Anti-inflammatory Activity Of Compounds Research Articles

Chemical Constituents from the Leaves of Magnolia Denudata

20 compounds were isolated from the leaves of Magnolia denudata including 16 lignans, which belong to 6 structural types. Except for (7R, 8S, 1′S) -δ8′ - 1′, 4′ - dihydro - 5′- methoxy - 3, 4 -methylenedioxy - 4′ - oxo -7.O.2′, 8.1′ - neolignan (6), magliflonenone (9), 2,5′ - diene-2′, 8′- epoxy - 5′ - methoxy - 8 - methyl - 4′ - oxo - 3,4-methylenedioxy - spiro (5,5) - undecane (10), veraguensin (16) and β-sitosterol (20), the other 15 compounds were obtained from this species for the first time. The absolute configurations of 3 compounds (1,4,10) were determined by CD spectroscopy for the first time. The anti-inflammatory activities of compounds 1, 2 and 16 were assessed and 2 was shown to have significant inhibition effect on mice hind-paw edema induced by carrageenan.

Anti-inflammatory activity of compound D {(E)-4-(3′,4′-dimethoxyphenyl)but-3-en-2-ol} isolated from Zingiber cassumunar Roxb

Compound D, (E)-4-(3',4'-dimethoxyphenyl)but-3-en-2-ol, is one of many compounds found in the hexane extract of Zingiber cassumunar Roxb. The anti-inflammatory activity of compound D was assessed using various inflammatory models in comparison with aspirin, indomethacin and prednisolone. The results obtained showed that the anti-inflammatory effect of compound D mediated prominently on the acute phase of inflammation. It exerted marked inhibition on carrageenin-induced rat paw edema as well as on the exudate formation, leukocyte accumulation and prostaglandin biosynthesis in carrageenin-induced rat pleurisy. Compound D possessed only slight inhibition on both primary and secondary lesions of adjuvant-induced arthritis and had no effect on cotton pellet-induced granuloma. Compound D elicited analgesic activity when tested on acetic acid-induced writhing response in mice but had weak inhibitory activity on tail flick responding to radiant heat. Compound D possessed marked antipyretic effect when tested on yeast-induced hyperthermia in rats.

Anti-Inflammatory Activity of Compounds Isolated fromZingiber cassumunar

Anti-Inflammatory Activity of Compounds Isolated from<i>Zingiber cassumunar</i>