Wireless communication systems rely on efficient and compact antennas to transmit and receive signals. Microstrip patch antennas have gained popularity due to their small size, low profile, and ease of fabrication. In this study, an inset fed microstrip rectangular patch antenna using a partial ground plane is designed for ISM band applications in the frequency range of 2.4 - 2.4835 GHz. The antenna is made on a low-cost FR4 substrate with a dielectric constant of 4.3 and a thickness of 1.6 mm. The dimensions of the antenna is 28.35 × 37.58 mm2. The antenna is fed by an inset feedline, which provides a compact and efficient feeding mechanism. The design of the antenna is carried out using CST Microwave Studio software. The performance of the antenna is evaluated based on various parameters such as return loss, bandwidth, VSWR, directivity, gain, and radiation pattern. The simulation results indicate that the proposed antenna achieves a return loss (S11) of -27.339 dB, a bandwidth of 0.01478 GHz (147.8 MHz), and a VSWR of 1.09. Additionally, the antenna provides a gain of 2.97 dBi, a directivity of 4.7 dBi, and an efficiency of -1.726 dB (67.20%). Overall, this design meets the requirements of decreased antenna size, lightweight, low profile, cost-effectiveness, simple manufacturing, and good performance for ISM band applications.