Amplification Mechanism Research Articles

Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum

Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation or plays a permissive role in determining the impact of synaptic weight increase. We use tactile stimulation and electrical activation of parallel fibers to probe intrinsic and synaptic contributions to receptive field plasticity in awake mice during two-photon calcium imaging of cerebellar Purkinje cells. Repetitive activation of both stimuli induced response potentiation that is impaired in mice with selective deficits in either synaptic or intrinsic plasticity. Spatial analysis of calcium signals demonstrated that intrinsic, but not synaptic plasticity, enhances the spread of dendritic parallel fiber response potentiation. Simultaneous dendrite and axon initial segment recordings confirm these dendritic events affect axonal output. Our findings support the hypothesis that intrinsic plasticity provides an amplification mechanism that exerts a permissive control over the impact of long-term potentiation on neuronal responsiveness.

Mechanisms of multi-bandgap inertial amplification applied in metamaterial sandwich plates

The design concept of integrating locally resonant metamaterials with sandwich plates has demonstrated promising prospects in the development of lightweight, load-bearing structures endowed with excellent capabilities for noise and vibration attenuation. However, achieving low-frequency vibration attenuation in the locally resonant metamaterial sandwich plates remains a challenging task that frequently requires the inclusion of additional centralized mass or heavy local resonators. This study proposes a novel multi-bandgap metamaterial sandwich plate with the lever-type inertial amplification mechanism (LIA-MMSP) for achieving the low-frequency vibration attenuation. Compared with the metamaterial sandwich plates incorporating multi-frequency local resonators (LR-MMSP) with equivalent additional mass, the LIA-MMSP exhibits the ability to achieve lower-frequency multiple bandgaps. The theoretical dynamic model is employed to elucidate the underlying mechanism behind the generation of multiple bandgaps at lower frequencies in the LIA-MMSP. The vibration attenuation performances of the LIA-MMSP are analyzed through both the finite element method and experiment study. The effect of various parameters on the vibration transmission characteristics of the LIA-MMSP is studied. The results show that the boundary frequencies of the LIA-MMSP are precisely one of the lever ratios of the LR-MMSP. By altering the lever ratio within the LIA-MMSP, precise fine-tuning and optimization of the low-frequency multiple bandgaps are achievable. When the attached mass is constrained, increasing the lever ratio enables the achievement of lower bandgaps. In addition, as the eigenfrequency of the primary lever-type IA resonator fp and secondary lever-type IA resonator fs decrease, both the first attenuation zone (AZ1) and the second attenuation zone (AZ2) of the LIA-MMSP shift towards lower frequencies. However, as fp decreases, the width of AZ1 expands, and the minimum accelerations within the AZs decrease even further. Moreover, a normalized comparison provides validation of the exceptional performance of the proposed LIA-MMSP in terms of lightweight design, as well as its ability to achieve low-frequency broadband vibration attenuation.

Seismic vulnerability analysis of a high‐rise steel frame structure equipped with novel displacement‐amplified viscoelastic dampers

SummaryThe energy dissipation capacity of conventional viscoelastic dampers (VEDs) cannot be fully exerted due to the relatively small inter‐story displacement of building structures. Thus, a novel VED with a displacement amplification mechanism based on the lever principle is developed in this study to achieve small displacement but high energy dissipation ability. First, the structural layout of an amplified viscoelastic damper (AVED) system is briefly introduced, and then the displacement amplification effect is described in detail. According to the working principle of the AVED and the relationship of force and geometric displacement in an actual frame structure, the restoring force theoretical formula of the corresponding amplified damper is derived. Based on the restoring force of the AVED and in combination with the secondary development function of the ABAQUS unit, a VUEL subroutine suitable for the explicit algorithm is programmed with the FORTRAN language. Then, the correctness of the subroutine is verified through a comparative analysis of the ABAQUS simulation and theoretically calculated results. Consequently, the vulnerability analysis of a high‐rise steel frame structure is conducted by using the incremental dynamic analysis (IDA) method, and the influence of the AVED on the seismic performance of the steel frame structure is quantitatively analyzed from the perspective of probability statistics. The analysis results show that compared with the VED structure, the failure probability of the AVED‐2 and AVED‐3 structures reaching the ultimate failure state at all levels is reduced by approximately 43% and 57%, respectively, and the collapse margin ratio (CMR) of structures under large earthquakes is increased by approximately 35% and 68%, respectively. This indicates that the AVED structures with displacement‐amplified dampers have a better effect on the seismic stability of tall steel frame structures under random seismic excitations. This study aims to provide comprehensive information for the seismic‐resistant design of tall buildings in earthquake‐prone regions.

Optical amplification across the whole communication windows in PbS quantum-dot-doped fiber

The surge of big data, cloud computing, and AI bring in explosive requirement of data transmission capacities. However, the transmission capacity of traditional single-mode-fiber already reaches its limit due to the narrow emission bandwidth of rare-earth-ion. Here, we achieved ultra-broadband optical amplification in O + E + S + C + L bands for the first time in PbS quantum-dot-doped glass fiber with the maximum gain of 5 dB at 1370 nm under 100 mW pump. The mechanism of the broadband optical amplification, the advantages of quantum dot-doped fiber amplifier (QDFA), and a new measurement scheme for QDFA are systematically discussed. It is believed that in the future, the further optimization of the composition and architectures of the glass fiber, and the preparation method of quantum dot-doped fiber may lead to important applications in optical interconnection, artificial intelligence, Internet of things, mobile electronics and so on.

Quantum Dot‐Doped Optical Fibers

AbstractGain medium‐doped active optical fibers for optical amplification and long‐range transmission have triggered a lot of researches. Traditional rare‐earth ion‐doped active fibers have non‐adjustable emissions, narrow band luminescence, limited gain enhancement, and other challenges. The unique optical properties of quantum dots (QDs) can further improve the doped optical fibers in the light amplification capacity, temperature sensitivity and to gain a broad‐spectrum coverage and lower laser threshold and other superiorities. However, there are few systematic discussions on the development of the technologies and applications of those QD‐doped optical fibers. In this review, the optical properties, temperature characteristics and optical amplification mechanisms of QD‐doped optical fibers are outlined. Then, the preparation technologies and the applications of QD‐doped optical fibers are highlighted. Additionally, the existing challenges and future development prospects of QD‐doped optical fibers are discussed.

Low-frequency broadband vibration isolation study of inertial amplification Meta-lattice sandwich structure

In the pursuit of excellent mechanical properties, the realization of lightweight structure has attracted great attention from researchers in recent years. To reduce the mass of structures while providing them with low-frequency, broadband vibration damping and multifunctional integration capabilities, this paper presents the use of a Meta-lattice sandwich structure designed using the inertial amplification mechanism. By utilizing a combination of Bloch boundary conditions and the finite element method, we calculated the band gap of the metamaterial structure through finite element software. Afterwards, we examined the impact of the internal structural dimensions and the angle of the internal core truss on the bandgap of the metamaterial structure, as well as their effects on the load-bearing performance. The results demonstrate that the implementation of the concept of inertial amplification achieves low-frequency broadband vibration damping while decreasing the overall mass of the structure, while also retaining good load-bearing performance.

Design and Testing of a Compliant ZTTΘ Positional Adjustment System with Hybrid Amplification.

This article presents the design, analysis, and prototype testing of a four-degrees-of-freedom (4-DoFs) spatial pose adjustment system (SPAS) that achieves high-precision positioning with 4-DoFs (Z/Tip/Tilt/Θ). The system employs a piezoelectric-driven amplification mechanism that combines a bridge lever hybrid amplification mechanism, a double four-bar guide mechanism, and a multi-level lever symmetric rotation mechanism. By integrating these mechanisms, the system achieves low coupling, high stiffness, and wide stroke range. Analytical modeling and finite element analysis are employed to optimize geometric parameters. A prototype is fabricated, and its performance is verified through testing. The results indicate that the Z-direction feed microstroke is 327.37 μm, the yaw motion angle around the X and Y axes is 3.462 mrad, and the rotation motion angle around the Z axis is 12.684 mrad. The x-axis and y-axis motion magnification ratio can reach 7.43. Closed-loop decoupling control experiments for multiple-input-multiple-outputs (MIMO) systems using inverse kinematics and proportional-integral-derivative feedback controllers were conducted. The results show that the Z-direction positioning accuracy is ±100 nm, the X and Y axis yaw motion accuracy is ±2 μrad, and the Z-axis rotation accuracy is ±25 μrad. Due to the ZTTΘ mechanism, the design proved to be feasible and advantageous, demonstrating its potential for precision machining and micro-nano manipulation.

Lightweight Periodic Vibration Isolator Design via Compliant Inertial Amplification Mechanisms with Stiffness Maximized Topologies

Lightweight Periodic Vibration Isolator Design via Compliant Inertial Amplification Mechanisms with Stiffness Maximized Topologies

Design and analysis of novel microelectromechanical system based microgripper for manipulating microbiological species and micro objects

Design and analysis of a pair of novel microelectromechanical system (MEMS) microgrippers having single and multiple sets of jaws respectively, incorporated with displacement amplification mechanism and electrostatic force sensor is presented in this research work. The novelty of the proposed microgrippers is their unique and efficient designs, having the versatility of gripping ranges. The size of the microgripper is 3.2 × 3.7 mm2 in both cases and has one and three sets of jaws with gripping ranges of 30–64 µm, 175–200 µm, and 350–380 µm respectively. The three jaw sets are application-specific to the multicellular small organism, eukaryotic cells, and microcells, respectively. The microgrippers are being actuated by an optimized V-shaped thermal chevron actuator whose input is amplified by using a pantograph displacement amplification mechanism with an amplification factor of 54. The force applied to the gripping object is sensed by a rotary comb electrostatic force sensor. Special attention has been paid to the structural design, and detailed stress analysis has been discussed. This research work includes static, electrostatic, parametric, and electrothermal analysis carried out using Finite Element Method (FEM) techniques and analytical modeling. The results show that the operating voltage range of the devices is from 4 to 9.25 V, having a maximum operational temperature of 380 °C with a factor of safety of 1.026. The maximum capacitance change with the full operational range of microgrippers is 0.63 µf, having a capacitive sensitivity of 19.6 nf/µm. The microgrippers can be used as an instrument to grip not only the microbiological species but also can be beneficial to carry out manipulations at the micro-level like micro-assembly. The proposed microgripper has a substantial structural stability, has a high amplification factor and accommodates manipulation of a wide range of microorganism.

Design, analysis, and experimental investigations of an asymmetrical under-actuated micro-gripper

In this paper, we present a new asymmetrical under-actuated micro-gripper which can perform twisting and gripping operation to the target simultaneously actuated by a single piezoelectric actuator. Two improved hybrid amplification mechanisms were designed integrated with three different flexure hinges to enhance dynamic performances. Kinematics and dynamics models of the micro-gripper including input stiffness, displacement amplification ratio, and natural frequency based on pseudo-rigid-body method and Lagrange’s equations were derived. Proposed models were evaluated by finite element simulation studies. Experimental results shown that our designed micro-gripper possesses good performance in terms of clamping reliability and dynamic response.

Negative refraction of elastic waves in two-dimensional inertial amplification metamaterials

Tailoring wave behaviors governed by dispersion relations is a huge challenge in wave manipulation. Inertial amplification (IA) mechanism has been introduced in metamaterials and phononic crystals to obtain a low-frequency bandgap without adding mass to the system. In this work, we demonstrate unique wave propagation behaviors in two-dimensional inertial amplification metamaterials (2D IAMs). Through analytical derivations and numerical simulations, negative refraction and refractive steering of elastic waves are realized with the IA mechanism. The positive (negative) inertia of the system can be tuned by the IA angle, which determines whether the passband of the lattice is positive (negative) group velocity. By analyzing the dispersion relations of the 2D IAMs, we find that the IA angle 45° is the critical point where the group velocity flips. Negative refraction occurs at the interface between two lattices, which have opposite signs of group velocity. We can also achieve a wide range of angles for wave steering in the system. The normalized displacement fields of 2D IAMs are measured via harmonic excitation. We believe that the research results may inspire the design of ‘elastic lenses’ and multifunctional metamaterial devices.

Sensitive sandwich-type electrochemical biosensor with gold nanoparticles and enzyme catalytic amplification for specific detection of MicroRNA-26a

A high sensitive sandwich-type electrochemical biosensor utilizing capture probe (CP), target probe (TP), and signal probe (SP) was first developed for specific detection of microRNA-26a (miR-26a), a biomarker with diagnostic significance for atherosclerosis. In general, gold nanoparticles (Au NPs) were electrodeposited on to a glassy carbon electrode to enhance conductivity, followed by immobilization of 5′-thiolated CP through a gold-sulfur bond. Subsequently, the modified electrode was hybridized with the mixture of miR-26a and 3′-biotin-tagged SP in sequence. Furthermore, horseradish peroxidase-streptavidin (HRP) with potent reducing capability was finally grafted on the SP via the strong affinity between biotin and streptavidin. Additionally, the fabrication process of the miR-26a biosensor was thoroughly investigated. Based on the dual amplification mechanism facilitated by Au NPs and HRP-catalytic activity, the proposed biosensor demonstrated outstanding electrochemical properties, including good reproducibility and stability, as well as high sensitivity for miR-26a detection down to 0.88 fM with a linear range from 1 fM to 1 nM. The biosensor also displayed exact specificity, which could discriminate miR-26a from a range of base mismatched microRNAs. Moreover, it was successfully applied to the determination of miR-26a in serum samples. In conclusion, given the excellent analytical performance, this biosensor shows promise for potential use in clinical diagnostics for atherosclerosis.

Development, modeling and analysis of a differential lever-bridge amplification mechanism

The displacement amplification mechanism is commonly utilized in micro/nano-manipulating systems to enhance the output stroke of piezoelectric actuators. Aiming at large amplification ratio, this paper proposes a symmetrical dual-stage amplification mechanism consisting of a differential lever mechanism and a half-bridge mechanism. With consideration of the coupling effect between the dual-stage amplification mechanism, a kinematic modeling method is developed for the symmetrical differential lever-bridge hybrid (SDLBH) mechanism on top of the static balance and constraint conditions of the branch chain. In particular, the force-deformation relationship of the flexible hinge is derived according to the flexibility matrix method. Based on the path constraint conditions of the branch chain, the static equilibrium equation as well as the displacement constraint conditions are obtained. Consequently, the input-output model of the SDLBH mechanism is established, which is capable of accurately predicting the amplification ratio and the mechanical stiffness. Finite element simulations and real time experiments on the SDLBH prototype effectively validate the mechanical performance as well as the accuracy of proposed modeling method. The performance sensitivity of the developed SDLBH mechanism is further analyzed by the Taguchi method, aiming to offer the optimization guideline for real applications.

Chiral Transfer and Evolution in Cysteine Induced Cobalt Superstructures.

Chiral organic additives have unveiled the extraordinary capacity to form chiral inorganic superstructures, however, complex hierarchical structures have hindered the understanding of chiral transfer and growth mechanisms. This study introduces a simple hydrothermal synthesis method for constructing chiral cobalt superstructures with cysteine, demonstrating specific recognition of chiral molecules and outstanding electrocatalytic activity. The mild preparation conditions allow in situ tracking of chirality evolution in the chiral cobalt superstructure, offering unprecedented insights into the chiral transfer and amplification mechanism. The resulting superstructures exhibit a universal formation process applicable to other metal oxides, extending the understanding of chiral superstructure evolution. This work contributes not only to the fundamental understanding of chirality in self-assembled structures but also provides a versatile method for designing chiral inorganic nanomaterials with remarkable molecular recognition and electrocatalytic capabilities.

Large post-liquefaction deformation of sand: Mechanisms and modeling considering water absorption in shearing and seismic wave conditions

Large deformation of sand due to soil liquefaction is a major cause for seismic damage. In this study, the mechanisms and modeling of large post-liquefaction deformation of sand considering the significant influence of water absorption in shearing and seismic wave conditions. Assessment of case histories from past earthquakes and review of existing studies highlight the importance of the two factors. Based on the micro and macro scale mechanisms for post-liquefaction shear deformation, the mechanism for water absorption in shearing after initial liquefaction is revealed. This is aided by novel designed constant water-absorption-rate shear tests. Water absorption in shearing can be classified into three types, including partial water absorption, complete water absorption, and compulsory water absorption. Under the influence of water absorption in shearing, even a strongly dilative sand under naturally drained conditions could experience instability and large shear deformation. The mechanism for amplification of post-liquefaction deformation under surface wave load is also explained via element tests and theoretical analysis. This shows that surface wave–shear wave coupling can induce asymmetrical force and resistance in sand, resulting in asymmetrical accumulation of deformation, which is amplified by liquefaction. A constitutive model, referred to as CycLiq, is formulated to capture the large deformation of sand considering water absorption in shearing and seismic wave conditions, along with its numerical implementation algorithm. The model is comprehensively calibrated based on various types of element tests and validated against centrifuge shaking table tests in the liquefaction experiments and analysis projects (LEAP). The model, along with various numerical analysis methods, is adopted in the successful simulation of water absorption in shearing and Rayleigh wave-shear wave coupling induced large liquefaction deformation. Furthermore, the model is applied to high-performance simulation for large-scale soil-structure interaction in liquefiable ground, including underground structures, dams, quay walls, and offshore wind turbines.

Computational Modeling of Extrasynaptic NMDA Receptors: Insights into Dendritic Signal Amplification Mechanisms.

Dendritic structures play a pivotal role in the computational processes occurring within neurons. Signal propagation along dendrites relies on both passive conduction and active processes related to voltage-dependent ion channels. Among these channels, extrasynaptic N-methyl-D-aspartate channels (exNMDA) emerge as a significant contributor. Prior studies have mainly concentrated on interactions between synapses and nearby exNMDA (100 nm-10 µm from synapse), activated by presynaptic membrane glutamate. This study concentrates on the correlation between synaptic inputs and distal exNMDA (>100 µm), organized in clusters that function as signal amplifiers. Employing a computational model of a dendrite, we elucidate the mechanism underlying signal amplification in exNMDA clusters. Our findings underscore the pivotal role of the optimal spatial positioning of the NMDA cluster in determining signal amplification efficiency. Additionally, we demonstrate that exNMDA subunits characterized by a large conduction decay constant. Specifically, NR2B subunits exhibit enhanced effectiveness in signal amplification compared to subunits with steeper conduction decay. This investigation extends our understanding of dendritic computational processes by emphasizing the significance of distant exNMDA clusters as potent signal amplifiers. The implications of our computational model shed light on the spatial considerations and subunit characteristics that govern the efficiency of signal amplification in dendritic structures, offering valuable insights for future studies in neurobiology and computational neuroscience.

Plasmonic tuning of nano-antennas for super-gain light amplification

Nanoscale conductive materials are often used for inducing localized free electron oscillations known as plasmons. This is due to their high electronic excitability under optical irradiation owing to their super-small volume. Recently, plasmons have been of interest for enhancing the gain-bandwidth product of optical amplifiers. There are currently two well-established mechanisms for light amplification. The first one is via stimulated emission of radiation (lasers) using a given energy source and often an optical feedback mechanism. The second one is based on the nonlinear coupling of a low-intensity input wave and a high-intensity pump wave for energy exchange (parametric amplifiers). Both techniques have shortcomings. Lasers have a small operation bandwidth and offer a limited gain, but require moderate energy pumping to operate. Whereas optical parametric amplifiers (OPAs) offer a high operation bandwidth along with a much higher optical gain, with the drawback of requiring intense pumping to be functional. The aim of this paper is to introduce a technique that combines the advantages and eliminates the drawbacks of both techniques in the nanoscale to allow for a better amplification performance in integrated optical devices. This is achieved by inducing a plasmonic chirp in conductive nanomaterials a.k.a nano-antennas, which enables the confinement of an enormous electric energy density that can be coupled to an input beam for amplification. Using the Finite Difference Time Domain numerical-method with the material parameters of well-known semiconductors, intramaterial condensation of electric energy density is observed in semiconductor nano-antennas for certain plasmonic chirp-frequencies which enables broadband high-gain optical amplification based on free-electron oscillations that is promising for small-scale optical devices requiring a high gain-bandwidth product. The results are in good agreement with semiempirical data.

Bus Riding as Amplification Mechanism for SARS-CoV-2 Transmission, Germany, 20211.

To examine the risk associated with bus riding and identify transmission chains, we investigated a COVID-19 outbreak in Germany in 2021 that involved index case-patients among bus-riding students. We used routine surveillance data, performed laboratory analyses, interviewed case-patients, and conducted a cohort study. We identified 191 case-patients, 65 (34%) of whom were elementary schoolchildren. A phylogenetically unique strain and epidemiologic analyses provided a link between air travelers and cases among bus company staff, schoolchildren, other bus passengers, and their respective household members. The attack rate among bus-riding children at 1 school was ≈4 times higher than among children not taking a bus to that school. The outbreak exemplifies how an airborne agent may be transmitted effectively through (multiple) short (<20 minutes) public transport journeys and may rapidly affect many persons.

Design and Control of a Flexure-Based Dual Stage Piezoelectric Micropositioner

In the field of advanced manufacturing technology, there is a growing need for high-precision micro/nano positioners. The traditional single stage actuated positioners have encountered performance limitation in achieving longer travel range and higher precision. This motivates us to develop a novel dual stage piezoelectric-actuated micropositioner presented in this paper. The micropositioner incorporates displacement amplification mechanisms to overcome the limited range of piezoelectric actuators. Design considerations such as flexure characteristics and material selection are discussed, and structural analysis is performed using finite element analysis (FEA). For precise positioning, the dual stage control strategy is investigated and compared with the conventional proportional-integral-derivative (PID) single stage control method. In the proposed positioner, a combination of parallelogram and bridge mechanisms is utilized. The bridge mechanism works to amplify the piezoelectric actuator displacement output. The parallelogram mechanism, integrated within the system, helps mitigate resonance modes and contributes to the achievement of linearized motion. The characteristics of the micropositioner were evaluated using analytical modelling and FEA. Multiple analysis was used to optimise the positioner’s design parameters. Furthermore, experimental studies were carried out to validate the characteristics of the micropositioner performance in terms of achievable output travel range and sustained positioning accuracy.

Above-77 K operation of charge sensitive infrared phototransistor with dynamically controlled optical gate

Charge sensitive infrared phototransistors (CSIPs) show great promise for sensitive mid-infrared photodetection, extending up to single-photon counting, owing to the built-in amplification mechanism. However, the operating temperature of previously reported CSIPs has been limited to below 30 K. In this work, we propose a technique that enhances the operating temperature to above liquid nitrogen temperature by dynamically controlling the electrostatic potential of the optical floating gate (FG). This control effectively suppresses the annihilation of photogenerated holes in the FG, mitigating the vertical recombination process of thermally excited electrons. We detected the photosignal up to ∼85 K under a photon flux of Φ∼3.6×108 s−1. An outstanding photoresponsivity (R=39.11 A/W) to external blinking light at the peak wavelength of λ=11μm is achieved at 77 K. Our work not only extends the practical application of CSIPs, meeting the high demand for high temperature operation, but also offers more flexibility in fabricating more general highly sensitive phototransistors.