Annual Sales Research Articles

Price, Consumer Expectations, Policy Impact on the Automobile Industry in the United States Empirical Evidence from 2005 to 2020

Automobiles are good partners for the American people to live and work with, and the automobile industry has made remarkable contributions to the economic development of the United States. In this paper, the development level of the automobile industry is measured by the annual sales volume. With the help of economic demand determination theory, through the combination of qualitative analysis and quantitative analysis, it is found that prices, policies, and consumer expectations will impact automobile sales volume and then affect the development level of the automobile industry. This paper can provide a reference for the decision-making of government, automobile enterprises, and consumers.

Factors Influencing Firm Sales Growth: An Instrumental Variable Analysis

Although several studies have been done on sales growth, the mistake was that firm growth and sales growth were understood as the same thing, using the same perspective and variables for both growth studies. This study takes different perspectives focusing merely on factors influencing sales growth using micro-level data from the World Bank Enterprises Survey (WBES) datasets to examine whether sales growth in sub-Sahara Africa has different stories to tell employing the OLS and 2SLS analyses. Unlike other studies, the results indicated that top management gender diversity has no correlation to sales growth, but temporary employees do. The results also reveal that the key drivers of a firm’s sales growth are skilled labour, labour productivity, and fixed assets, which are statistically significant and have a positive relationship with annual sales growth.

Broadband Microwave Microfluidic Spectroscopy to Capture Product Evolution in Electrosynthesis Reactions

Electrosynthesis plays an important role in chemical manufacturing with over 2 billion dollars in annual sales worldwide of products such as chlor-alkali and aluminum. Synthesis with an electrochemical driving force can afford unique chemical products that are difficult to achieve with conventional synthesis techniques. Electrosynthesis can also provide a more sustainable alternative to energy-intensive processes. For example, the most profitable electro-organic synthesis in industry is adiponitrile production, a precursor to Nylon 6,6, and the electrochemical route consumes less energy than conventional thermochemical methods. However, electrosynthesis reaction mechanisms are often complex and involve multiple biproducts that are difficult to distinguish, limiting product yield and cost efficiency. Prior work involves characterization with techniques such as NMR spectroscopy, mass spectrometry, and optical spectroscopy to understand product evolution during the reaction. These methods tend not to capture intermolecular interactions between substances, which is important for understanding the influence of the dielectric environment on reaction outcomes.Here, we propose to analyze the dielectric environment of electrosynthesis reaction mixtures with on-chip broadband microwave microfluidic spectroscopy (MMS) from 40 kHz – 110 GHz (see attached figure). MMS has been implemented previously for capturing broadband fluid effects such as electric double layer formation, ionic conduction, ion pairing, and dipole relaxations in a single measurement. We want to use MMS to diagnose the interactions between species during an electrolysis reaction and correlate these interactions with specific electrochemical mechanisms. We plan to test our idea by analyzing a model reaction, namely the Shono oxidation of N-Boc pyrrolidine, which is a well-studied electrosynthesis reaction. The goal is to validate our method with a known electrosynthesis reaction mechanism, then extend the technique to systems with an unknown mechanism.We performed broadband MMS of the reaction mixture at different time points to capture product evolution during the electrolysis. Then, we calibrated the resulting S-parameters and fit the data to equivalent circuit models. The equivalent circuit parameters were correlated to signatures from specific entities in the product mixture and used to develop a picture of the evolving dielectric environment. After validating our models with known literature about the Shono oxidation mechanism, we plan to extend our technique to other electrolysis reactions with unknown mechanisms. The goal is to provide a high-throughput technique for identifying key species and interactions that influence the outcome of electrolysis reactions. Figure 1

The impact of COVID-19 on hip and knee arthroplasty surgical volume in China.

The reduction of hip and knee arthroplasty surgical volume has been reported in many countries during the COVID-19 pandemic. In China, there is no national joint registry system and the impact of COVID-19 towards surgical volume remains unclear. The aim of this study was to investigate the hip and knee arthroplasty surgical volume in China during the pandemic and evaluate its change trends. Annual sale numbers of prostheses used in total knee arthroplasty (TKA), total hip arthroplasty (THA), and femoral head replacement (FHR) from 2011 to 2021 was collected from providers registered in National Medical Products Administration (NMPA). Annual surgical volume of TKA, THA, FHR, unicompartmental knee arthroplasty (UKA), and revision of hip/knee arthroplasty (RJA) was collected from member hospitals of Beijing Joint Society (BJS). We used linear regression to estimate the loss of surgical volume. Annual surgical volume obtained from Britain and Australian joint registries were used to make comparison. In China, the surgical volume of THA/FHR, TKA, and UKA in 2020 all decreased compared to the predicted value, with a reduction of 82,525 cases (13.46%), 165,178 cases (33.50%), and 151 cases (0.65%), respectively. All the three procedures showed significant recovery in 2021. The surgical volumes of THA/FHR and UKA were 68,813 and 9402 cases higher than predicted levels, respectively, while TKA volume remained slightly below the predicted level. The regional statistics in Beijing showed similar change mode. In 2020, the surgical volume of THA/FHR, TKA, FHR, and UKA all decreased compared to the predicted value, with a reduction of 5031 cases (43.37%), 5290 cases (40.69%), 620 cases (29.18%), and 925 cases (39.11%), respectively. In 2021, with the exception of FHR, the number of these procedures increased compared to 2020, but remained below the predicted value. Compared with the data from Britain and Australia, China experienced less reduction and faster recovery in the proportions of elderly people (> 65years old) who undergo hip and knee arthroplasty during the COVID-19 pandemic. During the COVID-19 pandemic, although hip and knee arthroplasty surgical volume in China showed a similar "restoration-recovery" change pattern with other countries, China took fewer losses in this field.

Signalling or Pecking Order Theory: An Evidence From Mining and Energy Sector

Purpose: The purpose of the research is to determine the impact of asymmetric information on capital structure decisions.
 
 Theoretical framework: The perspective of the Pecking Order Theory (POT) suggests that managers are more informed about new investments than shareholders, making external financing issuance more prone to asymmetric information.
 
 Design/Methodology/Approach: The data was collected from companies in the mining or energy sectors listed on the Indonesia Stock Exchange during the period of 2007 to 2022, resulting in 647 observation units. Growth opportunities were proxied by total sales (Lang et al., 1996), and the debt ratio was used to measure capital structure decisions (Myers & Majluf, 1984). OLS regression was employed to determine the impact of growth opportunities on capital structure decisions.
 
 Findings: Annual sales are sufficiently increased, companies send positive signals, leading to the issuance of more debt than equity (Akerlof, 1970; S. Ross, 1977; S. A. Ross, 2005).. Companies follow the financing hierarchy when annual sales are lower than the signaling mechanism.
 
 Research, practical & social implications: Facts and empirical evidence have challenged the signaling and pecking order theories, leading to significant debates. The obligation of financial disclosure has resulted in a reduction of asymmetric information, consequently leading to an increase (decrease) in annual sales, which in turn causes a decrease (increase) in the debt ratio.
 
 Originality/Value: The value of the study was extended in Indonesia with abundant of natural resource (energy and mining).

Capacity optimization of a wind-photovoltaic-electrolysis-battery (WPEB) hybrid energy system for power and hydrogen generation

Utility-scale (>10 MW) Wind-Photovoltaic-Electrolysis-Battery (WPEB) system is an emerging technology that adopts open loop “Power-to-H2” architecture for large-scale green hydrogen production. It applies to curtailment reduction in the area with abundant wind and solar energy resources. The traditional residential-scale (0–1 MW) or commercial/facility-scale (1–10 MW) WPEB systems usually adopt the close loop “Power-to-H2-to-Power” structure for power supply in the microgrid. The capacity optimization of the commercial-scale, residential-scale WPEB system have been studied extensively, but the researches for utility-scale WPEB system are rare. This work proposes a multi-constraints single objective capacity optimization method for the utility-scale WPEB system. The optimization objective is to minimize the levelized cost of electricity (LCOE) and the constraints of power balance, annual grid sales rate (AGSR), wind/PV/electrolysis station capacity are considered. The feasible domain is identified by the 8760-h production simulation and the gradient descent method is applied to search the optimal solution. The main conclusions are summarized below: (1) Increasing the wind-to-generation capacity ratio can reduce the LCOE, required grid sales capacity, and net generation curve fluctuation. (2) The lower and upper limits of the electrolysis station capacity are determined by the AGSR constraint and the LCOE target. (3) The battery bank time-shifts electricity to reduce the downtime of the electrolysis station. Thus, its power capacity should be no less than the minimum load ratio of the electrolysis station and the discharge duration greater than 1 h is preferred. Overall, this work provides a capacity optimization roadmap for the utility-scale WPEB system which plays a significant role in renewable electricity-based hydrogen production and curtailment reduction.

Linking social media marketing to restaurant performance – the moderating role of advertising expenditure

PurposeBuilt upon customer engagement marketing theory and uses and gratification theory, this study examines the link between individual social media marketing (SMM) performance indicators and restaurant sales performance at the firm level. Moreover, the study investigates the moderating effect of advertising expenditure on this proposed relationship.Design/methodology/approachRandom effect regression models were developed in Stata to examine the associations between SMM performance indicators, advertising expenditure, and restaurant firm revenue. Twelve years of SMM data from brands' Facebook pages were collected with a web scraper built in Python. Natural language processing was used to analyze the sentiment of user-generated content (UGC).FindingsThe results suggest that restaurant annual sales revenue increases as the volume of brand posts, “like”s, “share”s and positive comments on restaurants' Facebook pages increase. However, the total number of comments and the number of negative comments show non-significant associations with revenue. Firm advertising expenditure negatively moderates the relationships between sales revenue and the number of “like”s, “share”s, total comments and positive comments.Practical implicationsRestaurants benefit from making frequent posts on SNSs. Promotions that motivate online users to “like”, share, and comment on brand posts should be implemented. Firms with limited advertising budgets are encouraged to actively create buzz on SNSs due to evidenced stronger effects of UGC on sales performance than large advertisers.Originality/valueThis research bridges the gap by studying the effects of individual SMM performance indicators on restaurant financial outcomes. The findings support the effectiveness of SMM; and, for the first time, demonstrate that SMM could generate a more profound impact for firms with low advertising budgets.

The Influence of Financial Literacy, Financial Management, and Financial Technology on Business Performance And Sustainability of Micro, Small, and Medium Enterprises In Sumatera, Indonesia

Business performance and business sustainability are crucial for business owners to achieve their targets. The business performance and sustainability of micro, small, and medium enterprises (MSMEs) contribute positively to the country's economy. When compared to large companies, MSMEs employ the most people. MSMEs more significantly influence the Gross Domestic Product (GDP) growth or development. MSMEs are the backbone of a nation's economy, increasing employment possibilities. The worst issue is the decline in annual sales and potential economic headwinds brought on by dropping commodity prices. This study aims to analyze the influence of financial literacy, financial management, and financial technology on business performance and the sustainability of MSMEs in Sumatra. This study was designed using a quantitative approach and questionnaire survey of MSME owners in Sumatra, Indonesia. A simple random sampling technique is used. The data were analyzed using a structural equation model (SEM). The validity, reliability test, statistical descriptive, and multiple regression tests were conducted. Financial literacy and technology affect business performance; meanwhile, financial management does not. Furthermore, the result shows financial literacy and management affect business sustainability. Financial technology does not affect the sustainability of MSMEs.

SALE PRICE COMPARISON OF SAGGIAN FLOWER MARKET: A CASE STUDY

In order to reach the required standard, an effort has been made to cover all facets of the flower business in this paper, including the current environment and potential future developments. The sale and price of various flowers, including gladioli, cut roses, tuberose, gruss an teplitz, and marigolds, are presented in this study as well as the current state of the Saggian flower market. This article makes it easier for people to decide whether to launch a flower business in Pakistan. In Pakistan, the flower industry has grown significantly since previous years, however this growth is insufficient to meet customer demand. Compared to the winter season, production drops throughout the summer. This article provides a summary of the annual sales and projected rates of various flowers in the Saggian Flower Market.

Changes in Pack Features Among Top-Selling Cigarettes in the U.S., 2018 and 2021

Cigarette packaging is designed to increase consumer appeal and remains a primary promotional tool in many countries, including the U.S. This study documented changes in the prevalence of pack characteristics among the top-selling cigarette products in the U.S. in 2018 and 2021. The 50 cigarette packs with the highest national unit sales in U.S. convenience stores in 2018 and 2021 were identified using Nielsen's Scantrack data and subsequently purchased. Packs were coded for features such as dominant color(s), descriptive text, and promotional language. Descriptive analyses conducted in 2022 weighted by total annual unit sales compared the prevalence of pack characteristics between years. Three brands-Marlboro, Newport, and Camel-constituted over 80% of pack sales among the top-selling products. Packs with red as a dominant color grew less popular between years (33.3% vs 29.5%), whereas those with green became more prevalent (25.2% vs 28.9%), consistent with a rise in the proportion of menthol sales. The prevalence of descriptors such as flavor and fresh decreased from 46.0% to 39.4% and 9.7% to 5.2%, respectively. Meanwhile, the prevalence of promotional language (e.g., rewards programs) increased from 60.9% to 69.0%. The use of visual and named colors remains common, which can implicitly communicate sensory or health-related attributes. Moreover, promotions may help recruit and retain consumers in the context of more restrictive tobacco control policies and price increases. Given the strong influence that cigarette packaging exerts on consumers, packaging-focused policies, such as plain packaging laws, may reduce appeal and accelerate declines in cigarette use.

Implementation of risk-sharing agreements in Saudi Arabia: Comparison and reflection on the NICE Model

In recent years, healthcare spending has increased, due to factors such as aging population, lifestylebased diseases, and high-cost health technologies. These factors have put enormous pressure on policymakers to curtail costs and shift towards value-based healthcare system. In this system, drug companies must demonstrate the value of their products in real-world settings. However, evidence may not be available at the time of product launch, leading to delays in reimbursement decisions and access of patients to products. To address this gap, risk-sharing agreements (RSA) have been introduced between manufacturers and payers. The most common type of RSA is the financial-based agreement which may take various forms such as annual sales caps, price-volume agreements, and comparator rebates. These agreements allow for rapid access to innovative medications. Another type of RSA is the outcome-based agreement which ties reimbursement to the real-world outcomes of products. These agreements are more complex, but they are expected to grow rapidly with the availability of real-world data. In the Middle East, the use of RSA is limited, although it is expected to increase with the ongoing shift towards a value-based healthcare system and introduction of health technology assessment. Saudi Arabia is leading these efforts in the region. This study was aimed at describing the current status of RSAs, trends in utilization of RSAs, and challenges of RSA implementation in Saudi Arabia (KSA). Real-world examples of RSAs in various healthcare sectors are also provided. Overall, the use of RSA facilitates access to innovative medications while ensuring value for money and efficient utilization of limited healthcare resources

Comparison of the Smoking Cessation of Heated Tobacco Product Users and Conventional Cigarette Smokers in Korea.

Since the introduction of heated tobacco products (HTPs) in Korea in 2017, their annual sales have increased. Several studies have investigated the perceptions of HTPs and smoking cessation behaviors. For the first time, In 2019, questions focused on HTP use were introduced in the Korea National Health and Nutrition Examination Survey (KNHNES). This study aimed to compare smoking cessation behaviors between HTP users and conventional cigarette smokers using KNHANES data. Data of 947 current adult smokers from the 8th KNHNES (2019) were analyzed. Current smokers were divided into conventional cigarette (CC)-only, HTP-only, and dual-use groups. The general characteristics of the three groups were investigated. Differences in current intention to quit smoking and past attempts to quit smoking among the three groups were analyzed using multivariate logistic regression analysis by IBM SPSS ver. 25.0. HTP-only users demonstrated fewer future smoking cessation plans (adjusted odds ratio [AOR], 0.398; 95% confidence interval [CI], 0.195-0.813; P=0.012) and fewer smoking cessation attempts in the past year (AOR, 0.533; 95% CI, 0.298-0.954; P=0.034) than CC-only smokers. However, there was no significant difference between dual-use (CC+HTP) and CC-only smokers. While dual-use and CC-only smokers showed similar smoking cessation behaviors, HTP-only users had fewer previous attempts to quit smoking and were less likely to be currently ready to quit smoking. These findings can be explained by a decrease in the need to quit smoking due to the convenience of HTP and the perception that HTPs are less harmful than CC.

Gross turnover assessment and tax compliance in Uganda’s small businesses: a deep inquiry on the certainty of presumptive tax law

PurposeThis study aims to investigate the certainty of small business (SB) taxpayers about the presumptive tax law concerning the assessment of income tax based on gross turnover and how this impacts their income tax compliance.Design/methodology/approachThe study adopted the exploratory research design. The saturation point was attained upon interviewing nine owners of SB enterprises, eight tax officers from the Uganda Revenue Authority and eight tax consultants. Themes were identified and explained using verbatim texts from the various interviews. Data were analyzed using the content analysis technique.FindingsThe findings indicate that SB taxpayers are uncertain about the nature of the presumptive tax, that it is assessed based on annual sales, indicators used to determine gross turnover and their actual tax liability. This has occasioned resistance to the tax system and inhibited voluntary compliance. SB taxpayers thus opt to wait for the tax officers to make tax assessments. However, they have used this opportunity to bribe or bargain with tax officers to pay low amounts in tax or no tax at all. Thus, policymakers and revenue authorities ought to concentrate on creating massive sensitization of the law on presumptive tax, in this case, the existing tax base on which the tax is imposed and its elements to improve income tax compliance of SBs.Research limitations/implicationsThese results are relevant to policymakers and Revenue authorities in developing countries, especially in Africa, in improving income tax compliance of SBs.Originality/valueThis study examines the contribution of certainty of the income tax law on the tax base (gross turnover) on which presumptive tax is imposed to income tax compliance of SBs, which has hardly been covered in previous studies.

Business Roundup

BUSINESS Business Roundup ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2023, 101 (15), p 15May 8, 2023Cite this:C&EN 101, 15, 15AbstractJohnson Matthey has agreed to sell its diagnostics services business to Sullivan Street Partners and Souter Investments for $69 million. The business, which provides equipment for diagnosing problems in oil and gas production, has annual sales of about $72 million. LyondellBasell Industries is buying the 50% of the plastics recycler Quality Circular Polymers (QCP) that it doesn’t already own from the waste management firm Veolia. QCP operates mechanical recycling plants in Belgium and the Netherlands. PureCycle Technologies has achieved mechanical completion of its plant in Ironton, Ohio, which will use a solvent-based process to purify postconsumer polypropylene for recycling. When operating, the plant will be able to produce nearly 50,000 metric tons of recycled polypropylene per year. Nouryon will expand capacity at its facility in Ningbo, China, for the organic peroxides Perkadox 14 and Trigonox 101. The firm says annual capacity for each polymer additive will double, to 6,000 metricView: PDF | Full Text HTML

The Control and Comprehensive Safety Assessment of Heavy Metal Impurities (As, Pb, and Cd) in Green Tea Camellia sinensis (L.) Samples (Infusions) Available in Poland

Tea is the world’s most common drink after water, and the world’s annual sales exceed $43 billion, of which more than $11 billion is green tea (Camellia sinensis (L.)). Increasing evidence continues to show that green tea consumption and its ingredients have a variety of potential health benefits. The aim of the study was to control and assess the toxicological risk (TRA) of three heavy metals (As, Pb, and Cd) in infusions of green tea (n = 12) from Polish markets. We applied the method of inductive coupled plasma mass spectrometry (ICP-MS) to determine the selected heavy metal and designed a specific toxicological risk assessment with three crucial tiers. The first tier of our strategy was to determine the elements investigated (heavy metal impurities, µg/L). The second step was to estimate the weekly intake of green tea infusions (µg/week) based on weekly consumption. The third tier was to estimate the weekly intake per weight (µg/L/week/bw), based on the average weekly intake of green tea infusion per adult compared to the provisional weekly intake (PTWI) established by the FAO/WHO Joint Food Additives Expert Committee (JECFA). The levels of the investigated heavy metals occur at different levels in all of the investigated green tea infusions. The heavy metal profile indicated that As (0.0721–10.585 µg/L), Pb (0.386–1.695 µg/L), and Cd (0.126–0.346 µg/L) were present in all samples. Basic analysis of general content shows that As (average = 0.325 µg/L) was at a level similar to Cd (average = 0.214 µg/L). Surprisingly, the Pb content (average 0.891 µg/L) was approximately 2.75–4 times higher than that of As and Cd, respectively. The application of our proposed safety assessment methodology (three tiers) provides satisfactory results for regulatory purposes. The evaluation of the investigated heavy metals in all products analysed from green tea samples (infusions) showed that there were no health hazards to consumers due to weekly exposure. The results indicated that after drinking green tea infusions from Polish markets, the amount of investigated elements in weekly doses does not represent any health risks to consumers.

Boosting SMEs Performance in Surabaya on Post Pandemic Era

Small and medium-sized enterprises (SMEs) are playing a major role in many country including Indonesia, the definition of SMEs under Law No.20 of 2008 are corps owned by individual or groups of people, and it’s defined by their assets and annual sales, cited from ilo.org Indonesia’s SMEs are reaching 816.000 in total, employing 97 percent of local workforce in Indonesia and contributing 27 percent of GDP and we can say that SMEs are the backbone of the economy in Indonesia. Despite the fact, many SMEs failed to sustain in this era of globalization and pandemic, cited from bbc.com there are around 30 million of SMEs were bankrupt and closed during pandemic, hence the researcher did some research to find what are the most important factors to make SMEs sustain in this era. This study is located in Surabaya considering Surabaya as the second largest and fastest trading city with a significant SMEs growth since 2008 and high economic maneuver. Multiple linear regression was used for this study with a total 53 samples using google form as the data collection platform. Findings that all factors such customer value, transformational leadership, innovation and online marketing are significantly related to business performance. This study will accelerate SMEs growth to support indonesia economyKeywords: SMEs, pandemic, business, performance, key factors

An Analysis of Financial and Operational Strategies of Lululemon Athletica Inc.

Lululemon is a high-end fashion sportswear manufacturer founded in Vancouver in the 1990s and listed on NASDAQ in 2007. The company has experienced rapid growth over the past two decades to become an industry giant with annual sales of over $6 billion, a net profit of nearly $1 billion, and a market capitalization of approximately $38 billion. Moreover, the company has a unique market position, and a very high brand premium. This paper conducted a deep analysis by scanning its financial statements as the starting point, to find out the financial strategy and marketing strategy behind the company's success. At the same time, based on the SWOT model, Porter's Five Forces model analysis, the company's competitive strengths and weaknesses, and the potential problems underlying and challenges it faces have been extracted. Recommendations for the company are given based on the above analysis in order to maintain high growth in revenue, net profit, and market share.

Cinven beats Ineos to buy MBCC Admixtures

Private equity firm Cinven has snatched a last-minute deal to buy MBCC Admixtures, part of BASF’s former construction chemical group, from the Swiss company Sika. As recently as Jan. 16, the chemical giant Ineos had announced that it was acquiring MBCC Admixtures . Since then, however, the UK’s Competition and Markets Authority (CMA) indicated that it had concerns that such an agreement would adversely affect the competitiveness of the UK construction chemical sector. Sika then turned to Cinven. MBCC Admixtures has annual sales of about $1 billion and over 1,600 staff at 35 production sites across Australia, Canada, Europe, New Zealand, and the US. Headquartered in Mannheim, Germany, the firm provides a broad range of products used in the construction industry, including materials that reduce carbon dioxide emissions in the production of concrete. Sika’s sale of MBCC Admixtures has itself been triggered by the CMA. If the business isn’t sold,

Comparison of Linear Regression, Neural Net, and Arima Methods For Sales Prediction of Instrumentation and Control Products In PT. Sarana Instrument

PT. Sarana Instrument is a national private company which is an authorized sales agent for several instrumentation and control products originating from European countries and the United States for sales in Indonesia. Every company certainly targets sales to be achieved every year, for that the company certainly needs sales forecasting. PT. Sarana Instrument does not currently have a prediction system so that for making annual sales targets, it still uses manual estimates by looking at sales data from the previous year's sales. So that PT. Sarana Instrument cannot get accurate sales predictions and the company cannot prepare human resources and financial resources according to the company's needs. Therefore, a forecasting system is needed to help make forecasts. The purpose of this study was to analyze the error rate of forecasting sales data for 2013-2021 at PT. Sarana Instrument uses a forecasting algorithm, namely the Linear Regression Algorithm, Neural Net and Arima, in order to obtain a sales forecast method with the smallest error rate and can be implemented at PT. PT. Sarana Instrument.

Clinical Trials Portfolio and Regulatory History of Idelalisib in Indolent Non-Hodgkin Lymphoma

Idelalisib is a first-in-class phosphatidylinositol 3-kinase inhibitor that received US Food and Drug Administration accelerated approval in July 2014 as a single-agent treatment for relapsed follicular lymphoma (FL) and small lymphocytic lymphoma (SLL). Serious adverse effects were reported in 2016 leading to termination of postmarketing registry trials. However, idelalisib remained on the market until 2022 when Gilead voluntarily withdrew the drug for the accelerated approval indication. Evaluate the regulatory oversight of the accelerated approval pathway and evidence generation for idelalisib during premarketing (2008-2014), postmarketing (2014-2016), and premarketing withdrawal periods (2016-2022). ClinicalTrials.gov, FDA.gov, PubMed database. Clinical trials investigating the safety and effectiveness of idelalisib. Study characteristics and relative risk (RR) of safety outcomes were abstracted. Data were pooled using random effects meta-analysis. The analysis was performed in October of 2022. Trial status, recruitment status, publication status, serious adverse events (SAEs), fatal adverse events (FAEs), and all-cause mortality. Overall, 31 idelalisib trials met selection criteria. In total, 20 of 30 (65%) included SLL and/or FL; 13 (42%) trials were completed, 13 (42%) had published results, and 7 (23%) were randomized clinical trials (RCTs). Overall, 6 RCTs of idelalisib had publicly available data on safety outcomes. By the initial postmarketing period (2016), the cumulative RR for SAEs was 1.86 (95% CI, 1.63-2.11), for FAEs was 3.30 (95% CI, 1.56-7.00), and for death was 1.35 (95% CI, 0.85-2.12). In the premarketing withdrawal period, only a single phase 3 trial was enrolling patients for FL and was terminated. However, idelalisib was not withdrawn from the market until 2022. Gilead reported cumulative sales revenue of $842 million during market authorization (2014-2022) and annual sales had a steady decline from $168 million to $62 million during the premarketing withdrawal period (2016-2021). Findings of this systematic review and meta-analysis show that serious risks of SAE, FAE, and death with idelalisib treatment were evident by 2016. However, idelalisib remained on the market for another 6 years, with minimal evidence generation. It was voluntarily withdrawn for FL and SLL accelerated approval indications coinciding with decreasing revenue generation. Closer attention for safety and effectiveness of drugs reaching market by accelerated approval is needed.