Anthropometric Parameters Of Obesity Research Articles

Association of FoxP3<sup>+</sup> T regulatory lymphocytes with epicardial adipose tissue thickness in patients with coronary heart disease

Background. Increase ofthe epicardial adipose tissue (EAT) thickness isassociated with development of inflammation and cardiovascular complications, however, there is no data on the relationship between EAT thickening and the number of immunosuppressive regulatory T lymphocytes.The aim. To study the number of circulating T regulatory lymphocytes and nuclear translocation ofthe FoxP3 transcription factor in patients with stable coronary heart disease (CHD) depending on the epicardial adipose tissue thickness.Materials and methods. We examined 30 patients with chronic stable CHD. The EAT thickness was measured by echocardiography. Patients were divided into groups depending on the presence and absence of EAT thickening above 5 mm (groups 1 and 2, respectively). Imaging flow cytometry was used to determine the number of T regulatory lymphocytes and the level of FoxP3 nuclear translocation. The concentration of cytokines and high sensitivity C-reactive protein (hsCRP) was determined using enzyme-linked immunosorbent assay in blood serum.Results. Anthropometric indicators of obesity and the severity of atherosclerosis were comparable between groups. In group 2, there was an increase in low-density lipoprotein cholesterol concentration (p = 0.043), ratio of low-density lipoprotein cholesterol tohigh-density lipoprotein cholesterol (p = 0.017) and the concentration ofhsCRP (p = 0.044) andIL-1β (p = 0.005), adecrease in the number and relative count of Tregulatory lymphocytes (p = 0.020 andp = 0.026, respectively), aswellas thenumber of cells withFoxP3 nuclear translocation (p = 0.018) compared togroup1. According tomultiple logistic regression, the concentration ofhsCRP, IL-1β and T regulatory lymphocytes relative count in total were the predictors of EAT thickening (accuracy 80 %; sensitivity 75 %; specificity 84,6 %; AUC = 0.89).Conclusions. Thickening of epicardial adipose tissue inpatients withcoronary heart disease is associated with a decrease in the number of T regulatory lymphocytes andFoxP3 nuclear translocation inthem in presence of comparable anthropometric parameters of obesity and the severity of coronary atherosclerosis.

A cross-sectional study of association between peak expiratory flow rate and anthropometric obesity parameters in young Indian adult males

Background: Obesity increases the risk of and modifies the severity of various pulmonary illnesses. There is a variation in the published literature regarding the association between peak expiratory flow rate (PEFR) and anthropometric obesity parameters, particularly in young adult males. Aim and Objectives: The aim and objectives of the study are to determine the impact of general obesity and abdominal obesity markers on PEFR in young adult males with and without obesity. Materials and Methods: A cross-sectional observational study was conducted on 140 healthy young Indian adult males in the age group of 18–25 years. Participants were divided into two groups: The study group (n = 70; BMI ≥ 25 kg/m2) and the control group (n = 70; BMI: 18.5–22.9 kg/m2), based on the Asia–Pacific body mass index (BMI) classification. Weight and BMI were considered measures of general (overall or relative) obesity. For abdominal (central) obesity, hip circumference (HC), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were calculated. PEFR was recorded with the Mini-Wright’s peak flow meter, and the best of three readings was considered. Statistical analysis was done with the Mann–Whitney U-test and Kendall’s tau correlation coefficient; P < 0.05 was considered statistically significant. Results: The PEFR value did not show any significant difference between the study groups, while a significant negative correlation was observed in the study (obese) group between BMI and PEFR. Conclusion: BMI can be a better obesity marker to evaluate pulmonary disorders with PEFR and should be included in prediction equations for PEFR in young Indian adult males.

Metabolic syndrome, HOMA-IR and adiponectin in obese adolescents

Background: Homeostasis model assessment (HOMA) is a method used to measure insulin resistance (IR). Adiponectin is involved in the development of atherosclerosis. Objectives: This study aimed to assess metabolic syndrome (MetS) prevalence in adolescents with obesity; correlate HOMA-IR and IR incidence with MetS biochemical parameters and MetS components; as well as correlate adiponectin levels and hypoadiponectinemia incidence with MetS biochemical parameters and MetS components. Methods: This study was conducted at the Outpatient Installation Unit of Nutrition and Metabolic Diseases, Child Health Department, Dr. Soetomo General District Hospital, Surabaya, Indonesia with a cross-sectional study design. It lasted for nine months and focused on obese adolescents aged 13-18 years. Anthropometric measurements and blood biochemistry analyses were done. HOMA-IR was calculated using the formula [glucose (mg/dL) x Insulin (µu/L)]/405. Results: A total of 216 obese adolescents took part in the study. MetS was found in 81 subjects (37.96%). There was weak correlation between HOMA-IR ​​with anthropometric measurements, lipid profiles, fasting blood glucose, and serum adiponectin levels (p<0.05). IR was found to increase the risk of MetS development by 1.661-times, dyslipidemia by 1.845-times, and abdominal obesity by 3.077-times. IR increased the risk of MetS incidence with more than three IDF criteria by 9.368-times. There was a correlation between adiponectin levels with the HDL-c. Hypoadiponectinemia was correlated with the incidence of MetS, abdominal obesity, and hypertriglyceridemia. It also increased the risk of developing MetS by 2.220-times. There was a positive relationship between IR HOMA value ​​and the anthropometric parameters of obesity and MetS parameters. Conclusions: IR was found to be associated with dyslipidemia, abdominal obesity, and MetS incidence with more than three IDF criteria. There was a relationship between hypoadiponectinemia and waist circumference, hip circumference, HDL-c, and triglycerides. Insulin resistance and hypoadiponectinemia were associated with Mets and hypertriglyceridemia incidence.

A Cross-Sectional Study to Assess the Prevalence of Obesity among Second Professional MBBS Students of One of the Medical Colleges of Indore, Madhya Pradesh

Introduction: Obesity is a complex multifactorial preventable disease. The problem of obesity is important to discuss because it is closely associated with an increasing risk to many diseases. Objective: To assess the prevalence of obesity among Second MBBS students and find the anthropometric parameters of obesity. Method: This was a cross-sectional, observational study conducted among 100 second MBBS students. Demographic data and anthropometric measures, such as Height, Weight, Body mass index, Waist circumference, and Waist/Hip ratio of the students were collected. Results: BMI was < 18.5 in 17.34% of male and 28% of female students. Around 18.67% of male and 24% of female students had BMI of more than 25 and where as student shaving BMI of more than 30 were 6.66% and 4% in male and female students, respectively. According to the Waist/Hip ratio,16% male (>0.95) and16% female (>0.86) students were categorized as at risk for obesity (p-value 0.86). Conclusion: Almost half of the male and female students were having normal BMI. More number of female students had BMI lower than normal. Students falling in the category of overweight were higher as compared to obese students. Such students were advised for nonpharmacological measures of weight reduction through proper exercise, consuming a healthy balanced diet, and role of physical activity, so as to maintain proper bodyweight and to prevent future complications of obesity were advised to the students.

CORRELATIVE STUDY OF FIBRINOGEN LEVEL,BMI AND LIPID PROFILE IN TYPE 2 DIABETES MELLITUS WITH HYPERTENSION

Background: Diabetic hypertensives are at greater risk for cardiovascular morbidity & mortality than general population. Though certain risk factors like age, BMI, hypertension, smoking, dyslipidemia, etc have been studied extensively, but still these together cannot explain increased cardiovascular morbidity and mortality in diabetes. There are several studies showing that brinogen is a powerful independent risk factor for cardiovascular disease. This study was done to estimate brinogen levels in diabetics and to study its relation to BMI and lipid parameters.Aim Of The Study: To estimate plasma brinogen levels in patients with type 2 diabetes mellitus and hypertension. To correlate plasma brinogen with BMI and lipid prole parameters. Materials And Methods: This study was a case control study done in 70 patients between November 2020 – October 2021 at Alluri Sitarama Raju Academy of Medical Sciences, Eluru ,Andhra Pradesh. For all the subjects anthropometric parameters of obesity were measured as per WHO recommendations. All patients were subjected to investigations fasting serum lipid prole, venous plasma glucose and plasma brinogen levels. All the results were tabulated and comparison of various parameters were performed by t test. Correlation between two variables was done by pearson's correlation coefcient. Results: In diabetic hypertensives higher brinogen levels were found (449.06±131.26). There was a signicantly positive correlation between plasma brinogen and BMI(P<0.05). There was a signicantly positive correlation between BMI and total cholesterol levels.(p<0.05) Conclusion: Diabetic hypertensives have higher brinogen levels, which was related to BMI and total cholesterol levels in a statistically signicant manner

Anthropometric parameters of obesity can be alternative biomarkers for the potential cardiac dysfunction in obese children.

Childhood obesity, as one of the potential risk factors of cardiovascular diseases, is closely associated with the incidence of cardiovascular disease at a younger age and has become a public health concern worldwide. However, its potential effects on the cardiovascular system have still remained elusive. In this study, we systematically evaluated the cardiovascular characteristics of 79 obese children and 161 normal weight children in Guangzhou (China) using the potential biomarkers for cardiovascular disease. Compared with normal weight children, obese children not only exhibited significantly higher levels of creatine kinase (CK), lactate dehydrogenase (LHD), soluble fms-like tyrosine kinase-1 (s-Flt-1), high-sensitivity C-reactive protein (hs-CRP), and uric acid (UA) (p = 0.0062, 0.0012, 0.0013, 0.0225, and <0.0001, respectively) but also significantly higher diastolic blood pressure (p = 0.0074) and the heart rate (p = 0.0049) were found in obese children. Of 79 obese children, cardiac functions of 40 cases were further assessed by color Doppler echocardiography. The results showed that there were significant differences between the obesity group and the healthy weight group in terms of interventricular septal wall thickness at end-diastolic (IVSd), the left ventricular posterior wall thickness at end-diastolic (LVPWD), and aortic annulus (AO) (p < 0.0001, 0.0003, and p < 0.0001, respectively). Besides, the left and/or right ventricular functions were declined in 52.4% of obese children. Correlation analysis revealed that the anthropometric parameters of obesity were not only significantly correlated with a blood lipid profile but also exhibited a more significant correlation with most of the parameters of cardiac dysfunction than a blood lipid profile. Therefore, our study indicated that obese children in Guangzhou suffered from functional damages related to cardiovascular events, which were characterized by cardiac dysfunction, and the anthropometric parameters of obesity could be economically alternative biomarkers for monitoring of cardiac dysfunction in obese children.

Consortium of Indigenous Fecal Bacteria in the Treatment of Metabolic Syndrome.

The features of gut microbiota in metabolic syndrome (MS) and ways to correct it using autoprobiotics, based on indigenous bacteria obtained from fecal samples of the host, remain unexplored. The aim of the study was to investigate the effectiveness of an indigenous consortium (IC) of fecal bacteria in treatment of patients with MS. The study was carried out on 36 patients with MS, manifested with abdominal obesity, eating disorders, dyslipidemia, and hypertension. The control group was formed by 20 healthy volunteers. Samples of IC and gut microbiota content were examined by qPCR and metagenome (16S rRNA) analysis before and after therapy. The decrease in anthropometric parameters of obesity, liver enzyme level correction, reduction in C reactive protein and triglyceride concentrations were revealed after IC usage. The decrease in genera Bifidobacterium, Enterobacter, Paraprevotella, and Prevotella, as well as an increase in Bacteroides fragilis and Oscillospira spp. populations were shown after consumption of IC. A negative correlation between the quantity of B. fragilis and the anthropometric parameters of obesity (r = −0.48) and C reactive protein level (r = −0.36) in serum was established. Thus, IC can be considered as a potential functional personified product for the therapy of MS.

A study of the effect of yoga on C-reactive protein, lipid profile and insulin resistance in obese patients

Background: Obesity is defined as a state of excess adipose tissue mass. In the last decade, there has been an alarming prevalence of obesity in the developed and developing countries like India. While modern medicine has so far been unable to control the menace of obesity, yoga offers an alternative holistic approach to tackle the problem of obesity by inculcating an approach towards balanced diet (Satwik aahar), physical activity and behavior modification (through pranayama). In this study, we have included the core anthropometric parameters of obesity, as well as associated abnormalities secondary to obesity like, insulin resistance, glucose intolerance, hypertension, atherogenic dyslipidemia.Methods: The study was conducted in the department of medicine, L. L. R. M. Medical College and associated S. V. B. P. Hospital, Meerut, U.P. during 2020-2021 with the objective to assess the role of yoga therapy in modifying anthropometric and biochemical parameters of obese patients. It was a prospective, controlled trial in which 120 obese patients (BMI≥25 kg/m2) were enrolled and followed for a period of six months.Results: Yoga therapy along with dietary restrictions is highly effective in improving the various anthropometric and biochemical parameters in obese patients and also beneficial in controlling complications like hypertension, diabetes and dyslipidemias secondary to obesity. It also improved the quality of life of these patients.Conclusions: This study is a modest attempt to ascertain the role of yoga in obesity and it hopes to encourage further research in the field.

Correlation of Serum Alanine Aminotransferase with Anthropometric and Biochemical Obesity Indices in Healthy Males

Background: The anthropometric obesity indices in this study included; body mass index, waist circumference, waist to hip ratio, mid arm circumference and triceps skin fold thickness. Biochemical obesity indices included; serum high density lipoprotein (HDL), serum triglycerides and serum cholesterol. Aim: To find the correlation of serum alanine aminotransferase (ALT) levels with anthropometric and biochemical obesity indices in apparently healthy male subjects. Methodology: This was an observational descriptive study. Study population included 60 healthy male subjects. They were between 30-50 years of age. All subjects were apparently healthy having no history of diabetes mellitus, hypertension or intake of antihypertensive or lipid/glucose lowering agents. Study data was gathered by a structured questionnaire after written informed consent. Anthropometric measurements, blood pressure and venous blood sample was taken by the standard methods. Data interpretation was carried by SPSS-21. Results: Significant positive correlation of serum ALT was observed with waist circumference (rho=0.371; p=0.008*), mid arm circumference (rho=0.410; p=0.000*), triceps skin fold thickness (rho=0.360; p=0.011*), serum triglycerides (rho=0.493; p=0.005*) and serum HDL (rho=0.423; p=0.000*). Linear regression analysis was applied. Serum ALT was taken as the dependent variable whereas other covariates such as age , serum HDL, triglycerides, cholesterol, body mass index, waist circumference, waist to hip ratio, mid arm circumference and triceps skin triceps skin fold thickness were taken as the predictor variables. Correlation of the mid-arm circumference with serum ALT remained significant after controlling all the given co-variates (p=0.004*). Conclusion: There is significant positive correlation of serum ALT with anthropometric obesity parameters such as waist circumference, mid arm circumference and triceps skin fold thickness. Correlation of anthropometric indices with ALT can provide us with a convenient and an inexpensive tool for prediction of serum ALT levels. Keywords: Serum alanine aminotransferase, biochemical obesity, body mass index

Correlation of Serum Alanine Aminotransferase with Anthropometric &amp; Biochemical obesity indices in apparently healthy males

Background: The anthropometric obesity indices in this study included; body mass index, waist circumference, waist to hip ratio, mid arm circumference and triceps skin fold thickness. Biochemical obesity indices included; serum high density lipoprotein (HDL), serum triglycerides and serum cholesterol. Aim: To find the correlation of serum alanine aminotransferase (ALT) levels with anthropometric and biochemical obesity indices in apparently healthy male subjects. Methodology: This was an observational descriptive study. Study population included 60 healthy male subjects. They were between 30-50 years of age. All subjects were apparently healthy having no history of diabetes mellitus, hypertension or intake of antihypertensive or lipid/glucose lowering agents. Study data was gathered by a structured questionnaire after written informed consent. Anthropometric measurements, blood pressure and venous blood sample was taken by the standard methods. Data interpretation was carried by SPSS-21. Results: Significant positive correlation of serum ALT was observed with waist circumference (rho=0.371; p=0.008*), mid arm circumference (rho=0.410; p=0.000*), triceps skin fold thickness (rho=0.360; p=0.011*), serum triglycerides (rho=0.493; p=0.005*) and serum HDL (rho=0.423; p=0.000*). Linear regression analysis was applied. Serum ALT was taken as the dependent variable whereas other covariates such as age , serum HDL, triglycerides, cholesterol, body mass index, waist circumference, waist to hip ratio, mid arm circumference and triceps skin triceps skin fold thickness were taken as the predictor variables. Correlation of the mid-arm circumference with serum ALT remained significant after controlling all the given co-variates (p=0.004*). Conclusion: There is significant positive correlation of serum ALT with anthropometric obesity parameters such as waist circumference, mid arm circumference and triceps skin fold thickness. Correlation of anthropometric indices with ALT can provide us with a convenient and an inexpensive tool for prediction of serum ALT levels. Keywords: Serum alanine aminotransferase, biochemical obesity, body mass index

Гендерные и возрастные особенности связи антропометрических параметров ожирения с нарушениями липидного обмена

Гендерные и возрастные особенности связи антропометрических параметров ожирения с нарушениями липидного обмена

Effect of weight loss orientation on BMI in obese and overweight infertile patients.

The aim of this study was to evaluate the response to weight loss guidance in the anthropometric parameters of obesity and overweight infertile patients assisted fertilization treatment (high and low complexity). Retrospective cohort study. This survey was conducted in a population of overweight and obese infertile patients. In the first consultation at the assisted reproduction clinic (Human Reproduction Laboratory HC / UFG), obese and overweight patients were weighed, measured and instructed to lose weight and informed that being overweight could reduce the chances of success in the treatment. We analyzed 56 overweight and obese patients admitted for infertility treatment at the Human Reproduction Center HC/UFG. The mean age of overweight and obese patients was 35.78 years, SD 3.70. After the orientation, only 8.92% of patients would achieve the normality rating for BMI, overweight 39.28% (decreased 14.29%), obesity I 37.5%, obesity II 10.71% and obesity III 3.57% (all degrees of obesity increased 1.79%). The mean weight of patients before and after guidance was statistically significant (p<0.0046). The mean values of BMI before and after guidance were also statistically significant (p<0.0038). Weight loss guidance in this population had no effect on weight loss. On the contrary, the mean weight of patients after guidance was statistically higher than the mean in the first consultation (both weight and BMI). It is suggested that for obese and overweight infertile patients, in addition to guidance for reduction, an appointment with a nutritionist and/or endocrinologist should be immediately scheduled.

Associations between Depression, Nutritional Status and Mediterranean Diet in Dalmatian Kidney Transplant Recipients.

Depression has been addressed as a predictor of worse outcomes in kidney transplant recipients (KTRs). Nutritional status plays a great role in treatment of this population. The Mediterranean diet (MeDi) has been associated with lower levels of depressive symptoms. The aim of this cross-sectional study was to determine the rate of depression and its correlations to nutritional status and dietary habits according to the MeDi in Dalmatian KTRs. We included 115 KTRs, and data about body composition and anthropometric, laboratory and clinical parameters were obtained for each study participant. The Beck Depression Inventory-II (BDI-II) questionnaire was used to assess depressive symptoms and the Mediterranean Diet Serving Score (MDSS) was used to assess adherence to the MeDi. We found the presence of depressive symptoms in 21.73% of the Dalmatian KTRs. BDI-II score was reciprocally associated with fat mass, trunk visceral fat, anthropometric parameters of obesity, triglyceride levels and olive oil consumption. Inverse associations were found between BDI-II score and skeletal muscle mass, handgrip strength, MCV, hemoglobin levels and consumption of fish and white meat, as suggested by the MeDi. Our results showed the interconnections between nutritional status, dietary habits and depression in Dalmatian KTRs.

Assessment of the visceral adipose tissue by magnetic resonance imaging in patients with coronary artery disease: link to metabolism disorders and condition of the abdominal aorta

Abstract Aim MRI-quantification of the visceral and subcutaneous adipose tissue (AT) and investigation of its interconnections with anthropometric parameters of obesity, carbohydrate metabolism and condition of abdominal aorta in patients with chronic coronary artery disease (CAD). Methods The study included 55 patients (mean age 61.2±7.2 y.o.) with chronic CAD. All patients underwent MRI of the abdominal AT and abdominal aorta segment on a 1.5 T MRI in standard modes. Calculation of the area and volume of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) was conducted at L4-L5 level; the total volumes of abdominal SAT and VAT were calculated. Parameters of lipid and carbohydrate metabolism as well adipokines' profile were measured in blood serum. Results To eliminate gender bias the data in the total group was corrected for the sex, height and body weight. In the course of the multiple linear regression analysis, we detected the independent determinants, which described 95% of the total VAT volume variability and were represented by waist circumference and serum levels of HDL cholesterol and adiponectin. The model was characterized by the significance level p&amp;lt;0,ehab724.116501, the residues of the model were normal. The evaluation of the coefficients in the model was as following: 1,39 for waist circumference, −0.26 for HDL cholesterol and −0,19 for adiponectin. We detected direct correlation between the aorta diameter and total SAT volume (rs=0.30), which was independent from sex; and reverse correlations between the aorta diameter and HbA1c level (rs=−0.40) and postprandial glycemia (rs=−0.40). Patients with dilated aorta when compared to the patients with normal aorta diameter did not differ in the AT accumulation, but demonstrated decreased levels of HbA1c and postprandial glycaemia, which was dependent upon the lower numbers of patients with diabetes mellitus type 2. Conclusion We have identified the independent determinants of the total volume of the abdominal visceral AT increase, which appeared to be increment of the waist circumference and decrease of the serum adiponectin and HDL cholesterol. Results of the study indicate the presence of the interconnection between the processes of the abdominal aorta remodeling, accumulation of subcutaneous adipose tissue and carbohydrate metabolism impairments. Funding Acknowledgement Type of funding sources: None. MRI of the abdominal tissueMRI of the abdominal aorta

The level of reactive oxygen species production by adipocytes of epicardial adipose tissue is associated with an increase in postprandial glycemia in patients with severe coronary atherosclerosis

The mechanisms of oxidative stress in adipocytes of local fat depots in patients with cardiometabolic diseases have been studied insufficiently.Purpose. To study the levels of reactive oxygen species (ROS) production in adipocytes of epicardial (EAT) and subcutaneous adipose tissue (SAT) in patients with stable coronary artery disease (CAD) and severe coronary atherosclerosis who underwent coronary artery bypass grafting; to investigate the potential relationships between the levels of ROS production by EAT and SAT adipocytes and obesity parameters, EAT accumulation, basal and postprandial glycemia, and blood lipid transport function.Material and Methods. The study included 19 patients (12 men and 7 women including 6 patients (31.5%) with type 2 diabetes mellitus) aged 53–72 years with stable CAD and severe coronary atherosclerosis. The material for the study was EAT and SAT adipocytes obtained by the enzymatic method from intraoperative explants. The ROS level in adipocytes was determined using the fluorimetry with 2,3-dihydrodichlorofluorescein diacetate. Anthropometric parameters of obesity and EAT thickness were studied using echocardiography. The blood lipid transport function and the levels of basal and postprandial glucose were assessed.Results. The levels of ROS production by EAT and SAT adipocytes in the overall group of patients did not differ significantly and amounted to 1710 (1608; 2079) and 1876 (1374; 2215) arbitrary units, respectively. The level of ROS production by SAT adipocytes did not correlate with the parameters of obesity, EAT thickness, or biomarker levels. The level of ROS production by EAT adipocytes directly correlated with the level of postprandial glycemia (rs = 0.62, p &lt; 0.05), but did not correlate with measures of general and abdominal obesity, EAT thickness, and dyslipidemia. The level of ROS production by EAT adipocytes in patients with postprandial glycemia ≥ 7.7 mmol/L (n = 9) exceeded the corresponding value in patients with lower level of postprandial glycemia (n = 10): 2079 (1710; 2458) against 1625.5 (1332; 1699) arbitrary units (p = 0.015), respectively.Conclusion. We showed for the first time that the level of ROS production by EAT adipocytes in CAD patients with severe coronary atherosclerosis was directly associated with the level of postprandial glycemia. The highest level of ROS production in EAT adipocytes occurred in these patients when the level of postprandial glycemia exceeds 7.7 mmol/L.

Association of Hypertension with Anthropometric Parameters among Indian Male Adults

Obesity is chronic disease characterized by BMI &gt;30 and body fat percentage &gt;20%. It is often associated with non-communicable diseases including cardiovascular diseases like hypertension. While the hypertension has been associated with obesity previously, present study aims to assess association of anthropometric parameters of obesity with hypertension including central obesity indicators and body fat percentage. Total 152 subjects were included for the study, 76 of them were of hypertensive and 76 were controls. All of the participants were subjected to evaluation of obesity parameters. BMI, Waist Hip Ratio, Body Fat Percentage and Ponderal index were found to significantly associated with hypertension. While BMI, Waist Hip ratio, body fat percentage and Ponderal index has the significant association with hypertension, central obesity indicators like waist hip ratio and body fat percentage using skinfold thickness measurement also show a significant association with hypertension with higher odds compared to BMI.

Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls.

Evaluate the association between overweight/obesity with serum gonadotropin and androgen levels in Egyptian pubertal girls. A case-control study carried out in "Obesity Clinic" of "Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU)", Pediatric Hospital, Cairo University. It included 40 overweight and obese girls and 40 age-matching normal weight (control) ones, aged 12-18 years. Anthropometric assessment (weight, height and hip and waist circumferences) was done, and waist/hip and BMI were calculated. Laboratory investigations: lipid profile, serum gonadotropin (LH, FSH), androgen (free and total testosterone), estradiol, insulin, and FBG were quantified, while insulin resistance (IR) was calculated. Hypogonadotropins (FSH and LH) and hyperandrogenaemia (total and free testosterone) were significantly prominent among obese girls. Correlation between gonadotropin, androgen and all of the studied variables, for the three studied groups (obese, overweight and control) revealed constant relations. Gonadotropin and androgens showed opposing correlations. Gonadotropin had significant negativ e correlations with the anthropometric parameters of obesity (BMI, Waist C, and W/H ratio), insulin, insulin resistance and lipid profile (triglycerides, total cholesterol and LDL), whereas androgens had significant positiv e ones. In addition, gonadotropin showed significant positiv e correlations with estradiol and HDL, while androgens showed significant negative ones. Overweight/obesity had no effect on the correlations between gonadotropin and androgen on one side, with the anthropometric measurements and laboratory investigations on the other one. Alterations in androgen levels occur at earlier ages than gonadotropin, among both overweight and obese girls.

Assessment of arrhythmias and cardiac autonomic tone at a relatively young age patients with obesity class III.

There is no sufficient data on arrhythmias occurrence in obesity class III. The influence of hyperinsulinemia and insulin resistance on arrhythmias and cardiac autonomic tone is also of ongoing interest in these subjects. We prospectively studied 81 selected patients with body mass index >40 kg/m2 , aged 34 (18-65) years. Among other examinations all subjects underwent electrocardiography and Holter monitoring with heart rate variability (HRV) and turbulence (HRT) evaluation. Controls consisted of 45 healthy, sex- and aged-matched lean volunteers. In patients median BMI was 44.5 kg/m2 (40.1-58.1), benign arterial hypertension was present in 43.2% and dysglycemia in 27.2% of cases. In the group with obesity longer PR interval (P < .001) and corrected QT interval (P < .001) were observed, while in Holter monitoring no significant differences in supraventricular or ventricular arrhythmias and also bradyarrhythmias prevalence were observed in comparison to controls. In individuals with obesity HRV indices associated with sympathetic tone were significantly impaired and also abnormal HRT values (21.9 vs 0%, P = .04) were more frequently observed. There were no significant correlations between anthropometric obesity parameters and fasting insulin concentration, insulin resistance index and also HRV/HRT parameters in studied individuals. Univariate regression analysis revealed that only age influenced abnormal HRT occurrence (OR 1.69, 95%CI 1.08-2.98, P = .04). In conclusions, patients with obesity class III at a relatively young age who reported they felt healthy, do not present increased prevalence of arrhythmias, including life-threatening ones. Cardiac autonomic dysfunction is observed in these patients, however it has not been shown to be associated with anthropometric measurements.

Evaluation of the Effect of Heart Failure Reversal Therapy on Anthropometric Obesity Parameters in Patients with Chronic Heart Failure: A Retrospective Analysis.

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Potential Role of New Anthropometric Parameters in Childhood Obesity with or Without Metabolic Syndrome.

BACKGROUND:Obese children and adolescents are more prone to have metabolic syndrome (MS).MS is a cluster of cardiovascular risk factors associated with insulin resistance. Body round index [BRI], visceral adiposity index [VAI] and a body shape index [ABSI] are among the new obesity anthropometric parameters.AIM:To evaluate the new markers for obesity in children and their possible association with other laboratory and clinical variables of MS.METHODS:Eighty nine obese children and 40 controls aged 10-18 years were recruited. Full history taking, thorough clinical examination, anthropometric and biochemical features were performed in the studied groups. Subcutaneous fat thickness (SFT) and visceral fat thickness (VFT) were estimated by ultrasonography.RESULTS:Obese children, exhibited significantly higher values in all anthropometric measurements (P < 0.001). Diastolic and systolic blood pressure were significantly higher (P < 0.001) in the obese group. ABSI, BRI and VAI have been found to be significantly higher in obese subjects (P < 0.001), with no significant gender difference. BMI, WHtR, WC/HR, SBP, DBP, subcutaneous fat thickness and visceral fat thickness, Liver Span, ABSI, BRI, VAI and HOMA_IR were significantly higher among children with MS than those without MS. Positive significant correlations of VAI with BMI, WC/Ht, WC/Hip, SBP, DBP, SFT, VFT, Liver size and HOMA-IR (r = 0.384, 0.239, 0.268, 0.329, 0.516, 0.320, 0.254, 0.251, and 0.278 respectively) are shown. The area under the ROC curve (AUC) of BMI, VAI, ABSI, BRI for predicting MS was 0.802 (0.701-0.902), 0.737 (0.33-0.841), 0.737 (0.620-0.855), 0.816 (0.698-0.934).CONCLUSION:We suggest using the VAI and WHtR indexes, as they are better predictor of MS.