In this study, a comprehensive assessment of disaster hazards in Elazığ province, where the Eastern Anatolian Fault Zone passes through, was conducted. Hazard maps for earthquakes, floods, landslides, rockfalls, avalanches, desertification, and erosion were integrated to create a multi-hazard map. Various methods, such as the Analytic Hierarchy Process (AHP) and machine learning models, including the Random Forest algorithm, were employed to assess the severity and probability of exposure for each hazard type. Independent variables, including VS30, liquefaction potential, Digital Elevation Model (DEM)-derived data, and climatic data, were selected based on relevant literature and the study area. For earthquake and erosion hazards, intuitive models were used due to the absence of a single dependent variable. The desertification map was obtained from the Ministry of Environment, Urban Planning, and Climate Change. The Random Forest model was used for other disaster hazard maps. All hazard maps were combined using a hierarchical approach with the Weighted Overlay tool. The study generated a spatial synthesis and database intended to offer proactive insights into disaster preparedness, optimizing resource allocation, and expediting recovery efforts post-disaster within the Elazığ Province. Its primary objective is to provide assistance to local authorities and emergency response teams. In the province, a significant portion of urban settlements and the majority of rural areas face high earthquake hazards. Floods pose a considerable risk, particularly in low-lying areas downstream of numerous dams scattered across the province, as well as at the confluence points of seasonal riverbeds. The hazard of landslides is high in the rugged areas along the EAF and in steep terrains eroded by rivers. Moreover, rock falls occur more frequently in mountainous areas along the Hazarbaba-Akdağ axis due to erosion and physical dissolution. Erosion and desertification represent significant slow-moving hazards, with erosion intensifying on steep slopes and barren lands, while desertification notably affects Baskil and its surrounding low-lying areas in the western part of the province. Considering multiple hazards, areas with concentrated settlements and economic activities such as Elazığ, Baskil, Kovancılar, Karakoçan, and Behrimaz plains are categorized as very high and high-risk zones.