<i>Background: </i>in increased LV afterload as in hypertension, early systolic LV dysfunction (SD) in late compares to early peak systolic LV load for P-V area, stroke work, potential energy with effective LV work (EW) is not being defined (aortic stenosis, arterial hypertension or coarctation of the aorta) in LVH remodeling. <i>Objectives:</i> to assess in porcine model how LV stroke work, PVA and EW are related to LVH remodeling in developing early SD with HF, between 4<sup>th</sup> vs 8<sup>th</sup> week in chronic LL compares to EL. It is suggested that reduced proximal thoracic or asc. aortic compliance results with myocardial ischemia. However, difference for LV O<sub>2</sub> demand and effective LV work in different LV afterload is not understood in early development systolic HF. <i>Methods:</i> in fourteen domestic male pigs (28±3 kg) with moderate descending aortic banding having chronic late LV load (LL=8) or ascending aortic stenosis with early systolic LV load (EL=6) SD was assessed, from PVA, in invasive LV pressure-volume loops’ measurements, at 4<sup>th</sup> vs. 8<sup>th</sup> week, to assess LV maximal ESPVR, with Millar 5Fr P-V pig-tailed conductance catheter. LV stroke work, and pressure-volume area PVA, reflecting the maximal LV O<sub>2</sub> demand were assessed in chronic LL compares to EL from nonlinear regression analysis of maximal LV end-systolic stiffness, in special software. For variance analysis, two-way repeated measures ANOVA was performed, with normality assessment. Results are means±(SEM) or medians for significant p<0.05. <i>Results: </i>LV PVA was not different, in LL compared to EL at 4<sup>th</sup> vs. 8<sup>th</sup> week. LV stroke work with effective works were not different and potential energy, neither were changed between 4<sup>th</sup> vs. 8<sup>th</sup> week. No difference was found in different LV afterload, in both indexed and absolute LVO<sub>2</sub> demand, in LL vs. EL at 4<sup>th</sup> or 8<sup>th</sup> week. Indexed PVA parameters with LV stroke work, effective work and potential energy were not different or changed in LL compares to EL between 4<sup>th</sup> vs. 8<sup>th</sup> weeks, normalized per body surface-area (in m<sup>2</sup>). <i>Conclusion:</i> Both absolute and indexed LV stroke work, potential LV energy, PVA with EW and maximum LV O<sub>2</sub> demand are not different in LL compares to EL at 4<sup>th</sup> vs. 8<sup>th</sup> week of LVH remodeling, indicating no difference in early SD development in increased late vs. early LV afterload.
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