Antibacterial Dressings Research Articles

Study on the Effect and Mechanism of Antibacterial Adhesive Hydrogel on Wound Healing.

Bleeding and infection can cause significant increases in mortalities. Hydrogel sealants have attracted extensive attention for their ability to control bleeding. In this study, the adjuvant treatment with antibacterial adhesive hydrogel dressings was applied to patients with deep second-degree burns/scalds. The traditional medical dressing was regarded as control adjuvant treatment. The results indicated that the total positive rate of bacteria in wound secretions and the pain during dressing change in patients who used antibacterial adhesive hydrogel dressings were significantly reduced. The number of fibroblasts and new capillaries in the granulation tissue of the wound increased, and the patient's wound healing is accelerated. The overall clinical effectiveness has been significantly improved. It is proven that the antibacterial adhesive hydrogel dressing has a significant effect on wound healing.

Continuous and controllable electro-fabrication of antimicrobial copper-alginate dressing for infected wounds treatment

The contamination of chronic wound with bacteria especially methicillin-resistant Staphylococcus aureus (MRSA) is considered as the major factor interferencing normal wound healing. There still remain great challenges in developing safe and effective wound dressings with wide-spectrum antibacterial functions. Alginate hydrogel is a common dressing for wound treatment. Copper is one of the trace elements in human body with inherent antibacterial activity. Traditional methods for preparing a structure-controlled copper-alginate antibacterial matrix are difficult however, due to the fast and uncontrolled gelation between alginate and metal ions. In this work, we report an electrodeposition method for rapid fabrication of copper cross-linked alginate antibacterial films (Cu2+-Alg) with controlled structure and copper content, which is relied on an electrical signal controlled release of copper ions from the reaction of insoluble salt Cu2(OH)2CO3 and the generated protons via water electrolysis on anode. The results prove that the physical structure and chemical composition of the electrodeposited Cu2+-Alg films can be continuously modulated by the imposed charges during electrodeposition. In vitro tests demonstrate the film has Cu2+ content-dependent bactericidal activities. Film’s cytocompatibility is well controlled by the imposed charges for Cu2+-Alg fabrication. The MRSA infected wound model in vivo also indicates that Cu2+-Alg film can effectively eliminate bacterial infection and suppress host inflammatory responses. We believe this study demonstrates a convenient and controllable strategy to fabricate alginate antibacterial dressings with potential applications for infected wound treatment. More broadly, our work reveals electrodeposition is a general and simple platform to design alginate films with versatile functions.

Local Management of Malignant and Unresectable Fungating Wounds: PEBO Assessment.

Malignant fungating wounds (MFWs) represent a major problem for public health. The most common symptoms associated with MFWs are pain, exudate, bleeding and odor. The aim of the study was to optimize the local management and dressing of MFWs. We developed a standardized 4- step approach to MFWs based on Pain, Exudate, Bleeding and Odor management in a case series of 24 patients: we call this the PEBO approach. We analyzed etiologies, localization, Quality of Life (QoL), pain and clinical signs and symptoms. We assessed the ulcers at baseline, after two weeks and after one month. In our study, most patients showed an improvement in the QoL using PEBO approach, although some experienced a deterioration in their general clinical conditions. Non-cytolesive cleansing, atraumatic dressings were applied to allow pain relief. Non-adherent dressings were combined with a secondary dressing in the case of exudate. Achieving hemostasis with dressing or medication is a priority in MFW management. Antibacterial dressings and odor absorbent dressings were used for odor absorption. Surgical debridement, adherent dressing and occlusive dressings were avoided. Dressing changes were programmed twice a week for four weeks. PEBO simplified the complex aspects of this type of ulcer, and could help physicians, nurses, and also the rest of the team, including the patients themselves and their family, in the multidisciplinary palliative care of MFWs.

Multifunctional 3D printed porous GelMA/xanthan gum based dressing with biofilm control and wound healing activity

Bacterial infections are the major challenges of wound treatment in current clinical applications. In this study, Three-dimensional (3D) antibacterial wound dressing has been fabricated via introducing N-halamine/TiO2 to gelatin methacrylate and xanthan gum. The prepared 3D printed dressings showed ideal swelling ratio and excellent water uptake efficiency. TiO2 nanoparticles were introduced by in-situ to improve the ultraviolet stability of N-halamines. The 3D printed GX2-TiO2-PSPH-Cl prepared dressings containing titanium dioxide retained 0.19% active chlorine after ultraviolet irradiation for 20 min, which was much higher than that of N-halamine dressings without the addition of TiO2. The 3D printed dressings showed good antibacterial activity, and 100% of Escherichia coli O157:H7 and Staphylococcus aureus were inactivated after 60 min of contact. Furthermore, the biofilm test indicated that the 3D antibacterial dressings were able to inhibit the formation of bacterial biofilm. The 3D printed dressings possess outstanding biocompatibility. Moreover, in vivo data demonstrated that the 3D printed dressings could significantly accelerate wound healing in a mouse model, indicating that the developed 3D printed dressings are ideal candidates for wound treatment.

Dermlin and Silver Nanoparticles Combined Antibacterial Dressing for Skin Wound Repair

As an important immune organ of the human body, skin can resist external damage. Wounds are damage to normal skin (tissue) caused by external injury factors such as external forces, surgical operations, chemical substances, etc., which seriously affect the daily life of patients. Conventional debridement and bandaging treatment of skin wounds takes a long time, so frequent dressing changes are difficult to manage. In this study, we treated patients in our hospital with Dermlin combined with nano-silver medical antibacterial dressing (nano-silver-MAD) to explore the skin wound repair effect. The results showed that the effectiveness rate of the observation (obs) group effectiveness 95.12% higher than control (con) group 82.93%. In comparison with the con group, the obs group presented a lower visual analog (VAS) pain score during wound treatment. In comparison to the con group, the obs group presented a higher vascular endothelial growth factor and epidermal growth factor levels at 1 week and 2 weeks after treatment. The total positive rate of bacteria in obs group was 9.76% lower than 26.83% in con group. It was proven that Dermlin combined with nano-silver-MAD is effectively relieves pain, promotes recovery, and reduces inflammation.

Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing.

Due to the spread of drug-resistant bacteria in hospitals, the development of antibacterial dressings has become a strategy to control wound infections caused by bacteria. Here, we reported a green strategy for in situ biomimetic syntheses of silver nanoparticles@organic frameworks/graphene oxide (Ag@MOF–GO) in sericin/chitosan/polyvinyl alcohol hydrogel. Ag@MOF–GO was synthesized in situ from the redox properties of tyrosine residues in silk sericin without additional chemicals, similar to a biomineralization process. The sericin/chitosan/Ag@MOF–GO dressing possessed a high porosity, good water retention, and a swelling ratio. The hemolysis rate of the composite was 3.9% and the cell viability rate was 131.2%, which indicated the hydrogel possessed good biocompatibility. The composite also showed excellent lasting antibacterial properties against drug-sensitive and drug-resistant pathogenic bacteria. The composite possessed excellent hemostatic activity. The coagulation effect of the composite may be related to its effect on the red blood cells and platelets, but it has nothing to do with the activation of coagulation factors. An in vitro cell migration assay confirmed and an in vivo evaluation of mice indicated that the composite could accelerate wound healing and re-epithelialization. In summary, the composite material is an ideal dressing for accelerating hemostasis, preventing bacterial infection, and promoting wound healing.

Facile One-Step Deposition of Ag Nanoparticles on SiO2 Electrospun Nanofiber Surfaces for Label-Free SERS Detection and Antibacterial Dressing

The fabrication of highly active and free-standing surface-enhanced Raman scattering (SERS) substrates in a simple and low-cost manner has been a crucial and urgent challenge in recent years. Herein, SiO2 nanofiber substrates modified with size-tunable Ag nanoparticles were prepared by the combination of electrospinning and in situ chemical reduction. The results demonstrate the presence and uniform adsorption of Ag nanoparticles on the SiO2 matrix surface. The free-standing composite nanofibrous substrates show high-performance SERS response toward 4-mercaptophenol and 4-mercaptobenzoic acid, and the detection limit can be as low as 10-10 mol/L. Most importantly, the as-prepared substrate as a versatile SERS platform can realize label-free detection of bio-macromolecules of bacteria, i.e., Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the substrates also possess outstanding antibacterial activities against S. aureus and E. coli. Briefly, the significance of this study is that size-tunable Ag nanoparticles can be decorated on SiO2 nanofiber surfaces with triethanolamine as a bridging and reducing agent through a one-pot reaction, and the as-prepared nanofibrous membranes are expected to act as a candidate for label-free SERS detection as well as antibacterial dressing.

Effect of enhanced recovery after surgery management combined with nano-antibacterial dressing during perioperative nursing practice on rehabilitation of patients with gynecological tumor

The nano-silver antibacterial dressing is processed and formed after being expanded and cut by medical degreased gauze and nano-silver solution. The nano-silver content is 0.4%–1.0% of the dressing mass (the nano-silver content per square meter of the dressing is 0.28–0.7 g). Nano silver plays an auxiliary role in reducing wound infections. This study is the first to report the rehabilitative effect of enhanced recovery after surgery (ERAS) management combined with nano antibacterial dressing in the perioperative period of gynecological cancer. The times until first exhaust, first defecation, ambulation, and the duration of hospitalization of the ERAS group were shorter than in the regular group. The VAS scores at 6 and 12 h after operation in the ERAS group were lower than those in the regular group. The levels of self-responsibility, self-concept, self-care skills, and health knowledge in the ERAS group were higher than those in the regular group. The total incidence of complications in the ERAS group was 9.09%, which was lower than that in the regular group (23.64%). The level of satisfaction with nursing care in the ERAS group was 98.18%, which was higher than that in the regular group (83.64%). The findings confirmed that ERAS combined with nano antibacterial dressing can promote the rehabilitation of patients, relieve pain, strengthen the self-care ability of patients, reduce the occurrence of complications, and improve satisfaction with nursing care.

Antibacterial and Biocompatible Hydrogel Dressing Based on Gelatin- and Castor-Oil-Derived Biocidal Agent.

Favored antibacterial activity associated with excellent biocompatibility, mechanical durability, and exudate handling needs to be addressed by modern dressing to achieve the desired wound healing. This paper deals with developing a new green and facile approach to manufacturing nonleachable antibacterial gelatin-based films for wound dressing. Therefore, a reactive methoxy-silane-functionalized quaternary ammonium compound bearing a fatty amide residue originating from castor oil (Si-CAQ) was initially synthesized. The antibacterial dressings were then fabricated via sol-gel and condensation reactions of the mixture containing gelatin, Si-CAQ, (3-glycidyloxypropyl) trimethoxysilane, and poly(vinyl alcohol). By utilizing bioactive polymers as starting materials and eliminating organic solvents during the dressing preparation, desirable clinical safety could be ensured. The gelatin-based films presented appropriate mechanical properties, such as flexibility and strength, in both dried and hydrated states (tensile strength >6 MPa and elongation >100). It is due to the in situ generations of the inorganic silicon domain in the organic framework via the sol-gel cross-linking process. The prepared dressings exhibited desirable features, including excellent biocompatibility (cell viability >95%), proper wound-exudate-managing characteristics (equilibrium water contact (EWA) 280-350% and water vapor transmission rate (WVTR) 2040-2200 g/m2/day), fluid handling capacity (FHC) (3-3.35 g), as well as commendable hemocompatibility. The promising bactericidal activity of the dressing against Bacillus subtilis, methicillin-resistant Staphylococcus aureus, and Escherichia coli strains with a contact-killing efficacy of 100% could prevent infection development at the wounded area. As evaluated by the wound scratch assay, the desired fibroblast cell growth, migration, and proliferation indicated the capability of the dressing to facilitate the healing process by encouraging fibroblast cell migration to the damaged area. In vivo wound-healing results showed that the prepared biocidal dressing stimulates wound healing and enhances epithelialization, collagen maturation, and vascularization of wounds due to their antibacterial effects and accelerated cellular functions.

Enhanced wound repair ability of arginine-chitosan nanocomposite membrane through the antimicrobial peptides-loaded polydopamine-modified graphene oxide

Skin wound healing is a complicated and lengthy process, which is influenced by multiple factors and need a suitable cellular micro-environment. For skin wound, wound dressings remain a cornerstone of dermatologic therapy at present. The dressing material can create an effective protective environment for the wound, and the interactions between the dressing and the wound has a great impact on the wound healing efficiency. An ideal wound dressing materials should have good biocompatibility, moisturizing property, antibacterial property and mechanical strength, and can effectively prevent wound infection and promote wound healing. In this study, in order to design wound dressing materials endowed with excellent antibacterial and tissue repair properties, we attempted to load antimicrobial peptides onto dopmine-modified graphene oxide (PDA@GO) using lysozyme (ly) as a model drug. Then, functionalized GO was used to the surface modification of arginine-modified chitosan (CS-Arg) membrane. To evaluate the potential of the prepared nanocomposite membrane in wound dressing application, the surface morphology, hydrophilic, mechanical properties, antimicrobial activity, and cytocompatibility of the resulting nanocomposite membrane were analyzed. The results revealed that prepared nanocomposite membrane exhibited excellent hydrophilic, mechanical strength and antimicrobial activity, which can effectively promote cell growth and adhesion. In particular, using PDA@GO as drug carrier can effectively maintain the activity of antimicrobial peptides, and can maximize the antibacterial properties of the nanocomposite membrane. Finally, we used rat full-thickness wound models to observe wound healing, and the surface interactions between the prepared nanocomposite membrane and the wound. The results indicated that nanocomposite membrane can obviously accelerated wound closure, and the wounds showed reduced inflammation, improved angiogenesis and accelerated re-epithelialization. Therefore, incorporation of antimicrobial peptides-functionalize graphene oxide (ly-PDA@GO) into CS-Arg membrane was a viable strategy for fabricating excellent wound dressing. Together, this study not only prepared a wound dressing with excellent tissue repair ability, but also provided a novel idea for the development of graphene oxide-based antibacterial dressing.

Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and Quercetin as antibacterial dressings

Burn injury has posed devastating burdens on the public health due to its inevitable damage to the skin structure resulting in the increased risk of infection. Therefore, it is highly demanding to develop efficacious antibacterial wound-healing dressing. Despite the favourable wound-healing activities, the curative efficacy of phytochemical compounds of quercetin (Qe) and its derivatives is limited by their poor water solubility. Here, we have fabricated a novel electrospun nanofiber membrane (ENM) consisting of polycaprolactone (PCL), chitosan oligosaccharides (COS), and Qe/Rutin (Ru) as the potential bioactive dressing for wound healing. The incorporation of chitosan oligosaccharides (COSs) in the PCL scaffold at the optimized molar ratio not only contributed to the improved hydrophilicity and water absorption performance of the ENM but effectively increased the specific surface area of the formed nanofibers. In particular, the antioxidant and antibacterial activities of the Qe/rutin-loaded nanofiber membranes were tested, which revealed that the PCL-COS-Qe membrane exhibited superior performance among all nanofiber membranes. Therefore, the developed PCL-COS-Qe/Ru nanofiber membranes hold enormous potential as healthcare products, such as wound dressings for burn injuries.

High Antibacterial Effect of Impregnated Nanofiber Mats with a Green Nanogel Against Major Human Pathogens

Opportunistic environmental pathogens, particularly bacteria, could enter the body through injured skin; therefore, developing green dressing with growth inhibitory effects on bacteria is crucial. In this study, the essential oil of Zataria multiflora was used as a natural antibacterial agent, and its nanoemulsion-based nanogel was prepared to maximize potency and stability. The essential oil was first formulated into nanoemulsion with a 74.9 ± 5-nm droplet size and droplet size distribution (SPAN) of 0.966 ± 0.01. By adding carbomer 940 (1.5% w/v) to the nanoemulsion, a nanogel was prepared. This nanogel was then impregnated on the chitosan-polycaprolactone’s electrospun nanofibers to facilitate its topical application. The prepared prototype’s antibacterial effect (named NGelNFs) was investigated using the textures standard method (ATCC100). Interestingly, the NGelNFs fully (~ 100%) inhibited the growth of four important human pathogens, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia. Green constituents, complete inhibition effect on bacterial growth, and the straightforward and repeatable preparation method are the main strengths of this designed drug system. Therefore, the prepared prototype, NGelNFs, could be used as a natural and potent antibacterial dressing.

Injectable and Degradable PEG Hydrogel with Antibacterial Performance for Promoting Wound Healing.

Injectable and degradable PEG hydrogel was prepared via Michael-type addition between cross-linking monomer 4-arm-PEG-MAL and two cross-linkers of hydrolysis degradable PEG-diester-dithiol and non-degradable PEG-dithiol, and it had a porous structure with the uniform pore size. The biocompatibility assays in vitro indicated that PEG hydrogel had excellent biocompatibility and can be degraded naturally without leading to any negative impact on cells. The results of antibacterial experiments showed that PEG hydrogel can inhibit the growth of bacteria. Furthermore, the Cell Counting Kit-8 (CCK-8) assay, LIVE/DEAD cell staining, and scratch healing experiments proved that PEG hydrogel can promote cell proliferation and migration, which had been further confirmed in in vivo experiments on the rat wound models. All experimental results demonstrated that PEG hydrogel is an injectable antibacterial dressing, which can promote the process of wound healing and has great potential in the field of wound healing.

Sprayable antibacterial Persian gum-silver nanoparticle dressing for wound healing acceleration

Wound infection is considered a significant challenge in skin injuries. Sprayable antibacterial wound dressings are interesting alternatives to their traditional counterparts because of their facile preparation, ease-of-use, and the possibility of topical delivery of antibacterial materials. Herein, novel sprayable antibacterial dressings are formulated and reported. The dressings were developed by in-situ formation of Ag-nanoparticles (Ag-NPs) using Persian gum (PG) as a carbohydrate polymer. Several tests were conducted to investigate the effect of polymer concentration on the sprayablity, biocompatibility, and antibacterial activity of the dressings (PG/Ag-NPs). Results showed that formulations up to 2 wt.% PG/Ag-NPs could be sprayed properly and form intact films. Antibacterial evaluations also showed biocidal activity of 1% PG/Ag-NPs against Pseudomonas aeruginosa and Staphylococcus aureus. Cytotoxicity and in vivo full-thickness wound healing evaluation confirmed that 1% PG/Ag-NPs spray was safe and improved wound healing process. All the results confirmed the high potential of formulated sprayable dressings for wound repair.

Research on the Treatment of Diabetic Foot with Ulcer Based on Nano-Silver Antibacterial Dressing.

The incidence of diabetes has been increasing year by year. Long-term growth in blood sugar causes complications such as diabetic foot ulcer and infections, which will increase the difficulty of ulcer treatment. The diabetes brings great pain and heavy economic burden to patients and their families. In view of the above problems, a nano-silver antibacterial dressing is synthesized in this paper to control bacterial infection on the ulcer surface and promote wound healing. This paper describes the preparation process and morphological characterization of nano-silver antibacterial dressings. 100 patients were selected, which divided into two groups for comparative experiments. The conventional group used conventional vaseline dressing, and the control group was nano-silver antibacterial dressing. The ulcer surface healing time, the number of dressing changes, and the control of infection were analyzed separately, and statistical analysis was performed with SPSS19.0. The experimental results are as follows. The use of nano-silver antibacterial dressing can significantly reduce the incidence of infection in diabetic foot patients, which is helpful to reduce the number of dressing changes, shorten the healing time of ulcer, and accelerate the turnover rate. It helps to shorten the course of diabetic foot, and it is recommended to promote its clinical application.

A moisture balanced antibacterial dressing loaded with lysozyme possesses antibacterial activity and promotes wound healing.

Wound moisture management is very important in wound healing. Previous wound management has included dry healing and moist healing, and the theory of wound moisture balance is currently generally accepted. However, current studies have not reported which humidity is suitable for wound healing and how to appropriately use antibacterial compounds when the humidity is suitable. Our study explored the moisture balance of polyurethane foam dressings through a moisture balance test and constructed a safe and effective moisture balanced antibacterial dressing by loading lysozyme onto a polyurethane foam dressing. Wound healing experiments showed that the wound healing speed was the fastest when the humidity was 25%. In vivo and in vitro antibacterial experiments showed the superior antibacterial performance of the dressing after lysozyme loading. We loaded lysozyme on moisture balanced polyurethane dressings by means of dopamine adsorption, and the modified dressings were named PU/DA-LYS (polyurethane/dopamine-lysozyme). Experiments on wound healing in infected mice indicated that PU/DA-LYS helps fight infection while promoting wound healing. Cytotoxicity experiments and in vivo biological safety experiments indicated that PU/DA-LYS was safe for use. Our study found that the lysozyme loaded polyurethane dressing can provide appropriate wound moisture and prevent bacterial infection, which is a future developmental direction for wound dressings.

Advancements and future directions in the antibacterial wound dressings - A review.

Wound repair is a complex process that has not been entirely understood. It can conclude in several irregularities. Hence, designing an appropriate wound dressing that can accelerate the healing period is critical. Infections, a major obstacle to wound repair, cause an elevated inflammatory responses and result in ultimate outcome of incomplete and prolonged wound repair. To overcome these shortcomings, there is a growing requirement for antibacterial wound dressings. Dressings with antibacterial activities and multifunctional behaviors are highly anticipated to avoid the wound infection for successful healing. The aim of this review is not only to concentrate on the importance of antibacterial dressings for wound healing applications but also to discuss recent studies and some future perspectives about antibacterial wound dressings.

An antimicrobial peptide-immobilized nanofiber mat with superior performances than the commercial silver-containing dressing

Silver-containing dressings are widely used for the treatment of infected wounds in clinics, but the potential risks of heavy metals are still a common concern. In this study, we prepared a type of electrospun starch nanofiber mat containing the antimicrobial peptide ε-poly-lysine (Starch-EPL) and compared its relevant properties with a representative silver-containing dressing 3M™ Tegaderm™ Alginate Ag (Alginate-Ag). SEM, FTIR and EDAX results show the two samples have similar fiber structures and are loaded with antibacterial agents. The comparison results indicate that the Starch-EPL nanofiber mat has equivalent permeability and absorbency with Alginate-Ag but higher mechanical property and wettability. Moreover, the Starch-EPL nanofiber mat has comparable antibacterial activity against both Gram-negative and Gram-positive bacteria with Alginate-Ag, but markedly better biocompatibility than that. The Starch-EPL nanofiber mat can inhibit the growth of bacteria for at least 14 days by sustainably releasing EPL, showing great potential as a long-term antibacterial dressing. All these results demonstrate that the Starch-EPL nanofiber mat may be a good candidate to replace the traditional silver-containing dressings.

Preparation, Characterization, and Cytotoxicity Evaluation of Zinc Oxide–Bacterial Cellulose–Chitosan Hydrogels for Antibacterial Dressing

AbstractIn this work, a kind of novel antibacterial and biocompatible composite hydrogels composed of zinc oxide, bacterial cellulose (BC), and chitosan (CS) are prepared via immersing the oxidized BC hydrogels in CS solution and then combining zinc oxide in alkaline environment. The structure and properties of the composite hydrogels are characterized by different techniques. The results of Fourier transform infrared spectroscopy and X‐ray diffraction prove the successful preparation of composite hydrogels. Scanning electron microscopy is used to study the microscopic morphology of hydrogels. The results show that the zinc oxide particles are successfully attached to the bacterial cellulose. From the results of thermogravimetric analysis, it can be seen that the hydrogels exhibit well thermal stability. For 0.03m zinc oxide @bacterial cellulose‐chitosan (ZnO@BCCS) hydrogels, the compressive stress is as high as 440 kPa at a deformation of 60%, which is 15 times that of BC hydrogels. Its maximum tensile stress is 880 kPa. The maximum inhibition rates of 0.05mZnO@BCCS hydrogels against Escherichia coli and Staphylococcus aureus are 78.9% and 77.6%, respectively. The cytotoxicity evaluation results show that the hydrogels have low cytotoxicity and good cell compatibility.

Influence of silver ion dressing on central venous catheter-related infection in severe burn patients

Objective: To investigate the influence of silver ion dressing on related infections induced by inserted central venous catheter through wounds in patients with severe burn. Methods: From June 2017 to December 2018, 90 severe burn patients who were admitted to the First Hospital of Hebei Medical University and met the inclusion criteria were included in this prospectively randomized control study. According to the random number table, they were divided into silver ion dressing group (30 patients, 20 males and 10 females, aged (37.2±3.4) years), sterile dressing group (30 patients, 18 males and 12 females, aged (35.2±4.1) years), and Anerdian dressing group (30 patients, 17 males and 13 females, aged (36.3±2.6) years). After admission, the patients in three groups were treated with a 16 G single-lumen central venous catheter inserted into the subclavian vein of burn wounds, with the depth of 19 cm. The puncture points of the patients in silver ion dressing group, sterile dressing group, and Anerdian dressing group were covered with silver ion medical antibacterial dressing, sterile dressing, and sterile gauze dressing infiltrated with Anerdian skin and mucous membrane washing and disinfecting solution, respectively. The patients in three groups underwent catheter maintenance and dressing change every 12 hours. The thousand-day infection rates of catheter outlet infection and catheter-related bloodstream infection (CRBSI), catheter indwelling days, and pathogen detection of the patients in three groups were counted. Data were statistically analyzed with chi-square test, one-way analysis of variance, least significant difference test, Fisher's exact probability test, and Bonferroni correction. Results: (1) The thousand-day infection rates of catheter outlet infection of patients in sterile dressing group and Anerdian dressing group were 22.29‰ (7/314) and 20.83‰ (7/336), respectively, which were similar (P>0.05), and both were significantly higher than 1.54‰ (1/651) in silver ion dressing group (P<0.01). The thousand-day infection rates of CRBSI of patients in sterile dressing group and Anerdian dressing group were 25.48‰ (8/314) and 20.83‰ (7/336), respectively, which were similar (P>0.05), and both were significantly higher than 1.54‰ (1/651) in silver ion dressing group (P<0.01). The catheter indwelling days of patients in sterile dressing group and Anerdian dressing group were similar (P>0.05), and both were significantly shorter than the days in silver ion dressing group (P<0.01). (2) A total of 16 cases of CRBSI occurred in all the patients in 3 groups. A total of 16 pathogenic bacteria were isolated from catheter tip attachment microbial culture and blood microbial culture. The detections rates of pathogenic bacteria of patients in sterile dressing group and Anerdian dressing group were significantly higher than the rate in silver ion dressing group (P<0.05). Conclusions: For severe burn patients, the use of silver ion dressings in the maintenance of central venous catheters inserted through wounds can effectively reduce the rate of central venous catheter-related infections and extend the catheter indwelling days.