Amusic Brain Research Articles

Explicit processing of melodic structure in congenital amusia can be improved by redescription-associate learning

Congenital amusia is a neurodevelopmental disorder of musical processing. Previous research demonstrates that although explicit musical processing is impaired in congenital amusia, implicit musical processing can be intact. However, little is known about whether implicit knowledge could improve explicit musical processing in individuals with congenital amusia. To this end, we developed a training method utilizing redescription-associate learning, aiming at transferring implicit representations of perceptual states into explicit forms through verbal description and then establishing the associations between the perceptual states reported and responses via feedback, to investigate whether the explicit processing of melodic structure could be improved in individuals with congenital amusia. Sixteen amusics and 11 controls rated the degree of expectedness of melodies during EEG recording before and after training. In the interim, half of the amusics received nine training sessions on melodic structure, while the other half received no training. Results, based on effect size estimation, showed that at pretest, amusics but not controls failed to explicitly distinguish the regular from the irregular melodies and to exhibit an ERAN in response to the irregular endings. At posttest, trained but not untrained amusics performed as well as controls at both the behavioral and neural levels. At the 3-month follow-up, the training effects still maintained. These findings present novel electrophysiological evidence of neural plasticity in the amusic brain, suggesting that redescription-associate learning may be an effective method to remediate impaired explicit processes for individuals with other neurodevelopmental disorders who have intact implicit knowledge.

Talker normalization in typical Cantonese-speaking listeners and congenital amusics: Evidence from event-related potentials.

Despite the lack of invariance in the mapping between the acoustic signal and phonological representation, typical listeners are capable of using information of a talker's vocal characteristics to recognize phonemes, a process known as “talker normalization”. The current study investigated the time course of talker normalization in typical listeners and individuals with congenital amusia, a neurodevelopmental disorder of refined pitch processing. We examined the event-related potentials (ERPs) underling lexical tone processing in 24 Cantonese-speaking amusics and 24 typical listeners (controls) in two conditions: blocked-talker and mixed-talker conditions. The results demonstrated that for typical listeners, effects of talker variability can be observed as early as in the N1 time-window (100–150 ms), with the N1 amplitude reduced in the mixed-talker condition. Significant effects were also found in later components: the N2b/c peaked significantly earlier and the P3a and P3b amplitude was enhanced in the blocked-talker condition relative to the mixed-talker condition, especially for the tone pair that is more difficult to discriminate. These results suggest that the blocked-talker mode of stimulus presentation probably facilitates auditory processing and requires less attentional effort with easier speech categorization than the mixed-talker condition, providing neural evidence for the “active control theory”. On the other hand, amusics exhibited comparable N1 amplitude to controls in both conditions, but deviated from controls in later components. They demonstrated overall later N2b/c peak latency significantly reduced P3a amplitude in the blocked-talker condition and reduced P3b amplitude irrespective of talker conditions. These results suggest that the amusic brain was intact in the auditory processing of talker normalization processes, as reflected by the comparable N1 amplitude, but exhibited reduced automatic attentional switch to tone changes in the blocked-talker condition, as captured by the reduced P3a amplitude, which presumably underlies a previously reported perceptual “anchoring” deficit in amusics. Altogether, these findings revealed the time course of talker normalization processes in typical listeners and extended the finding that conscious pitch processing is impaired in the amusic brain.

Normal pre-attentive and impaired attentive processing of lexical tones in Cantonese-speaking congenital amusics

The neural underpinnings of congenital amusia, an innate neurogenetic disorder of musical pitch processing, are not well understood. Previous studies suggest that amusia primarily impairs attentive processing (P300) of small pitch deviations in music, leaving pre-attentive pitch processing (mismatch negativity or MMN) more or less intact. However, it remains unknown whether the same neuro-dynamic mechanism of deficiency underlies pitch processing in speech, where amusics also often show impairment behaviorally. The current study examined how lexical tones are processed in pre-attentive (MMN) and attentive (P300) conditions in 24 Cantonese-speaking amusics and 24 matched controls. At the pre-attentive level, Cantonese-speaking amusics exhibited normal MMN responses to lexical tone changes, even for tone pairs with small pitch differences (mid level vs. low level tone; high rising vs. low rising tone). However, at the attentive level, amusics exhibited reduced P3a amplitude for all tone pairs, and further reduced P3b amplitude for tone pairs with small pitch differences. These results suggest that the amusic brain detects tone changes normally pre-attentively, but shows impairment in consciously detecting the same tone differences. Consistent with previous findings in nonspeech pitch processing, this finding provides support for a domain-general neuro-dynamic mechanism of deficient attentive pitch processing in amusia.

Functional neural changes associated with acquired amusia across different stages of recovery after stroke

Brain damage causing acquired amusia disrupts the functional music processing system, creating a unique opportunity to investigate the critical neural architectures of musical processing in the brain. In this longitudinal fMRI study of stroke patients (N = 41) with a 6-month follow-up, we used natural vocal music (sung with lyrics) and instrumental music stimuli to uncover brain activation and functional network connectivity changes associated with acquired amusia and its recovery. In the acute stage, amusic patients exhibited decreased activation in right superior temporal areas compared to non-amusic patients during instrumental music listening. During the follow-up, the activation deficits expanded to comprise a wide-spread bilateral frontal, temporal, and parietal network. The amusics showed less activation deficits to vocal music, suggesting preserved processing of singing in the amusic brain. Compared to non-recovered amusics, recovered amusics showed increased activation to instrumental music in bilateral frontoparietal areas at 3 months and in right middle and inferior frontal areas at 6 months. Amusia recovery was also associated with increased functional connectivity in right and left frontoparietal attention networks to instrumental music. Overall, our findings reveal the dynamic nature of deficient activation and connectivity patterns in acquired amusia and highlight the role of dorsal networks in amusia recovery.

Altered intrinsic connectivity of the auditory cortex in congenital amusia.

Congenital amusia, a neurodevelopmental disorder of music perception and production, has been associated with abnormal anatomical and functional connectivity in a right frontotemporal pathway. To investigate whether spontaneous connectivity in brain networks involving the auditory cortex is altered in the amusic brain, we ran a seed-based connectivity analysis, contrasting at-rest functional MRI data of amusic and matched control participants. Our results reveal reduced frontotemporal connectivity in amusia during resting state, as well as an overconnectivity between the auditory cortex and the default mode network (DMN). The findings suggest that the auditory cortex is intrinsically more engaged toward internal processes and less available to external stimuli in amusics compared with controls. Beyond amusia, our findings provide new evidence for the link between cognitive deficits in pathology and abnormalities in the connectivity between sensory areas and the DMN at rest.

Altered retrieval of melodic information in congenital amusia: insights from dynamic causal modeling of MEG data.

Congenital amusia is a neuro-developmental disorder that primarily manifests as a difficulty in the perception and memory of pitch-based materials, including music. Recent findings have shown that the amusic brain exhibits altered functioning of a fronto-temporal network during pitch perception and short-term memory. Within this network, during the encoding of melodies, a decreased right backward frontal-to-temporal connectivity was reported in amusia, along with an abnormal connectivity within and between auditory cortices. The present study investigated whether connectivity patterns between these regions were affected during the short-term memory retrieval of melodies. Amusics and controls had to indicate whether sequences of six tones that were presented in pairs were the same or different. When melodies were different only one tone changed in the second melody. Brain responses to the changed tone in “Different” trials and to its equivalent (original) tone in “Same” trials were compared between groups using Dynamic Causal Modeling (DCM). DCM results confirmed that congenital amusia is characterized by an altered effective connectivity within and between the two auditory cortices during sound processing. Furthermore, right temporal-to-frontal message passing was altered in comparison to controls, with notably an increase in “Same” trials. An additional analysis in control participants emphasized that the detection of an unexpected event in the typically functioning brain is supported by right fronto-temporal connections. The results can be interpreted in a predictive coding framework as reflecting an abnormal prediction error sent by temporal auditory regions towards frontal areas in the amusic brain.

Chapter 33 - Congenital amusias

In contrast to the sophisticated music processing reported in the general population, individuals with congenital amusia show deficits in music perception and production. Congenital amusia occurs without brain damage, sensory or cognitive deficits, and has been suggested as a lifelong deficit with genetic origin. Even though recognized for a long time, this disorder has been systematically studied only relatively recently for its behavioral and neural correlates. The currently most investigated hypothesis about the underlying deficits concerns the pitch dimension, notably with impaired pitch discrimination and memory. Anatomic and functional investigations of pitch processing revealed that the amusic brain presents abnormalities in the auditory and inferior frontal cortices, associated with decreased connectivity between these structures. The deficit also impairs processing of pitch in speech material and processing of the time dimension in music for some of the amusic individuals, but does not seem to affect spatial processing. Some studies suggest at least partial dissociation in the disorder between perception and production. Recent studies revealed spared implicit pitch perception in congenital amusia, supporting the power of implicit cognition in the music domain. Current challenges consist in defining different subtypes of congenital amusia as well as developing rehabilitation programs for this "musical handicap."

Training Mandarin-speaking amusics to recognize pitch direction: Pathway to treat musical disorders in congenital amusia?

Congenital amusia is a lifelong disorder of musical perception and production that has been hypothesized as due to impaired pitch direction recognition. This study investigated whether amusics could be trained to identify pitch direction in speech and music, and if so, whether enhanced pitch direction recognition would benefit musical processing in amusia. Eighteen Mandarin-speaking amusics and 18 matched controls were evaluated using the Montreal Battery of Evaluation of Amusia (Peretz et al., 2003) and tested on two psychophysical pitch threshold tasks for identification of pitch direction in the Mandarin syllable /ma/ and its piano tone analog. Subsequently, nine of the eighteen amusics undertook a 10-session training program on pitch direction identification in /ma/ and piano tone. Compared with those untrained, trained amusics demonstrated significantly improved thresholds for pitch direction identification in speech syllables [pretest: 2.92 (4.63) semitones; posttest: 0.16 (0.06)], and marginally significant improvement in pitch direction identification thresholds for piano tones [pretest: 5.20 (4.56); posttest: 0.89 (1.46)]. These findings suggest that pitch sensitivity of individuals with congenital amusia could be improved through auditory training, providing evidence for neural plasticity in the amusic brain, which may lead the way to other rehabilitative programs for treating this musical disorder.

Electrophysiological correlates of melodic processing in congenital amusia

Music listening involves using previously internalized regularities to process incoming musical structures. A condition known as congenital amusia is characterized by musical difficulties, notably in the detection of gross musical violations. However, there has been increasing evidence that individuals with the disorder show preserved musical ability when probed using implicit methods. To further characterize the degree to which amusic individuals show evidence of latent sensitivity to musical structure, particularly in the context of stimuli that are ecologically valid, electrophysiological recordings were taken from a sample of amusic and control participants as they listened to real melodies. To encourage them to pay attention to the music, participants were asked to detect occasional notes in a different timbre. Using a computational model of auditory expectation to identify points of varying levels of expectedness in these melodies (in units of information content (IC), a measure which has an inverse relationship with probability), ERP analysis investigated the extent to which the amusic brain differs from that of controls when processing notes of high IC (low probability) as compared to low IC ones (high probability). The data revealed a novel effect that was highly comparable in both groups: Notes with high IC reliably elicited a delayed P2 component relative to notes with low IC, suggesting that amusic individuals, like controls, found these notes more difficult to evaluate. However, notes with high IC were also characterized by an early frontal negativity in controls that was attenuated in amusic individuals. A correlation of this early negative effect with the ability to make accurate note expectedness judgments (previous data collected from a subset of the current sample) was shown to be present in typical individuals but compromised in individuals with amusia: a finding in line with evidence of a close relationship between the amplitude of such a response and explicit knowledge of musical deviance.

Impaired pitch perception and memory in congenital amusia: the deficit starts in the auditory cortex

Congenital amusia is a lifelong disorder of music perception and production. The present study investigated the cerebral bases of impaired pitch perception and memory in congenital amusia using behavioural measures, magnetoencephalography and voxel-based morphometry. Congenital amusics and matched control subjects performed two melodic tasks (a melodic contour task and an easier transposition task); they had to indicate whether sequences of six tones (presented in pairs) were the same or different. Behavioural data indicated that in comparison with control participants, amusics' short-term memory was impaired for the melodic contour task, but not for the transposition task. The major finding was that pitch processing and short-term memory deficits can be traced down to amusics' early brain responses during encoding of the melodic information. Temporal and frontal generators of the N100m evoked by each note of the melody were abnormally recruited in the amusic brain. Dynamic causal modelling of the N100m further revealed decreased intrinsic connectivity in both auditory cortices, increased lateral connectivity between auditory cortices as well as a decreased right fronto-temporal backward connectivity in amusics relative to control subjects. Abnormal functioning of this fronto-temporal network was also shown during the retention interval and the retrieval of melodic information. In particular, induced gamma oscillations in right frontal areas were decreased in amusics during the retention interval. Using voxel-based morphometry, we confirmed morphological brain anomalies in terms of white and grey matter concentration in the right inferior frontal gyrus and the right superior temporal gyrus in the amusic brain. The convergence between functional and structural brain differences strengthens the hypothesis of abnormalities in the fronto-temporal pathway of the amusic brain. Our data provide first evidence of altered functioning of the auditory cortices during pitch perception and memory in congenital amusia. They further support the hypothesis that in neurodevelopmental disorders impacting high-level functions (here musical abilities), abnormalities in cerebral processing can be observed in early brain responses.

Pitch discrimination without awareness in congenital amusia: Evidence from event-related potentials

Congenital amusia is a lifelong disorder characterized by a difficulty in perceiving and producing music despite normal intelligence and hearing. Behavioral data have indicated that it originates from a deficit in fine-grained pitch discrimination, and is expressed by the absence of a P3b event-related brain response for pitch differences smaller than a semitone and a bigger N2b–P3b brain response for large pitch differences as compared to controls. However, it is still unclear why the amusic brain overreacts to large pitch changes. Furthermore, another electrophysiological study indicates that the amusic brain can respond to changes in melodies as small as a quarter-tone, without awareness, by exhibiting a normal mismatch negativity (MMN) brain response. Here, we re-examine the event-related N2b–P3b components with the aim to clarify the cause of the larger amplitude observed by Peretz, Brattico, and Tervaniemi (2005), by experimentally matching the number of deviants presented to the controls according to the number of deviants detected by amusics. We also re-examine the MMN component as well as the N1 in an acoustical context to investigate further the pitch discrimination deficit underlying congenital amusia. In two separate conditions, namely ignore and attend, we measured the MMN, the N1, the N2b and the P3b to tones that deviated by an eight of a tone (25 cents) or whole tone (200 cents) from a repeated standard tone. The results show a normal MMN, a seemingly normal N1, a normal P3b for the 200 cents pitch deviance, and no P3b for the small 25 cents pitch differences in amusics. These results indicate that the amusic brain responds to small pitch differences at a pre-attentive level of perception, but is unable to detect consciously those same pitch deviances at a later attentive level. The results are consistent with previous MRI and fMRI studies indicating that the auditory cortex of amusic individuals is functioning normally.

Prediction, attention, and unconscious processing in hierarchical auditory perception

Prediction, attention, and unconscious processing in hierarchical auditory perception

Auditory and Cognitive Deficits Associated with Acquired Amusia after Stroke: A Magnetoencephalography and Neuropsychological Follow-Up Study

Acquired amusia is a common disorder after damage to the middle cerebral artery (MCA) territory. However, its neurocognitive mechanisms, especially the relative contribution of perceptual and cognitive factors, are still unclear. We studied cognitive and auditory processing in the amusic brain by performing neuropsychological testing as well as magnetoencephalography (MEG) measurements of frequency and duration discrimination using magnetic mismatch negativity (MMNm) recordings. Fifty-three patients with a left (n = 24) or right (n = 29) hemisphere MCA stroke (MRI verified) were investigated 1 week, 3 months, and 6 months after the stroke. Amusia was evaluated using the Montreal Battery of Evaluation of Amusia (MBEA). We found that amusia caused by right hemisphere damage (RHD), especially to temporal and frontal areas, was more severe than amusia caused by left hemisphere damage (LHD). Furthermore, the severity of amusia was found to correlate with weaker frequency MMNm responses only in amusic RHD patients. Additionally, within the RHD subgroup, the amusic patients who had damage to the auditory cortex (AC) showed worse recovery on the MBEA as well as weaker MMNm responses throughout the 6-month follow-up than the non-amusic patients or the amusic patients without AC damage. Furthermore, the amusic patients both with and without AC damage performed worse than the non-amusic patients on tests of working memory, attention, and cognitive flexibility. These findings suggest domain-general cognitive deficits to be the primary mechanism underlying amusia without AC damage whereas amusia with AC damage is associated with both auditory and cognitive deficits.

The Amusic Brain: Lost in Music, but Not in Space

Congenital amusia is a neurogenetic disorder of music processing that is currently ascribed to a deficit in pitch processing. A recent study challenges this view and claims the disorder might arise as a consequence of a general spatial-processing deficit. Here, we assessed spatial processing abilities in two independent samples of individuals with congenital amusia by using line bisection tasks (Experiment 1) and a mental rotation task (Experiment 2). Both amusics and controls showed the classical spatial effects on bisection performance and on mental rotation performance, and amusics and controls did not differ from each other. These results indicate that the neurocognitive impairment of congenital amusia does not affect the processing of space.

Automatic Brain Responses to Pitch Changes in Congenital Amusia

Congenital amusia is a lifelong disorder affecting the processing of pitch. This pitch deficit can be traced down to abnormal brain responses elicited by pitch changes smaller than a semitone in conditions requiring attention. Here, we use the mismatch negativity (MMN) to investigate pre-attentive pitch change detection in 10 amusics and eight matched controls. Results indicate similar MMN in amusics and controls, even for an eighth of a tone change, revealing that the amusic brain can process small pitch changes at a pre-attentive level. Thus, the pitch deficit in congenital amusia may be related to a problem of perceptual awareness.

The amusic brain: in tune, out of key, and unaware

Like language, music engagement is universal, complex and present early in life. However, approximately 4% of the general population experiences a lifelong deficit in music perception that cannot be explained by hearing loss, brain damage, intellectual deficiencies or lack of exposure. This musical disorder, commonly known as tone-deafness and now termed congenital amusia, affects mostly the melodic pitch dimension. Congenital amusia is hereditary and is associated with abnormal grey and white matter in the auditory cortex and the inferior frontal cortex. In order to relate these anatomical anomalies to the behavioural expression of the disorder, we measured the electrical brain activity of amusic subjects and matched controls while they monitored melodies for the presence of pitch anomalies. Contrary to current reports, we show that the amusic brain can track quarter-tone pitch differences, exhibiting an early right-lateralized negative brain response. This suggests near-normal neural processing of musical pitch incongruities in congenital amusia. It is important because it reveals that the amusic brain is equipped with the essential neural circuitry to perceive fine-grained pitch differences. What distinguishes the amusic from the normal brain is the limited awareness of this ability and the lack of responsiveness to the semitone changes that violate musical keys. These findings suggest that, in the amusic brain, the neural pitch representation cannot make contact with musical pitch knowledge along the auditory-frontal neural pathway.

The amusic brain: In tune, out of key, and unaware

Event Abstract Back to Event The amusic brain: In tune, out of key, and unaware Elvira Brattico1, 2*, Isabelle Peretz3, Miika Järvenpää1, 2 and Mari Tervaniemi1, 2 1 Department of Psychology,University of Helsinki, Finland 2 Department of Music, University of Jyväskylä , Finland 3 BRAMS, Université de Montréal, Canada Music perception and appreciation is universal and it is present early in life. However, for about 4% of the population what others call music is merely disturbing noise. Tone-deafness or congenital amusia, a lifelong disorder of music perception and appreciation, cannot be explained by hearing loss, brain damage, intellectual deficiencies or lack of exposure. Congenital amusia is hereditary and is associated with abnormal grey and white matter in the auditory cortex and the inferior frontal cortex. In order to relate these anatomical anomalies to the behavioral expression of the disorder, we measured the electrical brain activity of amusic subjects and matched controls while they listened to melodies and screened them for the presence of pitch anomalies. Here we show for the first time that the amusic brain can track quarter-tone pitch differences, as reflected from an early right-lateralized brain response. This indicates near-normal neural processing of musical pitch incongruities in congenital amusia. The importance of this finding lies in the revelation of an amusic brain equipped with the essential neural mechanisms to perceive fine-grained pitch differences. What distinguishes the amusic from the normal brain is the absence of awareness of this ability. The study opens avenues for the rehabilitation of congenital amusics, searching for appropriate ways to expose them to music and to allow their implicit melodic pitch perception become explicit. * E. Brattico and I. Peretz are equally contributing authors Conference: Tuning the Brain for Music, Helsinki, Finland, 5 Feb - 6 Feb, 2009. Presentation Type: Oral Presentation Topic: Session Talks Citation: Brattico E, Peretz I, Järvenpää M and Tervaniemi M (2009). The amusic brain: In tune, out of key, and unaware. Conference Abstract: Tuning the Brain for Music. doi: 10.3389/conf.neuro.09.2009.02.004 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Jan 2009; Published Online: 23 Jan 2009. * Correspondence: Elvira Brattico, Department of Psychology,University of Helsinki, Helsinki, Finland, elvira.brattico@clin.au.dk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elvira Brattico Isabelle Peretz Miika Järvenpää Mari Tervaniemi Google Elvira Brattico Isabelle Peretz Miika Järvenpää Mari Tervaniemi Google Scholar Elvira Brattico Isabelle Peretz Miika Järvenpää Mari Tervaniemi PubMed Elvira Brattico Isabelle Peretz Miika Järvenpää Mari Tervaniemi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Cortical Thickness in Congenital Amusia: When Less Is Better Than More

Congenital amusia (or tone deafness) is a lifelong disorder characterized by impairments in the perception and production of music. A previous voxel-based morphometry (VBM) study revealed that amusic individuals had reduced white matter in the right inferior frontal gyrus (IFG) relative to musically intact controls (Hyde et al., 2006). However, this VBM study also revealed associated increases in gray matter in the same right IFG region of amusics. The objective of the present study was to better understand this morphological brain anomaly by way of cortical thickness measures that provide a more specific measure of cortical morphology relative to VBM. We found that amusic subjects (n = 21) have thicker cortex in the right IFG and the right auditory cortex relative to musically intact controls (n = 26). These cortical thickness differences suggest the presence of cortical malformations in the amusic brain, such as abnormal neuronal migration, that may have compromised the normal development of a right frontotemporal pathway.

Morphometry of the amusic brain: a two-site study

Congenital amusia (or tone deafness) is a lifelong disability that prevents otherwise normal-functioning individuals from developing basic musical skills. Behavioural evidence indicates that congenital amusia is due to a severe deficit in pitch processing, but very little is known about the neural correlates of this condition. The objective of the present study was to investigate the structural neural correlates of congenital amusia. To this aim, voxel-based morphometry was used to detect brain anatomical differences in amusic individuals relative to musically intact controls, by analysing T1-weighted magnetic resonance images from two independent samples of subjects. The results were consistent across samples in highlighting a reduction in white matter concentration in the right inferior frontal gyrus of amusic individuals. This anatomical anomaly was correlated with performance on pitch-based musical tasks. The results are consistent with neuroimaging findings implicating right inferior frontal regions in musical pitch encoding and melodic pitch memory. We conceive the present results as a consequence of an impoverished communication in a right-hemisphere-based network involving the inferior frontal cortex and the right auditory cortex. Moreover, the data point to the integrity of white matter tracts in right frontal brain areas as being key in acquiring normal musical competence.