Schiff bases are the nitrogen analogs of ketones or aldehydes, with the carbonyl functional group replaced by an imine or azomethine group. They are formed by the condensation reaction of a primary amine and a carbonyl group, and they are widely employed in industry and have a variety of biological activities. Four Schiff base derivatives were successfully synthesized from benzaldehyde (PC1), anisaldehyde (PC2), 4-nitrobenzaldehyde (PC 2), and cinnamaldehyde (PC4) and tested for their antibacterial capabilities were evaluated against bacteria and fungi. The Schiff base had a high percentage yield of 98.28% (PC1), 95.7% (PC2), 91.6% (PC3), and 98% (PC4), with melting points ranging from 178 -187°C, 183-191°C, 160-164°C, and 195-205°C respectively. All Schiff bases showed activity against Escherichia coli with a Minimum Inhibitory Concentration (MIC) of 62.5ug/ml (PC1, PC4) and 250ug/ml (PC2, PC3). The Minimum Bactericidal Concentrations (MBC) were 125ug/ml, 500ug/ml, and 250ug/ml for PC1, PC2 and PC4 respectively. PC3 showed no bactericidal activity against Escherichia coli. Schiff bases PC1, PC2, and PC3 showed activity against Staphylococcus aureus with MIC of 62.5ug/ml. The MBC obtained was 125ug/ml for PC1 and PC2, while 125ug/ml, and 250ug/ml for PC3. PC4 showed no bacteriostatic and bactericidal activity against Staphylococcus aureus. Schiff bases showed fungistatic activity against Candida albican with MIC of 250ug/ml, 62.5ug/ml, and 125ug/ml for PC1, PC2/PC3, and PC4 respectively. However, none showed fungicidal activity.