Antacid Drugs Research Articles

In-silico Studies, Synthesis, and Antacid Activities of Magnesium (II) Complexes.

Nowadays, acidity is a severe problem worldwide caused by excessive gastric acid secretion by the stomach and proximal intestine. Antacids are drugs capable of buffering stomach acid. Therefore, in our research work, we have reported the in-silico studies, synthesis, characterization, and evaluation of antacid activities of magnesium (II) complexes via the acid-base neutralization process. In this research, some magnesium complexes were synthesized and their antacid behavior was compared with marketed products. Also, in-silico studies were performed on H+/K+ ATPase (Proton pump). All synthesized compounds were characterized by various spectroscopic techniques like UV-Vis, FT-IR, XRD, and DSC techniques. Spectroscopic analysis results showed that the semicarbazone ligand shows keto-enol isomerism and forms a coordinated stable complex with magnesium ions in the crystalline phase. The FT-IR results confirmed the presence of Mg-O stretching, N-H bending, and C=N stretching vibrations in Mg (II) complexes. The antacid activities of Mg (II) complexes were excellent as compared to the semicarbazone ligand and comparable with that of marketed antacid drugs like ENO, and Pantop-D. Insilco studies also confirmed that semicarbazone ligand and its Mg (II) complexes were both found to be fitted into the active sites of molecular targets, and Mg (II) complexes showed better binding affinities towards macromolecular as compared to semicarbazone ligand.

History and physycal examination

The most effective method for diagnosing food allergy is the clinical history, which includes anamnesis and physical examination. The anamnesis must include a directed and detailed questioning, and together with the physical examination, it will provide the necessary data to guide the diagnosis and suggest whether the pathophysiology is mediated or not by IgE, which is relevant for the selection and interpretation of the tests. specific and establish the accurate diagnosis, in addition to evaluating the possibility of distinguishing between the different differential diagnoses. It is important to assess the clinical history, because no in vivo or in vitro test is relevant if it is not confirmed with it. Even if there is a strong history of food allergy detected in the history, positive tests can confirm the diagnosis without the need for oral challenge, thus avoiding the risk and cost of performing it. The expression of food allergy is influenced by non-modifiable risk factors that include sex, race and genetics (familial), and modifiable factors: atopic dermatitis, vitamin D deficiency, diet high in polyunsaturated fats and deficient in antioxidants, consumption of antacid drugs, obesity, increased hygiene, influence of the microbiota, time and route of food exposure (increased risk by delaying oral ingestion of allergens and concomitant environmental exposure of the same that leads to sensitization and allergy).

Use Of Drugs And Polypharmacy In Dyspepsia Patients At UPT. Narumonda Health Center

Changes in lifestyle and eating patterns are one of the causes of digestive tract disorders. The most common digestive disorder suffered is dyspepsia. Dyspepsia is a group of clinical symptoms or syndromes consisting of pain, bloating, heat and discomfort in the stomach top. This study aims to determine the description of drug use and polypharmacy in dyspepsia patients at UPT. Narumonda Health Center for the January-April 2023 period based on drug class, type of drug, other types of drug and polypharmacy. This research is a descriptive study with a retrospective approach carried out in June 2023, data obtained from the Patient Visit Book at UPT. Narumonda Community Health Center using total sampling method. The data obtained is presented in the form of frequency tables and diagrams. The research results showed that there were 73 patients from January-April 2023. Based on the antacid drug class (antacid) 73.97%, proton pump inhibitor (Lansoprazole) 63.51%, prokinetic (domperidone) 18.92%, H2 receptor antagonist group (Cetirizine) 61.54%. Based on other drugs, the most widely used is the analgesic group (paracetamol) 36.99%. Minor group polypharmacy 91.89%, major group 8.11%.

The Overview of Community Knowledge on the Use of Doen Antacid Drugs at Narisa Pharmacy

Heartburn is a condition characterized by pain in the stomach area. Heartburn is caused by a high concentration of stomach acid. Disease with the same symptoms is gastritis but with different levels, inflammation of the gastric mucosa accompanied by damage or erosion of the mucosa. Gastritis can also occur due to infection from the bacterium Helicobacter pylori. The condition of antacid drugs does which is an over-the-counter drug that can be found anywhere is a drug that can relieve the disease, but in the service of purchasing this drug it takes people who struggle in the world of pharmacy such as pharmacists to provide information. Previous researchers have found that if you do not receive treatment that is not in accordance with medical indications it can be bad for patients, namely worsening disease conditions, decreased life expectancy, and increased health care costs. This is dangerous for buyers of these drugs if they are not right on target of the diseases and drugs they buy, so researchers are interested in seeing a picture of public knowledge about the use of Antacid Doen drugs at Narisa Pharmacy. The method used in this study is descriptive with survey techniques where data collection uses questionnaires as a measuring tool containing questions about several knowledge domains, namely Know (Know) Understand (Comprehension) Analyze (Analysis) Apply (Application) Synthesize Unite Elements into a whole then use the Gutman scale as a choice of Yes and No answers, of course prioritizing respondents' rights including inclusion and exclusion criteria. This study is a Non Probability Sampling study with an Accidental Sampling approach, namely anyone who by chance comes to buy Antacid drugs Doen met at the pharmacy, the population in this study is the surrounding community who came to buy drugs at Apotek Narisa with the number of samples based on the selection of results from the Slovin formula as many as 68 respondents. The results showed that based on the total percentage value of p score = 85.61% entered the category (76%-100%) which is can be conluded as a category of good knowledge.

Establishment of the mechanism of purification and levigation of green chemistry-assisted biocomposites of red ochre (Gairika): synthesis, characterization, and antibacterial, prebiotic, antioxidant, and antacid activities of the traditional Ayurvedic medicine Laghu Sutashekhara Rasa

Gairika (red ochre) has a long history of influencing human civilization. Gairika is a rich source of nutrients used for reproductive and brain health. Gairika is mentioned as an antacid drug in Indian Ayurvedic medicine under Laghu Sutashekhara Rasa (LSR). However, a detailed study on LSR has not been reported to date. In the present study, LSR was prepared, and a pharmaceutical SOP (standardization procedure) was reported to obtain batch-to-batch reproducibility. LSR was characterized using FTIR, XRD, SEM-EDX, and TGA analyses. LSR was tested in vitro for its antacid activity. Advanced instrumentation revealed that LSR formation produced symmetrical particles (5–8 µm) with kaolin, kaolinite, quartz, goethite, and hematite, along with the phytoconstituents of Goghrita (clarified cow’s butter), Shunthi, and Nagawalli, as confirmed by GC-MS/MS analysis. The FTIR study revealed the formation of a chelating complex of goethite and hematite along with their phytoconstituents. XRD analysis confirmed the presence of kaolin, kaolinite, quartz, goethite, and hematite. Using in vitro antacid experiments, LSR and Shunthi demonstrated significant antacid activity as compared to antacid drugs and standards in the market, such as CaCO3. The DPPH assay revealed IC50 values of 12.16 ± 1.23 mg/mL, which is 0.0029 of Trolox-equivalent antioxidant activity. The inhibition (18 ± 4 mm) against pathogens (S. aureus, E. coli, P. aeruginosa, and B. subtilis) and the prominent growth of gut microbiota-supported strains (S. boulardii, L. paracasei, and L. plantarum) observed on LSR formulation were indicative of LSR application as a prebiotic. Here, the mechanism of purification and levigation mentioned in the classical literature of LSR was established. Overall, purification of Gairika with cow ghee and levigation with Nagawalli may enhance the solubility, bioavailability, and shelf-life of LSR through hydration and co-crystallization mechanisms. This is the first comprehensive report on the pharmaceutical validation of LSR and its characterization. The results of the present study could contribute to the development and reliable reproduction of LSR and the utility of environmental red ochre as a medicine in combination with Shunthi (Zingiber officinale Roxb.), as prescribed under Indian Ayurvedic medicine.

Methemoglobinemia in the postoperative period against the background of taking Almagel (clinical case)

Methemoglobinemia were recorded in two patients with intestinal paresis and gastrostasis in the early postoperative period and unauthorized intake of Almagel by patients for the relief of heartburn.In the presented cases, drugs that can cause methemoglobinemia were used in the treatment: ropivacaine, metoclopramide, ketoprofen. Nevertheless, taking into account the pairing of the presented cases, it is impossible to exclude the effect of the drug Almagel on methemoglobin genesis.CONCLUSION: the presented cases demonstrate manifestations of rare and poorly recognized drug methemoglobinemia, probably as a result of taking the antacid drug Almagel. Timely diagnosis and treatment of this condition ensures the rapid reversibility of a complex multifactorial biochemical process.

Knowledge and Practice Regarding Self-Medication of Analgesic Drugs of the Students of Nursing Institute, Naogaon

This was a cross-sectional type of descriptive study that was carried out with a view to assessing knowledge and practice regarding self-medication of analgesic drugs of the students of the Nursing Institute, Naogaon. The sample size was 175 which were selected purposively. The mean age was 19.34±0.95 years. Here, 56.0% knew self-medication practice is a bad habit for a nursing student, 92.0% of respondents said that pain-relieving drugs are dangerous without anti-acid drugs, 60.0% told that self-medication practice is completely unethical, most 85.7% told that purchase of medicine needs a prescription, 67.43% respondents took medicine without doctor`s advice. This study provides some important information which might help the concerned people to take appropriate measures and might be the basis for further in-depth study on this issue.’’

Liquid-like Oral Sustained-Release System Based on Acid-Sensitive in situ Hydrogel for Alleviate Gastrointestinal Side Effects of Indobufen

Commonly, most oral non-steroidal anti-inflammatory drugs (NSAIDs) have known gastric adverse reactions due to their long-term and high dose administration. In this study, a novel liquid sustained-release system based on multiple-unit in situ hydrogel beads was designed to address this issue. The system is composed of sodium alginate (SA), gellan gum (GG), zinc oxide (ZnO), and magnesium oxide (MgO). Furthermore, indobufen was loaded into the system to evaluate its gastric mucosal protection effect. This effect can be attributed to the topical antacid, pepsin inhibition, and sustained drug release properties of the system. It was proven that the stored solid gel system could undergo a “solid to liquid” transition after shaking. Once swallowed, the liquid gel could disperse well in the stomach as hydrogel beads. Then, the “liquid to solid” gelation occurred from the exterior to interior of each multiple-unit gel bead, triggered by the release of Zn2+ and Mg2+ from neutralization reactions. The formed gel demonstrated mild antacid effect that lasted for 3 hours and 66.3% pepsin inhibition in vivo. Moreover, the rats treated with the indobufen gel system showed a drug plasma concentration versus time curve with less fluctuation compared to the rats treated with the marketed preparation (YinDuo®) group. The gel system also exhibited an extended Tmax (6.50 hours) and reduced Cmax (52.87 μg/mL). Additionally, the gastric mucosal protection of the gel system was verified using three types of peptic gastric ulcer models. These findings suggested that this multiple-unit in situ gel could be a potential oral liquid sustained release delivery system for NSAIDs.

Rhodamine B-Quinoline based schiff base as fluorescent ‘turn on’ sensor of Al3+, Cr3+, HSO4− and its cytotoxicity and cell imaging application on TPC-1 and HtH-7 cell lines

A designed Rhodamine-B-quinoline based Schiff base chemosensor (RhBQ) has been synthesized and characterized using various spectroscopic techniques. It shows ‘turn on’ fluorescence emission and also colorimetric sensitivity and selectivity towards trivalent metal ions (Al3+ and Cr3+) and anion (HSO4−) present in aqueous medium. Stoichiometry of both metal (Al3+ & Cr3+) - RhBQ complexes are found to be 1:1 using Job’s plot. A notable enhancement in emission intensity for RhBQ-Al3+ (∼341 fold), RhBQ-Cr3+ (∼292 fold), and RhBQ-HSO4− (∼136 fold) complexes compare to RhBQ are observed. Sensing mechanism i.e. opening of spirolactam ring of RhBQ has been confirmed through various spectroscopic techniques such as; 1H NMR, 13C NMR, ESI-MS, TRPL, FT-IR, and DFT based computational study. The limit of detection (LOD) for Al3+, Cr3+, and HSO4− are found to be 2.2 × 10−8 M, 2.12 × 10−8 M and 8.63 × 10−7 M respectively. An advanced level 3 input OR–INHIBIT logic gate are constructed using chelating ligand EDTA. For onsite detection, TLC paper strip spot of the probe, RhBQ is prepared and the detection of Al3+ in few antacid drug are presented. In addition, cell-imaging analysis of Al3+, Cr3+, and HSO4− ions in the Human papillary thyroid carcinoma cell line (TPC-1) & Human anaplastic thyroid cancer cell lines (HtH-7) are presented and shows promising concentration and time-dependent detection results.

Correlation of Anxiety and Depression to the Development of Gastroesophageal Disease in the Younger Population.

Gastroesophageal reflux disease (GERD) is a condition characterized by the reflux of stomach contents into the esophagus, which leads to heartburn and regurgitation. GERD has been categorized its types according to severity. The categories that have been discussed in this studyare reflux esophagitis (RE), non-erosive reflux disease (NERD), and Barrett's esophagus. Our study compared various studies and showed that the subjects with GERD had a high level of anxiety and depression. Gastroesophageal reflux disease has a significant negative impact on the quality of life (QoL) by perturbing daily activities. The majority of GERD patients use antacid drugs to control their acid symptoms. However, these symptoms are sometimes difficult to control, even with the most potent proton-pump inhibitors (PPIs), and these patients tend to have a lower response rate. According to the clinical data, Anxiety and Depression are linked to the development of GERD. A major focus of this study is to explore psychological influences such as anxiety and depressionand how they relate to GERD. This study also reviews the effect of these conditions on the younger population. It is concluded that the quality of life (QoL) of subjects with GERD is reduced by depression and anxiety.

IDEAS OF ACADEMICIAN O. O. SHALIMOV I N LIFE

Summary. The paper presents a clinical observation that can be an example of the use of vagotomy as an alternative method of reducing the secretory activity of the stomach in massive multiple gunshot lesions of the gastrointestinal tract due to the absence of antacid drugs. The impetus for this was the possessions and teachings of Academician O. O. Shalimov on the introduction of vagotomy into surgical practice, whose ideas live on to this day and are worthily continued by surgeons — our contemporaries and compatriots.

The Effect of Education Using Slide Media on Students' Knowledge of Antacid Drug Self-Medication

Self-medication is a person’s attempt to self-treat themself. In previous studies, it has been stated that the level of knowledge of students regarding self-medication of antacid drugs is lacking, so education is needed to increase students’ knowledge of how to carry out self-medication properly. Slide media is an educational tool that can be more effective than leaflets for health promotion. The purpose of this study was to determine the effect of education using slide media on students’ knowledge about self-medication of antacid drugs at the Luhur Islamic Boarding School in Malang City. This was quantitative research with a pre-experimental method and one-group pretest-posttest research design. The sampling was carried out non-randomly with the number of samples determined by the Slovin formula, and 68 respondents were selected. Respondents filled out the pretest to determine their knowledge of antacid self-medication, then education on the subject was given by using PowerPoint slides and respondents were given a posttest afterwards. The findings showed that education about self-medication of antacid drugs using slide media had a significant effect on students’ knowledge at the Luhur Islamic Boarding School.
 Keywords: self-medication, antacids, education, PowerPoint slides media, knowledge level

Factors Affecting the Level of Community Knowledge on the Use of Antacid Medication

Knowledge can be affected by internal and external factors. Internal factors include education, age, occupation and experience, while external factors include the environment, economy and information. The purpose of this study was to determine the level of public knowledge of the use of antacid drugs in several pharmacies in Lowokwaru District, Malang City. This was a descriptive study that examined health problems that occur in this particular community. This study used a cross-sectional approach. Incidental or accidental sampling was used to obtain 96 respondents. The results of the Chi-square test showed that, among the 7 factors examined, there were 2 factors that had a significant influence on the level of public knowledge about the self-medication of antacid drugs, namely education (p < 0.001) and employment (p = 0.005).
 Keywords: ulcer, drug use, antacids, self-medication, knowledge level

Proton Pump Inhibitors and Bone Health: An Update Narrative Review.

Proton pump inhibitors (PPIs) are an antacid drug often used in acid-related disorders. They decrease acid secretion in the stomach by blocking an enzyme called H+/K+ ATPase which controls acid production. Introduced to the market in 1989, their use has increased rapidly worldwide and they are now among the top 10 most prescribed drugs in the United States. As of 2015, the FDA has already approved six drugs of this class (omeprazole, esomeprazole, lansoprazole, dexlansoprazole, pantoprazole and rabeprazole). Recently, the risks and benefits of long-term PPI use were questioned and many studies indicated that their use should be carefully considered, especially in young patients, whose treatment with these drugs could last many years. Even greater concerns have been raised about a potential positive association between PPIs and osteoporotic fracture risk including the hip, spine and wrist. Although based on observational studies, there is substantial evidence associating the long-term use of PPIs and fracture. This relationship is only partially admitted due to the lack of consistent effects of PPIs on bone mineral density loss. Therefore, this narrative review aimed to discuss the recent findings pertaining to the risk of osteoporotic fracture associated with PPIs, in particular prolonged use, and to call for further research to elucidate the mechanisms associated with this bone fragility.

Equilibrium, Kinetic and Thermodynamic Studies of Adsorption Behaviour of 3D Porous NiFe Nanoparticles for The Removal of Antacid Drug Ranitidine from Waste Water

The adsorption of the ranitidine on 3D porous NiFe2O4 nanoparticles was studied under different experimental conditions. Adsorbent used in this study, was characterized by SEM, XRD, EDX and BET. The prepared highly pure 3D porous NiFe2O4 nanoparticles displayed a high specific surface area of 65.179 m2/g with a total pore volume of 8.495 nm. The effect of ranitidine concentration, mass of 3D porous NiFe2O4 nanoparticles as adsorbent, contact time (5-30 min.), temperature (30–50 0C), and pH (2-10) on adsorption process were investigated. The adsorption of ranitidine reached equilibrium within 15 min, indicating that 3D porous NiFe2O4 is a promising adsorbent for removing pharmaceuticals from aqueous media. Equilibrium isotherms for the adsorption viz, Freundlich, Langmuir and DR equation were applied and determined characteristic parameters for each adsorption isotherm. Thermodynamic analysis of the adsorption data showed negative ΔG0 and positive ΔH0 suggesting that the adsorption was a spontaneous and endothermic process, associated with mainly physical adsorption.

Is patient satisfaction sufficient to validate endoscopic anti-reflux treatments?

Endoscopic anti-reflux treatment is emerging as a new option for gastro-esophageal reflux disease (GERD) treatment in patients with the same indications as for laparoscopic fundoplication. There are many techniques, the first of which are transoral incisionless fundoplication (TIF) and nonablative radio-frequency (STRETTA) that have been tested with comparative studies and randomized controlled trials, whereas the other more recent ones still require a deeper evaluation. The purpose of the latter is to verify whether reflux is abolished or significantly reduced after intervention, whether there is a valid high pressure zone at the gastroesophageal junction, and whether esophagitis, when present, has disappeared. Unfortunately in a certain number of cases, and especially in the more recently introduced ones, the evaluation has been based almost exclusively on subjective criteria, such as improvement in the quality of life, remission of heartburn and regurgitation, and reduction or suspension of antacid and antisecretory drug consumption. However, with the most studied techniques such as TIF and STRETTA, an improvement in symptoms better than that of laparoscopic fundoplication can often be observed, whereas the number of acid episodes and acid exposure time are similar or higher, as if the acid refluxes are better tolerated by these patients. The suspicion of a local hyposensitivity taking place after anti-reflux endoscopic intervention seems confirmed by a Bernstein test at least for STRETTA. This examination should be done for all the other techniques, both old and new, to identify the ones that reassure rather than cure. In conclusion, the evaluation of the effectiveness of the endoscopic anti-reflux techniques should not be based exclusively on subjective criteria, but should also be confirmed by objective examinations, because there might be a gap between the improvement in symptoms declared by the patient and the underlying pathophysiologic alterations of GERD.

COMPREHENSIVE OVERVIEW ON RECENT UPDATES OF GASTRORETENTIVE RAFT-FORMING SYSTEMS

A Raft-forming system is an auspicious approach for systematic drug delivery with steady plasma profiles and drug sustained release manner. It has advantages like enhanced bioavailability, better floating capabilities than other floating systems, more patient compliance, and promoting drug efficacy. Although, it has some problems as it can’t be used for drugs that possess low acid solubility, drugs that are unstable in gastric media, and drugs used for selective release in the colon along with stability difficulties. This system can be successfully prepared by three methods: the physical approach, chemical approach, and physiologically-stimuli approach. The comparative studies showed that the raft-forming system has more advantage over the other comparatives in the antacid potency and in vitro gastric residence time, allowing an intact prolonged delivery of the antacid drug. All the listed applications of the raft system were, fortunately, possessing promising drug delivery with a well-designed drug delivery system. There was a good variety in the active ingredients formulated in a raft, starting from some anti-coughs, anti-spasmodic, anti-inflammatories, and antacids to drugs treating osteoporosis and finally anti-depressants and anti-epileptic drugs. This diversity along with simple in vitro and in vivo evaluations, gives the potentiality to raft for leading the other gastro retentive drug delivery systems for decades.

Controlled long term outcome of pyloromyotomy for pyloric stenosis: No long-term adverse effect

PurposePyloromyotomy for pyloric stenosis is one of the more common surgical procedures performed on infants. The long-term effects of the procedure are however unclear. The purpose of this study was to study the effects into adult life, compare them with controls and to see if there is a need for structured follow up of patients. MethodsOf the 101 patients operated for pyloric stenosis between 1972 and 1974 at our tertiary referral center 91 could be traced. They were all invited to participate in the study and were sent validated questionnaires (PAGI-SYM, GIQLI) as well as a study-specific questionnaire examining the use of antacid drugs, incidence of gastroscopy and abdominal surgery. Sixty patients responded (66%, mean age 45 years, 46 male) and were included. Thereafter, 600 age and sex-matched controls were sent the same questionnaires. 132 responded (22%, 90 male) and were includes as controls. ResultsNo significant differences could be found in any of the examined parameters when looking at the whole material or the male patients. Female patients had higher PAGI-SYM-scores for post prandial fullness (mean 1.11 vs 0.43, P = 0.035) and heartburn (mean 0.59 vs 0.14, P = 0.043) when compared to controls. ConclusionsThe present study shows that most patients operated for pyloric stenosis during infancy experience no negative effects into adulthood. The finding in the female patient group is interesting but is unlikely to have any clinical implications.The results from this study strongly implicate that there is no need for follow up of patients into adulthood. Level of evidenceLevel III.

Effect of Exchanged MgAl-Hydrotalcite with Carbonate on Increases of Acid Neutralizing Capacity: A Good Candidate as an Antacid

Background: In this study, we determined the acid-neutralizing capacity (ANC) of Mg/Al-Hydrotalcite-like compounds. The MgAl-hydrotalcites were synthesized by the co-precipitation method at room temperature using Mg/Al molar ratios 2:3. The synthesized bioactive nanomaterials were characterized by various physicochemical techniques such as TG/dTG, XRD, FT-IR spectroscopy, BET/BHJ, and SEM/EDX. The antacid activity assay was done by converting both synthesized samples into liquids, 1 g of which was added to 50 ml of deionized water at 37°C under vigorous agitation. The acid-neutralizing capacity (ANC) was evaluated with 0.1N HCl. The pH was constantly measured using a pH meter and values were recorded every minute up to 35 min. In order to improve the neutralizing power of the samples, we performed an exchange of chlorides by carbonates on the MgAl-HT3 synthesized. The exchanged Mg/Al-Hydrotalcite (MgAl- HTE) showed high acid neutralization capacity (up to 13.5 mEq/g). Objective: This study aimed to synthesize MgAl-hydrotalcite-like compounds and evaluate their acid-neutralizing capacity. In order to can be good candidates for pharmaceutical applications as antacid drugs. Methods: Following methods are used in this study: - Preparation of MgAl-hydrotalcite-like compounds was done by coprecipitation methods. - Characterization of samples was done by physico-chemical techniques such as TG/dTG, XRD, FT-IR spectroscopy, BET/BHJ and SEM/EDX. - Evaluation of acid-neutralizing capacity was done by titration procedure (Dose-titration). Results: This protocol describes the preparation of MgAl-hydrotalcite-like compounds using the classical coprecipitation method. The synthesized samples were characterized by various physicochemical techniques such as TG/dTG, XRD, FT-IR spectroscopy, BET/BHJ, and SEM/EDX. The as-synthetized samples were used for the evaluation of their acid-neutralizing capacity (ANC). Further, an exchanged of MgAl-Hydrotalcite with carbonate was done for the purpose to increase the acid-neutralizing capacity. Conclusion: In summary, this study describes a simple synthesis of MgAl-Hydrotalcites compounds by a co-precipitation method at constant pH around 10, with a ratio Mg/Al = 3:2 (referred to as MgAl-HT3 and MgAl-HT2). An exchange of the chlorides (not eliminated by washing) by the carbonates was carried out on hydrotalcite with a ratio Mg/Al = 3, and the solid obtained was named MgAl-HT3E. The materials MgAl-HT2, MgAl-HT3, and MgAl-TH3E were used to evaluate antacid activity. To this end, a study was conducted to determine the acid-neutralizing capacity (ANC). As result, the MgAl-HT3E was able to increase acid-neutralizing capacity and maintain an ideal pH. These results could be interesting to prepare novel antacid drugs (due to the low cost of synthesized materials) essentially the hydrotalcite of mg/Al ratio equal to 3 because of its relatively slow kinetics of releasing basic species and therefore of its beneficial action as an antacid.

Iron Deficiency in Cystic Fibrosis: A Cross-Sectional Single-Centre Study in a Referral Adult Centre.

Iron deficiency (ID) diagnosis in cystic fibrosis (CF) is challenging because of frequent systemic inflammation. We aimed to determine the prevalence and risk factors of ID in adult patients with CF. We conducted a single-centre prospective study in a referral centre. ID was defined by transferrin saturation ≤16% or ferritin ≤20 (women) or 30 (men) μg/L, or ≤100 μg/L in the case of systemic inflammation. Apparent exacerbation was an exclusion criterion. We included 165 patients (78 women), mean age—31.1 ± 8.9 years. ID prevalence was 44.2%. ID was significantly associated with female gender (58.9% vs. 38%), lower age (29.4 ± 8.5 vs. 32.5 ± 9.1), lower body mass index (20.5 ± 2.2 vs. 21.3 ± 2.5), and Pseudomonas aeruginosa colonization (70.8% vs. 55.1%). Diabetes mellitus, antiacid drug use and low pulmonary function were more frequent in patients with ID with no statistical significance. The use of CFTR correctors was not associated with ID. In the multivariate analysis, ID was associated with female gender (OR 2.64, CI95% 1.31–5.31), age < 30 years (OR 2.30, CI95% 1.16–4.56), and P. aeruginosa (OR 2.09, CI95% 1.04–4.19).