The monitoring and analysis of the spatiotemporal distribution of anthropogenic carbon emissions is an important part of realizing China’s regional “dual carbon” goals; that is, the aim is for carbon emissions to peak in 2030 an to achieve carbon neutrality by 2060, as well as achieving sustainable development of the ecological environment. The column-averaged CO2 dry air mole fraction (XCO2) of greenhouse gas remote sensing satellites has been widely used to monitor anthropogenic carbon emissions. However, selecting a reasonable background region to eliminate the influence of uncertainty factors is still an important challenge to monitor anthropogenic carbon emissions by using XCO2. Aiming at the problems of the imprecise selection of background regions, this study proposes to enhance the anthropogenic carbon emission signal in the XCO2 by using the regional comparison method based on the idea of zoning. First, this study determines the background region based on the Open-Data Inventory for Anthropogenic Carbon dioxide (ODIAC) dataset and potential temperature data. Second, the average value of the XCO2 in the background area was extracted and taken as the XCO2 background. On this basis, the XCO2 anomaly (XCO2ano) was obtained by regional comparison method. Finally, the spatiotemporal variation characteristics and trends of XCO2ano were analyzed, and the correlations between the number of residential areas and fossil fuel emissions were calculated. The results of the satellite observation data experiments over China from 2010 to 2020 show that the XCO2ano and anthropogenic carbon emissions have similar spatial distribution patterns. The XCO2ano in China changed significantly and was in a positive growth trend as a whole. The XCO2ano values have a certain positive correlation with the number of residential areas and observations of fossil fuel emissions. The purpose of this research is to enhance the anthropogenic carbon emission signals in satellite observation XCO2 data by combining ODIAC data and potential temperature data, achieve the remote sensing monitoring and analysis of spatiotemporal changes in anthropogenic carbon emissions over China, and provide technical support for the policies and paths of regional carbon emission reductions and ecological environmental protection.