Chemical Constituents from the Leaves of Magnolia Denudata

Abstract

20 compounds were isolated from the leaves of Magnolia denudata including 16 lignans, which belong to 6 structural types. Except for (7R, 8S, 1′S) -δ8′ - 1′, 4′ - dihydro - 5′- methoxy - 3, 4 -methylenedioxy - 4′ - oxo -7.O.2′, 8.1′ - neolignan (6), magliflonenone (9), 2,5′ - diene-2′, 8′- epoxy - 5′ - methoxy - 8 - methyl - 4′ - oxo - 3,4-methylenedioxy - spiro (5,5) - undecane (10), veraguensin (16) and β-sitosterol (20), the other 15 compounds were obtained from this species for the first time. The absolute configurations of 3 compounds (1,4,10) were determined by CD spectroscopy for the first time. The anti-inflammatory activities of compounds 1, 2 and 16 were assessed and 2 was shown to have significant inhibition effect on mice hind-paw edema induced by carrageenan.