To reliably measure multiple spatio-temporal distribution parameters of fragments in the blast field, a measurement method for spatio-temporal distribution of fragments based on a high-speed camera network is proposed. The method is based on the principle of binocular stereo vision measurement and consists of four steps: fragment image acquisition, target detection of multi-view images, fitting of motion trajectory, and calculation of the spatio-temporal distribution parameters. The test results demonstrate that the method can simultaneously measure multiple parameters in the intersecting field of view. Compared with the measurement results of the array target, the absolute value of the measurement relative error of velocity was less than 1.5%, and the measurement results of scatter angle and distribution density were consistent. It indicates that the measurement results of the proposed method are reliable, and the method is a feasible and effective measurement method for spatio-temporal distribution parameters of fragments in the explosion filed.