This paper introduces a new GeoAI solution to support automated mapping of global craters on the Mars surface. Traditional crater detection algorithms suffer from the limitation of working only in a semiautomated or multi-stage manner, and most were developed to handle a specific dataset in a small subarea of Mars’ surface, hindering their transferability for global crater detection. As an alternative, we propose a GeoAI solution based on deep learning to tackle this problem effectively. Three innovative features are integrated into our object detection pipeline: (1) a feature pyramid network is leveraged to generate feature maps with rich semantics across multiple object scales; (2) prior geospatial knowledge based on the Hough transform is integrated to enable more accurate localization of potential craters; and (3) a scale-aware classifier is adopted to increase the prediction accuracy of both large and small crater instances. The results show that the proposed strategies bring a significant increase in crater detection performance than the popular Faster R-CNN model. The integration of geospatial domain knowledge into the data-driven analytics moves GeoAI research up to the next level to enable knowledge-driven GeoAI. This research can be applied to a wide variety of object detection and image analysis tasks.