Increased knee osteoarthritis risk in patients with unilateral lower extremity limb loss is attributed to increased intact limb loading. Modulating powered ankle prosthesis push-off power may be an effective way to modulate intact limb loading. We examined how changes in the parameter settings of a commercial prosthetic ankle affect power delivery during push-off and the resulting collisional work experienced by the intact limb in persons with unilateral lower extremity limb loss. Five subjects with unilateral transtibial amputation were fitted with a commercially available powered ankle prosthesis (Ottobock Empower). Subjects walked on a treadmill in seven conditions, where ankle power delivery settings were adjusted using methods accessible to clinicians. Kinetics and kinematics data were collected. Standard adjustment of parameter settings within the prosthetic foot did not alter timing of peak prosthesis power or intact limb collisional work but did have a significant effect on the magnitude of positive prosthesis ankle work. Increased prosthesis work did not decrease intact limb collisional work as predicted. Altering the parameter settings on a commercial powered ankle prosthesis affected the magnitude, but not the timing, of power delivered. Increased prosthesis push-off power did not decrease intact limb loading.