Activity In Anterior Insula Research Articles

Always on my mind: Cross-brain associations of mental health symptoms during simultaneous parent-child scanning

How parents manifest symptoms of anxiety or depression may affect how children learn to modulate their own distress, thereby influencing the children's risk for developing an anxiety or mood disorder. Conversely, children’s mental health symptoms may impact parents' experiences of negative emotions. Therefore, mental health symptoms can have bidirectional effects in parent-child relationships, particularly during moments of distress or frustration (e.g., when a parent or child makes a costly mistake). The present study used simultaneous functional magnetic resonance imaging (fMRI) of parent-adolescent dyads to examine how brain activity when responding to each other's costly errors (i.e., dyadic error processing) may be associated with symptoms of anxiety and depression. While undergoing simultaneous fMRI scans, healthy dyads completed a task involving feigned errors that indicated their family member made a costly mistake. Inter-brain, random-effects multivariate modeling revealed that parents who exhibited decreased medial prefrontal cortex and posterior cingulate cortex activation when viewing their child's costly error response had children with more symptoms of depression and anxiety. Adolescents with increased anterior insula activation when viewing a costly error made by their parent had more anxious parents. These results reveal cross-brain associations between mental health symptomatology and brain activity during parent-child dyadic error processing.

Rewards Enhance Proactive and Reactive Control in Adolescence and Adulthood.

Cognitive control allows the coordination of cognitive processes to achieve goals. Control may be sustained in anticipation of goal-relevant cues (proactive control) or transient in response to the cues themselves (reactive control). Adolescents typically exhibit a more reactive pattern than adults in the absence of incentives. We investigated how reward modulates cognitive control engagement in a letter-array working memory (WM) task in 30 adolescents (12–17 years) and 20 adults (23–30 years) using a mixed block- and event-related functional magnetic resonance imaging design. After a Baseline run without rewards, participants performed a Reward run where 50% trials were monetarily rewarded. Accuracy and reaction time (RT) differences between Reward and Baseline runs indicated engagement of proactive control, which was associated with increased sustained activity in the bilateral anterior insula (AI), right dorsolateral prefrontal cortex (PFC) and right posterior parietal cortex (PPC). RT differences between Reward and No reward trials of the Reward run suggested additional reactive engagement of cognitive control, accompanied with transient activation in bilateral AI, lateral PFC, PPC, supplementary motor area, anterior cingulate cortex, putamen and caudate. Despite behavioural and neural differences during Baseline WM task performance, adolescents and adults showed similar modulations of proactive and reactive control by reward.

Interoceptive attention in opioid and stimulant use disorder.

Blunted anterior insula activation during interoceptive perturbations has been associated with stimulant (cocaine and amphetamine) use disorder (SUD) and is related to risk for and prognosis of SUD. However, little is known whether these interoceptive alterations extend to opioid use disorder (OUD). This exploratory study used the same experimental probe during functional magnetic resonance imaging (fMRI) to test the hypothesis that SUD and OUD exhibit interoceptive discrepancies characterized by subjective ratings and activation within the insula. Recently, abstinent individuals diagnosed with current SUD (n = 40) or current OUD (n = 20) were compared with healthy individuals (CTL; n = 30) on brain and self-report responses during an interoceptive attention task known to elicit insula activation. Participants selectively attended to interoceptive (heartbeat and stomach) and exteroceptive signals during blood-oxygen-level-dependent fMRI recording. Groups and conditions were compared on (a) activation within probabilistic cytoarchitectonic segmentations of the insula and (b) self-reported stimulus intensity. First, SUD showed amplified ratings of heart-related sensations but attenuation of dorsal dysgranular insula activity relative to CTL. Amplified ratings were linked to drug use recency, while attenuation was normalized with greater past-year stimulant use. Second, SUD and OUD showed attenuation of dorsal dysgranular insula activity during attention to stomach sensations relative to CTL. Taken together, these results are consistent with altered neural processing of interoceptive signals in drug addiction, particularly as a function of SUD. Future studies will need to determine whether interoceptive metrics help to explain substance use disorder pathophysiology and are useful for predicting outcomes.

Appetite change profiles in depression exhibit differential relationships between systemic inflammation and activity in reward and interoceptive neurocircuitry

Appetite change is a defining feature of major depressive disorder (MDD), yet little neuroscientific evidence exists to explain why some individuals experience increased appetite when they become depressed while others experience decreased appetite. Previous research suggests depression-related appetite changes can be indicative of underlying neural and inflammatory differences among MDD subtypes. The present study explores the relationship between systemic inflammation and brain circuitry supporting food hedonics for individuals with MDD. Sixty-four participants (31 current, unmedicated MDD and 33 healthy controls [HC]) provided blood samples for analysis of an inflammatory marker, C-reactive protein (CRP), and completed a functional magnetic resonance imaging (fMRI) scan in which they rated the perceived pleasantness of various food stimuli. Random-effects multivariate modeling was used to explore group differences in the relationship between CRP and the coupling between brain activity and inferred food pleasantness (i.e., strength of the relationship between activity and pleasantness ratings). Results revealed that for MDD with increased appetite, higher CRP in blood related to greater coupling between orbitofrontal cortex and anterior insula activity and inferred food pleasantness. Compared to HC, all MDD exhibited a stronger positive association between CRP and coupling between activity in striatum and inferred food pleasantness. These findings suggest that for individuals with MDD, systemic low-grade inflammation is associated with differences in reward and interoceptive-related neural circuitry when making hedonic inferences about food stimuli. In sum, altered immunologic states may affect appetite and inferences about food reward in individuals with MDD and provide evidence for physiological subtypes of MDD.

What Difference Does it Make? Risk-Taking Behavior in Obesity after a Loss is Associated with Decreased Ventromedial Prefrontal Cortex Activity.

Altered activity in decision-making neural circuitry may underlie the maladaptive food choices found in obesity. Here, we aimed to identify the brain regions purportedly underpinning risk-taking behavior in individuals with obesity. Twenty-three adult women with obesity and twenty-three healthy weight controls completed the Risky Gains Task during functional magnetic resonance imaging (fMRI). This task allows participants to choose between a safe option for a small, guaranteed monetary reward and risky options with larger rewards. fMRI analyses comparing losing trials to winning trials found that participants with obesity presented decreased activity in the left anterior insula in comparison to controls (p < 0.05, AlphaSim corrected). Moreover, left insula activation during losses vs. wins was negatively correlated with UPPS-P questionnaire sensation seeking scores. During safe vs. risky trials following a loss, the control group exhibited increased activation in the ventromedial prefrontal cortex (vmPFC) (p < 0.05, AlphaSim corrected) in comparison to the OB group. Moreover, vmPFC response in the obesity group during post-loss trials was negatively correlated with risky choices on the task overall. As a whole, our findings support that diminished tuning of the insula towards interoceptive signals may lead to a lack of input to the vmPFC when weighing the costs and benefits of risky choices.

Neural Correlates of Self-Construal Priming in the Ultimatum Game.

Research from cultural and social psychology has identified a central role of self-construal, or the way one views themselves in relation to others, in social cognition. Accordingly, it is plausible that self-construal plays an instrumental role in important aspects of decision-making relating to fairness considerations. Prior research has shown that priming methodology is a useful tool to experimentally isolate the effect of self-construal on social decision-making processes. In the current study we investigated the neural effects of self-construal priming on fairness considerations, using an Ultimatum Game setup (N = 97). Based on previous findings, we predicted an interaction between the self-construal prime and gender on Ultimatum Game behavior; males primed with interdependence would reject the offer relatively more compared to independence, and vice versa for females. As previous neuro-imaging research has established an instrumental role of the anterior insula (AI) and ventromedial prefrontal cortex (vmPFC) in the rejection of unfair offers, we expected higher rejection rates to be mirrored by increased activity in these regions. However, the analyses did not confirm these predictions. As further inspection of the data revealed a habituation effect, we performed a follow-up analysis on the first block (N = 59). This subsequent analysis revealed that priming interdependence resulted in reduced AI activity compared to priming independence, although no behavioral differences were observed. The difference was theorized to result from motivations as conflict avoidance and harmony maintenance, commonly associated with interdependence. Furthermore, the analysis revealed greater vmPFC activity for females compared to males for rejected offers, although this effect was not robust when controlled for trait self-construal. These follow-up analyses suggest that self-construal priming influences insula activity, as well as implicating an underlying role of trait self-construal in observed gender differences in vmPFC activity relating to fairness considerations.

Effects of centric mandibular splint therapy on orofacial pain and cerebral activation patterns.

To investigate the effects on pain, movement kinematics, and cerebral representation by a 3-month mandibular splint therapy. Thirteen patients with temporo-mandibular joint disease (TMD) and moderate pain intensity were investigated before (PRE), within (after 2weeks, POST1) and after a period of 12weeks (POST2) using functional magnetic resonance imaging (fMRI) of representation of occlusal movements on natural teeth and on an individually fitted mandibular splint. In addition, kinematic investigations of jaw movements, muscle electromyography and pain ratings using a pain diary (VAS-scale 0-100) were measured. Although the patient's pain ratings decreased about 60%, kinematic and electromyographic characteristics over therapy were not significantly altered. Over therapy, we observed a decrease of fMRI activation magnitude in the primary somatosensory cortex (S1) and secondary somatosensory cortex (S2) and insular cortex during occlusion. Left hemispheric anterior insula and the cerebellar fMRI activation decrease were associated with decrease in pain over time. Within the limitations of this pilot study, a reduction in both discriminative (primary and secondary somatosensory cortex) and affective (anterior insula) areas for pain processing suggest that altered pain anticipation is critical for the therapeutic effects of mandibular splint therapy after TMD. A 3-month mandibular splint therapy moderately decreases pain and anticipatory anterior insular activation.

Topography and timing of activity in right inferior frontal cortex and anterior insula for stopping movement

Topography and timing of activity in right inferior frontal cortex and anterior insula for stopping movement

Healthy women with severe early life trauma show altered neural facilitation of emotion inhibition under acute stress.

Across psychopathologies, trauma-exposed individuals suffer from difficulties in inhibiting emotions and regulating attention. In trauma-exposed individuals without psychopathology, only subtle alterations of neural activity involved in regulating emotions have been reported. It remains unclear how these neural systems react to demanding environments, when acute (non-traumatic but ordinary) stress serves to perturbate the system. Moreover, associations with subthreshold clinical symptoms are poorly understood. The present fMRI study investigated response inhibition of emotional faces before and after psychosocial stress situations. Specifically, it compared 25 women (mean age 31.5 ± 9.7 years) who had suffered severe early life trauma but who did not have a history of or current psychiatric disorder, with 25 age- and education-matched trauma-naïve women. Under stress, response inhibition related to fearful faces was reduced in both groups. Compared to controls, trauma-exposed women showed decreased left inferior frontal gyrus (IFG) activation under stress when inhibiting responses to fearful faces, while activation of the right anterior insula was slightly increased. Also, groups differed in brain-behaviour correlations. Whereas stress-induced false alarm rates on fearful stimuli negatively correlated with stress-induced IFG signal in controls, in trauma-exposed participants, they positively correlated with stress-induced insula activation. Neural facilitation of emotion inhibition during stress appears to be altered in trauma-exposed women, even without a history of or current psychopathology. Decreased activation of the IFG in concert with heightened bottom-up salience of fear related cues may increase vulnerability to stress-related diseases.

The awareness of the scared - context dependent influence of oxytocin on brain function.

Oxytocin is both a hormone and a neurotransmitter and has been originally recognized for its role in childbirth and lactation. Later, it became widely known as a "cuddle hormone" that induces trusting behavior towards strangers and reduces social stress and anxiety. Several studies showed that oxytocin influences empathic behavior and has prosocial effects. The anterior cingulate cortex and the anterior insula are brain regions that are active when humans observe fear in others. Therefore, the aim of this study was to investigate whether oxytocin administration affects activity in these regions depending on whether a threat is directed at another person (empathy) compared to when the threat is directed at the subject itself (fear). Our findings demonstrate increased anterior cingulate cortex activation after oxytocin administration in the fear, but not in the empathy condition. Furthermore, oxytocin administration was associated with deceased anterior insula activity in the empathy condition. However, our findings do not support the idea that oxytocin generally augments activity in brain regions associated with empathy. Thereby this study supports current research questioning that oxytocin has exclusively prosocial effects on human behavior. Rather, the effect of oxytocin depends on various contextual (e.g. presence of a familiar person) and interindividual (e.g. sex, mental disorder) factors. Therefore, to consider oxytocin an empathy inducing hormone is an oversimplification and future research should focus on factors moderating oxytocin effects.

Dissociable Neural Responses to Monetary and Social Gain and Loss in Women With Major Depressive Disorder.

Neuroimaging studies have revealed aberrant reward and loss processing in patients with major depressive disorder (MDD). While most studies use monetary stimuli to study these processes, it is important to consider social stimuli given that the social environment plays a significant role in the development and maintenance of MDD. In the present study, we examined whether monetary gain/loss and social acceptance/rejection would elicit dissociable salience-related neural responses in women diagnosed with MDD compared to healthy control (HC) women. Twenty women diagnosed with MDD and 20 matched HC women performed the monetary incentive delay task (MID) and the social feedback task (SFT) during functional magnetic resonance imaging (fMRI). This study focused on women since women have a higher rate of MDD, higher frequency of relapse, and are more likely to develop MDD as a consequence of negative interpersonal relationships compared to men. We found that during the MID, HCs but not MDD patients demonstrated strong overlapping activations in the right anterior insula (AI) in response to both monetary gain and loss. During the SFT, MDD patients but not HCs showed overlapping activations in the AI in response to social acceptance and rejection. Our results may suggest a dissociation such that MDD patients show decreased sensitivity to monetary stimuli whether gain or loss, and increased sensitivity to social stimuli whether acceptance or rejection, although this will need to be verified in larger samples with direct comparisons between groups and stimuli. These data demonstrate distinct abnormalities in reward and loss processing that converge within the AI. Our findings also highlight the critical need to assess across both non-social and social domains when examining reward and loss systems in MDD to broaden our understanding of the disorder and identify novel targets for treatment.

Individual differences in resting-state connectivity and giving social support: implications for health.

There is a growing appreciation for the health benefits of giving support, though variability in such behavior exists. Based on the possibility that the dorsomedial (DMPFC) default network subsystem is associated with social thinking and behavior, integrity of this subsystem may facilitate giving support to others. The current study tested associations between DMPFC subsystem connectivity at rest and tendencies related to giving support. During a functional magnetic resonance imaging session, 45 participants completed an emotional social cues task, a resting-state scan and self-report measures of social support. Supportive behavior during the month following the scan was also assessed. Greater DMPFC subsystem connectivity at rest was associated with greater support giving (though not receiving or perceiving support) at the time of the scan and one month later. Results held after adjusting for extraversion. In addition, greater resting-state DMPFC subsystem connectivity was associated with attenuated dorsal anterior cingulate cortex, anterior insula and amygdala activity to others’ negative emotional social cues, suggesting that DMPFC subsystem integrity at rest is also associated with the dampened withdrawal response proposed to facilitate care for others in need. Together, results begin to hint at an additional role for the ‘default’ social brain: giving support to others.

Effects of mindfulness training on the default mode network in borderline personality disorder.

Patients with borderline personality disorder (BPD) present dysfunctions of the default mode network (DMN). Mindfulness training has proven effective to improve the symptoms of BPD. The present study examines the effect of mindfulness training on BPD symptomatology and DMN activity during the performance of a working memory task in patients with BPD. Sixty-five individuals with BPD were randomized to receive psychotherapy with either the mindfulness module of dialectical behavioural therapy (DBT-M) or with interpersonal effectiveness module (DBT-IE). The impact of treatments was evaluated with clinical and mindfulness variables as well as with functional magnetic resonance imaging during performance of the task. Both groups showed improvement in BPD symptoms and other clinical variables after treatment. Unexpectedly, there were no between-group differences in DMN activation or deactivation. However, activation of the left anterior insula increased in both groups after the intervention. Compared with the control group, participants in the DBT-M group presented higher deactivation in a cluster extending bilaterally from the calcarine to the cuneus and superior occipital gyri.

Interaction of Self-Regulation and Contextual Effects on Pre-attentive Auditory Processing: A Combined EEG/ECG Study

Environmental changes are not always within the focus of our attention, and sensitive reactions (i.e., quicker and stronger responses) can be essential for an organism's survival and adaptation. Here we report that neurophysiological responses to sound changes that are not in the focus of attention are related to both ambient acoustic contexts and regulation ability. We assessed electroencephalograph (EEG) mismatch negativity (MMN) latency and amplitude in response to sound changes in two contexts: ascending and descending pitch sequences while participants were instructed to attend to muted videos. Prolonged latency and increased amplitude of MMN at fronto-central region occurred in ascending pitch sequences relative to descending sequences. We also assessed how regulation related to the contextual effects on MMN. Reactions to changes in the ascending sequence were observed with the attention control (frontal EEG theta/beta ratio) indicating speed of reaction, and the autonomous regulation (heart-rate variability) indicating intensity of reaction. Moreover, sound changes in the ascending context were associated with more activation of anterior cingulate cortex and insula, suggesting arousal effects and regulation processes. These findings suggest that the relation between speed and intensity is not fixed and may be modified by contexts and self-regulation ability. Specifically, cortical and cardiovascular indicators of self-regulation may specify different aspects of response sensitivity in terms of speed and intensity.

Purpose in life and conflict-related neural responses during health decision-making.

Having a strong sense of purpose in life is associated with positive health behaviors. However, the processes through which purpose leads to health are unclear. The current study compared neural activity among individuals with higher versus lower purpose while they made health-related decisions in response to messages promoting health behavior change. A total of 220 adults with a sedentary lifestyle who were likely to feel conflicted in response to health messages underwent functional MRI while viewing messages encouraging physical activity and indicated the self-relevance of the messages. We focused on activity within dorsal anterior cingulate cortex (dACC), anterior insula (AI), dorsolateral prefrontal cortex (DLPFC), and ventrolateral prefrontal cortex (VLPFC) as identified by meta-analytically defined maps of regions previously implicated in conflict-related processing, while participants considered the self-relevance of the messages. Individuals with higher (vs. lower) purpose showed less activity in dACC, AI, DLPFC, and VLPFC while making health-decisions. Lower brain response in these regions mediated the effect of higher purpose on greater endorsement of the messages. Individuals with strong purpose may be less likely to experience conflict-related regulatory burden during health decision-making, which may in turn allow them to accept conflicting yet beneficial health messages. Reduced brain reactivity in dACC, AI, DLPFC, and VLPFC may reflect reduced conflict-related processing during health decision-making relevant to longer term lifestyle goals. This adds to mounting evidence linking purpose and a range of positive health-related outcomes, as well as evidence suggesting that dACC, AI, DLPFC, and VLPFC track conflict-related processes relevant to longer term goals and values. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Enhanced Processing of Painful Emotions in Patients With Borderline Personality Disorder: A Functional Magnetic Resonance Imaging Study.

Previous research has demonstrated that patients with borderline personality disorder (BPD) are more sensitive to negative emotions and often show poor cognitive empathy, yet preserved or even superior emotional empathy. However, little is known about the neural correlates of empathy. Here, we examined empathy for pain in 20 patients with BPD and 19 healthy controls (HC) in a functional magnetic resonance imaging (fMRI) study, which comprised an empathy for pain paradigm showing facial emotions prior to hands exposed to painful stimuli. We found a selectively enhanced activation of the right supramarginal gyrus for painful hand pictures following painful facial expressions in BPD patients, and lower activation to nonpainful pictures following angry expressions. Patients with BPD showed less activation in the left supramarginal gyrus when viewing angry facial expressions compared to HC, independent of the pain condition. Moreover, we found differential activation of the left anterior insula, depending on the preceding facial expression exclusively in patients. The findings suggest that empathy for pain becomes selectively enhanced, depending on the emotional context information in patients with BPD. Another preliminary finding was an attenuated response to emotions in patients receiving psychotropic medication compared to unmedicated patients. These effects need to be replicated in larger samples. Together, increased activation during the observation of painful facial expressions seems to reflect emotional hypersensitivity in BPD.

Empathy to emotional voices and the use of real-time fMRI to enhance activation of the anterior insula

The right anterior insula (AI), known to have a key role in the processing and understanding of social emotions, is activated during tasks that involve the act of empathising. Neurofeedback provides individuals with a visualisation of their own brain activity, enabling them to regulate and modify this activity. Following previous research investigating the ability of individuals to up-regulate right AI activity levels through neurofeedback, we investigated whether this could be similarly accomplished during an empathy task involving auditory stimuli of human positive and negative emotional expressions. Twenty participants, ten with feedback from right anterior insula and ten with feedback from a sham brain region, participated in two sessions that included sixteen neurofeedback runs and four transfer runs. Results showed that for the second session participants in the right AI neurofeedback group demonstrated better ability to up-regulate their right AI compared to the control group who received sham feedback. Examination of the relationship between individual participants’ empathic traits and their ability to up-regulate right AI activity showed that participants low on empathic traits produced a greater increase in activation of right AI by the end of training. Moreover, the response to positively valenced audio stimuli was greater than for negatively valenced stimuli. These results have implications for therapeutic training of empathy in populations with limited empathic response.

Social support modulates the neural correlates underlying social exclusion.

Ostracism threatens the human need for social interactions, with negative consequences on cognition, affect and behavior. Understanding the mechanisms that can alleviate these consequences has therefore become an important research agenda. In this study, we used behavioral and fMRI measures to advance our understanding how social support can buffer the negative effects of social exclusion. We focused on two different types of support from a friend: emotional support, conveyed by gentle touch and appraisal support, implemented as informative text messages. Seventy-one female participants underwent fMRI scanning while playing a virtual ball-tossing game in the course of which they were excluded. Two consecutive runs of the game were separated according to the participant’s experimental condition (appraisal support, emotional support and no support). Results showed that the experience of social exclusion is modulated by the type of support received. Specifically, emotional support decreased negative emotions and anterior insula activity, while appraisal support increased negative emotions, with concomitant increase of subgenual anterior cingulate cortex and decrease of temporal-parietal junction activity. These divergent effects of social support point to the necessity to characterize whether and under which conditions it represents an effective and positive resource to alleviate the negative consequences of social exclusion.

Born for fairness: evidence of genetic contribution to a neural basis of fairness intuition.

Human beings often curb self-interest to develop and enforce social norms, such as fairness, as exemplified in the ultimatum game (UG). Inspired by the dual-system account for the responder’s choice during the UG, we investigated whether the neural basis of psychological process induced by fairness is under genetic control using a twin fMRI study (62 monozygotic, 48 dizygotic; mean age: 19.32 ± 1.38 years). We found a moderate genetic contribution to the rejection rate of unfair proposals (24%–35%), independent of stake size or proposer type, during the UG. Using a voxel-level analysis, we found that genetic factors moderately contributed to unfairness-evoked activation in the bilateral anterior insula (AI), regions representing the intuition of fairness norm violations (mean heritability: left 37%, right 40%). No genetic contributions were found in regions related to deliberate, controlled processes in the UG. This study provides the first evidence that evoked brain activity by unfairness in the bilateral AI is influenced by genes and sheds light on the genetic basis of brain processes underlying costly punishment.

Electrophysiological evidence of sustained spatial attention effects over anterior cortex: Possible contribution of the anterior insula.

Spatial attention can improve performance in terms of speed and accuracy; this advantage may be mediated by brain processes at both poststimulus (reactive) and prestimulus (proactive) stages. Here, we studied how visuospatial attention affects both proactive and reactive brain functions using event-related potentials (ERPs). At reactive stage, effects of attention on parietal-occipital components are well documented; little data are available on anterior components. Seventeen participants performed simple and discriminative response tasks, while voluntarily and steadily attending either the left or right visual hemifield throughout one block. Response speed was faster for the attended side. At ERP level, attending to one hemifield did not produce lateralization of proactive components-that is, the BP and the pN. As for poststimulus components, we confirmed the well-known amplitude effects on the P1, N1, and P3. More interesting are results for the prefrontal components previously neglected in tasks modulating spatial attention. Previous studies suggest that these components reflect perceptual and sensory-motor awareness (pN1 and pP1 components), and stimulus-response mapping (pP2 component) associated to anterior insular activity. Spatial attention enhanced the pN1 and the pP1 amplitude but had no effect on the pP2. Overall, results extend knowledge on spatial attention, showing that sustained spatial attention affects the activity of anterior areas, such as the anterior insula, in addition to the known influence on occipital-parietal areas. Top-down spatial attention is likely mediated by increased sensory and sensory-motor awareness for attended events; this effect is evident in reactive, not proactive, brain activity.