley (SD) rats, which showed progressive recovery in 14 days. The controllable release of multiple metal ions from ZnO/CuO-Cs might contribute to the wound recovery. This study highlighted the promising outcomes exhibited from ZnO/CuO-Cs-1wt.% in wound healing management.

Synthesis of Citronellol-Derived Antibacterial Polymers and Effect of Thioether, Sulfoxide, Sulfone, and Ether Functional Groups on Their Bactericidal Activity

Citronellol-derived methacrylate polymers with four side chain interconnecting groups of different polarities (PCHM-Xs) are synthesized to prepare bio-based bactericidal polymers. The PCHM-X bactericidal activities are significantly affected by the different functional groups determining the interaction between the polymer chain and bacterial membrane that disrupts the membrane integrity causing cytoplasmic leakage, the main contributor to the polymer antibacterial properties. PCHM-SO, with a large dipole moment and strong hydrogen bonding ability, shows the best bactericidal activity among PCHM-Xs due to the strongest interactions with the bacterial membrane components. A sulfoxide-group-containing polymer with excellent bactericidal activity (99.99%) and the systematic study of the effect of different functional groups on the bactericidal activity are first reported herein.

Tetrapodal ZnO nanomaterial synthesis for antibacterial fluoroethylene vinyl ether polymer coating

Antibacterial coatings can be nanofabricated to provide antimicrobial persistence, nanostructural tailoring, and superhydrophobicity. This study presents a method for preparing an effective antibacterial coating by introducing tetrapodal ZnO (T-ZnO) nanomaterials on a fluoroethylene vinyl ether polymer (FEVE). T-ZnO nanomaterials were as-synthesized by flame transport synthesis and characterized. The T-ZnO exhibited a tetrapodal micro- and nanostructure with four legs of ∼43 μm diameter, comprising 86.67 and 12.90 wt% of Zn and O, respectively. High-resolution images of a single leg with sharp whiskers exhibited well-developed crystallinity. The antibacterial capabilities of T-ZnO functional coatings were determined using a reaction solution consisting of FEVE directly soaked in various wt% of T-ZnO with ethyl acetate. The 10 wt% T-ZnO nanocomplex coating exhibited the best surface hydrophobicity, with a water contact angle of 155°. The proposed T-ZnO on a fluoroethylene polymer-based coating exhibited higher antibacterial efficacy toward Gram-positive S. Aureus and -negative E. Coli compared with a standard polymer-based coating. In examining cellular toxicity, no harm was found to NIH/3T3 cells using the CCK-8 assay. Hence, this study provides a simple method for preparing safe and effective antibacterial coatings for practical applications.

Capability of Copper Hydroxy Nitrate (Cu2(OH)3NO3) as an Additive to Develop Antibacterial Polymer Contact Surfaces: Potential for Food Packaging Applications

The globalization of the market, as well as the increasing world population, which require a higher demand for food products, pose a great challenge to ensure food safety and prevent food loss and waste. In this sense, active materials with antibacterial properties are an important alternative in the prolongation of shelf life and ensuring food safety. In this work, the ability of copper(II) hydroxy nitrate (CuHS) to obtain antibacterial films based on low density polyethylene (LDPE) and polylactic acid (PLA), was evaluated. The thermal properties of the composites, evaluated using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), showed that the concentrations of added CuHS do not particularly change these characteristics with respect to the neat polymer matrix films. The mechanical properties, determined using dynamic mechanical analysis (DMTA), indicate a small increase in the brittleness of the material in PLA-based composites. The antibacterial properties against Listeria monocytogenes and Salmonella enterica were evaluated using a surface contact test, and a bacterial reduction of at least 8 to 9 logarithmic units for the composites with 0.3% CuHS, both in LDPE and PLA and against both bacteria, were achieved. The reusability of the composite films after their first use demonstrated a higher stability against Listeria monocytogenes. The migration and cytotoxicity of the composites loaded with 0.3% CuHS was evaluated, demonstrating the safety of these materials, which reinforces their potential use in food packaging applications.

Formulation and Evaluation of Sustained Release Linezolid Tablet using Natural Antibacterial Polymer - <i>Aegle marmelos</i>

The objective of the current research study was to formulate and evaluate a sustained-release linezolid tablet using the natural antibacterial polymer Aegle marmelos. The natural gum of Aegle marmelos is becoming increasingly used in pharmaceutical formulations as a beneficial medication with excipients. Natural-based plant materials are biocompatible, free of side effects, biodegradable, and economic. Therefore, in order to maintain the drug releases from the matrix system, Aegle marmelos fruit gum as a natural polymer and HPMC grade (K100M) as a synthetic polymer were used in the formulation of the linezolid matrix tablet. The formulation of sustained-release matrix tablets included the wet granulation technique. The formulated matrix tablets were evaluated in terms of weight variation, hardness, diameter, physical appearance, friability, thickness, and in vitro drug release. Each formulation’s matrix tablet passed the required physical assessment tests. The formulation analyses of the tablets’ dissolution showed sustained releases of drugs for up to 10–12 hours. Additionally, several polymer combinations and fillers were used to improve drug release factors using the 32 factorial design approach, drug release kinetics were optimized, and the antibacterial study was evaluated.

Sustainable production of dimethyl-protected cyclic lysine over Pd/m-Al2O3-Si catalysts and its application in synthesis of antibacterial nylon‑6 copolymers

Antibacterial monomers are prerequisites for synthesizing antibacterial polymers, especially during the current COVID-19 pandemic. Dimethyl-protected cyclic lysine (DMCL) is a promising functional monomer for nylon-6 based self-cleaning antibacterial polymers. However, the production of DMCL still faces formidable challenges, such as harsh reaction conditions and low catalyst activities. In this study, we developed a Pd/m-Al2O3-Si catalyst, which exhibited high efficiency in converting α-amino-ε-caprolactam (α-ACL) to DMCL, affording a yield of as high as 97.1% at 100 °C and 1 MPa H2. The lack of Brönsted acid sites on the catalyst surface facilitated the formation of DMCL and suppressed undesirable hydrolysis or cracking by-products from the lactam-based reactant. The recycled experiments showed that Pd/m-Al2O3-Si performed excellent stability and physical strength with essentially no damage to its microspheres after the reaction. The nylon‑6 copolymers produced from the as-synthesized DMCL exhibited similar structure and thermal stability with pure nylon-6, showing great potential in synthesizing the self-cleaning antibacterial polymers. This work provides a sustainable and efficient method for producing DMCL and other lysine-based antibacterial monomers, showing a great prospect for the utilization of bio-based chemicals in synthesizing functional polymers.

A facile and scalable strategy for constructing Janus cotton fabric with persistent antibacterial activity

Natural cotton fibers have attached considerable attention due to their excellent wearing comfort, breathability and warmth. However, it remains a challenge to devise a scalable and facile strategy to retrofit natural cotton fibers. Here, the cotton fiber surface was oxidized by sodium periodate with a mist process, then [2-(methacryloyloxy) ethyl] trimethylammonium chloride (DMC) was co-polymerized with hydroxyethyl acrylate (HA) to obtain an antibacterial cationic polymer (DMC-co-HA). The self-synthesized polymer was covalently grafted onto the aldehyde-functionalized cotton fibers via an acetal reaction between hydroxyl groups of the polymer and aldehyde groups of the oxidized cotton surface. Finally, the resulted Janus functionalized cotton fabric (JanCF) revealed robust and persistent antimicrobial activity. The antibacterial test showed that when the molar ratio of DMC/HA was 50: 1, JanCF possessed the best BR (bacterial reduction) values of 100 % against Escherichia coli and Staphylococcus aureus. Furthermore, the BR values could be maintained over 95 % even after the durability test. In addition, JanCF exhibited excellent antifungal activity against Candida albicans. The cytotoxicity assessment confirmed that JanCF exhibited a reliable safety effect on human skin. Particularly, the intrinsic outstanding characteristics (strength, flexibility, etc.) of the cotton fabric were not considerably deteriorated compared to the control samples.

Irrigation in Endodontics: Polyhexanide Is a Promising Antibacterial Polymer in Root Canal Treatment.

chronic apical periodontitis is a common pathology in dentistry, especially in endodontics. It is necessary to systematize data concerning commonly used irrigation solutions. The development of new protocols for endodontic treatment is a very promising direction. The use of a polyhexanide-based antiseptic can positively affect the results of endodontic treatment. the review was carried out involving the search for English language research and meta-analyses in the Google Scholar and PubMed databases. the number of literary sources that were identified during the literature review is 180. After excluding publications that did not match the search criteria, the total number of articles included in the systematic review was determined to be 68. polyhexanide is a promising solution for infected root canal irrigation. The antibacterial activity of this substance is suitable for the elimination of pathogens responsible for the appearance of apical periodontitis.

Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers

AbstractCoating medical implants with antibacterial polymers may prevent postoperative infections which are a common issue for conventional titanium implants and can even lead to implant failure. Easily applicable diblock copolymers are presented that form polymer brushes via “grafting to” mechanism on titanium and equip the modified material with antibacterial properties. The polymers carry quaternized pyridinium units to combat bacteria and phosphonic acid groups which allow the linear chains to be anchored to metal surfaces in a convenient coating process. The polymers are synthesized via reversible‐addition‐fragmentation‐chain‐transfer (RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy and SEC. Low grafting densities are a major drawback of the “grafting to” approach compared to “grafting from”. Thus, the number of phosphonic acid groups in the anchor block are varied to investigate and optimize the surface binding. Modified titanium surfaces are examined regarding their composition, wetting behavior, streaming potential, and coating stability. Evaluation of the antimicrobial properties revealed reduced bacterial adhesion and biofilm formation for certain polymers, albeit the cell biocompatibility against human gingival fibroblasts is also impaired. The presented findings show the potential of easy‐to‐apply polymer coatings and aid in designing next‐generation implant surface modifications.