Twenty-two species of the bivalve order Pholadomyida, belonging to six genera and seven subgenera of the families Pholadomyidae, Pleuromyidae and Poromyidae are described from the Cenomanian–Coniacian Cotinguiba Formation of the Sergipe Basin, north-eastern Brazil. Eleven species, Pholadomya (Ph.) cf. agrioensis Weaver, Ph. (Ph.) kasimiri Pusch, Ph. (Ph.) nodulifera Munster, Ph. (Ph.) occidentalis Morton, Ph. (Procardia) vignesi Lartet, Pleuromya ligeriensis (d’Orbigny), Pl. servesensis Choffat, Liopistha (L.) aequivalvis (Goldfuss), L. (Psilomya) elongata Stanton, L. (P.) globulosa (Forbes) and L. (Sergipemya) gigantea (J. Sowerby) are recorded from the Sergipe Basin for the fi rst time. The new subgenus Sergipemya of the genus Liopistha, family Poromyidae, is erected on the basis of morphological characters such as numerous commarginal ribs, large and highly infl ated valves, a well-developed rounded umbonal anterior ridge bordering a deep depression on the anterior part, and the presence of two unequal cardinal teeth with a cardinal tear-shaped socket in the left valve. The pholadomyid fauna of Sergipe closely resembles that of other Tethyan regions in western and southern Europe, northern and western Africa and the Middle East. The distribution patterns of the taxa were probably influenced by east–west-directed currents. Southern Tethyan pholadomyids reached western Africa and north-eastern South America via the Trans-Saharan Seaway.