CORRELATIVE STUDY OF FIBRINOGEN LEVEL,BMI AND LIPID PROFILE IN TYPE 2 DIABETES MELLITUS WITH HYPERTENSION

Abstract

Background: Diabetic hypertensives are at greater risk for cardiovascular morbidity & mortality than general population. Though certain risk factors like age, BMI, hypertension, smoking, dyslipidemia, etc have been studied extensively, but still these together cannot explain increased cardiovascular morbidity and mortality in diabetes. There are several studies showing that brinogen is a powerful independent risk factor for cardiovascular disease. This study was done to estimate brinogen levels in diabetics and to study its relation to BMI and lipid parameters.Aim Of The Study: To estimate plasma brinogen levels in patients with type 2 diabetes mellitus and hypertension. To correlate plasma brinogen with BMI and lipid prole parameters. Materials And Methods: This study was a case control study done in 70 patients between November 2020 – October 2021 at Alluri Sitarama Raju Academy of Medical Sciences, Eluru ,Andhra Pradesh. For all the subjects anthropometric parameters of obesity were measured as per WHO recommendations. All patients were subjected to investigations fasting serum lipid prole, venous plasma glucose and plasma brinogen levels. All the results were tabulated and comparison of various parameters were performed by t test. Correlation between two variables was done by pearson's correlation coefcient. Results: In diabetic hypertensives higher brinogen levels were found (449.06±131.26). There was a signicantly positive correlation between plasma brinogen and BMI(P<0.05). There was a signicantly positive correlation between BMI and total cholesterol levels.(p<0.05) Conclusion: Diabetic hypertensives have higher brinogen levels, which was related to BMI and total cholesterol levels in a statistically signicant manner