For sake of enhancing dependability and broadening application of medical packing glass, this work is designed to develop a new-type aluminoborosilicate neutral glass and optimize its main performances by adjusting CaO, BaO and ZnO amounts. Based on X-ray photoelectron spectroscopy, infrared spectroscopy, nuclear magnetic resonance and performances analysis, the different effects of BaO, CaO and ZnO were interpreted. The partial replacing BaO with CaO facilitated formation of [AlO4] and thermal stability, while entirely substitution of CaO impaired the Si group network connectivity and chemical stability. The ZnO was testified as a weak network former which reversely hindered [BO4] and [AlO4] formations, and boosted the water resistance specifically. In summary, a series of neutral glasses fulfilled requirements for medical packing material was prepared, and improved thermal and chemical properties were obtained whilst BaO/CaO mixed ratio reached about 0.8; the ZnO bearing glasses showed higher water resistance but faintly weaker thermal and partial chemical performances.