Analysis Of Activation Research Articles

Effects of storage on quality and function of acid-treated platelets with reduced HLA Class I surface expression.

Refractory patients need to be provided with HLA-matched platelets (PLTs), which require time-consuming cross-matching. Treatment of PLTs with citric acid leads to denaturation of the HLA Class I complexes without significant damage to the PLTs. HLA Class I depleted PLTs could alternatively be used to HLA-matched PLTs for transfusion. These PLTs have verified normal function up to 4-6 h after acid treatment. Buffy coat (BC) PLT concentrates were depleted of HLA Class I complexes by incubation in citric acid. The days after acid-treatment, surface expression of HLA Class I complexes, CD62P and CD63 were determined by flow cytometry, in addition to viability and mitochondrial membrane potential (MMP). Thromboelastography (TEG) tested PLT functionality. Expression of HLA Class I complexes was reduced by 70%-75% in acid-treated PLTs compared to untreated PLTs from day 1 through day 7. Controls and acid-treated PLTs showed insignificant loss of MMP stored for 4 days. Analysis of the residual PLT activation and viability showed no significant differences for 4 days of storage. However, the residual PLT activation potential and viability were significantly decreased in acid-treated PLTs and control PLTs after 7 days of storage. Acid treatment caused a significant decrease in the TEG variable, reaction time (R time), for acid-treated PLTs as compared to control PLTs from days 1 through day 3. Our data suggest that extended storage of acid-treated PLTs is possible and will improve flexibility when planning for transfusion of patients with alloimmune PLT refractoriness caused by anti-HLA-antibodies.

Understanding of the Fate of α-Fe2O3 in CO2 Hydrogenation through Combined Time-Resolved In Situ Characterization and Microkinetic Analysis

CO2 hydrogenation over Fe-based catalysts is a promising pathway to mitigate emissions of this greenhouse gas and provides a possibility for crude-oil-free production of chemicals and fuels. Understanding of (i) the role of crystalline phases or/and surface species in the working catalysts, (ii) the factors affecting their formation under reaction conditions, and (iii) the kind and reactivity of surface precursors of gas-phase products is vital for controlling the efficiency of CO2 hydrogenation. In this study, we applied time-resolved in situ characterization techniques for monitoring phase transformations during Fe2O3 reduction, starting of CO2 hydrogenation, steady-state operation, and finally catalyst deactivation. The obtained structural information after different times on stream was related to kinetic data obtained from temporal analysis of H2 and CO2 activation as well as from steady-state isotopic transient kinetic analysis (SSITKA). Fe2O3 is easily reduced to Fe3O4 and Fe in H2 above 300 °C. Fe5C2 and Fe3C, which are quickly formed from metallic Fe/Fe3O4 under CO2 hydrogenation conditions, do not undergo oxidation with rising time on the reaction stream under ambient-pressure conditions. Nevertheless, the catalyst loses its initial activity and, particularly, the selectivity to hydrocarbons in favor of CO. Thus, we do not confirm the well-recognized deactivation mechanism of CO/CO2 hydrogenation through oxidation of iron carbides. Instead, surface carbonaceous species identified by in situ Raman and pseudo in situ XPS measurements were concluded to cause catalyst deactivation and deselectivation due to hindering the catalyst ability to generate surface species from H2 and CO2. Specifically, the strength of CO2 adsorption and the catalyst activity to dissociate adsorbed CO2 to adsorbed CO decrease in the presence of carbon deposits. Kinetic evaluation of SSITKA tests revealed the presence of (i) only one kind of surface intermediate yielding gas-phase CO after 1.5 h on reaction stream but (ii) at least two kinds (short-lived and long-lived) of surface intermediates participating in CH4 formation in parallel. Carbon deposits seem to block the sites responsible for the formation of short-lived intermediates.

Overview and prospects of an in vitro cell model for studying liver fibrosis

Liver fibrosis incidence and adverse outcomes are high; however, there are no known chemical drugs or biological agents that are specific and effective for treatment. The paucity of a robust and realistic in vitro model for liver fibrosis is one of the major causes hindering anti-liver fibrosis drug development. This article summarizes the latest progress in the development of in vitro cell models for liver fibrosis, with a focus based on the analysis of induction and activation of hepatic stellate cells, cell co-culture, and 3D model co-construction, as well as concurrent potential methods based on hepatic sinusoidal endothelial cell establishment.

Novinarski diskurs na portalima i Twitteru

Mainstream media often simply download information posted on social media from unreliable sources without critical thinking and verifying the content. Nowadays, the accuracy of information in all types of media is less important than the number of clicks and views per media content. Due to the fact that there is a proven correlation between the level of media literacy and democratic development of a society, as well as the fact that the media have a great influence on the shaping of public opinion via media framing and agendas, this paper explores the awareness on media literacy of Twitter users in Croatia (primarily journalists) and their perception of their own consumption and dissemination of fake news across social networks and traditional mass media. Although Twitter is not popular in Croatia, it is intensively used by Croatian journalists, and tweets often serve as topics for media processing, which gives Twitter great importance in creating the Croatian media discourse. The research was conducted by encouraging a discussion and undertaking further content analysis of tweets regarding the role of media literacy in combating the impact of fake news, especially on social networks. This was followed by semi-structured in-depth interviews with six journalists who are active Twitter users and content analysis of articles on media literacy and fake news available on Croatian web portals. Triangulation was used in order to reduce the echo chamber effect on the results of the study. The research has shown that respondents, i.e. Twitter users in Croatia – including journalists – are not sufficiently informed about media literacy and its impact on combating fake news. It has also pinpointed their lack of awareness regarding their own consumption and dissemination of fake news across social networks and mass media. The objective of the research was to create a model for analyzing the interrelationship between media literacy and creating fake news from two perspectives: (1) evaluating self-perception of Twitter users via content analysis and in-depth interviews, and (2) analyzing media publications on the topic of media literacy and fake news, whose content reflects the perception of the media on these topics.

Abcd1 deficiency accelerates cuprizone-induced oligodendrocyte loss and axonopathy in a demyelinating mouse model of X-linked adrenoleukodystrophy

X-linked adrenoleukodystrophy (X-ALD), the most frequent, inherited peroxisomal disease, is caused by mutations in the ABCD1 gene encoding a peroxisomal lipid transporter importing very long-chain fatty acids (VLCFAs) from the cytosol into peroxisomes for degradation via β-oxidation. ABCD1 deficiency results in accumulation of VLCFAs in tissues and body fluids of X-ALD patients with a wide range of phenotypic manifestations. The most severe variant, cerebral X-ALD (CALD) is characterized by progressive inflammation, loss of the myelin-producing oligodendrocytes and demyelination of the cerebral white matter. Whether the oligodendrocyte loss and demyelination in CALD are caused by a primary cell autonomous defect or injury to oligodendrocytes or by a secondary effect of the inflammatory reaction remains unresolved. To address the role of X-ALD oligodendrocytes in demyelinating pathophysiology, we combined the Abcd1 deficient X-ALD mouse model, in which VLCFAs accumulate without spontaneous demyelination, with the cuprizone model of toxic demyelination. In mice, the copper chelator cuprizone induces reproducible demyelination in the corpus callosum, followed by remyelination upon cuprizone removal. By immunohistochemical analyses of oligodendrocytes, myelin, axonal damage and microglia activation during de-and remyelination, we found that the mature oligodendrocytes of Abcd1 KO mice are more susceptible to cuprizone-induced cell death compared to WT mice in the early demyelinating phase. Furthermore, this effect was mirrored by a greater extent of acute axonal damage during demyelination in the KO mice. Abcd1 deficiency did not affect the function of microglia in either phase of the treatment. Also, the proliferation and differentiation of oligodendrocyte precursor cells and remyelination progressed at similar rates in both genotypes. Taken together, our findings point to an effect of Abcd1 deficiency on mature oligodendrocytes and the oligodendrocyte-axon unit, leading to increased vulnerability in the context of a demyelinating insult.

Construction of Bi2MoO6/CoWO4 Z-scheme heterojunction for high-efficiency photocatalytic degradation of norfloxacin under visible light: Performance and mechanism insights

In this work, we employed Bi2MoO6 and CoWO4 to fabricate a direct Z-scheme Bi2MoO6/CoWO4 (BMC-x) heterostructure with high redox potential for norfloxacin (NOR) photodegradation. Under visible light (λ > 420 nm) illumination, BMC-x composites displayed excellent photodegradation performance toward norfloxacin. The photodegradation rate of norfloxacin by BMC-30 reached 97.1% within 60 min of illumination, and the apparent rate constant (0.0588 min−1) was 2.42 and 17.8 times those of Bi2MoO6 and the CoWO4, respectively. The photocatalytic performance of BMC-x nanocomposites was mainly ascribed to the more efficient utilization of electrons (e−) and holes (h+) due to the fabrication of a direct Z-scheme heterostructure. In addition, the mechanisms of NOR degradation were investigated through active species capture experiments and ESR analyses, indicating that O− 2and h+ worked as primary components. Furthermore, the NOR photodegradation pathways were investigated by density functional theory (DFT) and intermediates analysis. More importantly, depending on the QSAR predictions and E.colicultivation, the comprehensive toxicity of the final intermediates was lower than that of the parent. Thus, this work offers a feasible idea for the design and construction of Z-scheme heterojunctions for the highly effective degradation of emerging contaminants in water.

Synthesis and Characterization of Novel Benzimidazolium Type NHC Molecule and Its Silver Complex and Their Theoretical Analysis for Potential Anti-Cancer Activity

N-heterocyclic carbenes have initially attracted great attention of the chemists in consequence of their catalytic activity. The favorable results were also obtained in bioactivity studies for N-heterocyclic carbenes, and their transition metal complexes in following years. Theoretical methods deliver beneficial data about the several activities of molecules. One of them is the frontier orbital analysis, which supplies data about the reactivity of molecules. Another method is investigation of the molecular activity against crystals of certain macromolecules using molecular docking methods. In this study, novel 1-allyl-3-(cyclohexylmethyl)benzimidazoliumbromide and bromo[1-allyl-3-(cyclohexylmethyl)benzimidazolium-2-ylidene]silver(I) were synthesized and characterized. The characterizations were also supported by spectroscopical and theoretical methods. In order to have foresight about the bioactivities of these molecules, molecular docking methods were used to get information about the interactions between molecules and VEGFR-2, which regulates the angiogenesis, and DNA.

Use of Adolescent "Community Researchers" to Address Obesity Among Mexican Immigrant Families.

Background: Mexican-American immigrants have a disparate prevalence of overweight/obesity, and obesogenic illness. One approach is to train immigrant adolescents as "community researchers." Aims: (1) Design a program to train community researchers to address obesity among Mexican immigrant families and (2) identify the key components of a successful program. Methods: The content included an overview of community research/citizen science; obesity and food insecurity; study design and data collection and analysis for nutrition and physical activity. The students concluded by analyzing the results of group concept mapping (GCM) activities. Results: Post-session class discussions reflected an increased understanding of weekly topics. Analysis of GCM data suggests that members of the Mexican immigrant community may use emotional eating as a way to manage structural stigma, eventually leading to truncal obesity, T2DM and increased cardiovascular risk. Conclusions: Adolescents of Mexican heritage can have a major impact in promoting healthy lifestyles in their communities.

Analysis of brain activation and wave frequencies during a sentence completion task: a paradigm used with EEG in aphasic participants.

Aphasia is a language disorder that occurs after brain injury and directly affects an individual's communication. The incidence of stroke increases with age, and one-third of people who have had a stroke develop aphasia. The severity of aphasia changes over time and some aspects of language may improve, while others remain compromised. Battery task training strategies are used in the rehabilitation of aphasics. The idea of this research is to use electroencephalography (EEG) as a non-invasive method, of electrophysiological monitoring, with a group of aphasic patients in rehabilitation process in a prevention and rehabilitation unit of the person with disabilities of the Unified Health System (SUS), of reference in the state of Bahia-Brazil. In this study, the goal is to analyze brain activation and wave frequencies of aphasic individuals during a sentence completion task, to possibly assist health professionals with the analysis of the aphasic subject's rehabilitation and task redefinition. We adopted the functional magnetic resonance imaging (fMRI) paradigm, proposed by the American Society for Functional Neuroradiology as a reference paradigm. We applied the paradigm in the group of aphasics with preserved comprehension, right hemiparesis, and left hemisphere injured or affected by stroke. We analyzed four electrodes (F3/F4 and F7/F8) corresponding to the left/right frontal cortex. Preliminary results of this study indicate a more robust activation in the right hemisphere (average of aphasics), with a difference of approximately 14% higher in Theta and Alpha frequencies, with 8% higher in low Beta (BetaL) and with approximately 1% higher in high Beta frequency (BetaH), Gamma frequency was higher by approximately 3% in the left hemisphere of the brain. The difference in electrical activation may be revealing to us a migration of language to the non-language dominant hemisphere. We point to possible evidence suggesting that EEG may be a promising tool for monitoring the rehabilitation of the aphasic subject.

Lunar active seismic profiler for investigating shallow substrates of the Moon and other extraterrestrial environments

To investigate the structures and properties of shallow material in extraterrestrial environments, we have developed a lunar active seismic profiler (LASP), which integrates active seismic sources and receivers in a short (~1 m) array that can be deployed on a rover. The small active source generates a chirp waveform that sweeps over a wide frequency range (20–250 Hz). The receivers are coupled to the ground by their own weight, but nevertheless deliver acceptable performance. We improve the signal-to-noise ratio of the seismic signal by stacking waveforms, enabling a minimal source to support the exploration of geological substrates. By processing shot gather of the LASP data, we calculated a dispersion curve of surface waves and obtained an accurate S-wave velocity profile from surface to 1 m depth. The results suggest that regions with even small amounts of subsurface ice (~0.5 wt%) can be identified in LASP results by their anomalously high S-wave velocity. Field experiments demonstrate that the LASP can support estimates of 3D S-wave velocity distributions and the identification of a buried geological boundary. The LASP also detected different degrees of compaction at the experimental site. If two rovers carry these profilers, or if a single rover combines one with a separately deployed receiver or active seismic source, seismic refraction and seismic reflection analyses can be conducted simultaneously in addition to surface wave analyses. These seismic surveys for longer-offset data achieve the exploration of deeper substrates in extraterrestrial settings such as the Moon, Mars, and other solid bodies.

Exploring the Pre-Service Teachers Experiences in Practice Teaching During Pandemic

The education system had shifted from face-to-face to online modality as a result of the COVID-19 pandemic. This shift in the educational paradigm also affected pre-service teachers in the delivery of their practice teaching. This phenomenological study explored the lived experiences of pre-service teachers in their practice teaching. Data were gathered from four student teachers during the focus group discussion using open-ended semi-structured questions. The gathered data were transcribed and analyzed using active analysis. Three themes were developed in the study; 1) Problems encountered by student teachers during practice teaching, 2) Actions taken to solve problems encountered, and 3) Reflections based on their practice teaching experiences. It is noted that the guidance of their respective cooperating teachers is necessary to bridge the gap between the expectations of the practice teachers and practice teaching as preparation for a real-world teaching career. Moreover, it necessitates support from the administration to amplify the results of pre-service students’ experiences. It is recommended the conduct exit assessments among the pre-service teachers on their experiences to further enhance programs to create more meaningful practice teaching experiences among future pre-service teachers. Keywords: Phenomenology, Practice Teaching, Pre-service Teachers, Philippines

Thesis Writing as Conduit of Behavior Transformation among Undergraduate Students

Thesis writing is one of the major requirements when completing an undergraduate degree in the Philippines. The process of conducting involves multiple phases such as proposal presentation, data collection, writing a report based on the findings, and presenting the manuscript to the panel members. Social Influence Theory was the theoretical framework of the study. The phenomenological design of qualitative research was utilized in this study to identify the behavior transformation among fourth-year students who finished their thesis writing subject. Participants were selected using a purposive sampling technique. Data were collected in an interview with the selected participants. Active analysis was utilized to determine the themes of behavior transformations. It was found that empathy, modesty, confidence, clarity, and collaboration were the transformed behavior caused by thesis writing. In conclusion, thesis writing not only enhances students’ cognitive and psychomotor skills in conducting research but it is also a conduit of behavior transformation among students. This paper recommends having an additional study utilizing in-depth interviews to further dig deeper into the impact of thesis writing. Moreover, a quantitative survey type or research may also be conducted to check behavior transformation in the majority of fourth-year students. Keywords: Behavior Transformation, Thesis writing, Phenomenological, Interview

The Stria Vascularis in Mice and Humans Is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation.

Age-related hearing loss, or presbyacusis, is a common degenerative disorder affecting communication and quality of life for millions of older adults. Multiple pathophysiologic manifestations, along with many cellular and molecular alterations, have been linked to presbyacusis; however, the initial events and causal factors have not been clearly established. Comparisons of the transcriptome in the lateral wall (LW) with other cochlear regions in a mouse model (of both sexes) of "normal" age-related hearing loss revealed that early pathophysiological alterations in the stria vascularis (SV) are associated with increased macrophage activation and a molecular signature indicative of inflammaging, a common form of immune dysfunction. Structure-function correlation analyses in mice across the lifespan showed that the age-dependent increase in macrophage activation in the stria vascularis is associated with a decline in auditory sensitivity. High-resolution imaging analysis of macrophage activation in middle-aged and aged mouse and human cochleas, along with transcriptomic analysis of age-dependent changes in mouse cochlear macrophage gene expression, support the hypothesis that aberrant macrophage activity is an important contributor to age-dependent strial dysfunction, cochlear pathology, and hearing loss. Thus, this study highlights the SV as a primary site of age-related cochlear degeneration and aberrant macrophage activity and dysregulation of the immune system as early indicators of age-related cochlear pathology and hearing loss. Importantly, novel new imaging methods described here now provide a means to analyze human temporal bones in a way that had not previously been feasible and thereby represent a significant new tool for otopathological evaluation.SIGNIFICANCE STATEMENT Age-related hearing loss is a common neurodegenerative disorder affecting communication and quality of life. Current interventions (primarily hearing aids and cochlear implants) offer imperfect and often unsuccessful therapeutic outcomes. Identification of early pathology and causal factors is crucial for the development of new treatments and early diagnostic tests. Here, we find that the SV, a nonsensory component of the cochlea, is an early site of structural and functional pathology in mice and humans that is characterized by aberrant immune cell activity. We also establish a new technique for evaluating cochleas from human temporal bones, an important but understudied area of research because of a lack of well-preserved human specimens and difficult tissue preparation and processing approaches.

Glycine Active Sites Analysis from a Geometrical Perspective: A DFT Study.

Density functional theory calculations of 2D materials and biological molecules have been used to evaluate disease progression through biosensing. In this case, a glycine molecule in normal and zwitterionic form was evaluated on its interaction with zigzag single-walled carbon nanotubes, graphene sheets, and molybdenum disulfide sheets. Glycine was rotated in order to interact with the materials at different active sites. Binding and cohesion energies, band gaps, and charge transfer for the systems were obtained. Binding and cohesion for the interaction between normal glycine and 2D materials result in better outcomes with the presence of a dangling bond using van der Waals correction, giving the more stable results for glycine and carbon nanotubes in the plane ZY and glycine with graphene in the plane YX, respectively. For zwitterion glycine, binding and cohesion energies are better without a dangling bond supported on graphene in the plane ZX. Charge transfer results for normal glycine show a better interaction for glycine and molybdenum disulfide in the plane ZY, while for zwitterion glycine, higher charge transfer is reported in graphene (ZX). Furthermore, the density of states of normal glycine exhibits an improvement in the band gap for carbon related materials (more semiconductor behavior) and a slight decrease in semiconductor behavior for molybdenum disulfide.

Impact of novel pan-RAS inhibitors on efficacy and resistance to AMG-510 and MRTX-1133 in pancreatic cancer cell lines.

4155 Background: Mutant-activated RAS genes are the most frequently mutated gene family associated with cancer (almost 30% of all cancers contain a mutant RAS gene). KRAS is the predominant isoform mutated in cancer and is the isoform exclusively mutated in pancreatic ductal carcinoma (PDAC). Since almost all PDAC cases harbor a mutant RAS, it is arguably the most RAS-addicted tumor type. There is now considerable evidence implicating mutant KRAS as a driver of PDAC. Recently, several mutant KRAS-targeted therapies (sotorasib and adagrasib) have been developed and show promise in PDAC patients. We have developed a direct inhibitor of RAS with a predicted unique interaction region capable of directly binding to wild-type H- and K-RAS, but which shows preferential binding for KRAS G12D and G12C mutants. This novel inhibitor disrupts the RAS effector domain and blocks the ability of RAS to signal through its effectors. Methods: We used in silico virtual library screening to identify an initial candidate inhibitor which was effective at inhibiting the 3D growth of PDAC cells without affecting their growth in 2D. Subsequent iterative rounds of medicinal chemistry was then performed to identify a series of derivatives with enhanced activity, as determined by 3D growth inhibition assays and effects on Ras signaling, as determined by Western blot analysis of phosphor-ERK, phosphor-Akt and activation of Ral A. Results: Our series of RAS inhibitors effectively block PDAC cell growth in 3D without impacting their 2D proliferation and suppress the interaction of KRAS with its effector cRAF. The inhibitors also effectively inhibit RAS signaling in mutant RAS containing PDAC cells. Since our novel compounds are predicted to bind to RAS at a different site to either AMG-510 (G12C specific inhibitor) and MRTX-1133 (G12D specific inhibitor), we tested the co-operativity of our compounds with these existing agents. Our compounds enhanced the anti-proliferative effects of both MRTX-113 and AMG-510 in mutant KRAS G12D and G12C PDAC cells, respectively. Conclusions: We have developed a series of novel RAS inhibitors that directly bind preferentially to mutant KRAS that may serve as new mutant KRAS-targeted therapeutics, and that may also have the potential to enhance the efficacy or suppress the resistance of AMG-510 and MRTX-1133.

Decipher the pharmacological mechanisms of raw and wine-processed Curculigo orchioides Gaertn. on bone destruction in rheumatoid arthritis rats using metabolomics.

Curculigo orchioides Gaertn. (CO), a traditional Chinese herb recorded in Chinese Pharmacopoeia, can nourish kidney yang, strengthen bones, and dispell cold-dampness. Raw CO (rCO) and wine-processed CO (pCO), the main processed products of CO for clinical application, show differences in nourishing kidney yang and ameliorate osteoporosis. However, the difference in efficacy and mechanism of rCO and pCO on bone destruction in rheumatoid arthritis (RA) remain unclear. To compare the pharmacodynamics of rCO and pCO in the treatment of bone destruction in RA and to reveal the potential mechanism by which rCO and pCO exert effects by metabolomics approach. Ultra-high performance liquid chromatography Q exactive mass spectrometry (UHPLC-Q-Exactive-MS) combined with multivariate data analysis was applied to identify the differential chemical components in rCO and pCO. Collagen-induced arthritis (CIA) rats were orally administrated with different doses of rCO and pCO for 4 weeks. The body weight, paw swelling, arthritis scores, serum inflammatory cytokines concentration, knee tumor necrosis factor (TNF)-α, interleukin (IL)-6 protein levels, and inflammatory cell infiltration were determined to investigate the effects of rCO and pCO on arthritic symptoms and inflammatory responses in CIA rats. The effects of rCO and pCO on bone destruction were assessed using safranin O-fast green and tartrate-resistant acid phosphatase (TRAP) staining, immunohistochemical analysis of osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) proteins, and micro-computed tomography (micro-CT) in rats. In addition, metabolomics was performed to explore the mechanism of rCO and pCO against bone destruction in RA. A total of 41 chemical constituents were identified in both rCO and pCO, 9 of which were screened out as discriminatory compounds. According to the pharmacodynamic assays, pCO exhibited a stronger effect than rCO in attenuating the severity of arthritis, reducing inflammation, and inhibiting bone destruction. The metabolomics results showed that pentose phosphate pathway was the key metabolic pathways regulated by rCO, while pCO regulated multiple metabolic pathways including phenylalanine metabolism pathways, phenylalanine, tyrosine and tryptophan biosynthesis, taurine and hypotaurine metabolism, and glycerophospholipid metabolism pathways. pCO displayed a better effect on alleviating bone destruction in RA was than rCO. This might be associated with that pCO can decrease inflammation in RA through regulating more metabolism pathways.

The influence of entrepreneurial capability and innovation capability on sustainable organization performance: Evidence of community enterprise in Thailand

The purpose of this study is to examine the influence of entrepreneurial capability and innovation capability on sustainable organization performance, as well as to explore the role of innovation capability as a mediator in the relationship between entrepreneurial capability and sustainable organization performance. Using questionnaires to collect data from community enterprises in Phuket, Thailand. The respondents were presidents and vice-presidents of their respective community enterprises. The analysis was conducted using (AMOS-SEM) approach. The results reveal that entrepreneurial capability plays a robust role in promoting innovation capability and sustainable organization performance. Furthermore, innovation capability has a positive influence on sustainable organization performance. Additionally, innovation partially mediates the relationship between entrepreneurial capability and sustainable organization performance. Entrepreneurial capability (EC) is influenced by several key factors, including Leadership and Management, Active Learning and Analysis, and Passion and Self-Achievement. These elements contribute to an individual's ability to identify and capitalize on opportunities, drive innovation, and create value in their ventures. While Innovation capability (IC) is determined by Management Potential, Process Potential, and Technology Potential. Sustainable Organization Performance (SOP) is measured by Economic Performance, Social Performance, and Environmental Performance. Consequently, the results of this research provide guidelines for policymakers to create an enabling environment for community enterprises to thrive, promote entrepreneurship and innovation, and contribute to sustainable organization performance.

Probing the Ononin and Corylin molecules against anti-influenza H1N1 A virus: a detailed active site analysis

Probing the Ononin and Corylin molecules against anti-influenza H1N1 A virus: a detailed active site analysis

Influence of displacement sensor runout on active magnetic bearing-rotor system and control analysis

In the active magnetic bearing (AMB)-rotor system, a displacement sensor is one of the indispensable components. It detects the displacement of the rotor in real time and feeds back to the control system to realize the stable suspension of the rotor. However, due to electromagnetic interference, unstable power supply, poor grounding, and uneven rotor surface, the signal runout of the displacement sensor can often occur, resulting in rotor vibration. Given the above problems, this paper establishes the control model of the AMB-rotor system, lists three typical sensor runout signals, then analyzes the influence of different types of sensor runout on the system, and discusses the control methods under different sensor runout conditions. The research results have a specific guiding significance for vibration control of the maglev rotor under sensor runout influence.

A Study of the Ordinal Scale Classification Algorithm for Cyber Threat Intelligence Based on Deception Technology

Cyber deception technology plays an important role in monitoring attackers’ activities and detecting new attack types. However, in a deceptive environment, low-risk attack traffic, such as scanning, is included in large quantities and acts as noise. Therefore, even though high-risk traffic is actually present, it may be overlooked, or the analysis algorithm’s accuracy regarding traffic may be reduced, causing significant difficulties in intrusion detection and analysis processes. In this study, we propose a model that can identify and filter the ordinal scale risk of the source IP in deceptive environment-generated traffic. This model aims to quickly classify low-risk attacks, including information gathering and scanning, which are widely and repeatedly performed, as well as high-risk attacks, rather than classifying specific types of attacks. Most existing deceptive technology-based Cyber Threat Intelligence (CTI) generation studies have been limited in their applicability to real-world environments because data labeling, learning, and detection processes using AI algorithms that consume significant amounts of time and computing resources. Here, the Naive Bayes discriminant analysis-based ordinary scale classification model showed higher accuracy for low-risk attack classification, while consuming significantly fewer resources than the models presented in other studies do. The accuracy of the current active deceptive environment traffic analysis research may be enhanced by filtering low-risk traffic via preprocessing.