Solamide is a complex compound of glypyl (a biologically active substance isolated from silkworm cocoon processing wastes) and zinc chloride. The results of pharmacological investigations showed that solamide exhibits stable hypoglycemic activity upon peroral administration. Creating highly effective medicinal forms requires the entire complex of mutually related variable factors to be thoroughly studied, including biopharmaceutical testing [1]. In order to solve numerous technological problems encountered in the creation of 0.20 g solamide tablets, we used an approach based on the methods of mathematical planning, including the Latin plans [2]. Using these plans, it is possible to considerably reduce the experimental error and qualitatively estimate the influence of various factors on the optimization parameters [3, 4]. In the first stage of investigation, we studied the main physicochemical and technological characteristics of the parent substance of solamide obtained by different methods, using either lyophilization or drying in a thermal box [5]. It was established that the drying method does not significantly influence the shape of particles of the parent substance of solamide (belonging to the anisometric group, possessing elongated rodlike or platelike form) but affect the technological properties of this substance. The product obtained by drying in a thermal box is characterized by a powder density of 646 kgm 3 , a friability of 1.48 10 –3 kgsec, and a void factor of 2.32; the analogous values for the lyophilized product are 176 kgm 3 , 0.29 10 –3 kgsec, and 7.43, respectively. With respect to the forming ability, both products belong to readily compacted and molded substances. Based on these data, it was recommended to develop a solamide tablet technology based on the wet granulation method. Among technological factors influencing the quality of tablets, we studied the type of binder (factor A(a 1 ,a 2 ,a 3 )), antifriction additives (factor B(b 1 ,b 2 ,b 3 )), and the method of drying (factor C(c 1 ,c 2 )). The intervals of variation of these