Annual Cost Research Articles

Healthcare resource utilization and related cost among hospitalized patients with prurigo nodularis: a retrospective cohort study using Italian health claims data.

Prurigo nodularis (PN) is a chronic, inflammatory skin disease characterized by intense itch. Little evidence exists on the burden of PN in Italy. This real-world analysis aimed to investigate the healthcare resource consumption and related direct costs of patients hospitalized for PN. The analysis utilized the administrative databases of healthcare units that cover approximately 12 million inhabitants across Italy. Adult patients were included by ICD-9-CM=698.3 (lichen simplex chronicus; neurodermatitis circumscripta; PN) as proxy of PN diagnosis, from 01/2010 to 09/2021, and had 1 year of data availability before (baseline) and after (follow-up) hospitalization (index date). These patients were 1:2 matched by age, sex, and index date (year) to adults without such hospitalization in the baseline period (matched non-PN controls). The analysis comprised 295 PN-hospitalized patients, matched with 590 non-PN individuals (mean age 63.2 years, 43.7% female). At baseline, patients had a greater comorbidity burden than non-PN controls, including higher prevalence of hypertension (56.6% vs. 36.6%, respectively), dyslipidemia (26.4% vs. 18.0%), diabetes (24.4% vs. 12.5%) and mental health conditions (14.9% vs. 7.8%). During 1-year follow-up, PN-hospitalized patients had significantly higher resource consumption than matched controls, in terms of mean number of prescriptions most commonly prescribed in PN patients (5.1 vs. 1.9, P<0.001), other drugs (11.7 vs. 6.5, P<0.001), all-cause hospitalization (1.4 vs. 0.1, P<0.001) and outpatient services (5.4 vs. 2.5, P<0.001). Mean annual all-cause healthcare costs for patients over 1-year follow-up were € 3847 total (€ 875 drugs, € 2652 hospitalization, € 320 outpatient services), higher than those for the matched controls, of € 711 total (P<0.001) (€ 353 drugs, € 228 hospitalization, € 130 outpatient services). Patients hospitalized for PN had a higher comorbidity burden at baseline and greater healthcare resource consumption during 1-year follow-up compared to matched controls, with a 5.4-fold increase in all-cause healthcare costs, indicating substantial clinical burden and remaining unmet need in these patients.

Factors impacting hospitalisation and related health service costs in cancer survivors in Australia: Results from a population data linkage study in Queensland (COS-Q).

The global economic cost of cancer and the costs of ongoing care for survivors are increasing. Little is known about factors affecting hospitalisations and related costs for the growing number of cancer survivors. Our aim was to identify associated factors of cancer survivors admitted to hospital in the public system and their costs from a health services perspective. A population-based, retrospective, data linkage study was conducted in Queensland (COS-Q), Australia, including individuals diagnosed with a first primary cancer who incurred healthcare costs between 2013 and 2016. Generalised linear models were fitted to explore associations between socio-demographic (age, sex, country of birth, marital status, occupation, geographic remoteness category and socio-economic index) and clinical (cancer type, year of/time since diagnosis, vital status and care type) factors with mean annual hospital costs and mean episode costs. Of the cohort (N = 230,380) 48.5% (n = 111,820) incurred hospitalisations in the public system (n = 682,483 admissions). Hospital costs were highest for individuals who died during the costing period (cost ratio 'CR': 1.79, p < 0.001) or living in very remote or remote location (CR: 1.71 and CR: 1.36, p < 0.001) or aged 0-24 years (CR: 1.63, p < 0.001). Episode costs were highest for individuals in rehabilitation or palliative care (CR: 2.94 and CR: 2.34, p < 0.001), or very remote location (CR: 2.10, p < 0.001). Higher contributors to overall hospital costs were 'diseases and disorders of the digestive system' (AU$661 m, 21% of admissions) and 'neoplastic disorders' (AU$554 m, 20% of admissions). We identified a range of factors associated with hospitalisation and higher hospital costs for cancer survivors, and our results clearly demonstrate very high public health costs of hospitalisation. There is a lack of obvious means to reduce these costs in the short or medium term which emphasises an increasing economic imperative to improving cancer prevention and investments in home- or community-based patient support services.

Kinetic insights into energy-saving and low-carbon reactive distillation processes for the transesterification to dimethyl carbonate

The transesterification of propylene carbonate (PC) or ethylene carbonate (EC) to dimethyl carbonate (DMC) by using catalytic reactive distillation (RD) is a promising approach for carbon dioxide utilization. However, there is still scarcity of comprehensive comparison between the two RD processes. Hence, using the UNIQUAC model and kinetics calibrated by literature and our experiments, we conduct an extensive comparison of the two RD processes. Based on the kinetic insights, laboratory RD processes for both reactions are modeled, analyzed, and experimentally validated. Consequently, two RD processes designed to produce 60 ktpy of DMC are optimized and compared. The interplay and control factors between reaction and separation are elucidated and clarified via investigating variations of the actual chemical equilibrium constant profile compared with theoretical values along the reactive section at various pressures, liquid holdups, etc. The results reveal that the optimized EC RD process achieves almost 50 % reductions in both total annual cost and carbon dioxide emission compared to the PC RD process. This work facilitates the carbon neutrality and provides an essential guide for quantitatively assessing the two routes.

Decision and economic evaluation of abortion availability in the United States military

BackgroundActive-duty service women rely on the civilian sector for most abortion care due to limits on federal funding for abortion. Abortion is now banned in many states with large military presences. The Department of Defense has implemented policies to assist active-duty service women in accessing abortion, but there is debate to reverse this support. ObjectiveOur goal was to compare the cost-effectiveness and incidence of adverse maternal and neonatal outcomes of a hypothetical cohort of active-duty service women living in abortion-restricted states comparing restricted abortion access (abortion not available cohort) to abortion available with Department of Defense travel support (abortion available cohort). Study DesignWe developed a decision tree model to compare abortion not available and abortion available cohorts for active-duty service women living in abortion-restricted states. Our cohorts were subdivided into normal pregnancies and those with a major fetal anomaly. Cost estimates, probabilities, and disability weights of various health conditions associated with abortion and pregnancy were obtained and derived from the literature. Effectiveness was expressed in disability-adjusted life years and the willingness to pay threshold was set to $100,000 per disability-adjusted life year gained or averted. We completed probabilistic sensitivity analyses with 10,000 simulations to test the robustness of our results. Secondary outcomes included numbers of stillbirths, neonatal deaths, neonatal intensive care unit admissions, maternal deaths, severe maternal morbidities, and first and second trimester abortions. ResultsThe abortion not available cohort had a higher annual cost to the military ($299.1 million, 95% CI 239.2 – 386.6, vs. $226.0 million, 95% CI 181.9 – 288.5) and was associated with 203 more disability-adjusted life years compared to the abortion available cohort. The incremental cost effectiveness ratio was dominant for abortion available. Abortion not available resulted in an annual additional 7 stillbirths, 1 neonatal death, 112 neonatal intensive care unit admissions, 0.016 maternal deaths, 24 severe maternal morbidities, 27 less second trimester abortions, and 602 less first trimester abortions. Probabilistic sensitivity analysis revealed that the chance of the abortion available cohort being the more cost-effective strategy was greater than 95%. ConclusionLimiting active-duty service women’s access to abortion care increases costs to the military, even with costs of travel support, and increases adverse maternal and neonatal outcomes. This analysis provides important information for policymakers about economic and health burdens associated with barriers to abortion care in the military.

Economy and energy flexibility optimization of the photovoltaic heat pump system with thermal energy storage

Photovoltaic systems have been widely applied in building energy systems. However, with the sharp increase in demand of electricity in buildings during heating and cooling seasons, the uncertainty of photovoltaic generation further exacerbates the peak-valley difference in electricity use. To improve the economy and energy flexibility of buildings in hot summer and cold winter zones of China, a rule-based operation strategy was proposed for the photovoltaic heat pump with thermal energy storage system to optimize the size of the thermal energy storage system and system operation, with aims of minimizing the total annual cost of the system and maximizing the self-consumption rate of the photovoltaic generation. The effects of grid export power limits, grid import power limits, feed-in tariffs, and PV generation on the system operation optimization results were also investigated. The results indicated that by integrating the thermal energy storage system into the photovoltaic heat pump system, the self-consumption rate of the photovoltaic generation was reduced by 2.39 %, the total annual cost of the system was decreased by 6.61 %, and the payback period of the thermal energy storage system was 1.31 years. The optimum size of the thermal energy storage system and the self-consumption rate of the photovoltaic generation decreased with the increasing grid export power limits and grid import power limits. In contrast, higher grid export power limits, grid import power limits, feed-in tariffs, and PV generation all resulted in a lower total annual cost. This study provided a systematic design and operation optimization method for building energy systems.

Incidence of Post-ERCP Pancreatitis in Patients Receiving Rectal Indomethacin vs. Compounded Rectal Diclofenac Prophylaxis.

Endoscopic retrograde cholangiopancreatography (ERCP) carries a 3-15% risk of post-ERCP pancreatitis (PEP). Rectal indomethacin reduces the risk of PEP, but its cost has increased more than 20-fold over the past decade. Rectal diclofenac is also used to prevent PEP but is not commercially available in the United States. The aim of this study is to compare the incidence of PEP after administration of commercially available rectal indomethacin versus compounded rectal diclofenac and assess financial implications. ERCP cases at our institution with administration of 100mg rectal indomethacin or 100mg compounded rectal diclofenac between May 2018 and January 2022 were retrospectively reviewed. The incidence and severity of PEP was compared between the indomethacin (n = 728) and diclofenac (n = 304) groups. Risk factors (young age, female sex, history of pancreatitis or PEP, sphincterotomy during procedure, pancreatic indication, trainee involvement) and protective factors (prior sphincterotomy, pancreatic duct stenting) for PEP were compared between groups. 60 patients (8.2%) in the rectal indomethacin group and 25 patients (8.2%) in the compounded rectal diclofenac group developed PEP, resulting in moderate or severe PEP in 9 (15.0%) and 2 (8.0%) patients, respectively. The compounded rectal diclofenac group had more trainee involvement (46.1% vs. 32.8%, p = 0.0001) and more prior sphincterotomy cases (15.8% vs. 10.6%, p = 0.0193) compared to the rectal indomethacin group; no statistically significant differences were observed in all other risk and protective factors. Following switch to compounded rectal diclofenac, institutional annual cost savings amounted to $441,460.62 and patient charge decreased 45-fold. This retrospective single-center real-world analysis showed similar efficacy of rectal indomethacin and compounded rectal diclofenac in preventing PEP but demonstrates substantial cost savings after switching to compounded rectal diclofenac.

The effect of hydropower bidding strategy on the iberian day-ahead electricity market

In 2021, the Iberian Electricity Market, which includes Portugal and Spain, experienced a significant increase in electricity prices. On average, prices tripled compared to pre-pandemic levels in 2019, despite stable demand. This trend, though less pronounced in other European markets, has raised concerns about the efficiency and competitiveness of wholesale electricity markets. This study investigates the bidding behavior of non-pumped hydropower plants in the Iberian market, employing a merit order model based on real data from 2019 to 2021. The analysis reveals a clear mismatch between hydropower bid prices and actual production costs. Although this practice is legal, it conflicts with the European Union's goal of promoting fair competition within the internal electricity market.Our findings suggest that aligning hydropower bid prices with 2019 levels could have reduced annual market costs by approximately 2324 million euros under a moderate scenario. This indicates substantial potential for cost savings and improved integration of hydropower. However, this strategy also benefits companies that own these hydropower plants, as they often possess large portfolios and can capitalize on increased market prices through other plants, particularly renewable energy units, which offer electricity at very low prices and have a high likelihood of being dispatched.Furthermore, the study highlights regulatory gaps allowing hydropower plants to price low-cost energy similarly to thermal plants, raising consumer costs and distorting market dynamics. These findings emphasize the need for stronger regulatory oversight and reforms to prevent excessive price inflation by hydropower, which plays a critical role in renewable energy integration and grid stability. Policymakers must ensure fair pricing while compensating hydropower plants for their flexibility and essential contributions to the energy system.

An economic evaluation on sub-optimal breastfeeding in Hong Kong: Infant health outcomes and costs.

This study estimated the healthcare cost savings for the government due to the prevention of gastroenteritis (GE) infections and lower respiratory tract infections (LRTI) in the first year of life, attributed to an increase in the exclusive breastfeeding rate at 4 months in Hong Kong. The model used the best available data inputs, with uncertainty considered using probabilistic sensitivity analysis. We additionally assessed the impact of neonatal jaundice (NNJ) on the economic benefits of increasing exclusive breastfeeding rates. During 2010-2019, five admissions for GE and three admissions for LRTI per 1000 births would have been prevented in the first year of life if the exclusive breastfeeding rate at 4 months increased from the actual levels (~15-30%) to 50%, resulting in annual healthcare cost savings of USD1.05 (95% CI 1.03-1.07) million/year. The cost saving would reach USD1.89 (95% CI 1.86-1.92) million/year if the exclusive breastfeeding rate at 4 months increase to 70%. However, if higher NNJ admissions during 7-90 days related to more exclusive breastfeeding are considered, the cost saving would reduce by 60%. Our findings can guide policymakers in allocating budget and resources for breastfeeding promotion in Hong Kong. The prevention of unnecessary NNJ admissions would maximise the economic benefits of exclusive breastfeeding at 4 months.

GDF15 Targeting for Treatment of Hyperemesis Gravidarum.

Nausea and vomiting during pregnancy (NVP), particularly its severe form, Hyperemesis gravidarum (HG), affects up to 70% of pregnancies and significantly impacts the quality of life for those with the condition as well as generates a great economic burden, with annual costs exceeding $1.7 billion in the United States. Despite the available treatments targeting neurotransmitters like serotonin and dopamine, many patients experience inadequate relief and suffer from severe side effects, including headaches and dizziness. Recent research has underscored the role of GDF15, a protein mainly produced by the placenta and linked to NVP symptoms. This protein, part of the TGF-β superfamily, has been implicated in appetite and weight regulation and is altered in those with HG due to specific genetic mutations. Addressing the challenges of delivering effective treatments, current innovations focus on targeting GDF15 to reduce symptoms while ensuring fetal safety. Promising therapeutic strategies include non-IgG immunotherapies, small peptide and molecule antagonists, and novel administration methods such as transdermal patches. These approaches aim to optimize dosage and reduce adverse effects. The effective development and testing of these treatments necessitate advanced animal models that closely resemble human pregnancy physiology, highlighting the need for further research and funding. This ongoing research holds significant potential to improve the clinical outcomes for HG patients and decrease the economic impact on healthcare systems, urging a dedicated response from the scientific and medical communities to advance these promising treatments.

Biologics and Biosimilars in Albania; Consumption and Costs

Biological therapies use proteins that have been produced with biological technology to generate targeted effects within the body, impact the body's immune system, and reduce inflammation at various stages. Biologics are used in the treatment of conditions such as rheumatoid arthritis, systemic lupus, ankylosing spondylitis, arthropathic psoriasis, and psoriatic arthritis. The aim of the study is to conduct a comprehensive review and analyze the market dynamics related to the use of these treatments in Albania. Methods: This is a retrospective and observational study based on FDSKSH’s data for 2023. Results: The total annual reimbursement cost for 2023 was ALL 188,208,780 (1 ALL = 0.01 USD). The average reimbursement cost per patient was ALL 209820.2679. The use of biologics and biosimilars represents 0.028% of all prescriptions and accounts for 1.56% of the total reimbursement costs for drugs. In 2023, the reimbursement cost covered by FDSKSH was 7.14% lower than in 2022. 87.17% of the patients were treated with Tumor Necrosis Factor (TNF) Inhibitors. Etanercept 25 mg (biosimilar) had the highest price reduction of 32.83% in 2024. The most expensive drug in 2023 was Secukinumab 150 mg. Biologics account for 61% of the total annual reimbursement cost, while biosimilars account for 39%. Conclusions: The prescription of biologics is lower compared to biosimilars, but they are associated with significant costs that impact the overall reimbursement costs. The prices of biologics and biosimilars were lower than those in Kosovo, Italy, Greece and will decrease in 2024. Costeconomic evaluations of the most expensive biologics and biosimilars are important for the management of financial resources.

A novel mass integration cogeneration system: Working fluid selection model and multi-criteria decision analysis

As the globe faces major difficulties such as climate change, environmental pollution, and limited energy resources, improving energy efficiency and decreasing the environmental effects of energy systems have become research priorities. A novel mass integration cogeneration (MICHP) system is proposed in this paper. In addition, a mathematical model relating the basic physical properties of the working fluid to the system's performance has been developed. R1233zd(E), R1224yd(Z), R601a, R245fa, and acetone have been chosen to be applied to the MICHP to confirm the model's accuracy. By utilizing the technique for order preference by similarity to an ideal solution, the entropy weight method, and energy, exergy, economic, and environmental analyses of the MICHP, the general efficiency of the working fluid is further explored. The results show that the intermediate heat exchanger is the largest exergy destruction equipment in the system. R601a has the highest return on investment of 0.53, and the annual operating cost is found to be proportional to the latent heat of the working fluid. R1233zd(E) has the lowest environmental impact, with a total equivalent warming impact of −4.89 × 106 kgCO2eq. The multi-criteria decision analysis of the working fluid agrees with the order of the proposed mathematical model's results, proving the model's accuracy. Consequently, the mathematical model can provide a helpful technique guide for working fluid selection in cogeneration systems.

The health and economic burden of breathlessness, Australia, 2019: a national survey.

To examine the impact of breathlessness on quality of life, health care use, productivity loss, and economic costs in Australia. National internet-based survey of Australian adults drawn from a web-based survey panel (National Breathlessness Survey). Australian adults (18 years or older), nationally representative by age group, gender, state of residence, and postcode-based socio-economic status (Index ofRelative Socioeconomic Disadvantage quintile), 13-30 October2019. Quality of life assessed with the EQ-5D 5-level version (EQ-5D-5L) and visual analogue scale (EQ-VAS), health care use, productivity loss, and societal cost, each by severity of breathlessness (modified Medical Research Council [mMRC] dyspnoea scale; mMRC grade 1: mild breathlessness; mMRC grades 2-4: clinically important breathlessness). Of 10 072 adults who completed the survey, mild breathlessness was reported by 3044 respondents (30.2%), and clinically important breathlessness by 961 (9.5%). The mean EQ-VAS score was 74.8 points (95% confidence interval [CI], 74.3-75.3 points) and the mean EQ-5D-5L score 0.846 (95% CI, 0.841-0.850) for respondents with mMRC grade 0 breathlessness; for each measure, the mean value declined with increasing severity of breathlessness (trends: each P < 0.001). Respondents with clinically important breathlessness were more likely than those with mild breathlessness to report non-urgent general practitioner visits, urgent general practitioner visits, and specialist visits (exception: mMRC scores of 4) during the preceding year. Among the 2839 respondents of working age, the likelihood of being employed declined with increasing breathlessness severity (mMRC grades 4 v 1: adjusted odds ratio, 0.34; 95% CI, 0.22-0.53). Adjusted mean annual societal cost per person was $1413 (95% CI, $1326-1501) for respondents with mMRC grade 1 breathlessness, $2065 (95% CI, $1766-2365) at mMRC grade 2, $1795 (95% CI, $1371-2218) at mMRC grade 3, and $2075 (95% CI, $1389-2762) at mMRC grade 4. Breathlessness imposes major burdens on individuals, the health care system, and the economy.

Technoeconomic analysis of solar PV electrification to remote areas of Dera Ghazi Khan: A case study

With the increase in population at an immense rate, electricity demand is growing exponentially. Researchers and policymakers are seeking alternating means of power generation to meet the load demand. These resources should be cost-effective, environmentally friendly and least carbon emissions. To mitigate the load demand Renewable Energy Sources (RES) are integrated into electrical networks. In this work, an off-grid solar photovoltaic (PV) system is designed for rural areas of Dera Ghazi Khan (DG Khan), Pakistan. These areas often lack access to reliable grid power. Installing PV systems in these areas can help provide a reliable source of electricity, reduce reliance on fossil fuels, and improve living conditions. This case study is simulated using PVsyst 7.2. of Roonghan village such as hospitals, shops, and residential houses for techno-economic analysis of off-grid solar PV. The economic viability shows that installing off-grid solar PV in DG Khan is much cheaper. The electricity taken from the grid that's almost 80.01%is expensive. This case study helps other researchers and policymakers to mitigate the electricity requirement of remote areas located far away from the national grid. To install a transmission line, having cost $26.98 corer but using an off-grid to provide electricity to the same area is $2.16 corer. Additionally, it integrates Battery Energy Storage (BES) with Renewable Energy Sources (RES) to achieve a 5 % annual energy cost reduction and enhanced self-sufficiency, filling a gap in existing literature.

Evaluating the impact and costs of conversional or revisional metabolic bariatric surgery on obstructive sleep apnea: Insights from a French nationwide cohort

BackgroundThis study assesses the effectiveness of 5 main conversional or revisional metabolic bariatric surgery sequences after sleeve gastrectomy, adjustable gastric banding and gastric bypass on reimbursement and cost of continuous positive airway pressure therapy, the first line treatment for obstructive sleep apnea, in France. MethodsThis nationwide observational population-based cohort study analyzed data from the French National Health Insurance database. It included all patients who had undergone primary metabolic bariatric surgery in France between January 1, 2012, and December 31, 2014, and followed until December 31, 2020. The study assessed continuous positive airway pressure therapy reimbursement discontinuation and costs of reimbursed continuous positive airway pressure therapy across 5 different conversional or revisional metabolic bariatric surgery sequences. ResultsDuring follow-up, 6,396 patients underwent the following sequences: sleeve gastrectomy–gastric bypass (n = 2,400), adjustable gastric banding–sleeve gastrectomy (n = 2,277), adjustable gastric banding–gastric bypass (n = 1,173), sleeve gastrectomy–sleeve gastrectomy (n = 546), and gastric bypass–others (n =332), with a rate of obstructive sleep apnea of 15.2%, 12.4%, 15.5% 12.8%, and 9.9% in the year before conversional or revisional metabolic bariatric surgery. The rates of patients who had a discontinuation of continuous positive airway pressure were at 2 and 4 years: 41.1%, 41.9%, 46.4%, 29.3%, and 33.3%; 62.3%, 57.0%, 78.2%; 57.5%, and 44.4%, respectively. At 4 years, the mean annual costs (euros) of obstructive sleep apnea treatment per patient were significantly lower (P < .01) than the costs in the year before conversional or revisional metabolic bariatric surgery for each sequence: 526.9 ± 414.4 vs 257.4 ± 349.7; 368.0 ± 247.5 vs 230.9 ± 288.4; 433.7 ± 326.0 vs 116.8 ± 238.3; 540.7 ± 275.3 vs 248.0 ± 308.4 and 501.2 ± 254.0 vs 281.1 ± 287.0, respectively. ConclusionsOur study underscore the effectiveness of conversional or revisional metabolic bariatric surgery in significantly reducing the need and associated costs of continuous positive airway pressure therapy for patients with obstructive sleep apnea postprimary metabolic bariatric surgery over a 4-year period.

Lacking knowledge or lacking support? An informed choice study of support for mileage fees as an alternative to gas taxes

Governing bodies are continuing to research, conduct pilot programs, and adopt policy for mileage fees as alternatives to the gas tax, yet public support remains critically low. Lack of support generally stems from assumptions that mileage fees will cost more, be inequitable for rural and low-income households, and will impede privacy through invasive mileage collection. In this study, we assess the extent to which these perceptions of mileage fees, which ultimately shape policy opinion formation, are related to low levels of information or lacking information. We also evaluate the unique aspects of policy opinion formation, including engagement with both individual and aggregate ideologies and material self-interests. Our survey instrument encourages issue engagement through iterative voting and educational experiences, through which we see information has a statistically significant effect on policy opinions and changes what we think we know about public support for mileage fees. Across the educational experiences, which include policy-relevant information provided through videos and tailored annual cost calculations for the policy alternatives, 24% of respondents changed their opinion by the end of the study, and 44% changed their opinion at least once during the study. We conclude with suggestions for public opinion polling around controversial policies that apply to both researchers and practitioners looking to engage with their constituents.

PCM as an energy flexibility asset: How design and operation can be optimized for heating in residential buildings?

In cold climates, residential buildings are often well-insulated to reduce heating costs but may lead to overheating. Incorporating Phase Change Material (PCM) into building envelope can serve as an effective measure to mitigate overheating and reduce cooling costs. However, the inappropriate incorporation of PCM in well-insulated building envelope might negatively affect the heating energy flexibility. Therefore, this paper explores the effectiveness of PCM in reducing heating costs by optimizing the PCM design and heating operation. The main objectives are to (i) quantify the performance of PCM in terms of overheating and cost savings, aligned with the recently introduced Time-of-Use (ToU) tariff and Spot pricing, (ii) identify the optimal design of PCM-incorporated building envelope, and (iii) apply a smart control with resetting temperature setpoints in-line with EN-ISO 52120-1 Standard. A multi-stage optimization process has been designed. It first identifies the optimal properties (i.e., melting temperature), position, and thickness of PCM. Secondly, it optimizes the profile of temperature setpoints, considering the seasonal thermal behavior of PCM. Co-simulation platform between IDA ICE 5.0 and Python 3.8 optimization engine is created for the heating control optimization. Results showed that PCM is more effective when incorporated into the interiors of external walls rather than in roofs. The optimal PCM design for Nordic buildings, featuring 75 mm-thick PCM with a melting temperature of 21 °C positioned within walls’ interior, has a varied impact on monthly energy savings across seasons, with a negative effect in spring and a significant positive effect in autumn. After the multi-stage optimization, the optimal scenario enables to achieve a maximum annual cost savings of 6.5 % with ToU tariff and 21.0 % with Spot pricing, while also eliminating overheating.

Mechanism analysis and performance comparison of extractive distillation with different extractants for separating methyl tert-butyl ether/methanol mixture

Methyl tert-butyl ether (MTBE) is an important chemical raw material and fuel additive commonly used in the chemical industry and can form minimum boiling azeotrope with methanol (MeOH). In this article, extractive distillation processes with common-extractant (diethylene glycol, DG), counter-extractant (chlorobenzene, CB) and ionic liquid ([MIM][HSO4]) for the separation of MTBE and MeOH binary azeotrope are investigated simultaneously for the first time. Moreover, five quantum chemical calculation methods of σ-profiles, electrostatic potential, interaction energy, Hirshfeld surface and weak interaction are used simultaneously for the first time to reveal the extractive distillation mechanism of different extractants in detail. Finally, three extractive distillation processes (CED-IL, CED-DG, CED-CB) are established and optimized with total annual costs (TAC) and CO2 emissions as objectives. Their performances are comprehensively compared from the aspects of economy, environment, energy, exergy and inherent safety under the optimal conditions. The results demonstrate that, in comparison to the CED-DG process, the CED-IL process reduces TAC by 31.0%, total energy consumption (TEC) and gas emissions by 27.7%, process route index (PRI) by 36.4% and increase thermodynamic efficiency by 46.4%, while the CED-CB process increases TAC by 29.1%, TEC and gas emissions by 23.2%, PRI by 22.1% and reduce thermodynamic efficiency by 11.4%.

Evaluation and Optimization of Hybrid Renewable Energy Systems for Sustainable Farm Machinery Operations in Northern Nigeria

This study aimed to assess and optimize hybrid renewable energy systems (HRES) integrating solar and wind energy for sustainable farm machinery operations in Northern Nigeria. A purposive sampling technique was used to select representative farms and agricultural sites within the Kaduna region. Qualitative data were collected through interviews and surveys with farm owners and operators to gain insights into energy use practices, challenges, and perceptions regarding renewable energy adoption. The comparative analysis of different HRES configurations revealed that Configuration C, with the highest solar (20 kW) and wind capacities (15 kW), achieved the highest renewable energy fraction of 90% and the lowest annual cost of $14,800. Configuration B, with increased capacities (15 kW solar and 10 kW wind) and a battery capacity of 200 kWh, achieved an 85% renewable fraction and reduced the annual cost to $16,200. The cost-benefit analysis confirmed that HRES are economically viable and offer significant environmental advantages compared to conventional diesel generators. These findings underscore the potential for optimizing energy resources to achieve higher renewable energy fractions and lower operational costs. The study provides practical recommendations for promoting HRES adoption, highlighting the necessity for financial support, technical training, and robust policy frameworks to facilitate the transition towards sustainable energy solutions in agriculture.

Indoor Environment Design and Energy Saving Analysis of Sustainable Development Integrated with Green Building

Modern architectural design has gradually distanced itself from the actual living needs of urban residents in the process of pursuing the integration of architecture and nature. To achieve the perfect combination of sustainable ecological concepts and effective energy utilization, green buildings have become an actively pursued design concept. Unlike relying solely on high-tech means, the core goal of green buildings is to build an environmentally friendly building environment by achieving sustainable and efficient utilization of energy and resources. In the design phase, green buildings should focus on functionality and economy, and be tailored to the local economic conditions, regional characteristics, natural resources, and climate conditions of the building's location to create green buildings with unique architectural and regional characteristics. This article endeavors to furnish both theoretical underpinnings and practical directives for the indoor environment design and energy conservation efforts of green buildings. By delving into the pivotal role of indoor environments as an essential architectural component, it integrates sustainable development principles with green building practices and delves into the intricate relationship between indoor environment design and energy efficiency, thus offering valuable insights and guidance for achieving sustainable and energy-efficient indoor spaces. In this process, this article examines the energy and resource utilization benefits that green building design can achieve, as well as the specific impact of indoor environment improvement on the quality of life of residents. Through an in-depth analysis of these aspects, this article aims to provide substantial contributions to achieving the sustainable development goals of green buildings. The experimental comparison results show that in terms of natural ventilation design, compared to mechanical ventilation, the proposed scheme can achieve an annual energy cost savings of 20%.

Optimal integration of PV generators and D-STATCOMs into the electrical distribution system to reduce the annual investment and operational cost: A multiverse optimization algorithm and matrix power flow approach

In this work, we address the problem of optimally integrating photovoltaic distributed generators (PV) and distributed static compensators (D-STATCOMs) in distributed electrical systems (DES). Previous methods have struggled with the complexities of non-linear mathematical models and the integration of operating and investment costs while meeting the operational constraints of these devices. We propose a solution using a master-slave methodology that combines a discrete-continuous version of the multiverse optimization algorithm (MVO), with a matrix power flow method based on successive approximation (MAX). This approach aims to reduce annual costs by efficiently managing the grid’s operating costs and the investment and operational costs of PV and D-STATCOMs. Various researchers have suggested methodologies for solving the problem of optimal D-STATCOM integration in DES, focusing on minimizing investment and operating costs as the objective function. However, these studies often lack comparative methodologies and statistical analysis to validate the performance of their proposed approaches. Additionally, they do not consider the impact of variable power demand. We compared our methodology with other master-slave approaches that utilize different optimization algorithms, including the vortex search algorithm (VSA), crow search algorithm (CSA), a continuous genetic algorithm (GA), and the particle swarm optimization algorithm (PSO). These comparisons were made using two test systems with 33 and 69 nodes, which incorporate variations in power demand and PV production from a region in Colombia. Our statistical analysis included evaluations of the best and average solutions, standard deviations, differences between the best and average solutions, and a dispersion analysis using box-and-whisker plots. The results demonstrate that MVO outperforms other methods, providing the best results with reduced processing times in both test systems.